Meghan A. Higman MD, PhD
Meghan A. Higman
MD, PhD
Clinical Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Pediatric Hematology-Oncology; Pediatrics
Education and Training:
- Postdoctoral Fellow, Oncology and Pediatrics, Johns Hopkins University School of Medicine (2001)
- Residency, Pediatrics, Children‘s Hospital of Pittsburgh (1998)
- Internship, Pediatrics, Children‘s Hospital of Pittsburgh (1996)
- PhD, Biochemistry, University at Buffalo, magna cum laude (1995)
- MD, Medicine, University at Buffalo, magna cum laude (1995)
- BA, Chemistry, Niagara University, summa cum laude (1986)
- BS, Biology, Niagara University, summa cum laude (1986)
Employment:
- Assistant Professor, Oncology, Roswell Park Comprehensive Cancer Center (2006-present)
- Attending Physician, Hematology/Oncology, UBMD Pediatrics, Oishei Children's Hospital (2006-present)
- Clinical Assistant Professor, Pediatrics, University at Buffalo (2006-present)
- Attending Physician, Hematology/Oncology, Pediatrics, Roswell Park Comprehensive Cancer Center (2006-present)
- Fellowship Program Director, Hematology/Oncology, Pediatrics, University at Buffalo (2006–2018)
- Assistant Professor, Pediatrics, Johns Hopkins University, School of Medicine (2001–2006)
- Assistant Professor, Oncology, Johns Hopkins University, School of Medicine (2001–2006)
Awards and Honors:
- Outstanding Female Graduate of Niagara Catholic High School (2004)
- American Cancer Society: Mid-Atlantic Task Team Recognition for Outstanding Medical Team Leadership (2003)
- Western New York Branch of the American Society for Microbiology: Erwin Neter Award (1993)
- Niagara University: Dr. Thomas H. Morton Medal for Excellence in Biology (1986)
- Father Dana Duggan Award (1986)
- Castle Connolly Medical Ltd: America‘s Top Doctors (2014-2018)
Journal Articles:
- Welch JJG, Schwartz CL, Higman MA, Chen L, Buxton A, Kanakry JA, Kahwash SB, Hutchison RE, Friedman DL, Ambinder RF. Epstein-Barr virus DNA in serum as an early prognostic marker in children and adolescents with Hodgkin lymphoma. Blood Adv. 2017; 1(11).
- Williams KM, Agwu AL, Dabb AA, Higman MA, Loeb DM, Valsamakis A, Chen AR. A clinical algorithm identifies high risk pediatric oncology and bone marrow transplant patients likely to benefit from treatment of adenoviral infection. J Pediatr Hematol Oncol. 2009; 31(11).
- Williams KM, Higman MA, Chen AR, Schwartz CL, Wharam M, Colombani P, Arceci RJ. Successful treatment of a child with late-onset T-cell post-transplant lymphoproliferative disorder/lymphoma. Pediatr Blood Cancer. 2008; 50(3).
- Savage WJ, DeRusso PA, Resar LM, Chen AR, Higman MA, Loeb DM, Jones RJ, Brodsky RA. Treatment of hepatitis-associated aplastic anemia with high-dose cyclophosphamide. Pediatr Blood Cancer. 2007; 49(7).
- Jacobsohn DA, Chen AR, Zahurak M, Piantadosi S, Anders V, Bolanos-Meade J, Higman MA, Margolis J, Kaup M, Vogelsang GB. Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. J Clin Oncol. 2007; 25(27).
- Neuman DL, Farrar JE, Moresi JM, Vogelsang GB, Higman MA. Toxic absorption of tacrolimus [corrected] in a patient with severe acute graft-versus-host disease. Bone Marrow Transplant. 2005; 36(10).
- Milstone AM, Ruff AJ, Yeamans C, Higman MA. Pseudomonas aeruginosa pre-septal cellulitis and bacteremia in a pediatric oncology patient. Pediatr Blood Cancer. 2005; 45(3).
- Swierczynski SL, Hafez MJ, Philips J, Higman MA, Berg KD, Murphy KM. Bone marrow engraftment analysis after granulocyte transfusion. J Mol Diagn. 2005; 7(3).
- Higman MA, Vogelsang GB, Chen A. Pentostatin - pharmacology, immunology, and clinical effects in graft-versus-host disease. Expert Opin Pharmacother. 2004; 5(12).
- Higman MA, Vogelsang GB. Chronic graft versus host disease. Br J Haematol. 2004; 125(4).
- Liem RI, Higman MA, Chen AR, Arceci RJ. Misinterpretation of a Calvert-derived formula leading to carboplatin overdose in two children. J Pediatr Hematol Oncol. 2003; 25(10).
- Higman MA, Port JD, Beauchamp NJ, Chen AR. Reversible leukoencephalopathy associated with re-infusion of DMSO preserved stem cells. Bone Marrow Transplant. 2000; 26(7).
- Niles EG, Christen LA, Higman MA. Direct photolinkage of GTP to the vaccinia virus mRNA (guanine-7-) methyltransferase GTP methyl acceptor site. Biochemistry. 1994; 33(33).
