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Gil                            Wolfe

Gil I. Wolfe MD, FAAN

Department of Neurology

Professor and Chairman

Specialty/Research Focus

Neurology; Neuromuscular Disorders

 
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Professional Summary:

I arrived in January 2012 to assume the role of Chair of the Department of Neurology at Univ. at Buffalo School of Medicine and Biomedical Sciences, the State University of New York. Prior to that time, I served as Professor of Neurology at University of Texas Southwestern Medical School in Dallas, Texas. In September 2004, I was named to the Dr. Bob and Jean Smith Foundation Distinguished Chair in Neuromuscular Disease Research. I also served as Co-Director of the Muscular Dystrophy Association Clinics and Director of the Myasthenia Gravis and Peripheral Neuropathy Clinics at UT Southwestern and was the Clinical Vice Chair for the department in Dallas.

My interests in neuromuscular medicine are wide but have mainly focused on myasthenia gravis and other disorders of neuromuscular transmission, as well as peripheral neuropathies. I am board certified both in neurology and neuromuscular medicine. I am also board certified in neurophysiology, and I perform electromyography and nerve conduction studies and monitor intraoperative evoked potentials for spine surgeries and other operative cases.

My main research interests include idiopathic and immune-mediated peripheral neuropathies and myasthenia gravis. My research has been sponsored by the National Institute of Health/NINDS, Muscular Dystrophy Association, Myasthenia Gravis Foundation of America, and Food and Drug Administration. I remain actively involved in the training of younger physicians, and have directed neuromuscular medicine and clinical neurophysiology fellowships and neurology residency training programs in the past.

Education and Training:
  • MD, Medicine, University of Texas Southwestern Medical School, #1 rank in class (1989)
  • BA, Biology, Princeton University, Cum Laude (1985)
Employment:
  • Professor, Neurology, University at Buffalo, State University of New York (2012-present)
  • Professor, University of Texas Southwestern Medical School (1994–2011)
  • Fellow, University of Pennsylvania Medical Center, Univ. of Pennsylvania (1993–1994)
  • Resident, University of Pennsylvania Medical Center, Univ. of Pennsylvania (1990–1993)
  • Intern, Internal Medicine, University of Pennsylvania Medical Center, Univ. of Pennsylvania (1989–1990)
Awards and Honors:
  • Teacher of the Year Award (2014)
  • Buffalo Spree Magazine Top Doctor (2014)
  • Keynote Speaker (2013)
  • Distinguished Lecturer (2013)
  • Inaugural Keynote Address (2013)
  • Guest Professor Univ. of Toronto (2013)
  • Buffalo Spree Magazine Top Doctor (2013)
  • Patricia A. Smith Distinguished Chair in Neuromuscular Disease Research (2012)
  • US News and World Report (2012)
  • Inaugural Mathilda Karel-Spak Lecturer (2011)
  • Best Doctors in America (2011)
  • Best Doctors in Dallas (2011)
  • Texas Super Doctor (2011)
  • Baldwin Myasthenia Gravis Lecturer (2008)
  • Marquis' Who's Who (2005)
  • American Academy of Neurology (2005)
  • American Neurological Society (2004)
  • Trephined Cranium Resident Teaching Award (2002)
  • Lippincott Scholar (1987)

Research Expertise:
  • Electromyography (EMG): Conduct electrophysiologic tests that assess the peripheral nervous system, including the neuromuscular junction and muscle.
  • Intraoperative monitoring (IOM): Monitoring electrophysiologic properties in individual patients during surgery. It is most commonly applied for spinal surgeries, but is also used for resection of tumors affecting the brainstem and brain, itself; and can be applied in a variety of other ways as well.
  • Neuromuscular clinical trials
  • Neuromuscular disease
  • Neuromuscular disorders: Evaluate and treat the diseases of the nervous system that impact motor neurons, peripheral nerve, the neuromuscular junction, and muscle. These include peripheral neuropathies, motor neuron disease, myasthenia gravis, and inflammatory and hereditary muscle disease.
  • Neuromuscular outcome measures
Grants and Sponsored Research:
  • September 2011–August 2018
    Network of Excellence in Neuroscience Clinical Trial: NeuroNEXT
    NIH/NINDS
    Role: Principal Investigator
    $1,500,000
  • September 2005–July 2015
    Thymectomy Trial in Non-thymomatous MG patients on prednisone
    NIH/NINDS
    Role: Principal Investigator
    $995,672
  • August 2012–July 2013
    The Effectiveness of Prednisone for the Treatment of Ocular Myasthenia (EPITOME)FDA
    FDA
    Role: Co-Investigator
    $13,000
  • January 2010–December 2012
    Genome-wide association study in myasthenia gravis
    MG Foundation of America
    Role: Co-Investigator
    $50,000
  • April 2014
    Safety and efficacy of eculizimab in subjects with refractory myasthenia gravis
    Alexion Pharmaceuticals
    Role: Co-Investigator
    $50,000

