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Edmund                         Egan

Edmund A. Egan II, MD

Department of Pediatrics


Professional Summary:

My research interests are as follows:
Clinical: lung surfactant for hyaline membrane disease (respiratory distress syndrome); prevention of neonatal necrotozing enterocolitis; investigations of congenital viral infections; causes of hypoxemia in neonatal patients and effects of obstetric strategies and neonatal care on the ultimate outcome of pregnancy; social effects of perinatal care.

Basic research: mechanisms for the absorption of fetal lung liquid at birth; alveolar epithelial solute permeability in the fetus, the newborn, normal adults and in the pulmonary edema; effects of the physical inflation status of the lung on lung epithelial solute permeability and water balance; effectiveness of exogenous surfactants in premature lungs; development of the reactivity of lung vascular to oxygen tensions during gestation; factors important in the development of primary pulmonary hypertension in newborn animals; pathophysiology of lung oxygen toxicity.

  • Assistant Professor, Pediatrics, University of Florida, College of Medicine
  • Associate Professor, Pediatrics, University of Florida, College of Medicine
  • Associate Professor, Pediatrics, University at Buffalo
  • Assistant Professor, Physiology, University at Buffalo
  • Associate Professor, Physiology, University at Buffalo
  • Professor, Pediatrics, University at Buffalo

