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James                          Lohr

James W. Lohr MD

Department of Medicine


Specialty/Research Focus


Professional Summary:

I work primarily at the Buffalo VA Medical Center (VAMC) where I served as the chief of nephrology for many years. I care for patients with a variety of kidney diseases, including acute and chronic kidney disease, end-stage renal disease, glomerulonephritis, polycystic disease and hypertension. I have a particular interest in the treatment of patients with resistant hypertension. I also care for patients with advanced chronic kidney disease. Together with a team of other health care professionals at the VAMC, I help patients to decide the optimal modality of dialysis for themselves and, when warranted, to consider the possibility of renal transplantation. I care for inpatients as a consultant on the nephrology consultation services. I see patients at outpatient clinics at the VAMC, and I follow patients in the VAMC outpatient dialysis unit.

I participate in clinical trials related to treatment of diabetic kidney disease, treatment of anemia in chronic kidney disease and hypertension. My past research focused on understanding the response of cells to conditions of hypo- and hyperosmolality. I have published on hyponatremia and hypernatremia, and continue to have a clinical interest in these areas.

I am the program director for the nephrology fellowship program and have served in this role since 1997. I oversee the nephrology fellowship training experience at the multiple clinical sites of UB’s Division of Nephrology, and I contribute to the development of the curriculum. I also serve as the coordinator of the four-week, organ-based “renal module” for first-year medical students: I plan the curriculum, identify speakers, organize the case-based small group sessions and write test questions. I also give 12 lectures and participate in four small-group sessions each year. I am committed to teaching and devote significant time in the medical school teaching medical students. In addition, I hold an adjunct appointment in the Department of Pharmacology and Toxicology, and I give lectures on renal pharmacology, hypertension and adverse drug reactions each year to students in that department. I also teach pharmacology and toxicology students in a recitation session focused on discussion of a clinical research paper.

Education and Training:
  • Fellowship, University of Kansas Medical Center (1985)
  • Internship and Residency, University of Kansas Medical Center (1983)
  • MD, Medicine, University of Kansas (1980)
  • BA, Chemistry, College of Wooster (1975)
  • Professor, University at Buffalo (2002-present)
  • Chief of Nephrology, Buffalo VA Medical Center (2001-present)
  • Consultant, Roswell Park Cancer Institute (1990-present)
  • Attending Physician, Sisters of Charity Hospital (1988-present)
  • Staff Physician, Buffalo VA Medical Center (1986-present)
  • Associate Professor, Medicine, Univeristy at Buffalo (1992–2002)
  • Assistant Professor, Medicine, University at Buffalo (1986–1992)
  • Instructor, Medicine, University of Kansas Medical Center, School of Medicine (1985–1986)
Awards and Honors:
  • Faculty Development Award (1987)

Research Expertise:
  • Clinical informatics
  • Epidemiology of acute kidney injury
Grants and Sponsored Research:
  • April 2000–March 2001
    MRI for early detection of cysts in rats with PKD
    Glaxo Smith-Kline
    Role: Principal Investigator

