Geovanny Perez MD

Geovanny Perez

Geovanny Perez
MD

Associate Professor of Pediatrics

Department of Pediatrics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Pediatric Pulmonology; Pediatrics

Contact Information
UBMD Pediatrics
Division of Pulmonology
1001 Main Street
Buffalo, NY 14203
Phone: (716) 323-0110
Fax: (716) 323-0296
gperez9@buffalo.edu


Patient Care

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Education and Training:

  • MS, Clinical and Translational Research, George Washington University (2018)
  • Fellowship, Pediatric Pulmonology, George Washington University/Children’s National Medical Center (2014)
  • Residency, Pediatrics, Miami Children’s Hospital (2011)
  • Internship, Pediatrics, Miami Children's Hospital (2009)
  • Residency, Pediatric Oncology, Hospital SOLCA (2008)
  • MD, Medicine, Universidad Central del Ecuador, summa cum laude (2004)

Employment:

  • Associate Professor, Pediatrics, University at Buffalo (2019-present)
  • Attending Physician, Pulmonology, UBMD Pediatrics, Oishei Children's Hospital (2019-present)
  • Assistant Professor, Genomics and Precision Medicine, George Washington University, School of Medicine (2014–2019)
  • Assistant Professor, Pediatrics, George Washington University, School of Medicine (2014–2019)
  • Adjunct Instructor, George Washington University, School of Medicine and Health Sciences (2012–2014)
  • Rural Physician, Ecuador Health Ministry, Yaruqui Hospital, Ecuador (2004–2005)

Awards and Honors:

  • International Congress on Pediatric Pulmonology: Young Investigator Award (2016)
  • American Thoracic Society International Conference: Abstract Scholarship Award (2015)
  • American Federation of Medical Research Eastern Regional Meeting: Poster Award Moderator (2015)
  • 10th Annual Respiratory Disease Young Investigators’ Forum: Finalist/Certificate of Honor (2014)
  • International Congress on Pediatric Pulmonology: Young Investigator Award (2014)
  • American Thoracic Society International Conference: Minority Trainee Development Scholarship Award (2014)
  • American Federation of Medical Research Eastern Regional Meeting: Henry Christian Award (2014)
  • American Federation of Medical Research Eastern Regional Meeting: Eastern Region Scholar Award (2014)
  • American Federation of Medical Research Eastern Regional Meeting: Eastern Region Scholar Award (2013)
  • Miami Children's Hospital: Emergency Medicine Award (2009)
  • Universidad Central del Ecuador School of Medicine: 2nd Best Student of the Class of 2004 (2004)

Research Expertise:

  • Invasive and non-invasive ventilation: Management of children's with complex respiratory disorders that require invasive (CPAP/BPAP) or invasive ventilator support
  • Neuromuscular Disorders: Management of children with Neuromuscular Disorders.
  • Severe Bronchopulmonary Dysplasia (BPD): Inpatient and outpatient management of infants/children with severe chronic lung disease of prematurity.
  • Translational Research: My expertise are on the egulatory mechanisms of innate airway epithelial immunity in infants during viral respiratory infections using nasal and bronchial airway epithelial cells (AEC) isolated from young children. I also have experience working on clinical and preclinical phenotyping of viral respiratory infections and have participated in several research projects in the area. Using a translational approach in the VIRAL project I have identified that infants exhibit a Th2-biased airway immune responses against rhinovirus and and paramixoviruses such as RSV and human metapneumovirus. We have also found that the epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) plays a key role in mediating Th2 responses during early life rhinovirus infection

Grants and Sponsored Research:

