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Julian                         Ambrus, Jr.

Julian L. Ambrus, Jr. MD

Department of Medicine

Associate Professor

Specialty/Research Focus

Allergy and Immunology; Autoimmunity; Immunology; Rheumatology

 
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Professional Summary:

My research revolves around IL-14 and its role in immunological memory. Studies delve into 3 areas - vaccination, autoimmunity and lymphoid malignancies.

Education and Training:
  • MD, Medicine, Jefferson Medical College (1979)
  • BA, Molecular Biophysics and Biochemistry, Yale University (1975)
Employment:
  • Director, Systemic Autoimmune Disease Research Center of WNY (1998-present)
  • Practicing Physician, University at Buffalo (1996-present)
  • Associate Professor, University at Buffalo (1996-present)
  • Associate Professor of Pathology, Pathology, WUSM, Washington Univeristy School of Medicine (1992–1996)
  • Associate Physician, Barnes Hospital (1992–1996)
  • Assistant Attending, Jewish Hospital of St. Louis (1989–1996)
  • Associate Professor, Medicine, Division of Rheumatology, Washington University School of Medicine (1989–1996)
  • Assistant Attending Physician, Barnes Hospital (1989–1992)
  • Medical Fellow, NIH-National Institute of Allergy and Infectious Diseases (1982–1985)
  • Chief Resident, University at Buffalo (1981–1982)
  • Medical Resident, University at Buffalo (1980–1982)
  • Medical Intern, University at Buffalo (1979–1980)
See All (12 Total) >
Awards and Honors:
  • Visionary Innovator Award (2013)
  • Laureate Award American College of Physicians (2010)
  • PHS Letter of Commendation (1989)
  • Dr. Norman Chassin Award for Outstanding Intern in Internal Medicine (1980)
  • Senior Biology Division (1970)

Research Expertise:
  • Immunology: Study of immunological memory in autoimmune diseaese, cancer and vaccine biology
Grants and Sponsored Research:
  • October 2012–September 2014
    Role of Interleukin 14 in Sjogren's disease
    PHS/NIDCR
    Role: Principal Investigator
    $435,875
  • July 2012–September 2013
    Evaluation of Autoantibodies in Sjogren's Syndrome at Various Stages of the Disease
    CAT
    Role: Principal Investigator
    $125,784
  • September 2001–July 2006
    Community Based Research on Autoimmune Disease and Asthma
    National Institute of Environmental Health Sciences
    Role: Co-Investigator
    $1,607,795
  • January 1996–December 2000
    Analysis of IL-14 production by a Burkitt lymphoma cell line
    Troupe Foundation
    Role: Principal Investigator
    $100,000
  • January 1997–December 1998
    Evaluation of immunologic tolerance in solid organ transplantation
    Role: Co-Principal Investigator
    $20,000
  • January 1993–December 1996
    Structural analysis of HMW-BCGF
    NIH
    Role: Co-Investigator
    $284,452
  • January 1991–December 1993
    Characterization of a unique protein in common variable immunodeficiency sera
    March of Dimes Birth Defects Foundation
    Role: Co-Investigator
    $50,000
  • January 1991–December 1993
    Role of eicosanoids in normal and SLE B cell function
    GD Searle and Company
    Role: Co-Investigator
    $161,500
  • January 1992
    Regulation of intracellular calcium during the induction of human B cell proliferation
    Arthritis Foundation - Eastern Missouri Chapter
    Role: Principal Investigator
    $30,000
See All (9 Total) >
Patents:
  • IL-14alpha RNA inhibitors IL-14alpha RNA inhibitors and antibodies to IL14alpha for treatment of autoimmune disease and malignancy (2007)
  • DNP-RNA to silence c-Myc DNP-RNA that can be used in vivo to block the transcription and translation of c-MyC (2005)
  • Method to remove viruses from blood Dialysis cartridge to remove blood borne viruses (1999)
  • HIV chemokines Chemokine produced by HIV (1999)