Journal Articles:
  • Arora P, Davari-Farid S, Gannon MP, Lohr JW, Dosluoglu HH, Nader ND. Low levels of high-density lipoproteins are associated with acute kidney injury following revascularization for chronic limb ischemia. Ren Fail. 2013; 35(6).
  • Yacoub R, Lohr JW, Rajagopalam S, Patel N, Nader ND, Aurora P. Acute Kidney Injury and Death Associated with Renin-Angiotensin System Blockade in Cardiothoracic Surgery: A Meta-analysis of Observational Studies. Am J Kidney Dis.. 2013; S0272(13).
  • Arora P, Kolli H, Nainani N, Nader N, Lohr J, Lohr JW. Preventable risk factors for acute kidney injury in patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2012; 26(4).
  • Arorer P, Kolli H, Nainani N, Nader ND, Lohr J. Preventable risk factors fo acute kidney injury in patients undergoing cardiac surgery. J Cardiothoac Vasc Anesth. 2012; 26(4).
  • Arora P, Rajagopalam S, Kolli KH, Ranjan R, Patel N, Venuto R, Lohr J, Nader ND. High volumes of intravenous fluid during cardiac surgery are associated with increased mortality. HSR Proc in Intensive Care Cardiovascular Anesth. 2010; 2.
  • Mahajan P., Weber-Shrikant E,, Iyer R, Sitrin MD, Lohr JW, Arora P. CKD in a patient with pancreatic cancer.. Am J Kidney Diseases. 2010; 56.
  • Kolli H, Rajagopalam S, Patel N, Ranjan R, Venuto R, Lohr J, Arora P, Lohr JW. Mild acute kidney injury is associated with increased mortality after cardiac surgery in patients with eGFR < 60 mL/min/1.73 m(2). Ren Fail. 2010; 32(9).
  • Arora P, Rajagopalam S, Ranjan R, Kolli H, Singh M, Venuto R, Lohr J, Lohr JW. Preoperative use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is associated with increased risk for acute kidney injury after cardiovascular surgery. Clin J Am Soc Nephrol. 2008; 3(5).
  • Arora P, Mustafa RA, Karam J, Khalil P, Wilding G, Ranjan R, Lohr J, Lohr JW. Care of elderly patients with chronic kidney disease. Int Urol Nephrol. 2006; 38(2).
  • Bowman CL, Yohe L, Lohr JW. Regulation of cytoplasmic calcium levels by two nitric oxide receptors.. Am J Physiol Cell Physiol. 2001; 281(3).
  • Mookerje BK, Lohr JW, Jenis EH, Heffner HM. Glomerulonephritis for the generalist. J Med. 2001; 32(3-4).
  • Lohr JW, Yohe L. Isovolumetric regulation of rat glial cells during development and correction of hypo-osmolality.. Neurosci Lett. 2000; 286(1).
  • Lohr JW, Lee TP, Farooqui M, Mookerjee BK. Increased levels of serum hepatocyte growth factor in patients with end-stage renal disease. J Med. 2000; 31(3-4).
  • Bowman CL, Yohe L, Lohr JW. Enzymatic modulation of cell volume in C6 glioma cells.. Glia. 1999; 27(1).
  • Farooqui MA, Berenson C, Lohr JW. Mycobacterium marinum infection in a renal transplant recipient.. Transplantation. 1999; 67(11).
  • Zadeii G, Lohr JW. Renal papillary necrosis in a patient with sickle cell trait.. J Am Soc Nephrol. 1997; 8(6).
  • Bowman CL, Lohr JW. Mechanotransducing ion channels in C6 glioma cells.. Glia. 1996; 18(3).
  • Lohr JW, Yohe LA. Mechanisms of hypoosmotic volume regulation in glioma cells.. Brain Res. 1994; 667(2).
  • Lohr JW. Osmotic demyelination syndrome following correction of hyponatremia: association with hypokalemia.. Am J Med. 1994; 96(5).
  • Sterns RH, Baer J, Ebersol S, Thomas D, Lohr JW, Kamm DE. Organic osmolytes in acute hyponatremia.. Am J Physiol. 1993; 264(5 Pt).
  • Harris GD, Lohr JW, Fiordalisi I, Acara M. Brain osmoregulation during extreme and moderate dehydration in a rat model of severe DKA. Life Sci. 1993; 53(3).
  • Lohr JW, Schwab SJ. Minimizing hemorrhagic complications in dialysis patients.. J Am Soc Nephrol. 1991; 2(5).
  • Lohr JW, Pochal MA, Acara M. Osmoregulatory betaine uptake by rat renal medullary slices.. J Am Soc Nephrol. 1991; 2(4).
  • Lohr J, Mazurchuk RJ, Acara MA, Nickerson PA, Fiel RJ, Lohr JW. Magnetic resonance imaging (MRI) and pathophysiology of the rat kidney in streptozotocin-induced diabetes. Magn Reson Imaging. 1991; 9(1).
  • Lohr JW. Isovolumetric regulation of renal proximal tubules in hypotonic medium. Ren Physiol Biochem. 1990; 13(5).
  • Lohr J, Acara M. Effect of dimethylaminoethanol, an inhibitor of betaine production, on the disposition of choline in the rat kidney.. J Pharmacol Exp Ther. 1990; 252(1).
