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Jacobs School of Medicine and Biomedical Sciences

Jerrold Winter

Jerrold C. Winter PhD

Department of Pharmacology and Toxicology

Professor

Specialty/Research Focus

Behavioral pharmacology; Neuropharmacology; Toxicology and Xenobiotics

 
Overview Research Publications Activities Latest News
Professional Summary:

Research in my laboratory centers on the study of psychoactive drugs with special emphasis on nootropics and drugs of abuse.

In collaboration with Dr. Richard Rabin of this department, behavioral data are correlated with biochemical indices of drug action in an attempt to understand at the receptor level the effects in intact animals of psychoactive drugs. Behavioral data are obtained using the techniques of operant behavior with special emphasis on the phenomenon of drug-induced stimulus control. Current interests include the serotonergic basis for the actions of indoleamine and phenethylamine hallucinogens including LSD and [-]-DOM as well as their interactions with selective monoamine reuptake inhibitors such as fluoxetine [Prozac]. In the area of nootropics, recent studies have examined the effects of EGb 761, an extract of Ginkgo biloba; for these investigations, a delayed non-matching to position task in a radial
maze is employed. Currently, studies are in progress to assess the serotonergic basis for the cognitive effects of drugs of abuse including LSD and MDMA [Ecstasy].

Behavioral pharmacology of psychoactive drugs, including psychotherapeutic agents and drugs of abuse; mechanisms of action of hallucinogens.

Research in Dr. Jerrold Winter‘s laboratory seeks to understand the ways in which drugs alter behavior. Many chemicals are candidates for study but attention in the last few years has centered on hallucinogens such as LSD, phencyclidine, DOM, and ibogaine. Another area of major interest is age-related memory impairment and those natural materials,
including ginseng and gingko biloba, which are purported to influence that impairment. The behavioral effects of these drugs are studied in rats trained with the techniques of operant conditioning. Specific variables in use at the present time include drug-induced stimulus control, radial maze acquisition and performance, and conditioned place preference and
aversion.

In addition, Dr. Winter actively collaborates with Dr. Richard Rabin of the Department of Pharmacology and Toxicology in order to correlate behavioral effects with biochemical indices of action at the receptor level and with functional efficacies in second messenger systems.

Education and Training:
  • PhD, Pharmacology, State University of New York at Buffalo (1966)
  • BS, Organic Chemistry, University of Rochester (1959)
Employment:
  • Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1976-present)
  • Associate Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1971–1976)
  • Assistant Professor, Pharmacology and Toxicology, State University of New York at Buffalo (1967–1971)
  • Postdoctoral Fellow, Radiation Biology and Biophysics, University of Rochester School of Medicine (1966–1967)
  • Commissioned Officer, United States Navy (1959–1962)
Grants and Sponsored Research:
  • August 2007–July 2010
    “Pharmacogenetics in indolealkylamine metabolism and drug interaction” Principal Investigator: Aiming Yu, Ph.D., co-investigator: Jerrold C, Winter, Ph.D. Type: RO1 [DA021172] Period: 08/01/2007-07/31/2011. The overall goal of this project is to
    NIDA
    Role: Co-Investigator
Journal Articles:
  • Bergman GJ, Winter JC, van Tulder MW, Meyboom-de Jong B, Postema K, van der Heijden GJ. Manipulative therapy in addition to usual medical care accelerates recovery of shoulder complaints at higher costs: economic outcomes of a randomized trial. BMC Musculoskelet Disord. 2010; 11.
  • Shen HW, Jiang XL, Winter JC, Yu AM. Psychedelic 5-Methoxy-N,N-dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions. Curr Drug Metab. 2010.
  • Winter JC. Hallucinogens as discriminative stimuli in animals: LSD, phenethylamines, and tryptamines. Psychopharmacology (Berl). 2009; 203(2).
  • Reissig CJ, Rabin RA, Winter JC, Dlugos CA. d-LSD-induced c-Fos expression occurs in a population of oligodendrocytes in rat prefrontal cortex. Eur J Pharmacol. 2008; 583(1).
  • Reissig CJ, Eckler JR, Rabin RA, Rice KC, Winter JC. The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component. Pharmacol Biochem Behav. 2008; 88(3).
  • Krall CM, Richards JB, Rabin RA, Winter JC. Marked decrease of LSD-induced stimulus control in serotonin transporter knockout mice. Pharmacol Biochem Behav. 2008; 88(3).
