I have two primary research interests. First, I use pharmacological approaches to seek novel therapeutics for pain. Pain is an agonizing symptom and disease that affects millions of people. Analgesics like opioids (e.g., OxyContin) are powerful for treating many pain conditions. However, opioids are not efficacious for some pain (e.g., neuropathic pain) and prolonged use of opioids has many side effects, including tolerance and dependence. My research has found that drugs acting on imidazoline I2 receptors may produce analgesic effects that are devoid of opioid-like side effects. I am continuing this line of research to further delineate the pharmacological properties of these drugs--how they work, how effective and safe they are, and how long the beneficial effects last--as a novel class of analgesics.
Second, I am interested in pharmacotherapy of stimulant abuse. Stimulants represent a large family of abused drugs, including traditional drugs of abuse such as cocaine and methamphetamine (“meth”) and valuable pharmacotherapies such as Adderall and Ritalin. Stimulant abuse and addiction remain challenging problems that lack FDA-approved pharmacotherapies. We use powerful behavioral pharmacological approaches, in animal models that are predictive of human stimulant abuse conditions, to study novel drug targets and evaluate potential pharmacotherapeutic treatments.
One unifying theme of the ongoing research in my laboratory is the application of receptor theory to the guidance and interpretation of the drug interactions in behaving animals. The long-term goal of my laboratory is to develop new analgesics for pain control and pharmacotherapeutics for stimulant addiction.