  • Rome L, Grantham J, Savin V, Lohr J, Lechene C. Proximal tubule volume regulation in hyperosmotic media: intracellular K+, Na+, and Cl-.. Am J Physiol. 1989; 257(6 Pt).
  • Lohr J, Springate J, Feld L. Seizures during correction of hypernatremic dehydration in an infant.. Am J Kidney Dis. 1989; 14(3).
  • Lohr JW, Sullivan LP, Cragoe EJ, Grantham JJ. Volume regulation determinants in isolated proximal tubules in hypertonic medium.. Am J Physiol. 1989; 256(4 Pt).
  • Lohr JW, Slusher S, Diederich D. Safety of regional citrate hemodialysis in acute renal failure.. Am J Kidney Dis. 1989; 13(2).
  • Lohr JW, McFarlane MJ, Grantham JJ. A clinical index to predict survival in acute renal failure patients requiring dialysis. Am J Kidney Dis. 1988; 11(3).
  • Lohr JW, McReynolds J, Grimaldi T, Acara M. Effect of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney. Life Sci. 1988; 43(3).
  • harris, G., Lohr, J., Fiordalisis, I., Acara, M.. Brain osmoregulation during extreme and moderate dehydration in a rat model of severe DKA. Life Sciences. ; 53.
  • Tufail, M and Lohr, J.. Treatment of hypertension in patients with chronic renal insufficiency. VHSJ. ; 4.
  • Lohr, J. Pochal, M. and Acara, M.. osmoregulatory uptake of betaine by renal medullary slices. J. Am. Soc. Nephrol. ; 2.
  • Lohr, J. Mazurchuk, R., Acara, M., Nickerson, P. and Fiel R.. Magnetic resonance imaging (MRI) and pathophysiology of the rat kidney in streptozotocin induced diabetes.. Magn Res Imaging. ; 9.
  • Lohr, J.W., Bennett, M.I., Pochal, M.A., McReynolds, J., Acara, M., and Willsky, G.R.. Effect of vanadate on renal hypertrophy and sorbitol accumulation in streptozotocin induced diabetic rats.. Res. Commun. in Chem. Path. and Pharm. ; 72.
  • dara, T. and Lohr, J.W.. Disseminated intravascular coagulation following percutaneous renal biopsy. Am. J. Nephrology. ; 11.
  • Lohr, J.W., Slusher, S., and Diederich, D.. Regional citrate anticoagulation for hemodialysis following cardiovascular surgery. Am. J. Nephrol.. ; 8.
  • Lohr, J., mcReynolds, J., Grimaldi, T., and Acara, M.. Effects of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney.. Life Sciences. ; 43.
  • Lohr, J.W., MacFarlane, M.J., and Grantham, J.J.. A clinical index to predict survival in acute renal failure patients requiring dialysis. Am. J. Kidney Diseases. ; 11.
  • James Lohr. Isovolumetric regulation of isolated S2 proximal tubules in anisotonic media. J. Clin. Invest.. ; 78.
  • Lohr, J.W., maDougall, M., chonko, A.M., Diederich, D., Grantham, JJ, Savin, V., and Wiegmann, T.. Percutaneous transluminal angioplasty in transplant renal artery stenosis:experience and review of the literature. Am. J. Kidney Disease. ; 7.
  • Hypertension Optimal Treatment Study Group (J.Lohr, Participating investigator). The Hypertension Optimal treatment study. patient characteristics: randomization, rsik profiles, and early blood pressure results.. Blood Pressure. ; 3.
  • Hypertension Optimal Treatment Study Group (J. lohr, Participating investigator). Effects of intensive blod pressure lowering and low dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomized trial.. Lancet. ; 351.
  • Lohr, J.W., Lee, T.P., Farooqui, M., and mokerjee, B.K.. Increased levels of hepatocyte growth factor in patients with end stage renal disease. J. Med.. ; 31.
See all (36 more)
  • lohr, J.W.. Isovolumetric regulation of renal proximal tubules in hypotonic medium.. Renal Physiol biochem. ; 13.
Evaluative Studies and Case Reports:

Professional Memberships:
  • American Society for Pharmacology & Experimental Therapeutics (1995–1999)
  • American Federation for Clinical Research (1987–present)
  • International Society of Nephrology (1986–present)
  • American Society of Nephrology (1985–present)
  • American College of Physicians (1985–present)
Service Activities:
  • Jacobs School of Medicine & Biomedical Sciences Unqualified Promotions; Member (1991–1994)
  • Jacobs School of Medicine & Biomedical Sciences Biomdedical Research; Member (1989–1992)
  • Jacobs School of Medicine & Biomedical Sciences Student Affairs & Academic Standing; Member (1987–1989)

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Contact Information

Veterans Hospital
3495 Bailey Avenue
Buffalo, NY 14215
Phone: (716) 862-3204
Fax: (716) 862-6784

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