  • Winter JC. Antagonism of phencyclidine-induced stimulus control in the rat by other psychoactive drugs. Pharmacol Biochem Behav. 2008; 88(3).
  • Fantegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter JC. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Pharmacol Biochem Behav. 2008; 88(3).
  • Winter JC, Rice KC, Amorosi DJ, Rabin RA. Psilocybin-induced stimulus control in the rat. Pharmacol Biochem Behav. 2007; 87(4).
  • Reissig CJ, Eckler JR, Rabin RA, Winter JC. The 5-HT1A receptor and the stimulus effects of LSD in the rat. Psychopharmacology (Berl). 2005; 182(2).
  • Winter JC, Kieres AK, Zimmerman MD, Reissig CJ, Eckler JR, Ullrich T, Rice KC, Rabin RA, Richards JB. The stimulus properties of LSD in C57BL/6 mice. Pharmacol Biochem Behav. 2005; 81(4).
  • Muschamp JW, Regina MJ, Hull EM, Winter JC, Rabin RA. Lysergic acid diethylamide and [-]-2,5-dimethoxy-4-methylamphetamine increase extracellular glutamate in rat prefrontal cortex. Brain Res. 2004; 1023(1).
  • Eckler JR, Reissig CJ, Rabin RA, Winter JC. A 5-HT(2C) receptor-mediated interaction between 2,5-dimethoxy-4-methylamphetamine and citalopram in the rat. Pharmacol Biochem Behav. 2004; 79(1).
  • Regina MJ, Bucelli RC, Winter JC, Rabin RA. Cellular mechanisms of serotonin 5-HT(2A) receptor-mediated cGMP formation: the essential role of glutamate.. Brain Res. 2004; 1003(1-2).
  • Winter JC, Eckler JR, Rabin RA. Serotonergic/glutamatergic interactions: the effects of mGlu2/3 receptor ligands in rats trained with LSD and PCP as discriminative stimuli.. Psychopharmacology (Berl). 2004; 172(2).
  • Regina MJ, Winter JC, Rabin RA. Characterization of a novel effect of serotonin 5-HT1A and 5-HT2A receptors: increasing cGMP levels in rat frontal cortex.. Neuropharmacology. 2003; 45(8).
  • Eckler JR, Chang-Fong J, Rabin RA, Smith C, Teitler M, Glennon RA, Winter JC. Behavioral characterization of 2-O-desmethyl and 5-O-desmethyl metabolites of the phenylethylamine hallucinogen DOM.. Pharmacol Biochem Behav. 2003; 75(4).
  • Eckler JR, Rabin RA, Winter JC. Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control.. Pharmacol Biochem Behav. 2003; 75(2).
  • Doat MM, Rabin RA, Winter JC. Characterization of the discriminative stimulus properties of centrally administered (-)-DOM and LSD.. Pharmacol Biochem Behav. 2003; 74(3).
  • Winter JC, Eckler JR, Doat MM, Rabin RA. The effects of acute and subchronic treatment with fluoxetine and citalopram on stimulus control by DOM.. Pharmacol Biochem Behav. 2002; 74(1).
  • Eckler JR, Doat MM, Rabin RA, Winter JC. Potentiation of DOM-induced stimulus control by fluoxetine and citalopram: role of pharmacokinetics.. Life Sci. 2002; 71(11).
  • Doat MM, Rabin RA, Winter JC. The effect of chronic treatment with clozapine and haloperidol on stimulus control by DOM.. Int J Neuropsychopharmacol. 2002; 5(2).
  • Rabin RA, Regina M, Doat M, Winter JC. 5-HT2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens.. Pharmacol Biochem Behav. 2002; 72(1-2).
  • Rabin RA, Regina M, Doat M, Winter JC. 5-HT(2A) receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens.. Pharmacol Biochem Behav. 2002; 72(1-2).
  • Richard Rabin, Regina, MJ, Doat, MM, Jerrold Winter. 5-HT2A receptor-stimulated phosphoinosistide hydrolysis in the stimulus effects of hallucinogens. Pharmacol Biochem Behav. 2002; 72.
  • Eckler, JR, Doat, M, Richard Rabin, Jerrold Winter. Potentiation of DOM-induced stimulus control by fluoretine and citalopram: the role of pharmacokinetics. Life Sci. 2002; 71.