Evaluative Studies and Case Reports:
Journal Articles:
  • Shen L, Suresh L, Malyavantham K, Kowal P, Xuan J, Lindemann MJ, Ambrus JL, Ambrus, Jr. JL. Different Stages of Primary Sjogren's Syndrome Involving Lymphotoxin and Type 1 IFN. J Immunol. 2013; 191(2).
  • Shen L, Suresh L, Lindemann M, Xuan J, Kowal P, Malyavantham K, Ambrus JL, Ambrus, Jr. JL. Novel autoantibodies in Sjogren's syndrome. Clin Immunol. 2012; 145(3).
  • Pankewycz O, Ambrus J, Shen L, Xuan J, Li H, Wu J, Guo LW, Feng L, Laftavi MR, Ambrus, Jr. JL. Inhibiting Wipf2 downregulation by transgenic expression of its 3' mRNA-untranslated region improves cytotoxicity and vaccination response. Eur J Immunol. 2012; 42(9).
  • Vishwanath S, Abdullah M, Elbalkhi A, Ambrus JL, Ambrus, Jr. JL. Metabolic myopathy presenting with polyarteritis nodosa: a case report. J Med Case Rep. 2011; 5.
  • Shen L, Suresh L, Wu J, Xuan J, Li H, Zhang C, Pankewycz O, Ambrus JL. A role for lymphotoxin in primary Sjogren's disease. J Immunol. 2010; 185(10).
  • Vega F, Davuluri Y, Cho-Vega JH, Singh RR, Ma S, Wang RY, Multani AS, Drakos E, Pham LV, Lee YC, Shen L, Ambrus J, Medeiros LJ, Ford RJ, Ambrus JL. Side population of a murine mantle cell lymphoma model contains tumour-initiating cells responsible for lymphoma maintenance and dissemination. J Cell Mol Med. 2010; 14(6B).
  • Shen L, Suresh L, Li H, Zhang C, Kumar V, Pankewycz O, Ambrus JL. IL-14 alpha, the nexus for primary Sj√∂gren's disease in mice and humans. Clin Immunol. 2009; 130(3).
  • Leca N, Laftavi M, Shen L, Matteson K, Ambrus J, Pankewycz O, Ambrus JL. Regulation of human interleukin 14 transcription in vitro and in vivo after renal transplantation. Transplantation. 2008; 86(2).
  • Ford RJ, Shen L, Lin-Lee YC, Pham LV, Multani A, Zhou HJ, Tamayo AT, Zhang C, Hawthorn L, Cowell JK, Ambrus JL. Development of a murine model for blastoid variant mantle-cell lymphoma. Blood. 2007; 109(11).
  • Shucard JL, Gaines JJ, Ambrus J, Shucard DW, Ambrus JL. C-reactive protein and cognitive deficits in systemic lupus erythematosus Cogn Behav Neurol. 2007; 20(1).
  • Ludwig LB, Ambrus JL, Krawczyk KA, Sharma S, Brooks S, Hsiao CB, Schwartz SA. Human Immunodeficiency Virus-Type 1 LTR DNA contains an intrinsic gene producing antisense RNA and protein products. Retrovirology. 2006; 3.
  • Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL. Development of autoimmunity in IL-14alpha-transgenic mice. J Immunol. 2006; 177(8).
  • Ambrus JL, Dembinski W, Chadha K, Ambrus JL, Chadha KC. Resistance to interferons. Discov Med. 2004; 4(23).
  • Ambrus JL, Dembinski W, Chadha K, Ambrus JL, Chadha KC. Resistance to interferons. Discov Med. 2004; 4(23).
  • Chadha KC, Ambrus JL, Dembinski W, Ambrus Jr JL. Interferons and interferon inhibitory activity in disease and therapy.. Exp Biol Med (Maywood). 2004; 229(4).
  • Chadha KC, Ambrus JL, Dembinski W, Ambrus Jr JL. Interferons and interferon inhibitory activity in disease and therapy.. Exp Biol Med (Maywood). 2004; 229(4).
  • Chadha KC, Ambrus JL, Dembinski W, Ambrus Jr JL. Interferons and interferon inhibitory activity in disease and therapy.. Exp Biol Med (Maywood). 2004; 229(4).
  • Shucard JL, Parrish J, Shucard DW, McCabe DC, Benedict RH, Ambrus J. Working memory and processing speed deficits in systemic lupus erythematosus as measured by the paced auditory serial addition test. J Int Neuropsychol Soc. 2004; 10(1).
  • Ambrus JL, Dembinski W, Ambrus JL, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC. Free interferon-alpha/beta receptors in the circulation of patients with adenocarcinoma.. Cancer. 2003; 98(12).
  • Ambrus JL, Dembinski W, Ambrus JL, Sykes DE, Akhter S, Kulaylat MN, Islam A, Chadha KC. Free interferon-alpha/beta receptors in the circulation of patients with adenocarcinoma.. Cancer. 2003; 98(12).