Evaluative Studies and Case Reports:
See All (27 Total) >
Journal Articles:
See All (45 Total) >

Professional Memberships:
  • American Neurological Association; Member (2004)
  • Myasthenia Gravis Foundation of America; Member of MSAB (2001)
  • AANEM; member and committee chair (1993)
  • American Academy of Neurology; Fellow (1991)
Presentations:
  • "Myasthenia Gravis: UnMuSKing a New Phenotype" Grand Rounds, LSU Health Sciences Center-Shreveport School of Medicine, Dept of Neurology (2014)
  • "Treatment of Painful Peripheral Neuropathy" American Academy of Neurology Annual Meeting, AAN (2014)
  • "What's New in Managing Adult Myasthenia Gravis" Muscular Dystrophy Association Clinical Conference, MDA (2014)
  • "Research Update on Myasthenia Gravis and Status of the MGTX Trial" Dept of Neurology Conference, Ichilov Hospital, Tel Aviv Univ Sackler School of Medicine, Dept of Neurology (2013)
  • "MGTX-the NIH-Funded Thymectomy Trial in Non-thymomatous MG" Second Annual Wright State University and Premier Health Neuroscience Institute Symposium, Wright State Univ. Boonshoft School of Medicine (2013)
  • "Research Update in Myasthenia Gravis" Fourth Annual MG Patient Education Conference, Houston Methodist Neurological Institute (2013)
  • "Overcoming Hurdles of Developing and Performing Clinical Trials" Muscle Study Group Annual Meeting, Muscle Study Group (2013)
  • "Myasthenia Gravis Research Update" First Annual MDA Muscle Summit, Penn State Hershey Medical Center (2013)
  • "Myasthenia Gravis Research Update" MG Foundation of America National Conference, MGFA (2013)
  • "Status of the MGTX Trial in Nonthymomatous MG Patients" International Workshop on the Thymus, Univ. of Padua (2013)
  • "Myasthenia Gravis: UnMuSKing a New Phenotype" University of Toronto Annual Neuromuscular Day, University of Toronto (2013)
  • "Update on the Thymectomy Trial in Nonthymomatous MG" 12th International Conference on MG and Related Disorders, New York Academy of Science (2012)
  • "Thymectomy trial in non-thymomatous MG patients receiving prednisone (MGTX)" Immune Globe International Conference of Nervous System Autoimmunity, Neuro Globe (2012)
  • "Thymectomy in Immune MG" UC Irvine MDA ALS and Neuromuscular Inaugural California Neuromuscular Sympsium, UC Irvine, Neurology (2011)
  • "Update for MG" Arizona Neurological Society CME Conference, Arizona Neurological Society (2009)
  • "UnMuSKing a New Phenotype and the Thymectomy Trial" Japanese Society of Neurology, Japanese Society of Neurology, 50th Annual Meeting (2009)
  • "Treatment update in MG and other disorders of the NMJ" Update in Neuromuscular Diseases, Oregon Health and Science University (2009)
See All (17 Total) >
Service Activities:
  • Neurology, School of Medicine & Biomedical Sciences Executive; Member (2012)
  • School of Medicine & Biomedical Sciences FPMP Governing Board; Member (2012)
  • Electromyography laboratory; Clinical Staff (2012)
  • Neurophysiology laboratory; EMG and intraoperative monitoring services; Clinical Staff (2012)
  • Inpatient General Neurology Service; Four weeks a year attending on service with residents; Teacher (2012)
  • Neuromuscular Clinic; Weekly clinic at BGMC; Clinical Staff (2012)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Dept. of Neurology
Buffalo General Hospital
100 High St.
Buffalo, NY 14203-1126
Phone: 716-859-2024
Fax: 716-859-2430
Email: gilwolfe@buffalo.edu

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