  • Doat, MM, Richard Rabin, Jerrold Winter. The effect of chronic treatment with clozapine and haloperidol on the stimulus effects of DOM. Int J Neuropharmacol. 2002; 5.
  • Jerrold Winter, Eckler, JR, Richard Rabin, Doat, MM. The Effects of Acute and Chronic Treatment with Fluoxetine and Citalopram on Stimulus Control by DOM. Pharmacol Biochem Behav. 2002; 74.
  • Eckler JR, Greizerstein H, Rabin RA, Winter JC. A sensitive method for determining levels of [-]-2,5,-dimethoxy-4-methylamphetamine in the brain tissue. J Pharmacol Toxicol Methods. 2001; 46(1).
  • Helsley S, Rabin RA, Winter JC. Drug discrimination studies with ibogaine. Alkaloids Chem Biol. 2001; 56.
  • Eckler, JR, Richard Rabin, Greizerstein, H, Jerrold Winter. A sensitive method for determining levels of [-]-2,5-dimethoxy-4-methylamphetamine in brain tissue. J Pharmacol Toxicol Methods. 2001; 46.
  • Rabin RA, Doat M, Winter JC. Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine.. Int J Neuropsychopharmacol. 2000; 3(4).
  • Winter JC, Doat M, Rabin RA. Potentiation of DOM-induced stimulus control by non-competitive NMDA antagonists: a link between the glutamatergic and serotonergic hypotheses of schizophrenia.. Life Sci. 2000; 68(3).
  • Winter JC, Filipink RA, Timineri D, Helsley SE, Rabin RA. The paradox of 5-methoxy-N,N-dimethyltryptamine: an indoleamine hallucinogen that induces stimulus control via 5-HT1A receptors.. Pharmacol Biochem Behav. 2000; 65(1).
  • Richard Rabin, Doat, M., Jerrold Winter. Role of serotonergic 5-HT2A receptors in the psychotomimetic actions of phencyclidine. Int J Neuropsychopharmacol. 2000; 3.
  • Winter JC, Fiorella DJ, Timineri DM, Filipink RA, Helsley SE, Rabin RA. Serotonergic receptor subtypes and hallucinogen-induced stimulus control.. Pharmacol Biochem Behav. 1999; 64(2).
  • Winter JC, Helsley S, Fiorella D, Rabin RA. The acute effects of monoamine reuptake inhibitors on the stimulus effects of hallucinogens.. Pharmacol Biochem Behav. 1999; 63(3).
  • Winter JC, Timineri D. The discriminative stimulus properties of EGb 761, an extract of Ginkgo biloba.. Pharmacol Biochem Behav. 1999; 62(3).
  • Helsley S, Rabin RA, Winter JC. Further investigations of the serotonergic properties of the ibogaine-induced discriminative stimulus.. Prog Neuropsychopharmacol Biol Psychiatry. 1999; 23(2).
  • Jerrold Winter, Fiorella, DJ, Helsley, SE, Richard Rabin. Partial Generalization of (-)DOM to Fluvoxamine in the Rat: Implications for SSRI-induced Mania and Psychosis. Int J Neuropsychopharmacol. 1999; 2.
  • Helsley S, Siegel TL, Fiorella D, Rabin RA, Winter JC. WAY-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze.. Prog Neuropsychopharmacol Biol Psychiatry. 1998; 22(7).
  • Winter JC, Helsley SE, Rabin RA. The discriminative stimulus effects of KA 672, a putative cognitive enhancer: evidence for a 5-HT1A component.. Pharmacol Biochem Behav. 1998; 60(3).
  • Helsley S, Fiorella D, Rabin RA, Winter JC. A comparison of N,N-dimethyltryptamine, harmaline, and selected congeners in rats trained with LSD as a discriminative stimulus.. Prog Neuropsychopharmacol Biol Psychiatry. 1998; 22(4).
  • Helsley S, Rabin RA, Winter JC. The effects of beta-carbolines in rats trained with ibogaine as a discriminative stimulus.. Eur J Pharmacol. 1998; 345(2).
  • Helsley S, Filipink RA, Bowen WD, Rabin RA, Winter JC. The effects of sigma, PCP, and opiate receptor ligands in rats trained with ibogaine as a discriminative stimulus.. Pharmacol Biochem Behav. 1998; 59(2).
