Ciprian N. Ionita PhD

Ciprian Ionita

Ciprian N. Ionita
PhD

Assistant Professor

Department of Biomedical Engineering

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Cardiovascular Disease; Diagnostic Radiology; Neuroradiology - Radiology; Radiological Physics; Vascular and Interventional Radiology; Vision science

Contact Information
8052 Clinical Translational Research Center
875 Ellicott Street
N/A
Buffalo, NY 14203
Phone: (716) 400-4283
cnionita@buffalo.edu



Professional Summary:

I am an Assistant Professor with a dual appointment in the Biomedical Engineering Department and Neurosurgery. I am the director of the Endovascular Devices and Imaging lab at Canon (former Toshiba) Stroke and Vascular Research Center. My research career focuses on improvement of endovascular image guided interventions and encompasses three major components: medical imaging, computer programming and endovascular device development.
The greatest breakthrough of my team in the last three years is the development of complex 3D printed (3DP) vascular patient specific phantoms based on 3D imaging. Using my previous experience in developing CT reconstruction algorithms and 3D data analysis, this step came naturally. We are using these phantoms to test devices and validate software such as CT-FRR, parametric imaging and material decomposition using spectral CT. The 3DP phantoms we develop are probably some of the most complex reported in literature. We created new tools for 3D mesh manipulation and workflow to build complex vascular trees, which maintain vessel down to 400 microns diameter. My team collaborates directly with 3D printing industry and engineers in academy, to optimize the 3DP materials and match tissue mechanical properties. As center of excellence for 3D printing, we contribute to identification of new clinical applications for the 3DP technology, 3DP material development, and testing, and software development.
One of the challenges my team is tackling, is the 3D printing material and 3D design optimization to build structures with controlled mechanical properties. In the last two years, my research focused on how to use the 3D printing technology to create digital structures which can simulate mechanical properties of vascular tissue, vascular networks and arterial disease. My effort is directed toward developing methods to warp 3D structures and embed them within the arterial wall. The embedded structures could be printed with different materials to different mechanical properties. This approach will allow optimization of phantom physical properties which match those of the arteries. Thus, by combining the 3D design with the new polymers used for the 3D printing while maintaining the patient specific geometry, I plan to develop a vascular model which will behave and react identical as a human vessel, both healthy and diseased.
On a secondary effort on 3DP, my team is involved in developing implantable devices; we are collaborating with metal printing industries in testing methods to develop 3DP patient specific devices. We are able to reproduce coronary stents, which match the physical size/geometry of those used in current practice. However, mechanical and corrosion aspects need more investigations. In this context, I believe that additive manufacturing can be another path towards personalized medicine, by allowing manufacturing of patient specific devices rather than one size fits all kind of approach used by current device manufacturers.
Concerning my involvement in the scientific community, in the last two years, I became deeply involved with the effort to implement the new advances of 3D printing into a clinical setting. I have given presentations and symposiums at conferences such as RSNA where I emphasized the new additive manufacturing advances and the close relation with the 3D medical imaging. The new digital material technologies, the improved resolution and fast building time make this technology practical for the high pace workflow in the hospitals. As of now I am involved with Special Interest Group from RSNA for standardization of 3DP printing operations in hospitals and development of a DICOM standard associated with the workflow and manufacturing of 3D printed medical objects.

Education and Training:

  • BS, Applied Nuclear Physics, University of Bucharest, Engineer (5)
  • PhD, Medical Physics, SUNY at Buffalo, PhD (2005)

Employment:

  • Faculty, Biomedical Engineering, SUNY at Buffalo (2014-present)

Awards and Honors:

  • Cum Laude (2015)
  • Honorable Mention (2009)
  • Educational Poster Award (2002)

Research Expertise:

  • 3D Printing
  • Computed Tomography and Micro-Computed Tomography
  • Endovascular Devices
  • Vascular Disease Diagnosis and Modeling

Grants and Sponsored Research:

  • August 2012–July 2016
    Microangiographic guidance of flow modifying stents - renewal
    NIH
    Role: Co-Investigator
    $2,526,475

Patents:

  • X-ray diagnostic apparatus and medical image processing method An X ray diagnostic apparatus includes an X ray tube generating X rays, a first detector detecting the X rays, at least one second detector arranged in front of a first detection surface of the first detector and including a second detection surface narrower than the first detection surface and indicator points provided on a rear surface of the second detection surface, a projection data generation unit generating first projection data based on an output from the first detector, and a positional shift detection unit detecting a positional shift of the second detector relative to the first detector in accordance with an imaging direction by using the first projection data and a predetermined positional relationship between the points and detection elements in the second detector. (2017)

Journal Articles:

See all (25 more)

Evaluative Studies and Case Reports:


Professional Memberships:

  • American Association of Phycists in Medicine (2003–present)
  • SPIE (2003–present)

Service Activities:

  • Past President: Upstate New York Association of Physicist in Medicine; 01/2013- 12/2013 President Elect: Upstate New York Association of Physicist in Medicine (UNYAPM) a chapter of the American Association of Physicist in Medicine; Past President (2015)
  • President: Upstate New York Association of Physicist in Medicine; President: Upstate New York Association of Physicist in Medicine; President (2013–2014)
  • Reviewer: American Association of Physicists in Medicine meetings; Reviewer: Medical Physics,AAPM meetings , Physics in Medicine and Biology (PMB), Biomechanics and Modeling in Mechanobiology, American Journal of Neuroradiology (AJNR).; Peer Reviewer (2010–present)
  • Treasurer: Upstate New York Association of Physicist in Medicine; 01/2009-12/2011 Treasurer: Upstate New York Association of Physicist in Medicine (UNYAPM) a chapter of the American Association of Physicist in Medicine.; Treasurer (2009–2011)
  • Reviewer: Physics in Medicine and Biology; Reviewer: Medical Physics,AAPM meetings , Physics in Medicine and Biology (PMB), Biomechanics and Modeling in Mechanobiology, American Journal of Neuroradiology (AJNR).; Peer Reviewer (2004–present)
  • Reviewer: Medical Physics; Peer Reviewer (2004–present)

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Contact Information

8052 Clinical Translational Research Center
875 Ellicott Street
N/A
Buffalo, NY 14203
Phone: (716) 400-4283
cnionita@buffalo.edu