Journal Articles:
  • Notter RH, Wang Z, Egan EA, Holm BA. Component-specific surface and physiological activity in bovine-derived lung surfactants.. Chem Phys Lipids. 2002; 114(1).
  • Egan EA, Solomon MJ. Cyclin-stimulated binding of Cks proteins to cyclin-dependent kinases.. Mol Cell Biol. 1998; 18(7).
  • Holm BA, Wang Z, Egan EA, Notter RH. Content of dipalmitoyl phosphatidylcholine in lung surfactant: ramifications for surface activity.. Pediatr Res. 1996; 39(5).
  • O‘Toole SJ, Karamanoukian HL, Morin FC, Holm BA, Egan EA, Azizkhan RG, Glick PL. Surfactant Decreases the Pulmonary Vascular Resistance and Increases Pulmonary Blood Flow in the Fetal Lamb Model of CDH.. J Pediatr Surg. 1996; 31(4).
  • Hudak ML, Farrell EE, Rosenberg AA, Jung AL, Auten RL, Durand DJ, Horgan MJ, Buckwald S, Belcastro MR, Donohue PK, Carrion V, Maniscalco WW, Balsan MJ, Torres BA, Miller RR, Jansen RD, Graeber JE, Laskay KM, Matteson EJ, Egan EA, Brody AS, Martin DJ, Riddlesberger MM, Montgomery P. A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome. J Pediatr. 1996; 128(3).
  • Hudak BB, Egan EA. Impact of lung surfactant therapy on chronic lung diseases in premature infants.. Clin Perinatol. 1992; 19(3).
  • Glick PL, Leach CL, Besner GE, Egan EA, Morin FC, Malanowska-Kantoch A, Robinson LK, Brody A, Lele AS, McDonnell M. Pathophysiology of congenital diaphragmatic hernia. III: Exogenous surfactant therapy for the high-risk neonate with CDH. J Pediatr Surg. 1992; 27(7).
  • Morin FC, Egan EA. Pulmonary hemodynamics in fetal lambs during development at normal and increased oxygen tension.. J Appl Physiol. 1992; 73(1).
  • Cummings JJ, Holm BA, Hudak ML, Hudak BB, Ferguson WH, Egan EA. A controlled clinical comparison of four different surfactant preparations in surfactant-deficient preterm lambs.. Am Rev Respir Dis. 1992; 145(5).
  • Carrion V, Egan EA. Prevention of neonatal necrotizing enterocolitis. J Pediatr Gastroenterol Nutr. 1990; 11(3).
  • Kwong MS, Holm BA, Egan EA. Use of surfactant in the delivery room.. Clin Perinatol. 1989; 16(4).
  • Morin FC, Egan EA. The effect of closing the ductus arteriosus on the pulmonary circulation of the fetal sheep.. J Dev Physiol. 1989; 11(5).
  • Morin FC, Egan EA, Norfleet WT. Indomethacin does not diminish the pulmonary vascular response of the fetus to increased oxygen tension.. Pediatr Res. 1988; 24(6).
  • Morin FC, Egan EA, Lundgren CE, Swartz DD. Prostacyclin does not change during an oxygen induced increase in pulmonary blood flow in the fetal lamb.. Prostaglandins Leukot Essent Fatty Acids. 1988; 32(3).
  • Morin FC, Egan EA, Ferguson W, Lundgren CE. Development of pulmonary vascular response to oxygen.. Am J Physiol. 1988; 254(3 Pt).
  • Kwong MS, Egan EA. Reduced incidence of hyaline membrane disease in extremely premature infants following delay of delivery in mother with preterm labor: use of ritodrine and betamethasone.. Pediatrics. 1986; 78(5).
  • Kwong MS, Egan EA, Ferguson W. Rabbit tissue composition: developmental aspects of tissue fluid and fractional exclusion of albumin.. Microvasc Res. 1986; 31(3).
  • Notter RH, Egan EA, Kwong MS, Holm BA, Shapiro DL. Lung surfactant replacement in premature lambs with extracted lipids from bovine lung lavage: effects of dose, dispersion technique, and gestational age.. Pediatr Res. 1985; 19(6).
  • Kwong MS, Egan EA. Validation of [57Co]cyanocobalamin as an extracellular fluid marker and measurement of albumin exclusion from the interstitium in the rabbit.. Microvasc Res. 1985; 29(2).
  • Matalon S, Egan EA. Interstitial fluid volumes and albumin spaces in pulmonary oxygen toxicity.. J Appl Physiol. 1984; 57(6).
  • Buckwald S, Zorn WA, Egan EA. Mortality and follow-up data for neonates weighing 500 to 800 g at birth.. Am J Dis Child. 1984; 138(8).
  • Egan EA, Dillon WP, Zorn S. Fetal lung liquid absorption and alveolar epithelial solute permeability in surfactant deficient, breathing fetal lambs.. Pediatr Res. 1984; 18(6).
  • Egan EA, Notter RH, Kwong MS, Shapiro DL. Natural and artificial lung surfactant replacement therapy in premature lambs.. J Appl Physiol. 1983; 55(3).
  • Egan EA. Fluid balance in the air filled alveolar space.. Am Rev Respir Dis. 1983; 127(5 Pt).