  • Helsley S, Fiorella D, Rabin RA, Winter JC. Behavioral and biochemical evidence for a nonessential 5-HT2A component of the ibogaine-induced discriminative stimulus.. Pharmacol Biochem Behav. 1998; 59(2).
  • Winter JC. The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat.. Physiol Behav. 1998; 63(3).
  • Fiorella D, Helsley S, Rabin RA, Winter JC. Further investigations of the interactions of antipsychotics with the (-)2,5-dimethoxy-4-methylamphetamine (DOM) discriminative stimulus.. Neuropharmacology. 1997; 36(10).
  • Helsley S, Fiorella D, Rabin RA, Winter JC. Effects of ibogaine on performance in the 8-arm radial maze.. Pharmacol Biochem Behav. 1997; 58(1).
  • Johnson RG, Fiorella D, Winter JC, Rabin RA. [3H]8-OH-DPAT labels a 5-HT site coupled to inhibition of phosphoinositide hydrolysis in the dorsal raphe.. Eur J Pharmacol. 1997; 329(1).
  • Helsley S, Dlugos CA, Pentney RJ, Rabin RA, Winter JC. Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat.. Brain Res. 1997; 759(2).
  • Winter JC. The effects of age on continuous learning in the radial maze.. Physiol Behav. 1997; 61(4).
  • Helsley S, Rabin RA, Winter JC. The effects of noribogaine and harmaline in rats trained with ibogaine as a discriminative stimulus.. Life Sci. 1997; 60(9).
  • Rabin RA, Winter JC. Ibogaine and noribogaine potentiate the inhibition of adenylyl cyclase activity by opioid and 5-HT receptors.. Eur J Pharmacol. 1996; 316(2-3).
  • Rabin RA, Winter JC. Effects of ibogaine and noribogaine on phosphoinositide hydrolysis.. Brain Res. 1996; 731(1-2).
  • Fiorella D, Helsley S, Rabin RA, Winter JC. Potentiation of LSD-induced stimulus control by fluoxetine in the rat.. Life Sci. 1996; 59(18).
  • Fiorella D, Rabin RA, Winter JC. The interaction of clozapine with the meta-chlorophenylpiperazine (mCPP) discriminative stimulus.. Life Sci. 1996; 58(24).
  • Fiorella D, Helsley S, Rabin RA, Winter JC. 5-HT2C receptor-mediated phosphoinositide turnover and the stimulus effects of m-chlorophenylpiperazine.. Psychopharmacology (Berl). 1995; 122(3).
  • Fiorella D, Helsley S, Lorrain DS, Rabin RA, Winter JC. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion.. Psychopharmacology (Berl). 1995; 121(3).
  • Fiorella D, Rabin RA, Winter JC. Role of 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. II: Reassessment of LSD false positives.. Psychopharmacology (Berl). 1995; 121(3).
  • Fiorella D, Rabin RA, Winter JC. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. I: Antagonist correlation analysis.. Psychopharmacology (Berl). 1995; 121(3).
  • Fiorella D, Helsley S, Rabin RA, Winter JC. The interactions of typical and atypical antipsychotics with the (-)2, 5,-dimethoxy-4-methamphetamine (DOM) discriminative stimulus.. Neuropharmacology. 1995; 34(10).
  • Fiorella D, Palumbo PA, Rabin RA, Winter JC. The time-dependent stimulus effects of R(-)-2,5-dimethoxy-4-methamphetamine (DOM): implications for drug-induced stimulus control as a method for the study of hallucinogenic agents.. Psychopharmacology (Berl). 1995; 119(2).
  • Fiorella D, Rabin RA, Winter JC. The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of m-chlorophenylpiperazine.. Psychopharmacology (Berl). 1995; 119(2).
  • Bonson KR, Johnson RG, Fiorella D, Rabin RA, Winter JC. Serotonergic control of androgen-induced dominance.. Pharmacol Biochem Behav. 1994; 49(2).
  • Palumbo PA, Winter JC. Interactions of clozapine with the stimulus effects of DOM and LSD.. Pharmacol Biochem Behav. 1994; 49(1).
  • Winter JC. The stimulus effects of serotonergic hallucinogens in animals. NIDA Res Monogr. 1994; 146.
  • Winter JC, Rabin RA. Discriminative stimulus properties of m-chlorophenylpiperazine.. Pharmacol Biochem Behav. 1993; 45(1).
  • Rabin RA, Winter JC. Studies of the biochemical basis for the discriminative properties of 8-hydroxy-2-(di-n-propylamino)tetralin.. Eur J Pharmacol. 1993; 235(2-3).