  • October 2018–December 2019
    Quantitative Proteomic Identification of Defective Innate Immune Secretory Responses to P. Aeruginosa in Cystic Fibrosis Bronchial Epithelium
    Gilead Sciencis, Inc.
    Role: Principal Investigator
    $88,142
  • January 2015–January 2017
    SRP-4045 and SRP-4053 in Duchene Muscular Dystrophy a 48-Week, Double-Blind, Placebo-Controlled, Multi-Center Study to Evaluate the Efficacy and Safety of SRP-4045 and SRP-4053 in Patients with Duchenne Muscular Dystrophy
    Sarepta Therapeutics, Inc.
    Role: Co-Investigator
  • June 2014–November 2016
    A Phase 3 Efficacy and Safety Study of Ataluren (PTC124®) in Patients with Nonsense Mutation Cystic Fibrosis
    PTC Therapeutics, Inc.
    Role: Co-Investigator
  • December 2012–December 2014
    Microbiome Characterization in Pediatric Respiratory Disorders
    Parson’s Family Foundation Grant
    Role: Co-Investigator
    $20,000
  • October 2014–November 2014
    Flexible Bronchoscopy Atlas of Normal and Abnormal Pediatric Airways to be Used as Training Model
    Board of Visitors
    Role: Principal Investigator
    $4,000
  • June 2018
    Respiratory CPG Development
    Hunter‘s Hope Foundation
    Role: Principal Investigator
    $10,000
  • July 2017
    ASPIRO A Phase 1/2, Randomized, Open-Label, Ascending-Dose, Delayed-Treatment Concurrent Control Clinical Study to Evaluate the Safety and Preliminary Efficacy of AT132, an AAV8-Delivered Gene Therapy in X-Linked Myotubular Myopathy (XLMTM) Patient
    Audentes Therapeutics
    Role: Contributor
  • October 2016
    A Prospective, Non Interventional Clinical Assessment Study in X-Linked Myotubular Myopathy (XLMTM) Subjects Aged 3 Years and Younger
    Audentes Therapeutics
    Role: Contributor

Journal Articles:

See all (32 more)

Books and Book Chapters:

  • Perez G, Koumbourlis A. "Pulmonary Function Test in the Intensive Care Unit". Paediatric Pulmonary Function Testing: Indications and Interpretation. 2015.

Professional Memberships:

  • American College of Chest Physicians (2017–present)
  • American Academy of Pediatrics Section on Pediatric Pulmonology: Fellow (2014–present)
  • American Thoracic Society (2011–present)
  • European Respiratory Society (2011–present)
  • Faculty of 1000 (2011–present)
  • American Federation of Medical Research (2011–present)
  • American Academy of Pediatrics: Fellow (FAAP) (2011–present)

Presentations:

  • "Clinical and Molecular Predictors of Recurrent Wheezing After the First Hospitalization Due to Viral Bronchiolitis" International Conference, American Thoracic Society (2019)
  • "Clinical and Non-Invasive Lung Imaging Predictors of Respiratory Hospitalizations During the First Year of Life in Infants Born Very Premature" International Conference, American Thoracic Society (2019)
  • "Don’t Take It for Granted! Improving Accurate Height Measurements for Pulmonary Function Testing in Non-Ambulatory Patients" International Conference, American Thoracic Society (2019)
  • "Dynamic PEEP Study: A Non-Invasive Diagnostic Exam to Assess for Effective PEEP in Fragile Children with Severe BPD" International Conference, American Thoracic Society (2019)
  • "Identification of Sub-Sets of Viral Bronchiolitis Based on Clinical Phenotyping, Quantitative Lung Imaging, Respiratory Outcomes and Airway Immune Responses" International Conference, American Thoracic Society (2019)
  • "Mechanisms of Hypoxemia and Hypoventilation in Neuromuscular Respiratory Failure" International Conference, American Thoracic Society, Management of Neuromuscular Respiratory Failure Syndromes: Nippv for Day, Night and the Soccer Field (2019)
  • "TSLP is the Predominant Innate Type 2 Cytokine Produced by the Human Infant Airway Epithelium" International Conference, American Thoracic Society (2019)
  • "Use of Quantitative Proteomic Analysis of CF and Non-CF Human Bronchial Epithelial (HBE) Cell Apical Secretome (AS) to Identify Changes in Innate Immunity of Lungs" International Conference, American Thoracic Society (2019)
  • "Young Children with Cystic Fibrosis Have Decreased Airway Microbial Diversity Compared to Healthy Controls of Similar Age" International Conference, American Thoracic Society (2019)
  • "Care of the Neuromuscular Patient and Care of the Patient with Severe BPD" Respiratorias Meeting, Sociedad Ecuatoriana de Tisiologia y Enfermedades (2019)
  • "Factors Associated with Extubation Failure in Pediatric Patients with Neuromuscular Disorders: A Retrospective Study" Annual Meeting, Pediatric Academic Societies (2019)
  • "Current Concepts on Prematurity" Pediatric Talk, HCAM Hospital (2018)
  • "Chronic Respiratory Failure (Noninvasive and Invasive Ventilation Tracheostomy)" Pulmonary Board Review, American College of Chest Physicians (2018)
  • "Restrictive Lung Disease" Pulmonary Board Review, American College of Chest Physicians (2018)
  • "'Trach Me Home': A Multidisciplinary Team Checklist to Reduce Readmissions and Emergency Department Visits Following Tracheostomy Placement in Ventilator Dependent Pediatric Patients" International Conference, American Thoracic Society (2018)
  • "Asthma is a Predictor of Continuous Positive Airway Pressure (CPAP) Initiation in Children with Severe Obstructive Sleep Apnea (OSA) Independent of Relevant Clinical and Demographic Variables" International Conference, American Thoracic Society (2018)
  • "Differing Changes within the Cystic Fibrosis Airway Microbiome" International Conference, American Thoracic Society (2018)
  • "Intrinsic Inflammatory and Innate Immune Gene Profiling in Pediatric Asthmatic Airway Epithelium" International Conference, American Thoracic Society (2018)
  • "Mixed Immune Response in Pediatric Severe Asthma Based on Bronchoalveolar Lavage" International Conference, American Thoracic Society (2018)
  • "Redefining Bronchiolitis: Respiratory Phenotyping of Viral Lower Respiratory Tract Infections Identifies Subsets with Distinct Acute Severity and Recurrence of Respiratory Illnesses During Early Life" International Conference, American Thoracic Society (2018)
  • "The Natural History of Patients with Congenital Muscular Dystrophy at Children’s National Health System: A Tertiary Medical Center Experience" International Conference, American Thoracic Society (2018)
  • "Transcriptomic Profiles of Conditional Reprogrammed Cells from Human Infant Airway Epithelial Cells Demonstrate Stability of Antiviral Immunity" International Conference, American Thoracic Society (2018)
  • "Functional Communication of Children with Spinal Muscular Atrophy Type 1" Clinical Conference, Muscular Dystrophy Association (2018)
  • "Implementation and Experience with Nusinersen (Spinraza) for Infants and Children with Spinal Muscular Atrophy (SMA) in Large Multidisciplinary Pediatric MDA Center" Clinical Conference, Muscular Dystrophy Association (2018)
  • "Using Spinraza to Treat Spinal Muscular Atrophy: Report of Practical Experience" Clinical Conference, Muscular Dystrophy Association (2018)
  • "Antibiotic Treatment Does Not Significantly Alter the CF Airway Microbiome" North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation (2017)
  • "An Unusual Cause of Hypercarbia in Premature Twins" International Conference, American Thoracic Society (2017)
  • "Antiviral Signaling and Cytokine Responses in Nasal and Bronchial Airway Epithelial Cells from Preschool Children" International Conference, American Thoracic Society (2017)
  • "Application of Pharmacokinetics And Pharmacodynamics to Determine Dose Optimization Using Beta Lactams in Pediatric Cystic Fibrosis Population" International Conference, American Thoracic Society (2017)
  • "Choosing Ventilatory Support for Patients with Neuromuscular Disorders" International Conference, American Thoracic Society (2017)
