Faculty Profile - UB School of Medicine and Biomedical Sciences

Professional Summary:

I arrived in January 2012 to assume the role of Chair of the Department of Neurology at Univ. at Buffalo School of Medicine and Biomedical Sciences, the State University of New York. Prior to that time, I served as Professor of Neurology at University of Texas Southwestern Medical School in Dallas, Texas. In September 2004, I was named to the Dr. Bob and Jean Smith Foundation Distinguished Chair in Neuromuscular Disease Research. I also served as Co-Director of the Muscular Dystrophy Association Clinics and Director of the Myasthenia Gravis and Peripheral Neuropathy Clinics at UT Southwestern and was the Clinical Vice Chair for the department in Dallas.

I completed my undergraduate studies at Princeton University and attended medical school at UT Southwestern. My training in internal medicine, neurology, and neuromuscular disease/electromyography was at the University of Pennsylvania Medical Center in Philadelphia. I am board certified by the American Board of Psychiatry and Neurology in neurology, neuromuscular medicine, and clinical neurophysiology and am current chair of the MSAB for the MG Foundation of America.

My main research interests include idiopathic and immune-mediated peripheral neuropathies and myasthenia gravis. My research has been sponsored by the National Institute of Health/NINDS, Muscular Dystrophy Association, Myasthenia Gravis Foundation of America, and Food and Drug Administration. I remain actively involved in the training of younger physicians, and have directed neuromuscular medicine and clinical neurophysiology fellowships and neurology residency training programs in the past.

Education and Training:

MD, Medicine, Univ of Texas Southwestern Medical School, #1 rank in class (1989)
BA, Biology, Princeton University, Cum Laude (1985)

Employment:

Professor, Neurology, Univ at Buffalo, State University of New York (2012-present)
Professor, Univ. of Texas Southwestern Medical School (1994–2011)
Fellow, Univ. of Pennsylvania Medical Center, Univ. of Pennsylvania (1993–1994)
Resident, Univ. of Pennsylvania Medical Center, Univ. of Pennsylvania (1990–1993)
Intern, Internal Medicine, Univ. of Pennsylvania Medical Center, Univ. of Pennsylvania (1989–1990)

Awards and Honors:

Guest Professor Univ. of Toronto (2013)
Buffalo Spree Magazine (2013)
US News and World Report (2012)
Inaugural Mathilda Karel-Spak Lecturer (2011)
Best Doctors in America (2011)
Best Doctors in Dallas (2011)
Texas Super Doctor (2011)
Baldwin Myasthenia Gravis Lecturer (2008)
Marquis' Who's Who (2005)
American Academy of Neurology (2005)
American Neurological Society (2004)
Trephined Cranium Resident Teaching Award (2002)
Lippincott Scholar (1987)

Research Expertise:

Neuromuscular clinical trials
Neuromuscular outcome measures

Grants and Sponsored Research:

September 2011–August 2018
Network of Excellence in Neuroscience Clinical Trial: NeuroNEXT
NIH/NINDS
Role: Principal Investigator
$1,500,000
September 2005–July 2015
Thymectomy Trial in Non-thymomatous MG patients on prednisone
NIH/NINDS
Role: Principal Investigator
$995,672

Evaluative Studies and Case Reports:

Muppidi S, Saperstein DS, Shaibani A, Nations SP, Vernino S, Wolfe GI. Isolated neck extensor myopathy: is it responsive to immunotherapy? J Clin Neuromuscul Dis. 2010; 12(1).
Nations SP, Boyer PJ, Love LA, Burritt MF, Butz JA, Wolfe GI, Hynan LS, Reisch J, Trivedi JR. Denture cream: an unusual source of excess zinc, leading to hypocupremia and neurologic disease. Neurology. 2008; 71(9).
Singer MA, Lazaridis C, Nations SP, Wolfe GI. Reversible nitrous oxide-induced myeloneuropathy with pernicious anemia: case report and literature review. Muscle Nerve. 2008; 37(1).
Oh SJ, LaGanke C, Powers R, Wolfe GI, Quinton RA, Burns DK. Multifocal motor sensory demyelinating neuropathy: inflammatory demyelinating polyradiculoneuropathy. Neurology. 2005; 65(10).
Wolfe GI, Young PK, Nations SP, Burkhead WZ, McVey AL, Barohn RJ. Brachial plexopathy following thoracoscapular fusion in facioscapulohumeral muscular dystrophy. Neurology. 2005; 64(3).
Torabi AM, Patel RK, Wolfe GI, Hughes CS, Mendelsohn DB, Trivedi JR. Transverse myelitis in systemic sclerosis. Arch Neurol. 2004; 61(1).
Wolfe GI, Nations SP, Burns DK, Herbelin LL, Barohn RJ. Benefit of IVIg for long-standing ataxic sensory neuronopathy with Sjögren's syndrome. Neurology. 2003; 61(6).
Trivedi JR, Wolfe GI, Nations SP, Burns DK, Bryan WW, Dewey RB. Adult polyglucosan body disease associated with lewy bodies and tremor. Arch Neurol. 2003; 60(5).
Katz JS, Barohn RJ, Kojan S, Wolfe GI, Nations SP, Saperstein DS, Amato AA. Axonal multifocal motor neuropathy without conduction block or other features of demyelination. Neurology. 2002; 58(4).
Wolfe GI, Brower RD, Burns DK. Perineurial cell hyperplasia in early-onset polyneuropathy with multiple cranial neuropathies. Neuromuscul Disord. 2000; 10(7).
Wolfe GI, Baker NS, Haller RG, Burns DK, Barohn RJ. McArdle's disease presenting with asymmetric, late-onset arm weakness. Muscle Nerve. 2000; 23(4).
Katz JS, Wolfe GI, Andersson PB, Saperstein DS, Elliott JL, Nations SP, Bryan WW, Barohn RJ. Brachial amyotrophic diplegia: a slowly progressive motor neuron disorder. Neurology. 1999; 53(5).
Katz JS, Wolfe GI, Iannaccone S, Bryan WW, Barohn RJ. The exercise test in Andersen syndrome. Arch Neurol. 1999; 56(3).
Nations SP, Wolfe GI, Amato AA, Jackson CE, Bryan WW, Barohn RJ. Distal myasthenia gravis. Neurology. 1999; 52(3).
Amato AA, Kagan-Hallet K, Jackson CE, Lampkin S, Wolfe GI, Ferrante M, Bigio EH, Barohn RJ. The wide spectrum of myofibrillar myopathy suggests a multifactorial etiology and pathogenesis. Neurology. 1998; 51(6).
Krampitz DE, Wolfe GI, Fleckenstein JL, Barohn RJ. Charcot-Marie-Tooth disease type 1A presenting as calf hypertrophy and muscle cramps. Neurology. 1998; 51(5).
Wasay M, Wolfe GI, Herrold JM, Burns DK, Barohn RJ. Chloroquine myopathy and neuropathy with elevated CSF protein. Neurology. 1998; 51(4).
Jackson CE, Amato AA, Bryan WW, Wolfe GI, Sakhaee K, Barohn RJ. Primary hyperparathyroidism and ALS: is there a relation? Neurology. 1998; 50(6).
Katz JS, Wolfe GI, Bryan WW, Tintner R, Barohn RJ. Acetylcholine receptor antibodies in the Lambert-Eaton myasthenic syndrome. Neurology. 1998; 50(2).
Wolfe GI, Burns DK, Krampitz D, Barohn RJ. Cylindrical spirals of myofilamentous origin associated with exertional cramps and rhabdomyolysis. Neuromuscul Disord. 1997; 7(8).
Katz JS, Wolfe GI, Burns DK, Bryan WW, Fleckenstein JL, Barohn RJ. Isolated neck extensor myopathy: a common cause of dropped head syndrome. Neurology. 1996; 46(4).
Wolfe GI, Galetta SL, Teener JW, Katz JS, Bird SJ. Site of autonomic dysfunction in a patient with Ross' syndrome and postganglionic Horner's syndrome. Neurology. 1995; 45(11).
Wolfe GI, Raps EC, Galetta SL, Siderowf AD, Brown MJ, Bird SJ. Systemic non-Hodgkin's lymphoma manifesting as neurogenic respiratory failure. Neurology. 1995; 45(3 Pt).
Wolfe GI, Galetta SL, Mollman JE. Spontaneous remission of papilledema and sixth nerve palsy in acute lymphoblastic leukemia. J Neuroophthalmol. 1994; 14(2).
Wolfe GI, Taylor CL, Flamm ES, Gray LG, Raps EC, Galetta SL. Ocular tilt reaction resulting from vestibuloacoustic nerve surgery. Neurosurgery. 1993; 32(3).
Wolfe GI, Ross ED. Sensory aprosodia with left hemiparesis from subcortical infarction. Right hemisphere analogue of sensory-type aphasia with right hemiparesis? Arch Neurol. 1987; 44(6).