  • Winter JC, Rabin RA. Antagonism of the stimulus effects of yohimbine and 8-hydroxydipropylaminotetralin.. Pharmacol Biochem Behav. 1993; 44(4).
  • Palumbo PA, Winter JC. Stimulus effects of ibogaine in rats trained with yohimbine, DOM, or LSD.. Pharmacol Biochem Behav. 1992; 43(4).
  • Winter JC, Rabin RA. Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination.. J Pharmacol Exp Ther. 1992; 263(2).
  • Bonson KR, Winter JC. Reversal of testosterone-induced dominance by the serotonergic agonist quipazine.. Pharmacol Biochem Behav. 1992; 42(4).
  • Winter JC. Relationship between sources of knowledge and use of research findings. J Contin Educ Nurs. 1990; 21(3).
  • McCann DJ, Rabin RA, Rens-Domiano S, Winter JC. Phencyclidine/SKF-10,047 binding sites: evaluation of function.. Pharmacol Biochem Behav. 1989; 32(1).
  • Winter J, Rabin R. Yohimbine and serotonergic agonists: Stimulus properties and receptor binding.. Drug Dev. Res.. 1989; 16.
  • Winter JC, Rabin RA. A comparison of the discriminative stimulus properties of l-5-hydroxytryptophan in the presence of either citalopram or Ro 4-4602.. Pharmacol Biochem Behav. 1988; 30(3).
  • Winter JC, Rabin RA. Interactions between serotonergic agonists and antagonists in rats trained with LSD as a discriminative stimulus.. Pharmacol Biochem Behav. 1988; 30(3).
  • Winter JC. Generalization of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ipsapirone to yohimbine.. Pharmacol Biochem Behav. 1988; 29(1).
  • Winter JC, Petti DT. The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: a possible role for 5-HT1A receptors in memory.. Pharmacol Biochem Behav. 1987; 27(4).
  • McCann DJ, Rabin RA, Winter JC. Use of the radial maze in studies of phencyclidine and other drugs of abuse.. Physiol Behav. 1987; 40(6).
  • McCann DJ, Rabin RA, Winter JC. Interactions of clonidine with phencyclidine and ketamine: studies of radial maze performance and righting reflex in rats.. Pharmacol Biochem Behav. 1987; 26(1).
  • Winter JC. Verapamil does not antagonize LSD-induced stimulus control.. Pharmacol Biochem Behav. 1986; 25(1).
  • McCann DJ, Winter JC. Effects of phencyclidine, N-allyl-N-normetazocine (SKF-10,047), and verapamil on performance in a radial maze.. Pharmacol Biochem Behav. 1986; 24(2).
  • Winter JC. Sedation and the stimulus properties of antihistamines.. Pharmacol Biochem Behav. 1985; 22(1).
  • Winter JC. The stimulus properties of para-methoxyamphetamine: a nonessential serotonergic component.. Pharmacol Biochem Behav. 1984; 20(2).
  • Winter JC. Caffeine-induced stimulus control.. Pharmacol Biochem Behav. 1981; 15(2).
  • Winter JC. The stimulus properties of gamma-hydroxybutyrate. Psychopharmacology (Berl). 1981; 73(4).
  • Winter JC. Drug-induced stimulus control and the concept of breaking point: LSD and quipazine. Psychopharmacology (Berl). 1981; 72(2).
  • Winter JC. Effects of the phenethylamine derivatives, BL-3912, fenfluramine, and Sch-12679, in rats trained with LSD as a discriminative stimulus. Psychopharmacology (Berl). 1980; 68(2).
  • Frey LG, Winter JC. Comparison of the discriminative stimulus properties of nefopam and morphine.. Psychopharmacology (Berl). 1979; 61(2).
  • Winter JC. Quipazine-induced stimulus control in the rat.. Psychopharmacology (Berl). 1979; 60(3).
  • Frey LG, Winter JC. Discriminative stimulus properties of intravenous morphine in the rat. Psychopharmacology (Berl). 1979; 66(3).
  • Winter JC. Yohimbine-induced stimulus control in the rat.. Arch Int Pharmacodyn Ther. 1978; 235(1).
  • Winter JC. Stimulus properties of phenethylamine hallucinogens and lysergic acid diethylamide: the role of 5-hydroxytryptamine.. J Pharmacol Exp Ther. 1978; 204(2).