  • Tullis RH, Duffin RP, Zech M, Ambrus JL. Affinity hemodialysis for antiviral therapy. I. Removal of HIV-1 from cell culture supernatants, plasma, and blood.. Ther Apher. 2002; 6(3).
  • Kandeel AA, Zeid M, Helm T, Lillie MA, Donahue E, Ambrus JL. Evaluation of chronic urticaria in patients with Hashimoto thyroiditis.. J Clin Immunol. 2001; 21(5).
  • Ambrus CM, Anthone S, Stadler A, Cameron MS, Wells K, Stadler I, Ambrus JL. Treatment of lead poisoning with an immobilized chelator comparison with conventional therapy. Res Commun Mol Pathol Pharmacol. 2001; 110(3-4).
  • Ambrus CM, Stadler I, Toumbis CA, Stadler A, Anthone S, Anthone R, DeAlarcon P, Deshpande G, Conway J, Vladutiu AO, Ambrus JL. Removal of non-transferrin-bound iron from blood with iron overload using a device with immobilized desferrioxamine. J Med. 1999; 30(3-4).
  • Ambrus CM, Lajos TZ, Stadler I, Stadler A, Alfano J, Tulumello JA, Ambrus JL. Myocardial release of non-transferrin-bound iron during cardio-pulmonary bypass surgery. J Med. 1999; 30(3-4).
  • Ambrus JL, Sridhar NR. Immunologic aspects of renal disease.. JAMA. 1997; 278(22).
  • Ambrus JL, Ambrus JL, Chadha S, Novick D, Rubinstein M, Gopalakrishnan B, Bernstein Z, Priore RL, Chadha KC. Mechanism(S) of interferon inhibitory activity in blood from patients with AIDS and patients with lupus erythematosus with vasculitis.. Res Commun Mol Pathol Pharmacol. 1997; 96(3).
  • Ambrus JL, Ambrus JL, Chadha S, Novick D, Rubinstein M, Gopalakrishnan B, Bernstein Z, Priore RL, Chadha KC. Mechanism(S) of interferon inhibitory activity in blood from patients with AIDS and patients with lupus erythematosus with vasculitis.. Res Commun Mol Pathol Pharmacol. 1997; 96(3).
  • Ambrus JULIAN, Contractor V, Joseph A, Long J, Blumenthal D. A Potential Role for PGE and IL-14 (HMW-BCGF) in B-Cell Hyperactivity of Patients with Systemic Lupus Erythematosus.. Am J Ther. 1995; 2(12).
  • Ford R, Tamayo A, Martin B, Niu K, Claypool K, Cabanillas F, Ambrus J. Identification of B-cell growth factors (interleukin-14; high molecular weight-B-cell growth factors) in effusion fluids from patients with aggressive B-cell lymphomas.. Blood. 1995; 86(1).
  • Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ. Identification of a cDNA for a human high-molecular-weight B-cell growth factor.. Proc Natl Acad Sci U S A. 1993; 90(13).
  • Levy E, Ambrus J, Kahl L, Molina H, Tung K, Holers VM. T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE).. Clin Exp Immunol. 1992; 90(2).
  • Ford RJ, Tamayo A, Ambrus JL. The role of growth factors in human lymphomas. Curr Top Microbiol Immunol. 1992; 182.
  • Ambrus JL, Haneiwich S, Chesky L, McFarland P, Engler RJ. Improved in vitro antigen-specific antibody synthesis in two patients with common variable immunodeficiency taking an oral cyclooxygenase and lipoxygenase inhibitor (ketoprofen).. J Allergy Clin Immunol. 1991; 88(5).
  • Ambrus JL, Haneiwich S, Chesky L, McFarland P, Peters MG, Engler RJ. Abnormal response to a human B cell growth factor in patients with common variable immunodeficiency (CVI).. J Allergy Clin Immunol. 1991; 87(6).
  • Young KR, Ambrus JL, Malbran A, Fauci AS, Tenner AJ. Complement subcomponent C1q stimulates Ig production by human B lymphocytes.. J Immunol. 1991; 146(10).
  • Ambrus JL, Chesky L, McFarland P, Young KR, Mostowski H, August A, Chused TM. Induction of proliferation by high molecular weight B cell growth factor or low molecular weight B cell growth factor is associated with increases in intracellular calcium in different subpopulations of human B lymphocytes.. Cell Immunol. 1991; 134(2).
  • Ambrus JL, Chesky L, Chused T, Young KR, McFarland P, August A, Brown EJ. Intracellular signaling events associated with the induction of proliferation of normal human B lymphocytes by two different antigenically related human B cell growth factors (high molecular weight B cell growth factor (HMW-BCGF) and the complement facto. J Biol Chem. 1991; 266(6).