  • "Clinical Definition of Respiratory Viral Infections in Young Children and Potential Bronchiolitis Misclassification" International Conference, American Thoracic Society (2017)
  • "Conditional Reprogramming of Pediatric Nasal Epithelial Cells: A New Model to Investigate Early Life Airway Immune Responses" International Conference, American Thoracic Society (2017)
  • "Distinguishing Characteristics of Severe Obstructive Sleep Apnea in Inner-City Children and Adolescents" International Conference, American Thoracic Society (2017)
  • "MRI Determination of Normal Volumes for the Upper Airway and Pharyngeal Lymphoid Tissue in Preterm and Term Infants" Annual Meeting, Society for Pediatric Radiology (2017)
  • "Peak Cough Flow Measurements in Children with Neuromuscular Disorders, 5 Years of Experience at Large Tertiary Children Hospital" International Conference, American Thoracic Society (2017)
  • "Marginal Shape Deep Learning: Applications to Pediatric Lung Field Segmentation" SPIE Medical Imaging, Society of Nuclear Medicine and Imaging (2017)
  • "Airway Molecular Phenotyping in Prematurity Identifies Intrinsic Secretory Signatures Linked to Th2 Inflammation and Airway Remodeling" International Congress on Pediatric Pulmonology, CIPP (2016)
  • "An Unusual Cause of Tachypnea and Hypoxemia in an Infant" International Conference, American Thoracic Society (2016)
  • "Automated Lung Segmentation And Longitudinal Air Trapping Quantification In Chronic Lung Disease Of Prematurity" International Conference, American Thoracic Society (2016)
  • "Different Sequencing Platforms Give Distinct Measures of Alpha Diversity of the Pulmonary Microbiome Detected in Cystic Fibrosis Sputum" Annual Meeting, Pediatric Academic Societies (2016)
  • "Physiological Biomarkers of Autonomic Dysfunction in Premature Infants Are Linked to High Risk of Hospital Readmission Due to Acute Life-Threatening Events (ALTE)" Annual Meeting, Pediatric Academic Societies (2016)
  • "Premature Infants Have an Intrinsic Airway Secretory Signature Characterized by Enhanced Production of Airway Remodeling Growth Factors" International Conference, American Thoracic Society (2016)
  • "Age-Related Effect of Viral-induced Wheezing in Severe Prematurity" International Conference, American Thoracic Society (2015)
  • "Characterization of Nasal Airway Microbiota During Acute Rhinovirus Infection in Full Term and in Premature Infants" International Conference, American Thoracic Society (2015)
  • "Clinical Phenotypic Characterization of Human Rhinovirus Infections in Severely Premature Children" International Conference, American Thoracic Society (2015)
  • "Cytokine Airway Responses to Acute Rhinovirus Infection and Respiratory Morbidity in Severe Premature Children" International Conference, American Thoracic Society (2015)
  • "Premature Infants have Impaired Airway Antiviral IFNγ Responses to Human Metapneumovirus Compared to Respiratory Syncytial Virus" International Conference, American Thoracic Society (2015)
  • "Premature Children Have Dysfunctional Airway Cytokine Responses to Rhinovirus and Respiratory Syncytial Virus" Annual Meeting, Pediatric Academic Societies (2015)
  • "Exosomal mir-155 Secretion During Rhinovirus Infection in Early Childhood" Annual Meeting, American Academy of Allergy, Asthma and Immunology (2015)
  • "Directional Immune Response and Polarity of Viral-Induced Thymic Stromal Lymphopoetin (TSLP) Secretion in Human Bronchial Epithelium" International Conference, American Thoracic Society (2014)
  • "Human Metapneumovirus is Associated with Severe Respiratory Disease in Premature Children" International Conference, American Thoracic Society (2014)
  • "Rhinovirus Infection in Early Childhood is Associated with Elevated Airway Thymic Stromal Lymphopoetin Levels and a Th2 Bias an Airway Immune Response" International Conference, American Thoracic Society (2014)
  • "REM Sleep-Related Vulnerability in Asthmatic Children is Independent of the Presence of OSA" SLEEP Meeting, Associated Professional Sleep Societies (2013)
  • "A Rare Case of Stridor, Wheezing and Pneumomediastinum" International Conference, American Thoracic Society, Pediatric Clinical Chest Round Cases (2013)
  • "Upper and Lower Airway Inflammation Modulate the Phenotypical Expression of OSA in Children" International Conference, American Thoracic Society (2013)
  • "High-Throughput Signal Processing of Polysomnography Identifies Airflow-Independent Respiratory Features of OSA in Adults" Eastern Regional Meeting, American Federation of Medical Research (2013)
  • "REM Sleep-Related Vulnerability in Asthmatic Children is Independent of the Presence of Obstructive Sleep Apnea (OSA)" Research Week, Children‘s National Medical Center (2013)
  • "Rhinovirus Infection is Associated with Increased Levels of Thymic Stromal Lymphopoietin (TSLP)" Eastern Regional Meeting, American Federation of Medical Research (2013)
  • "Upper and Lower Airway Inflammation Modulate the Phenotypical Expression of OSA in Children" Eastern Regional Meeting, American Federation of Medical Research (2013)
  • "Cystic Fibrosis Review for Parents" Cystic Fibrosis Symposium, Children’s National Medical Center/Hospital Carlos Andrade de Marin/Hospital Eugenio Espejo (2012)
  • "Complications of Nissen Fundoplication after Gastrostomy Tube Placement in CF Patients" North American Cystic Fibrosis Conference, Cystic Fibrosis Foundation, Pediatric Fellow Session (2011)
See all (51 more)