  • Winter JC. Morphine and ethanol as discriminative stimuli: absence of antagonism by p-chlorophenylalanine methyl ester, cinanserin, or BC-105.. Psychopharmacology (Berl). 1977; 53(2).
  • Winter JC. The stimulus properties of morphine and ethanol.. Psychopharmacologia. 1975; 44(3).
  • Winter JC. The effects of 2,5-dimethoxy-4-methylamphetamine (DOM), 2,5-dimethoxy-4-ethylamphetamine (DOET), d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus. Psychopharmacologia. 1975; 44(1).
  • York JL, Winter JC. Assessment of tolerance to barbital by means of drug discrimination procedures.. Psychopharmacologia. 1975; 42(3).
  • Hirschhorn ID, Winter JC. Differences in the stimulus properties of barbital and hallucinogens. Pharmacol Biochem Behav. 1975; 3(3).
  • Winter JC. Blockade of the stimulus properties of mescaline by a serotonin antagonist. Arch Int Pharmacodyn Ther. 1975; 214(2).
  • Winter JC. The behavioral pharmacology of psychoactive drugs. Psychopharmacol Bull. 1975; 11(2).
  • York JL, Winter JC. Long-term effects of barbital on spontaneous activity of rats trained to use the drug as a discriminative stimulus.. Psychopharmacologia. 1975; 42(1).
  • Winter JC. Propranolol and morphine: a lethal interaction. Arch Int Pharmacodyn Ther. 1974; 212(2).
  • Overton DA, Winter JC. Discriminable properties of drugs and state-dependent learning. Introduction. Fed Proc. 1974; 33(7).
  • Winter JC. Hallucinogens as discriminative stimuli. Fed Proc. 1974; 33(7).
  • Winter JC. The effects of 3,4-dimethoxyphenylethylamine in rats trained with mescaline as a discriminative stimulus.. J Pharmacol Exp Ther. 1974; 189(3).
  • Oglesby MW, Winter JC. Strychnine sulfate and piracetam: lack of effect on learning in the rat.. Psychopharmacologia. 1974; 36(2).
  • Oglesby MW, Rosenberg J, Winter JC. Behavioral and biochemical effects of chronic administration of bromide in the rat.. Psychopharmacologia. 1973; 32(1).
  • Sethy VH, Winter JC. Effect of chronic treatment with mescaline upon tissue levels of the drug.. Experientia. 1973; 29(5).
  • Winter JC. A comparison of the stimulus properties of mescaline and 2,3,4-trimethoxyphenylethylamine.. J Pharmacol Exp Ther. 1973; 185(1).
  • Frey LG, Winter JC. Effects of p-acetyldeoxyephedrine on punished behavior in the rat.. Arch Int Pharmacodyn Ther. 1973; 201(1).
  • Winter JC. Comparison of chlordiazepoxide, methysergide, and cinanserin as modifiers of punished behavior and as antagonists of N,N-dimethyltryptamine.. Arch Int Pharmacodyn Ther. 1972; 197(1).
  • Schechter MD, Winter JC. Effect of BOL on the LSD-induced alteration of flicker discrimination in the rat.. Arch Int Pharmacodyn Ther. 1972; 196(1).
  • Winter JC. Xylamidine tosylate: differential antagonism of the hypothermic effects of N,N-dimethyltryptamine, bufotenine, and 5-methoxytryptamine. Arch Int Pharmacodyn Ther. 1972; 198(1).
  • Sethy VH, Winter JC. Effects of yohimbine and mescaline on punished behavior in the rat. Psychopharmacologia. 1972; 23(2).
  • Winter JC. Tolerance to a behavioral effect of lysergic acid diethylamide and cross-tolerance to mescaline in the rat: absence of a metabolic component.. J Pharmacol Exp Ther. 1971; 178(3).
  • Schechter MD, Winter JC. Effect of mescaline and lysergic acid diethylamide on flicker discrimination in the rat.. J Pharmacol Exp Ther. 1971; 177(2).
  • Winter JC. Interaction of serotonin antagonists with harmaline-induced changes in operant behavior and body temperature in the rat.. Arch Int Pharmacodyn Ther. 1971; 191(1).
  • Hirschhorn ID, Winter JC. Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli. Psychopharmacologia. 1971; 22(1).