  • Chadha KC, Ambrus JL, Stadler I, Ambrus JL. Interferon inhibitor in the blood of patients with systemic lupus erythematosus. J Biol Regul Homeost Agents. 1991; 5(1).
  • Chadha KC, Ambrus JL, Stadler I, Ambrus JL. Interferon inhibitor in the blood of patients with systemic lupus erythematosus. J Biol Regul Homeost Agents. 1991; 5(1).
  • Ambrus JL, Chesky L, Stephany D, McFarland P, Mostowski H, Fauci AS. Functional studies examining the subpopulation of human B lymphocytes responding to high molecular weight B cell growth factor.. J Immunol. 1990; 145(12).
  • Goldstein H, Koerholz D, Chesky L, Fan XD, Ambrus JL. Divergent activities of protein kinases in IL-6-induced differentiation of a human B cell line.. J Immunol. 1990; 145(3).
  • Ambrus JL, Peters MG, Fauci AS, Brown EJ. The Ba fragment of complement factor B inhibits human B lymphocyte proliferation.. J Immunol. 1990; 144(5).
  • Begley CG, Burton JD, Tsudo M, Brownstein BH, Ambrus JL, Waldmann TA. Human B lymphocytes express the p75 component of the interleukin 2 receptor. Leuk Res. 1990; 14(3).
  • Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF, Meijer S, van der Giessen M, van der Hem GK, The TH. Association between active Wegener's granulomatosis and anticytoplasmic antibodies.. Arch Intern Med. 1989; 149(11).
  • Uckun FM, Fauci AS, Chandan-Langlie M, Myers DE, Ambrus JL. Detection and characterization of human high molecular weight B cell growth factor receptors on leukemic B cells in chronic lymphocytic leukemia.. J Clin Invest. 1989; 84(5).
  • Uckun FM, Myers DE, Fauci AS, Chandan-Langlie M, Ambrus JL. Leukemic B-cell precursors constitutively express functional receptors for human interleukin-1.. Blood. 1989; 74(2).
  • Lewis RA, Rankin JA, Allison AC, Ambrus JL. Regulated generation of leukotrienes in mononuclear cells. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19.
  • Peters MG, Ambrus JL, Fauci AS, Brown EJ. The Bb fragment of complement factor B acts as a B cell growth factor.. J Exp Med. 1988; 168(4).
  • Ambrus JL, Jurgensen CH, Brown EJ, McFarland P, Fauci AS. Identification of a receptor for high molecular weight human B cell growth factor.. J Immunol. 1988; 141(3).
  • Ambrus JL, Jurgensen CH, Witzel NL, Lewis RA, Butler JL, Fauci AS. Leukotriene C4 produced by a human T-T hybridoma suppresses Ig production by human lymphocytes.. J Immunol. 1988; 140(7).
  • Nakagawa T, Nakagawa N, Ambrus JL, Fauci AS. Differential effects of interleukin 2 vs B cell growth factor on human B cells.. J Immunol. 1988; 140(2).
  • Uckun FM, Jaszcz W, Ambrus JL, Fauci AS, Gajl-Peczalska K, Song CW, Wick MR, Myers DE, Waddick K, Ledbetter JA. Detailed studies on expression and function of CD19 surface determinant by using B43 monoclonal antibody and the clinical potential of anti-CD19 immunotoxins.. Blood. 1988; 71(1).
  • Uckun FM, Fauci AS, Heerema NA, Song CW, Mehta SR, Gajl-Peczalska K, Chandan M, Ambrus JL. B-cell growth factor receptor expression and B-cell growth factor response of leukemic B cell precursors and B lineage lymphoid progenitor cells.. Blood. 1987; 70(4).
  • Goldstein H, Ambrus JL, Grove JH, Margolick JB, Fauci AS. Functional and biochemical characterization of B-cell differentiation factor (BCDF) produced by an HTLV-I-transformed human T-cell clone and demonstration of specific binding of the factor to a BCDF responsive cell line.. Cell Immunol. 1987; 108(2).
  • Nakagawa N, Nakagawa T, Volkman DJ, Ambrus JL, Fauci AS. The role of interleukin 2 in inducing Ig production in a pokeweed mitogen-stimulated mononuclear cell system.. J Immunol. 1987; 138(3).
  • Ambrus JL, Jurgensen CH, Bowen DL, Tomita S, Nakagawa T, Nakagawa N, Goldstein H, Witzel NL, Mostowski HS, Fauci AS. The activation, proliferation, and differentiation of human B lymphocytes. Adv Exp Med Biol. 1987; 213.
