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Eaton                          Lattman

Eaton E. Lattman PhD

Department of Structural Biology

Professor University at Buffalo; Director BioXFEL, an NSF Science and Technology Center

Professional Summary:

Eaton Lattman holds a Ph.D. degree in Biophysics from Johns Hopkins, and a B.A. in Chemistry and Physics from Harvard College. He served as a post-doctoral fellow with Nobel laureate Robert Huber.

Lattman has spent many years in the fields of x-ray crystallography, structural biology, protein folding, and related areas, and maintained an active research program, having received over $30 million in grant support and authored over 60 refereed papers. His research contributions include methodological advances, such as the so-called “Lattman Angles”, that are still in widespread use. Along with Robert Kretsinger he is a co-author on a paper describing the first protein structure ever solved by molecular replacement: yellow-fin tuna myoglobin. His crystallographic work on “buried charge” mutants of staphylococcal nuclease led to a major rethink of protein electrostatics.

He has also had a significant administrative career, both in a university environment and externally. At Johns Hopkins he served as a Graduate Program Director, Institute co-Director, Departmental Chair, and Dean of Research and Graduate education. Highlight of his external involvements are the Editorship-in-chief of the highly ranked journal Proteins: Structure, Function, and Bioinformatics, and membership on the External Advisory Council for the National Institute of General Medical Sciences.

After many years at Johns Hopkins Lattman accepted the directorship of the Hauptman-Woodward Medical Research Institute (HWI) in 2008, a post he relinquished in 20014. He was appointed to the University at Buffalo faculty as Professor of Structural Biology in 2009.

In 2013 Lattman became director of a new NSF Science and Technology Center entitled X-ray Lasers in Biology. This Center is administered by the University at Buffalo on behalf of a consortium of eight research institutions around the US, but is effectively headquartered at the Hauptman-Woodward Institute. The Center is funded at $5 million per year for five years.

Education and Training:
  • Postdoctoral Fellow, Brandeis University (1977)
  • Postdoctoral Fellow, Structural Biologuy, Max Planck Institute for Biochemistry (1974)
  • Postdoctoral Fellow, Biophysics, Johns Hopkins University (1973)
  • PhD, Biophysics, Johns Hopkins University (1969)
  • BA, Chemistry and Physics, Harvard College, Cum laude (1962)
  • Professor, Materials Design and Innovation, University at Buffalo, SUNY (2016-present)
  • Principal Research Scientist, Hauptman-Woodward Institute (2014-present)
  • Research Professor, Structural Biology, University at Buffalo (2009-present)
  • Research Professor, Biophysics, Johns Hopkins University, Krieger School of Arts and Sciences (2008-present)
  • CEO and Executive Director, Hauptman-Woodward Institute (2008–2014)
  • Dean of Research and Graduate Education, Johns Hopkins University, Krieger School of Arts and Sciences (2004–2008)
  • Professor, Biophysics, Johns Hopkins University, Krieger School of Arts and Sciences (1996–2008)
  • Chair, Biophysics, Johns Hopkins University School of Arts and Sciences (1996–2004)
  • Professor, Biophysics, Johns Hopkins University, School of Medicine (1989–1996)
  • Associate Professor, Biophysics, Johns Hopkins University, School of Medicine (1983–1989)
  • Assistant Professor, Biophysics, Johns Hopkins University, School of Medicine (1977–1983)
  • Adjunct Assistant Professor, Laboratory for Structural Biology, Brandeis University, Rosenstiel Center (1976–1977)
  • Post-doctoral fellow, Laboratory for Structural Biology, Brandeis University, Rosenstiel Institute (1974–1976)
  • Post-doctoral fellow, Abteilung Huber, Max Planck Institute for Biochemistry, Germany (1974)
  • Post-doctoral fellow, Biophysics, Johns Hopkins University, Krieger School of Arts and Sciences (1970–1974)
  • Junior Instrutctor, Biophysics, Johns Hopkins University, Krieger School of Arts and Sciences (1962–1963)
See all (6 more)
Awards and Honors:
  • Member National Advisory General Medical Sciences Council (2004)
  • NIH Research Career Development Award (1977)

Research Expertise:
  • X-ray crystallography: Macromolecular structure determination
  • X-ray Lasers: new x-ray sources for imaging of biological specimens
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
  • October 2013–September 2018
    Biology with X-ray Lasers
    National Science Foundation
    Role: Principal Investigator

Journal Articles:
See all (40 more)
Books and Book Chapters:
  • Lattman E, Loll, Patrick J.. X-ray Crystallography: A Concise Guide. 2008.
  • Lattman E. X-ray Microscopy in the Study of Biological Structure: A Prospective View. 1988; 56.