  • Winter JC. Behavioral effects of N,N-diethyltryptamine: absence of antagonism by xylamidine tosylate.. J Pharmacol Exp Ther. 1969; 169(1).
  • Winter JC, Gessner PK. Phenoxybenzamine antagonism of tryptamines, their indene isosteres and 5-hydroxytryptamine in the rat stomach fundus preparation.. J Pharmacol Exp Ther. 1968; 162(2).
  • Winter JC, Gessner PK, Godse DD. Synthesis of some 3-indenealkylamines. Comparison of the biological activity of 3-indenealkylamines and 3-benzo[b]thiophenealkylamines with their tryptamine isosteres.. J Med Chem 10: 856-859, 1967. 1967; 10(5).
  • Helsley S, Rabin RA, Winter JC. Drug discrimination studies with ibogaine.. Alkaloids Chem Biol. ; 56.
  • Winter JC. The stimulus effects of serotonergic hallucinogens in animals.. NIDA Res Monogr. ; 146.
  • Hirschhorn ID, Winter JC. Differences in the stimulus properties of barbital and hallucinogens.. Pharmacol Biochem Behav. ; 3(3).
  • Winter JC. Relationship between sources of knowledge and use of research findings.. J Contin Educ Nurs. ; 21(3).
  • Winter JC. The stimulus properties of gamma-hydroxybutyrate.. Psychopharmacology (Berl). ; 73(4).
  • Winter JC. Drug-induced stimulus control and the concept of breaking point: LSD and quipazine.. Psychopharmacology (Berl). ; 72(2).
  • Winter JC. Effects of the phenethylamine derivatives, BL-3912, fenfluramine, and Sch-12679, in rats trained with LSD as a discriminative stimulus.. Psychopharmacology (Berl). ; 68(2).
  • Helsley S, Rabin RA, Winter JC. The effects of noribogaine and harmaline in rats trained with ibogaine as a discriminative stimulus.. Life Sci. ; 60(9).
  • Fiorella D, Helsley S, Rabin RA, Winter JC. Potentiation of LSD-induced stimulus control by fluoxetine in the rat.. Life Sci. ; 59(18).
  • Fiorella D, Rabin RA, Winter JC. The interaction of clozapine with the meta-chlorophenylpiperazine (mCPP) discriminative stimulus.. Life Sci. ; 58(24).
  • Eckler JR, Greizerstein H, Rabin RA, Winter JC. A sensitive method for determining levels of [-]-2,5,-dimethoxy-4-methylamphetamine in the brain tissue.. J Pharmacol Toxicol Methods. ; 46(1).
  • Hirschhorn ID, Winter JC. Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli.. Psychopharmacologia. ; 22(1).
  • Frey LG, Winter JC. Discriminative stimulus properties of intravenous morphine in the rat.. Psychopharmacology (Berl). ; 66(3).
  • Sethy VH, Winter JC. Effects of yohimbine and mescaline on punished behavior in the rat.. Psychopharmacologia. ; 23(2).
  • Winter JC. Xylamidine tosylate: differential antagonism of the hypothermic effects of N,N-dimethyltryptamine, bufotenine, and 5-methoxytryptamine.. Arch Int Pharmacodyn Ther. ; 198(1).
  • Jerrold Winter, Peter Gessner, Godse, DD. Synthesis of 5- and 6-methoxyindene. J Org Chem. ; 30.
  • Jerrold Winter, Peter Gessner, Godse, DD. Synthesis and preliminary pharmacology of indene isosteres of substituted tryptamines. J Med Chem. ; 10.
  • Schechter, MD, Jerrold Winter. Behavioral determination of critical flicker fusion frequency in the rat. Percep Mtr Skills. ; 29.
  • Hirschhorn, I., Jerrold Winter. Mescaline and LSD as discriminative stimuli. Psychopharmacologia. ; 22.
  • Sethy, VH, Jerrold Winter. Effects of yohimbine and mescaline on punished behavior in the rat. Psychopharmacologia. ; 23.
  • Jerrold Winter. Differential antagonism of the hypothermic effects of N,N-dimethyltryptamine, bufotenin, and 5-methoxytryptamine. Arch Int Pharmacodyn Ther. ; 198.
  • Overton, DA, Jerrold Winter. Discriminable properties of drugs and state-dependent learning. Fed Proc. ; 33.
  • Jerrold Winter. Hallucinogens as discriminative stimuli. Fed Proc. ; 33.