See All (26 Total) >

Journal Articles:

Trivedi JR, Silvestri NJ, Wolfe GI. Treatment of painful peripheral neuropathy. Neurol Clin. 2013; 31(2).
Pasnoor M, Nascimento OJ, Trivedi J, Wolfe GI, Nations S, Herbelin L, de Freitas MG, Quintanilha G, Khan S, Dimachkie M, Barohn R. North America and South America (NA-SA) neuropathy project. Int J Neurosci. 2013.
Silvestri NJ, Wolfe GI. Asymptomatic/pauci-symptomatic creatine kinase elevations (hyperckemia). Muscle Nerve. 2012.
Wolfe GI, Meriggioli MN, Ciafaloni E, Ruff RL. Introduction for myasthenia gravis and related disorders. Ann N Y Acad Sci. 2012; 1275(1).
Kaminski HJ, Kusner LL, Wolfe GI, Aban I, Minisman G, Conwit R, Cutter G. Biomarker development for myasthenia gravis. Ann N Y Acad Sci. 2012; 1275(1).
Benatar M, Sanders DB, Wolfe GI, McDermott MP, Tawil R. Design of the Efficacy of Prednisone in the Treatment of Ocular Myasthenia (EPITOME) trial. Ann N Y Acad Sci. 2012; 1275(1).
Silvestri NJ, Wolfe GI. Myasthenia gravis. Semin Neurol. 2012; 32(3).
Singer MA, Vernino SA, Wolfe GI. Idiopathic neuropathy: new paradigms, new promise. J Peripher Nerv Syst. 2012; 17 Su.
Minisman G, Bhanushali M, Conwit R, Wolfe GI, Aban I, Kaminski HJ, Cutter G. Implementing clinical trials on an international platform: Challenges and perspectives. J Neurol Sci. 2012; 313(1-2).
Cupler EJ, Berger KI, Leshner RT, Wolfe GI, Han JJ, Barohn RJ, Kissel JT. Consensus treatment recommendations for late-onset pompe disease. Muscle Nerve. 2011.
Burns TM, Grouse CK, Wolfe GI, Conaway MR, Sanders DB. The MG-QOL15 for following the health-related quality of life of patients with myasthenia gravis. Muscle Nerve. 2011; 43(1).
Sadeghian H, Wolfe GI. Therapy update in nerve, neuromuscular junction and myopathic disorders. Curr Opin Neurol. 2010; 23(5).
Pasnoor M, Wolfe GI, Nations S, Trivedi J, Barohn RJ, Herbelin L, McVey A, Dimachkie M, Kissel J, Walsh R, Amato A, Mozaffar T, Hungs M, Chui L, Goldstein J, Novella S, Burns T, Phillips L, Claussen G, Young A, Bertorini T, Oh S. Clinical findings in MuSK-antibody positive myasthenia gravis: a U.S. experience. Muscle Nerve. 2010; 41(3).
Muppidi S, Wolfe GI. Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis. Front Neurol Neurosci. 2009; 26.
Wolfe GI, Barohn RJ, Sanders DB, McDermott MP. Comparison of outcome measures from a trial of mycophenolate mofetil in myasthenia gravis. Muscle Nerve. 2008; 38(5).
Aban IB, Wolfe GI, Cutter GR, Kaminski HJ, Jaretzki A, Minisman G, Conwit R, Newsom-Davis J. The MGTX experience: challenges in planning and executing an international, multicenter clinical trial. J Neuroimmunol. 2008; 201-2.
Newsom-Davis J, Cutter G, Wolfe GI, Kaminski HJ, Jaretzki A, Minisman G, Aban I, Conwit R. Status of the thymectomy trial for nonthymomatous myasthenia gravis patients receiving prednisone. Ann N Y Acad Sci. 2008; 1132.
Wolfe GI, Oh SJ. Clinical phenotype of muscle-specific tyrosine kinase-antibody-positive myasthenia gravis. Ann N Y Acad Sci. 2008; 1132.
Singer MA, Statland JM, Wolfe GI, Barohn RJ. Primary lateral sclerosis. Muscle Nerve. 2007; 35(3).
Vernino S, Wolfe GI. Antibody testing in peripheral neuropathies. Neurol Clin. 2007; 25(1).
Oh SJ, Hatanaka Y, Hemmi S, Young AM, Scheufele ML, Nations SP, Lu L, Claussen GC, Wolfe GI. Repetitive nerve stimulation of facial muscles in MuSK antibody-positive myasthenia gravis. Muscle Nerve. 2006; 33(4).
