As a general cardiologist, I diagnose and treat a wide range of problems that affect the heart and blood vessels, including but not limited to coronary artery disease, valvular heart disease, heart failure, diseases of the myocardium and pericardium, cardiac arrhythmias, conduction disorders and syncope.
I care for patients at Buffalo General Medical Center (BGMC), the Gates Vascular Institute (GVI), the Buffalo VA Medical Center (VAMC) and am a member of the UBMD clinical practice. In addition to treating pre-existing cardiac conditions, I also believe in strong preventive care and addressing modifiable risk factors for coronary disease. I take time to get to know my patients, and I talk with them about measures they can take to reduce their risk for cardiovascular disease and improve their health.
As a clinician-scientist, I have a special interest in developing new stem cell based treatments for heart disease. My research is focused on understanding what stem cell secreted factors are responsible for improved heart function, what their targets are and how these can be modulated to develop new cell-free therapies that can help patients with a wide spectrum of coronary disease and heart failure. I welcome medical students, graduate students, residents and fellows to conduct research with me in my lab.
As a native Buffalonian, I am honored to partner with the patients in our community to help improve their heart health and cardiac knowledge base. I am equally excited to be involved in shaping the next generation of physicians through the teaching I conduct at the medical student, resident and fellow level.
Education and Training:
ABIM Research Pathway in Cardiovascular Diseases, American Board of Internal Medicine (2016)
Fellowship, Cardiology, University at Buffalo, Chief Cardiology Fellow (2015)
Residency, Internal Medicine, University at Buffalo (2012)
MD, University at Buffalo School of Medicine, Research Honors (2009)
BS, Dual Major in Molecular & Cellular Biology and Neurobiology, Cornell University, Cum Laude with Research Distinction (2003)
Assistant Professor, Biomedical Engineering, University at Buffalo (2018-present)
Staff Cardiologist, Cardiology, VA Medical Center (2018-present)
Assistant Professor, Medicine, University at Buffalo (2017-present)
Assistant Professor, Pharmacology and Toxicology, University at Buffalo (2017-present)
Graduate Faculty, Graduate School of Education, University at Buffalo (2017-present)
Assistant Professor, Medicine, Jacobs School of Medicine and Biomedical Sciences (2017-present)
Assistant Professor, Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences (2017-present)
Research Assistant Professor, Medicine, Jacobs School of Medicine and Biomedical Sciences (2015–2017)
Awards and Honors:
UB Siegel Award Teaching, runner-up (2019)
CTSI Scholar (2016)
Department of Medicine Research Day, 1st Place (2015)
John C. Sable Memorial Heart Fund Grant Recipient (2014)
Northwestern Cardiovascular Young Investigators’ Forum, Basic Research 3rd Place (2013)
Department of Medicine Research Day, Basic Research 2nd Place (2013)
Frawley Fellowship Recipient, University at Buffalo (2012)
Excellence in Neurology Award, American Academy of Neurology (2009)
Thesis with Research Honors, University at Buffalo (2009)
University at Buffalo Medical Student Research Forum Honors (2007)
Cornell Presidential Research Scholar, Cornell University (2003)
cum laude with Research Distinction, Cornell University (2003)
Advanced Placement (AP) Scholar, City Honors (1999)
International Baccalaureate Diploma Recipient, City Honors (1999)
CHS Science Research Program Diploma, City Honors and RPCI (1999)
Cardiovascular stem cell therapy
Center for Research in Cardiovascular Medicine
Grants and Sponsored Research:
October 2018–September 2023 The Functional Role of Exosomes in Stem Cell-Mediated Cardiac Repair. Veteran‘s Administration Role: Principal Investigator $1,389,635
December 2017–November 2022 The Functional Role of Exosomes in Stem Cell Mediated Cardiac Repair. NIH/NHLBI Role: Principal Investigator $1,006,430
June 2014–June 2015 The Functional Role of Exosomes in Stem Cell-Mediated Cardiac Repair John C. Sable Memorial Heart Fund Role: Principal Investigator $15,000
Wang W, Lang JK, Suzuki G, Canty JM Jr. and Cimato T.. Statins enhance clonal growth of late outgrowth endothelial progenitors and increase myocardial capillary density in the chronically ischemic heart.. PLoS One. 2011; 6(9).
Varjabedian L, JK Lang, A Kamouh, SJ Horn, T Kemaloglu, KA Sungur, KJ Mehta, K Bhagatwala, N Karia, MGA Escanuela, RP Gatewood and NC NANDA. Echocardiographic assessment of tumors and masses. In: Comprehensive Textbook of Echocardiography. 2013; 70.
Lang JK. A Transcriptomic Analysis of Cardiac Myofibroblasts Reveals Novel Anti-Fibrotic and Immunomodulatory Genes Modulated by CDC-derived Exosomes.. AHA BCVS Meeting 2019. 2019.
Lang JK. Association of CBR3 Polymorphisms With an Early Change in Cardiac Function as Assessed by Left Ventricular Global Longitudinal Strain in Breast Cancer Patients Treated with Doxorubicin. San Antonio Breast Care Symposium. 2018.