Professional Memberships:
  • Member External Advisory Committee Linac Coherent Light Source (2017–present)
  • Member Editorial Board IUCrJ (2016–present)
  • Chair, Advisory Committee Enzyme Function Initiative (2010–2015)
  • Member, Advisory Committee New York Structural Genomics Research Consortium (2010–2014)
  • Member: Protein Society (1990–present)
  • Member: AAAS (1970–present)
  • Member: Biophysical Society (1970–present)
  • Member: American Crystallographic Association (1964–present)
  • "Molecular Movies with X-ray Lasers" TEDx Symposium, Cornell College (2016)
  • "X-ray Lasers in Biology" UB Department of Chemistry Seminar, UB, Szyperski laboratory (2016)
  • "X-ray Lasers in Biology" Upstate NY Structural Biology Symposium, SUNY College for Environmental Science and Forestry (2015)
  • "Creating Cohesion in a Multi-institution Center" STC Directors Meeting 2015, The Center for Microbial Oceanography, University Hawaii (2015)
  • "X-ray Lasers: Can femtosecond pulses illuminate biology?" Systems Biology Seminar at Boston University, Boston University (2015)
  • "X-ray Lasers: Can femtosecond pulses illuminate biology?" UB Department of Physic Seminar Series, UB (2015)
  • "X-ray Lasers: Can femtosecond pulses illuminate biology?" Structural Biology Seminar Series, Northeastern University (2015)
  • "NCI Opportunities with XFELS" NCI Workshop on XFEL: The Biomedical Research Tool for the Coming Decades, National Cancer Institute (2014)
  • "Introduction to X-ray Free Electron Lasers in Crystallography" School of Engineering Seminar Series, University at Buffalo (2014)
  • "XFEL Imaging of Single Biological Particles: where are we?" SSRL Users Meeting, Stanford Synchrotron Radiation Laboratory, Plenary (2014)
  • "Expanding the Universe of Protein Structure Information" NSF Science and Technology Center Directors Meeting, Colorado State University (2014)
  • "Progress in XFEL Single Particle Imaging" SLAC Users meeting, SLAC (2014)
  • "Life at an Independent Research Institute" Rotary Club Monthly Meeting, Rotary Club, Buffalo (2014)
See all (3 more)
Service Activities:
  • Member Advisory Committee New York Structural Biology Research Consortium; The NYSGRC is a U54-funded center that is part of the NIGMS program PSI: Biology. It develops and implements cutting-edge experimental and computational technologies to examine the biologically important molecules that are the focus of PSI:Biology; Member (2011–present)
  • Advisory Committee for the Enzyme Function Initiative; The Enzyme Function Initiative is a so-called NIH Glue Grant that seeks to assign in vitro enzymatic functions, and in vivo physiological/metabolic functions to members of 5 large protein superfamilies. It is a very large collaborative effort led by a distinguished group of scientists.; Chair (2010–present)
  • Member, Advisory Committee, Energy Recovery Linac, CHESS; The Energy Recovery Linac is a new x-ray source being constructed at Cornell at a cost of several hundreds of millions of dollars. The advisory committee takes an active role in all aspects, from working with fun ding agencies to developing symposia to map out the uses of the facility.; Advisory Committee (2009–present)
  • Member Editorial Board, Journal of Biophysics; Board Member (2008–present)
  • NIGMS Advisory Committee for SGKB; The structural genomics knowledge base comprises the information gather by the NIH-funded Protein Structure Initiative and related projects. The PSI has determined thousands of protein structures, created clones to go with all of these, among many other activities. All these are catalogued and made available to the public via the Structural Genomics KNowledge Base.; Chair (2008–present)
  • Member NIGMS Advisory Council; Member National Advisory General Medical Sciences Council. Council approves all grants and new programs at NIGMD.; Member (2001–2004)
  • Proteins Editorial Board; Member of Editorial Board, and former EIC, of Proteins: Structure, Function, and Bioinformatics; Board Member (1991–present)

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Contact Information

Hauptman-Woodward Institute
700 Ellicott Street
Buffalo, NY 14203
Phone: (716) 898-8612
Fax: 716-898-8660

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