Sheth MN, Nations SP, Wolfe GI, Trivedi JR. Von hippel-lindau disease associated with thymoma and myasthenia gravis. J Clin Neuromuscul Dis. 2005; 7(2).
Singer MA, Kojan S, Barohn RJ, Herbelin L, Nations SP, Trivedi JR, Jackson CE, Burns DK, Boyer PJ, Wolfe GI. Primary Lateral Sclerosis: Clinical and Laboratory Features in 25 Patients. J Clin Neuromuscul Dis. 2005; 7(1).
Wolfe GI, Gross B. Treatment review and update for myasthenia gravis. J Clin Neuromuscul Dis. 2004; 6(2).
Haley RW, Vongpatanasin W, Wolfe GI, Bryan WW, Armitage R, Hoffmann RF, Petty F, Callahan TS, Charuvastra E, Shell WE, Marshall WW, Victor RG. Blunted circadian variation in autonomic regulation of sinus node function in veterans with Gulf War syndrome. Am J Med. 2004; 117(7).
Wolfe GI, Trivedi JR. Painful peripheral neuropathy and its nonsurgical treatment. Muscle Nerve. 2004; 30(1).
Saperstein DS, Wolfe GI, Gronseth GS, Nations SP, Herbelin LL, Bryan WW, Barohn RJ. Challenges in the identification of cobalamin-deficiency polyneuropathy. Arch Neurol. 2003; 60(9).
Wolfe GI, Hotz SE, Barohn RJ. Treatment of painful peripheral neuropathy. J Clin Neuromuscul Dis. 2002; 4(2).
Wolfe GI, Barohn RJ. Painful Peripheral Neuropathy. Curr Treat Options Neurol. 2002; 4(3).
Wolfe GI, der Sluis RW, Barohn RJ. Post-radiation lower motor neuron syndrome. J Clin Neuromuscul Dis. 2000; 2(2).
Kaminski HJ, Santillan C, Wolfe GI. Autoantibody Testing in Neuromuscular Disorders, Part II: Neuromuscular Junction, Hyperexcitability, and Muscle Disorders. J Clin Neuromuscul Dis. 2000; 2(2).
Chudnow RS, Wolfe GI, Sparagana SP, Delgado MR, Batchelor L, Roach ES. Abnormal sudomotor function in the hypomelanotic macules of tuberous sclerosis complex. J Child Neurol. 2000; 15(8).
Lindenbaum Y, Nations SP, Barobn RJ, Wolfe GI. Recurrent critical illness myopathy in an asthmatic patient treated with corticosteroids. J Clin Neuromuscul Dis. 2000; 1(3).
Wolfe GI, Baker NS, Amato AA, Jackson CE, Nations SP, Saperstein DS, Cha CH, Katz JS, Bryan WW, Barohn RJ. Chronic cryptogenic sensory polyneuropathy: clinical and laboratory characteristics. Arch Neurol. 1999; 56(5).
Saperstein DS, Amato AA, Wolfe GI, Katz JS, Nations SP, Jackson CE, Bryan WW, Burns DK, Barohn RJ. Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis-Sumner syndrome. Muscle Nerve. 1999; 22(5).
Wolfe GI, Herbelin L, Nations SP, Foster B, Bryan WW, Barohn RJ. Myasthenia gravis activities of daily living profile. Neurology. 1999; 52(7).
Barohn RJ, McIntire D, Herbelin L, Wolfe GI, Nations S, Bryan WW. Reliability testing of the quantitative myasthenia gravis score. Ann N Y Acad Sci. 1998; 841.
Wolfe GI, Barohn RJ. Cryptogenic sensory and sensorimotor polyneuropathies. Semin Neurol. 1998; 18(1).
Wolfe GI, El-Feky WH, Katz JS, Bryan WW, Wians FH, Barohn RJ. Antibody panels in idiopathic polyneuropathy and motor neuron disease. Muscle Nerve. 1997; 20(10).
Katz JS, Wolfe GI, Bryan WW, Jackson CE, Amato AA, Barohn RJ. Electrophysiologic findings in multifocal motor neuropathy. Neurology. 1997; 48(3).
Haley RW, Hom J, Roland PS, Bryan WW, Van Ness PC, Bonte FJ, Devous MD, Mathews D, Fleckenstein JL, Wians FH, Wolfe GI, Kurt TL. Evaluation of neurologic function in Gulf War veterans. A blinded case-control study. JAMA. 1997; 277(3).