  • Peters M, Ambrus JL, Zheleznyak A, Walling D, Hoofnagle JH. Effect of interferon-alpha on immunoglobulin synthesis by human B cells.. J Immunol. 1986; 137(10).
  • Jurgensen CH, Ambrus JL, Fauci AS. Production of B cell growth factor by normal human B cells.. J Immunol. 1986; 136(12).
  • Bowen DL, Ambrus JL, Fauci AS. Identification and characterization of a B cell activation factor (BCAF) produced by a human T cell line.. J Immunol. 1986; 136(6).
  • Margolick JB, Ambrus JL, Volkman DJ, Fauci AS. Human T4+ lymphocytes produce a phagocytosis-inducing factor (PIF) distinct from interferon-alpha and interferon-gamma.. J Immunol. 1986; 136(2).
  • Ambrus JL, Jurgensen CH, Brown EJ, Fauci AS. Purification to homogeneity of a high molecular weight human B cell growth factor; demonstration of specific binding to activated B cells; and development of a monoclonal antibody to the factor.. J Exp Med. 1985; 162(4).
  • Goldstein H, Volkman DJ, Ambrus JL, Fauci AS. Characterization of a T4+/Leu-8+ T cell clone that directly helps B cell Ig production by secreting B cell differentiation factor.. J Immunol. 1985; 135(1).
  • Tomita S, Ambrus JL, Volkman DJ, Longo DL, Mitsuya H, Reitz MS, Fauci AS. Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. Direct responsiveness of cloned cells to recombinant interleukin 2 by differentiation in the absence of enhanced proliferation.. J Exp Med. 1985; 162(1).
  • Ambrus JL, Fauci AS. Human B lymphoma cell line producing B cell growth factor.. J Clin Invest. 1985; 75(2).
  • Butler JL, Ambrus JL, Fauci AS. Characterization of monoclonal B cell growth factor (BCGF) produced by a human T-T hybridoma.. J Immunol. 1984; 133(1).
  • Kehrl JH, Muraguchi A, Falkoff RJ, Ambrus JL, Butler JL, Fauci AS. Activation and immunoregulation of human B lymphocytes. Uremia Invest. 1984; 8(3-4).
  • Sayyid SH, Bielat KL, Mahafzah MM, Ambrus JL. Ultrastructural study of a murine model for Chediak Higashi syndrome. J Med. ; 22(6).
  • Halpern J, Islam A, Simich JP, Piver MS, Ambrus JL, Bielat KL. Tumor-infiltrating lymphocytes: in vitro characterization of morphological and phenotypical changes. Cancer Detect Prev. ; 13(1).
  • Bielat KL, Halpern J, Simich JP, Huben RP, Ambrus JL. A morphological analysis of an in vitro model of cytotoxic antitumor activity. Cancer Detect Prev. ; 12(1-6).
  • Halpern J, Bielat KL, Simich JP, Klein E, Ambrus JL. Human peripheral blood mononuclear cells (PBM) cultured in serum-free medium. III. Morphological study of an in vitro microcytotoxicity model. J Med. ; 17(3-4).
  • Halpern J, Joy JV, Bielat KL, Ambrus JL. Human peripheral blood mononuclear cells (PBM's) cultured in serum free medium (II): Lymphocyte-macrophage interaction and related morphological changes. J Med. ; 16(4).
See All (72 Total) >

Professional Memberships:
  • Federation of American Societies for Experimental Biology
  • American Association of Immunologists
  • American Federation for Clinical Research
  • Buffalo Allergy Society
  • Buffalo Academy of Medicine; President
Presentations:
  • "Atypical Hemolytic Uremic Syndrome" Rheumatology Grand Rounds, Mount Sinai School of Medicine, Rheumatology (2013)
  • "Innate Immunity in Sjogren's Syndrome" CORA, CORA, Autoimmunity (2013)
  • "Role of Lymphotoxin and Interferon in Sjogren's Syndrome" Gordon Conference Salivary Gland biology, Federation of Biology, Sjogren's (2013)
  • "Early Events in Sjogren's Syndrome" American College of Rheumatology, American College of Rheumatology, Sjogren's (2012)
Service Activities:
  • United States Public Health Service; Active 1984-1989 Reserve Inactive 1989-1999 (1984–1989)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

Buffalo General Medical Center
100 High Street
Buffalo, NY 14203
Phone: (716) 859-2985
Fax: (716) 859-1249
Email: jambrus@buffalo.edu

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