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Jerome                         Roth

Jerome A. Roth PhD

Department of Pharmacology and Toxicology


Specialty/Research Focus

Apoptosis and cell death; Membrane Transport (Ion Transport); Neurodegenerative disorders; Proteins and metalloenzymes; Signal Transduction; Toxicology and Xenobiotics

Professional Summary:

Dr. Jerome Roth‘s research interests over the past several years have focused on the mechanism of action of manganese in producing neuronal cell death. Manganese is an essential mineral that at high concentration acts as a neurotoxin which produces a Parkinson-like syndrome. Although the identified brain lesions associated with manganism differ from those of Parkinson’s disease, there is increasing evidence that chronic exposure to Mn correlates with increased susceptibility to develop Parkinsonism. Current studies are focused on characterizing the signal transduction pathways stimulated by manganese and to determine whether they also play a role in the toxic actions of this divalent cation. As part of this project we are also investigating the transport mechanisms by which manganese is taken up into cells. We have focused our studies on the divalent metal transporter (DMT1) and its role in the transport of manganese and other divalent cations. We are currently studying the transcriptional and post-translational factors that regulate its expression in vivo. Preliminary studies have linked DMT1 expression to the protein, parkin, mutations in which lead to early onset of Parkinson‘s disease. Whether other gene linked to Parkinsonism are also associate with development of manganism is the current focus of my research. Current studies in my laboratory focus on how other early and late genes associated with Parkinson’s disease can influence Mn toxicity as these studies will provide a basis for the comorbidity between manganism and Parkinson’s; the manipulation of this mechanism may therefore provide new prophylactic and/or management treatment options for Parkinson’s disease.

Education and Training:
  • Postdoctoral Fellow, Biochemistry, Vanderbilt University (1972)
  • PhD, Biochemistry, Cornell University (1971)
  • MNS, Nutritional Science, Cornell University (1967)
  • BS, State University of New York at New Paltz (1965)
  • Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1985-present)
  • Director of the Medical Scientist Program, Pharmacology and Toxicology, State University of New York at Buffalo (1990–2000)
  • Associate Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1980–1985)
  • Assistant Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1976–1980)
  • Assistant Professor, Anesthesiology, Yale University School of Medicine (1973–1976)
  • Research Associate, Anesthesiology, Yale University School of Medicine (1972–1973)
Awards and Honors:
  • UB Exceptional Scholar Award 2010

Grants and Sponsored Research:
  • September 2012–August 2016
    Occupational exposure to manganese and noise potentiate hearing loss
    Role: Principal Investigator
  • December 2008–November 2011
    Mechanism and Treatment of Manganese Toxicity
    Role: Principal Investigator
  • September 2009–June 2011
    Role of Parkin in Regulating Manganese Toxicity
    Role: Principal Investigator
  • August 1997–June 1998
    Melatonin Suppression of PC-12 Cell Growth
    Multidisciplinary Pilot Program Grant
    Role: Co-Investigator

Journal Articles:
See all (91 more)

Professional Memberships:
  • Society of Toxicology (2005–2015)
  • ASPET (1995–present)
  • ASPET (1995–present)
  • Society of Toxicology
  • "Role of NF-κB and Parkin in Regulating DMT1 Expression and Manganese Toxicity," TEMA13 (Trace Elements in Man and Animals) (2008)
  • "Mechanism of Manganese-Induced Rat Pheochromocytoma (PC12) Cell Death and Cell Differentiation" Ninth International Ferroalloys Congress, Manganese 2001 Health Issues Symposium (2001)
  • "Mechanism of Manganese-Induced Neurotoxicity and Neurite Outgrowth in Rat PC12 Cells" Air and Waste Management Association, Measurement of Toxic and Related Air Pollutants (1998)
  • "University of Rochester, Department of Environmental Medicine, Environmental Health Sciences Center, Manganese Toxicity: Role and Regulation of Divalent Metal Transporter 1 (DMT1), August (2007)"
Service Activities:
  • Editorial Board: Biochemical Pharmacology; Ad Hoc Reviewer

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Contact Information

11 Cary Hall
Buffalo, NY 14214
Phone: (716) 829-3236
Fax: (716) 829-2801

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