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Fraser                         Sim

Fraser J. Sim PhD

Department of Pharmacology and Toxicology

Assistant Professor

Specialty/Research Focus

Genomics and proteomics; Neurobiology; Neurodegenerative disorders

Professional Summary:

My lab investigates the molecular control of cell fate and homeostasis of resident stem and progenitor cells in the human brain. Using a combination of multicolor cell sorting techniques and whole genome analysis, we are characterizing the signaling pathways which regulate the formation and fate of human oligodendrocyte progenitor cells. We are testing the functional significance of these pathways using both pharmacological and viral methods in culture and animal-based models of myelination and demyelination.

Education and Training:
  • PhD, Neuroscience, University of Cambridge (2001)
  • MA, Natural Sciences, University of Cambridge, 1st Class (1997)
  • Assistant Professor of Pharmacology and Toxicology, University at Buffalo (2009-present)
  • Assistant Professor of Neurology and Neurosurgery, University of Rochester (2006–2009)
  • Research Assistant Professor, University of Rochester (2004–2006)
  • Instructor, Neurology, University of Rochester (2003–2004)
  • Instructor, Neurology/Neuroscience, Cornell University Medical College (2003)
  • Postdoctoral Research Associate, Neurology/Neuroscience, Cornell University Medical College (2002–2003)
  • Postdoctoral Research Associate, Department of Clinical Veterinary Medicine, University of Cambridge, United Kingdom (2001)

Research Expertise:
  • Neuroscience
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
  • October 2013–September 2016
    Muscarinic Receptor Regulation of Oligodendrocyte Differentiation
    National Multiple Sclerosis Society
    Role: Principal Investigator
  • March 2013–February 2015
    Directed Reprogramming of Human Fibroblasts to Oligodendrocyte Progenitors
    Role: Principal Investigator
  • September 2010–August 2013
    Atlas of gene expression by progenitor cells of the human brain and its tumors
    Role: Co-Investigator
  • May 2012–April 2013
    Development of novel cerebral X-ALD model using human ABCD1-null oligodendrocyte progenitors
    European Leukodystophy Association
    Role: Principal Investigator
  • September 2010–August 2012
    Induction of Oligodendrocyte Fate from Human Neural Stem Cells
    Role: Principal Investigator
  • July 2007–July 2008
    Low-Grade Oligodendroglioma Brain Tumor Research Grant
    National Brain Tumor Foundation
    Role: Principal Investigator
  • August 2004–August 2005
    Does statin therapy reduce the self-renewal capacity of adult human oligodendrocyte progenitor cells?
    National Multiple Sclerosis Society
    Role: Principal Investigator
See All (7 Total) >
  • CD24 as a brain tumor marker CD24 as a brain tumor stem cell marker and a diagnostic and therapeutic target in primary neural and glial tumors of the brain (2008)
  • CD140a sorting Treating Myelin Diseases with Optimized Cell Preparations (2008)
  • Human NSC gene expression Genes and signaling pathways differentially active in neural stem cells and neuronal progenitor cells (2006)
  • WMPC gene expression Genes differentially expressed by acutely isolated resident progenitor cells of the human white matter (2004)

Journal Articles:
See All (30 Total) >

Professional Memberships:
  • Society for Neuro-Oncology (2007)
  • American Association for Cancer Research (2007)
  • International Society for Stem Cell Research (2006)
  • American Society for Neurochemistry (2005)
  • Society for Neuroscience (2003)
  • British Neuropathological Society (2000–2001)
  • "Identification and genomic analysis of human neural and oligodendrocyte progenitor cells" Euroglia XI (2013)
  • "Transcriptional control of oligodendrocyte fate in human brain" 11th Biennial ISN Satellite Meeting on Myelin Biology, ISN-ASN Meeting (2013)
  • "Genomic analyses of human A2B5-defined glioma initiating progenitor cells" Roswell Park Cancer Institute, Molecular and Developmental Genetics Seminar (2010)
  • "Human glial progenitor cell isolation and microarray-based molecular characterization: in search of oligoneogenic pathways" SUNY REACH Neurodegenerative Diseases and Stem Cell Therapeutics Symposium (2010)
  • "Transcriptional regulation of glial progenitor cells in the developing human brain" 41st Meeting of the American Society for Neurochemistry, American Society for Neurochemistry (2010)
  • "Directing human oligodendrocyte progenitor differentiation and repair" Biosymposia, Stem Cells and CNS regeneration, Biosymposia (2007)
  • "Fluorescence-based identification, isolation and transplantation of human stem cells" Keio International Symposium on Photonics and Molecular Therapy, Keio University (2007)
  • "Stem cell-based repair of the CNS" University of British Columbia, Vancouver, Brain research centre research day (2006)
  • "Fate-regulating pathways in adult human oligodendrocyte progenitors" 36th Meeting of the American Society for Neurochemistry, American Society for Neurochemistry (2005)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

119 Farber Hall
3435 Main Street
Buffalo, NY 14214
Phone: 829-2151

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