  • Egan EA. Lung inflation, lung solute permeability, and alveolar edema.. J Appl Physiol. 1982; 53(1).
  • Dillon WP, Egan EA. Aggressive obstetric management in late second-trimester deliveries.. Obstet Gynecol. 1981; 58(6).
  • Matalon S, Egan EA. Effects of 100% O2 breathing on permeability of alveolar epithelium to solute.. J Appl Physiol. 1981; 50(4).
  • Egan EA. Response of alveolar epithelial solute permeability to changes in lung inflation.. J Appl Physiol. 1980; 49(6).
  • Egan EA, Nelson RM, Beale EF. Lung solute permeability and lung liquid absorption in premature ventilated fetal goats.. Pediatr Res. 1980; 14(4 Pt).
  • Leal J, Walker D, Egan EA. Idiopathic priapism in the newborn.. J Urol. 1978; 120(3).
  • Nelson RM, McIntyre BR, Egan EA. Solute permeability of the alveolar epithelium in alloxan edema in dogs.. J Appl Physiol. 1978; 44(3).
  • Nelson RM, Bucciarelli RL, Eitzman DV, Egan EA, Gessner IH. Serum creatine phosphokinase MB fraction in newborns with transient tricuspid insufficiency.. N Engl J Med. 1978; 298(3).
  • Nelson RM, Egan EA, Eitzman DV. Increased hypoxemia in neonates secondary to the use of continuous positive airway pressure.. J Pediatr. 1977; 91(1).
  • Egan EA, Nelson RM, Gessner IH. Solute permeability of the alveolar epithelium in acute hemodynamic pulmonary edema in dogs.. Am J Physiol. 1977; 233(1).
  • Bucciarelli RL, Nelson RM, Egan EA, Eitzman DV, Gessner IH. Transient tricuspid insufficiency of the newborn: a form of myocardial dysfunction in stressed newborns.. Pediatrics. 1977; 59(3).
  • Egan EA, Hessler JR. Positive end expiratory pressure (PEEP) and right to left shunting in immature goats.. Pediatr Res. 1976; 10(11).
  • Egan EA, Nelson RM, Olver RE. Lung inflation and alveolar permeability to non-electrolytes in the adult sheep in vivo.. J Physiol. 1976; 260(2).
  • Bucciarelli RL, Egan EA, Gessner IH, Eitzman DV. Persistence of fetal cardiopulmonary circulation: one manifestation of transient tachypnea of the newborn.. Pediatrics. 1976; 58(2).
  • Egan EA, Boothby RJ, Prather EC. Florida's regional neonatal intensive care program--impact on mental retardation.. J Fla Med Assoc. 1975; 62(11).
  • Egan EA, Olver RE, Strang LB. Changes in non-electrolyte permeability of alveoli and the absorption of lung liquid at the start of breathing in the lamb.. J Physiol. 1975; 244(1).
  • Egan EA. Use and impact of neonatal intensive care in a nonreferral hospital.. South Med J. 1974; 67(5).
  • Doolittle WM, Ohmart D, Egan EA. Congenital bilateral pleural effusions. A cause for respiratory failure in the newborn.. Am J Dis Child. 1973; 125(3).
  • Monif GR, Egan EA, Held B, Eitzman DV. The correlation of maternal cytomegalovirus infection during varying stages in gestation with neonatal involvement.. J Pediatr. 1972; 80(1).
  • Egan EA, Eitzman DV. Umbilical vessel catheterization.. Am J Dis Child. 1971; 121(3).
  • Egan EA, Julius RL, Gessner IH. Neonatal hyperbilirubinemia associated with ingestion of maternal blood.. Pediatrics. 1969; 43(5).
  • Cummings JJ, Holm BA, Nickerson PA, Ferguson WH, Egan EA. Pre- versus post-ventilatory surfactant treatment in surfactant-deficient preterm lambs.. Reprod Fertil Dev. ; 7(5).
  • Egan EA. Effect of lung inflation on alveolar permeability to solutes.. Ciba Found Symp. ; (38).
  • Albert DM, Robinson NL, Fulton AB, Zakov ZN, Dryja TP, Puliafito CA, Smith AB, Egan EA. Epidemikological investigation of increased incidence of choroidal melanoma in a single population of chemical workers.. Int Ophthalmol Clin. ; 20(2).
  • Smith AB, Egan EA. The role of epidemiological investigations in the study of ocular tumors.. Int Ophthalmol Clin. ; 20(2).
  • Brown DR, Bloom BT, Cohen M, Myers MM, Egan EA, Kattwinkel J, Delmore P, Hall RT, Malloy MH, Holzman IR, Carlo WA, Pramanik AK, McCaffree MA, Weatherstone KB, Willett LD, Topper WH. Increased survival in low birth weight neonates given prophylactic surfactant.. J Perinatol. ; 18(6 Pt).
See all (40 more)

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Contact Information

Women and Children‘s Hospital of Buffalo
Division of Neonatology
219 Bryant Street
Buffalo, NY 14222
Phone: (716) 878-7673
Fax: (716) 878-7945

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