Lang JK, Mentkowski, K. Development of a Cardiomyocyte Targeting Delivery System Utilizing Cardiosphere-Derived Cell Exosomes. AHA BCVS Meeting, July 2018. 2018.
Mursleen, A, Mentkowski, K, Lang JK. CDC-Derived Exosomes Polarize Macrophages to a Distinct Arg1-High Phenotype. American Heart Association Meeting-Anaheim, CA. 2017.
Lang JK. Exploring the Functional Role of Exosomes in Stem Cell-Mediated Cardiac Repair. American Heart Association Annual Meeting 2015. 2015.
Lang JK. Ciliary Neurotrophic Factor Increases the Angiogenic Properties of Human Pluripotent Stem Cell Derived Neuropilin-1 CD34 Nascent Endothelial Cells Via a JAK2 Dependent Pathway. American Heart Association Annual Meeting 2012. 2012.
Lang JK. Transcriptional Profiling of Pluripotent Stem-Cell Derived Neuropilin1-1CD34 - Vascular Precursors Reveals Significant Overlap with Ventral Mesoderm and Identifies Signaling Pathways in Differentation to Vascular Cells. AHA Basic Cardiovascular Sciences (BCVS), American Heart Association. 2011.
Lang JK. Genomic Analysis of Early Endothelial Differentiation from Human Stem Cells Identifies Novel Growth Factor Signaling Pathways Involved in Vasculogenesis. AHA Arteriosclerosis, Thrombosis and Vascular Biology (ATVB), American Heart Association (2011). 2011.
Lang JK. Statin Treatment of Adult Human Oligodendrocyte Progenitors Induces Precocious PPAR gamma-mediated differentation. Society for Neuroscience (SFN) annual meeting 2005. 2005.
Lang JK. Quiescent Adult Human Glial Progenitors Tonically Antagonize the Astrogliogenic Effects of BMP4. Society for Neuroscience (SFN) annual meeting 2005. 2005.
Evaluative Studies and Case Reports:
Brouillard AM, Kasznica JM, Lang JK. Carcinoid Heart Disease and Recurrent Hypertensive Crises in a Patient with Primary High-Grade Ovarian Neuroendocrine Carcinoma. Journal of Integrative Cardiology. 2016; 3(1).
Andres E. Carmona-Rubio*, Narasa Madam, Jennifer Lang, Susan Graham and Umesh Sharma. Spontaneous triple-vessel coronary artery dissection in a patient with Ehlers-Danlos Type IV. Journal of Integrative Cardiology. 2015; 1(6).
American College of Cardiology, Fellow (2012–present)
American Heart Association (2012–present)
American College of Cardiology, Member (2012–present)
American Medical Association, Member (2010–present)
Society for Neuroscience, Member; Member (2003–2009)
"Exploring and Expanding the Therapeutic Roles of Exosomes in Cardioprotection" Medical College of Wisconsin Cardiology Grand Rounds, Medical College of Wisconsin (2018)
"Exploring and Expanding the Therapeutic Roles of Exosomes in Cardioprotection" CTRC Women in Science Month - 2018, University at Buffalo (2018)
"Exploring the Functional Role of Cardiosphere Derived-Cell (CDC) Exosomes as Paracrine Signal Mediators of Cardioprotection" University at Buffalo, Department of Pharmacology and Toxicology Seminar Series (2017)
"Gender Differences in Ischemic Heart Disease: Fact or Fiction?" University at Buffalo, Department of Medicine Grand Rounds (2017)
"EKG Review and Stress Laboratory Emergencies" Society of Nuclear Medicine and Molecular Imaging (SNMMI) EGL Meeting (2016)
"Pericarditis: When to Image, When to Treat" UBMD Primary Care Update: CME Conference (2016)
"ER Grand Rounds" Pericarditis - Diagnosis, Treatment and Triage in the ER, Gates Vascular Institute, University at Buffalo Grand Rounds (2015)
"Primary Care Update: Perioperative Beta-Blocker Controversy Begins Again!" UBMD Primary Care Update: CME Conference, UBMD (2015)
"Novel Signaling Pathways Regulate Nascent Endothelial Cells Derived From Human Pluripotent Stem Cells" Northwestern Cardiovascular Young Investigators‘ Forum (2013)
"BMP Regulation of Adult Human Oligodendrocyte Progenitor Fate" American Society for Neurochemistry (ASN), American Society for Neurochemistry (2005)
District Councilor of the NYS Chapter of the American College of Cardiology; 3-year elected term for the ACC; Delegate (2019–present)
Grant Reviewer - NIH, Early Career Reviewer Program; Cardiac Contractility and Heart Failure; San Francisco, June 29-30, 2017; Reviewer (2017–present)
Journal Reviewer - Experimental Biology and Medicine (ad hoc); Journal Reviewer - Experimental Biology and Medicine (ad hoc); Reviewer (2016–present)