See All (41 Total) >

Professional Memberships:

American Neurological Association; Member (2004)
Myasthenia Gravis Foundation of America; Member of MSAB (2001)
AANEM; member and committee chair (1993)
American Academy of Neurology; Fellow (1991)

Presentations:

"Status of the MGTX Trial in Nonthymomatous MG Patients" International Workshop on the Thymus, Univ. of Padua (2013)
"Myasthenia Gravis: UnMuSKing a New Phenotype" University of Toronto Annual Neuromuscular Day, University of Toronto (2013)
"Update on the Thymectomy Trial in Nonthymomatous MG" 12th International Conference on MG and Related Disorders, New York Academy of Science (2012)
"Thymectomy trial in non-thymomatous MG patients receiving prednisone (MGTX)" Immune Globe International Conference of Nervous System Autoimmunity, Neuro Globe (2012)
"Thymectomy in Immune MG" UC Irvine MDA ALS and Neuromuscular Inaugural California Neuromuscular Sympsium, UC Irvine, Neurology (2011)
"Update for MG" Arizona Neurological Society CME Conference, Arizona Neurological Society (2009)
"UnMuSKing a New Phenotype and the Thymectomy Trial" Japanese Society of Neurology, Japanese Society of Neurology, 50th Annual Meeting (2009)
"Treatment update in MG and other disorders of the NMJ" Update in Neuromuscular Diseases, Oregon Health and Science University (2009)

Service Activities:

Neurology, School of Medicine & Biomedical Sciences Executive; Member (2012)
School of Medicine & Biomedical Sciences FPMP Governing Board; Member (2012)

Electromyography laboratory; Clinical Staff (2012)
Neurophysiology laboratory; EMG and intraoperative monitoring services; Clinical Staff (2012)
Inpatient General Neurology Service; Four weeks a year attending on service with residents; Teacher (2012)
Neuromuscular Clinic; Weekly clinic at BGMC; Clinical Staff (2012)

Gil I. Wolfe MD, FAAN

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