  • Jerrold Winter. Propranolol and morphine: A lethal interaction. Arch int Pharmacodyn Ther. ; 212.
  • Jerrold Winter. Blockade of the stimulus properties of mescaline by a serotonergic antagonist. Arch int Pharmacodyn Ther. ; 214.
  • Jerrold Winter. The behavioral pharmacology of psychoactive drugs. Psychopharmacol Bul. ; 11.
  • Jerrold Winter. The effects of 2,5-dimethoxy-4-methylamphetamine [DOM], 2,5-dimethoxy-4-ethylamphetamine [DOET], d-amphetamine, and cocaine in rats trained with mescaline as a discriminative stimulus. Pschopharmacologia. ; 14.
  • Jerrold Winter. Yohimbine-induced stimulus control in the rat. Arch int Pharmacodyn Ther. ; 235.
  • Jerrold Winter. Effectsof phenethylamine derivatives, BL-3912, fenfluramine, and SCG-12,679 in rats trained with LSD as a discriminative stimulus. Psychopharmacology. ; 68.
  • Jerrold Winter. The stimulus properties of p-methoxyamphetamine: A nonessential serotonergic component. Pharmacol Biochem Behav. ; 20.
  • McCann, DJ, Smith, CM, Jerrold Winter. A caution against use of verapamil in phencyclidine intoxication. Amer J Psychiat. ; 143.
  • Jerrold Winter, Petti, DT. The effects of DPAT and other serotonergic agonists on performance in a radial maze: A possible role for 5-HT1A receptors in memory. Pharmacol Biochem Behav. ; 27.
  • Jerrold Winter. The radial maze in behavioral pharmacology and toxicology. Physiol Behav. ; 40.
  • Palumbo, PA, Jerrold Winter. The stimulus properties of ibogaine in rats trained with yohimbine, DOM, and LSD. Pharmacol Biochem Behav. ; 43.
  • Jerrold Winter. The redemonizing of marijuana. Pharmaceutical News. ; 5.
See all (148 more)
Books and Book Chapters:
  • Helsley, S, Richard Rabin, Jerrold Winter. Drug discrimination studies with ibogaine. Ibogaine. 1999.
  • Jerrold Winter. True Nutrition, True Fitness..
  • Frey, LG, Jerrold Winter. Current trends in the study of drugs as discriminative stimuli.. Drug Discrimination and State Dependent Learning..
  • Jerrold Winter. Drug-induced stimulus control. Contemporary Research in Behavioral Pharmacology..
  • Jerrold Winter. Introduction to pharmacology: Receptors. Textbook of Pharmacology..
  • Jerrold Winter. Dose-effect relationships, interactions, and therapeutic index. Textbook of Pharmacology..
  • Jerrold Winter. Drug absorption, distribution, and termination of drug action. Textbook of Pharmacology..
  • Jerrold Winter. Routes of administration. Textbook of Pharmacology..
  • Bonson, KR, Smith, CM, Jerrold Winter. Drug-induced psychiatric symptoms. Textbook of Pharmacology..
  • Jerrold Winter. The stimulus effects of serotonergic hallucinogens in animals. NIDA Monograph No 146, Hallucinogens, An Update..
  • Jerrold Winter. Introduction to pharmacology. Essentials of Pharmacology..
  • Jerrold Winter. Routes of administration. Essentials of Pharmacology..
  • Jerrold Winter. Tolerance, physical dependence, and drug abuse. Essentials of Pharmacology..
  • Jerrold Winter. Antipsychotic drugs [Neuroleptics]. Essentials of Pharmacology..
  • Smith, CM, Jerrold Winter. Drug therapies in obesity and attention deficit disorder. Essentials of Pharmacology..
  • Smith, CM, Bonson, KR, Jerrold Winter, Roger Cunningham. Adverse drug reactions and interactions. Essentials of Pharmacology..
See all (6 more)
Service Activities:
  • Pharmacology and Toxicology, Jacobs School of Medicine & Biomedical Sciences Admissions; Member
  • MSTP Admissions Committee; Other (1993–present)
  • Medical Scientist Training Program Steering Committee; Member (1992–present)
  • Medical Admissions Committee; Member (1985–present)
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Contact Information

102 Farber Hall
School of Medicine and Biomedical Sciences
University at Buffalo
Buffalo, NY 14214
Phone: (716) 829-3239
Fax: 716 829 2801
Email: jcwinter@buffalo.edu
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