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Juliane                        Nguyen

Juliane Nguyen PharmD PhD

Department of Pharmaceutical Sciences

Assistant Professor

 
Professional Summary:

The Therapeutic Biomaterials Laboratory designs and engineers novel nano-scale carriers based on genetically encoded materials, lipids, and polymers for the treatment of myocardial infarction and cancer. These will target to the site of disease, respond to changes in the microenvironment, and deliver nucleic acids and drugs to subcellular compartments.

Zip-code like sequences
Although great advances have been made in the field of nucleic acids and drug delivery, the specificity of delivery still remains a problem. We are utilizing cutting-edge technologies to identify zip-code like sequences for more efficient delivery of therapeutic molecules for the treatment of myocardial infarction and cancer.

Regeneration of Cardiac Tissue
Coronary heart diseases are among the leading causes of death worldwide. After myocardial infarction, a significant number of cardiomyocytes undergo apoptosis and are replaced by non-contractile scar tissue. Our goal is to repair damaged cardiac tissue by re-establishing the muscle population with newly generated cardiomyocytes. In order to achieve this aim, we are designing novel biomaterials for reprogramming different types of cells to cardiomyocytes.

Genetically Encoded materials
Nanoparticulate drug carriers allow the delivery of enzymatically susceptible, highly instable, and insoluble drugs to target tissues. One of the limitations of existing drug delivery systems is insufficient and non-specific drug release in the body that leads to toxic side effects for the patient. Our lab engineers genetically encoded nanomaterials that are able to disassemble and release therapeutic drugs when exposed to disease-specific microenvironments.

Please visit our lab‘s homepage for more information: http://www.acsu.buffalo.edu/~julianen/index.html

Education and Training:
  • Fellowship, University of California, San Francisco (Advisor: Dr. Francis Szoka) (2013)
  • PhD, Pharmaceutical Sciences, Philipps University (Advisor: Dr. Thomas Kissel) (2009)
  • PharmD, Philipps University (2005)
Employment:
  • Adjunct Assistant Professor, Experimental Therapeutics, Roswell Park Cancer Institute (2017-present)
  • Adjunct Assistant Professor, Biomedical Engineering, University at Buffalo, School of Engineering (2016-present)
  • Assistant Professor, Department of Pharmaceutical Sciences, University at Buffalo (2013-present)
  • Post Doctoral Fellow, UCSF (2009–2013)
Awards and Honors:
  • UB Exceptional Scholar: Young Investigator Award (2017)
  • German Research Fellowship Award - DFG (2013)
  • Biomedical Breakthrough Award (UCSF) (2011)
  • Controlled Release Society Travel Award (2007)

Grants and Sponsored Research:
  • July 2017–April 2021
    RNA EXO-Codes: A novel way to reprogram pathological exosomes
    National Institute of Biomedical Imaging and Bioenengineering
    Role: Principal Investigator
    $1,582,675
  • September 2015–June 2018
    Maximizing small RNA delivery with signaling peptides
    National Institute of Biomedical Imaging and Bioenengineering
    Role: Principal Investigator
    $432,013
  • July 2015–June 2018
    Self-replicating RNA-nanoplexes for Programming Monocytes to Regenerate the Heart
    National Heart Lung and Blood Institute
    Role: Principal Investigator
    $432,013
Patents:
  • Compositions and methods for programming extracellular vesicles Scott Ferguson and Juliane Nguyen. Provisional patent# 62/326,093 (2016)
  • Zwitterionic Lipids F. Szoka, C. Walsh, V. Venditto, J. Nguyen, and E. Perttu, WO 2012/024233 (2012)

Journal Articles:
See all (14 more)

Presentations:
  • "Nucleic acids go POSTAL" University at Buffalo (2016)
  • "Reprogramming pathological exosomes" University of Sao Paolo, University of Sao Paolo (2016)
  • "Targeting inflammatory cells to deliver therapeutics to the infarcted myocardium" Cardiovascular Research Conference, Buffalo (2015)
  • "Targeting the infarcted myocardium: A drug delivery approach" Thirteenth Buffalo Pharmaceutics Symposium (2014)
  • "Nanoengineering of nucleic acid and drug delivery vehicles." Department of Biological Sciences, University of Illinois at Chicago (2013)
  • "Nanoengineering of nucleic acid and drug delivery vehicles." Department of Bioengineering, University of Illinois at Chicago (2013)
  • "From fast degrading polymers to ionizable lipids: The role of carrier architectures in nucleic acid transfer" Department of Pharmaceutical Sciences, University of Illinois at Chicago (2012)
  • "Novel zwitterionic liposome approaches to lipid based nucleic acid delivery" Nanotech Conference & Expo 2012 (2012)
  • "The Silent Treatment of Genes: Degradable Polymers and Bioresponsive Lipids for siRNA Delivery." University of Groningen, Zernike Institute for Advanced Materials (2012)
  • "From fast degrading polymers to ionizable lipids: The role of carrier architectures in nucleic acid transfer" Division of Pharmaceutics & Translational Therapeutics, The University of Iowa (2012)
  • "Bioresponsive lipid nanoparticles as carriers for drug and gene delivery" University of Saarland, Department of Pharmaceutical Sciences, Germany (2012)
  • "RNAi nanocarrier-forming lipids, processes and use for in vivo protein knockdown" Pfizer Inc. Boston (2010)
  • "Nanoparticulate carriers for pulmonary gene and siRNA delivery based on amine modified polyvinyl alcohols," Pfizer, Inc. Boston (2009)
  • "Biodegradable polymeric nanocarriers for pulmonary drug and gene delivery" EUFEPS Conference, Uppsala, Sweden (2008)
  • "Effects of cell penetrating peptides and pegylation on polyplex size and transfection efficiency in mouse lungs" 34th Annual Meeting and Exposition of the Controlled Release Society, Long Beach, CA (2007)
  • "Mechanistic uptake studies of TAT-PEG-PEI polyplexes into lung epithelial cells A549 using confocal microscopy and FACS." Socrates Intensive Programme: Innovative Therapeutics from molecules to drugs, Athens, Greece, (2006)
  • "Cytotoxicity and uptake mechanism of bioconjugates based on TAT-derived peptides covalently coupled to PEG-PEI." 33rd Annual Meeting and Exposition of the Controlled Release Society, Vienna, Austria, (2006)
See all (7 more)
Service Activities:
  • Guest Editor with Dr. Steven Jay for AAPSJ on "Exosomes and other extracellular vesicles for therapeutics and diagnostics"; Guest Editor (2017–present)
  • NIH Gene and Drug Delivery Study Section; Grant Reviewer (2017)
  • British Council; Grant Reviewer (2016)
  • NIH Nano Study Section; Grant Reviewer (2016)
  • NIH SBIR Biomaterials, Delivery, and Nanotechnology [BST (10)]; Grant Reviewer (2015–2016)
  • NSF BMAT; Grant Reviewer (2015–present)

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:


Contact Information

304 Kapoor Hall
Buffalo, NY 14214-8033
Phone: (716) 645-4817
Email: julianen@buffalo.edu


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