Service Activities:

  • Lung Journal; Reviewer (2019–present)
  • Audentes Pharmaceuticals; Advisory Board (2018–present)
  • Journal of Pediatrics; Reviewer (2018–present)
  • Children's National Medical Center: Antimicrobial Subcommittee; Committee Member (2017–2019)
  • Children's National Medical Center: Pediatric Surgery Verification Program; Liaison (2017–2019)
  • American Thoracic Society International Conference: Pediatric Asthma Mini Symposium; Co-Chair (2017)
  • Cure CMD: Pulmonary Guidelines Committee; Committee Member (2017)
  • Santhera Pharmaceuticals; Advisory Board (2017–present)
  • Hunter’s Hope Foundation: Pulmonary Guidelines for Patients with Leukodystrophies Committee; Leader (2016–present)
  • Journal of Respiratory Medicine and Lung Disease; Editorial Team Member (2016–present)
  • Metropolitan District of Columbia Thoracic Society; Board Member (2016–present)
  • Children's National Medical Center: Grand Rounds Improvement Committee; Committee Member (2015–2019)
  • Children's National Medical Center: Tracheostomy and Mechanical Ventilation Committee of Excellence; Committee Member (2015–2019)
  • American Journal of Respiratory and Critical Care Medicine; Reviewer (2015–present)
  • Experimental Lung Research Journal; Reviewer (2015–present)
  • Children's National Medical Center: Pediatric Pulmonology Fellowship Program; Supervisor (2014–2019)
  • Children's National Medical Center: Pediatric Residency Program; Supervisor (2014–2019)
  • American Thoracic Society: Pediatrics International Relations Working Group; Member (2014–present)
  • Global Tracheostomy Consortium: Data Base Committee; Committee Member (2014–present)
  • Pediatric Pulmonology; Reviewer (2014–present)
  • American Thoracic Society: Assembly on Pediatrics; Member (2013–present)

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Contact Information

UBMD Pediatrics
Division of Pulmonology
1001 Main Street
Buffalo, NY 14203
Phone: (716) 323-0110
Fax: (716) 323-0296
gperez9@buffalo.edu

Looking for a doctor? This faculty member is affiliated with UBMD, the group comprised of practicing physicians who are also professors in the UB Jacobs School of Medicine and Biomedical Sciences.

View this faculty on UBMD