- Higman MA, Niles EG. Location of the S-adenosyl-L-methionine binding region of the vaccinia virus mRNA (guanine-7-) methyltransferase. J Biol Chem. 1994; 269(21).
- Higman MA. The mRNA (guanine-7-)methyltransferase domain of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli and structural and kinetic comparison to the intact capping enzyme. J Biol Chem. 1994; 269(21).
- Stuart DT, Upton C, Higman MA, McFadden G, Niles EG. A poxvirus-encoded uracil DNA glycosylase is essential for virus viability. J Virol. 1993; 67(5).
- Christen L, Higman MA, Niles EG. Phenotypic characterization of three temperature-sensitive mutations in the vaccinia virus early gene transcription initiation factor. J Gen Virol. 1992; 73(Pt 12).
- Higman MA, Christen LA, Niles EG. The vaccinia virus mRNA (guanine-N7-)-methyltransferase requires both subunits of the mRNA capping enzyme for activity. J Biol Chem. 1992; 267(23).
Books and Book Chapters:
- Fung HC, Higman MA, van Besien K. "Stem Cell Transplantation". American Society of Hematology Self-Assessment Program, 3rd Edition. 2007.
- Higman MA. "Leukemias and Lymphomas". Principle Practices of Pediatric Surgery. 2004.
- Vogelsang G, Huff CA, Higman MA. "Stem Cell Transplantation". American Society of Hematology Self-Assessment Program, 2nd edition. 2004.
Abstracts:
- Horton TM, Sheehan AN, Lopez-Terrada D, Hutchison RE, Narendra S, Higman MA, Wu M-F, Liu H. Coordinate Regulation of NF-B Subunit Expression in EBV Negative, but Not EBV Positive, Pediatric Hodgkin’s Lymphoma. Blood. 2008; 112(11).
- Higman MA. Epstein Barr Viral DNA in the Serum of Children and Adolescents with Hodgkin Disease and Early Response to Chemotherapy. ASCO Annual Meeting Abstracts. 2008; 26(15S).
- Mitchell S, Reeve B, Cowen E, Fall-Dickson J, Gilbert L, Guadagnini JP, Robinson M, Turner M, Willis G, Schubert M, Bolanos-Meade J, Higman MA, Jacobsohn D, Thormann K, Vogelsang G, Pavletic S. Feasibility and Reproducibility of the New NIH Consensus Criteria to Evaluate Response in Chronic GVHD - A Pilot Study. Blood. 2005; 106(11).
- Bolanos-Meade J, Jacobsohn D, Anders V, Higman MA, Chen A, Phelps M, Vogelsang GB. Pentostatin Steroid-Refractory Chronic Graft-Versus-Host Disease. Blood. 2005; 106(11).
- Jacobsohn D, Browning B, Thormann K, Higman MA, Phelps ML, Chen AR, Vogelsang GB. Pentostatin: Efficacy in Refractory Chronic GVHD in Children. Blood. 2004; 104(11).
Professional Memberships:
- American Association of Clinical Research (2000–2001)
- American Society for Blood and Marrow Transplantation
- American Society for Pediatric Hematology/Oncology
- American Academy of Pediatrics
- American Medical Association
- American Society of Hematology
- American Society of Clinical Oncology
Presentations:
- "Pediatric Cancer" Oncology for Scientists, Roswell Park Cancer Institute (2017)
- "Supportive Care for Pediatric Patients" Pediatric Resident Lecture, Women and Children's Hospital of Buffalo (2017)
- "Design Cancer Therapies: An Overview of Targeted Cancer Therapy" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2012)
- "Basics of Chemotherapy" Pediatric Resident Conference, Women and Children's Hospital of Buffalo (2008)
- "Cord Blood: Should We Save the Baby‘s Cord Blood?" Pediatric Grand Rounds, Women and Children‘s Hospital of Buffalo (2008)
- "What Should I Do with My Cord Blood?" Pediatric Grand Rounds, Women and Children's Hospital of Buffalo (2008)
- "Neuroblastoma" Pediatric Surgery Teaching Conference, Women and Children's Hospital of Buffalo (2007)
- "Cord Blood Transplantation - The Ins and Outs of Talking to Parents" Pediatric Trends, Johns Hopkins University (2005)
- "Lymphadenopathy in Children and Adolescents" Pediatric Trends, Johns Hopkins University (2002)
Service Activities:
- Roswell Park Comprehensive Cancer Center: Institutional Review Board III; Co-Chair (2008–present)
- Roswell Park Comprehensive Cancer Center: Institutional Review Board III; Board Member (2007–present)
- Women and Children‘s Hospital of Buffalo: Committee for Hematology/Oncology Center of Excellence; Committee Member (2006–present)
- University at Buffalo Jacobs School of Medicine and Biomedical Sciences: Pediatric Hematology/Oncology Fellows Conference; Advisor (2001–2006)
- Johns Hopkins University: Oncology Diversity Action Council; Member (2001–present)
- Women and Children‘s Hospital of Buffalo: Pediatric Oncology Performance Improvement Committee; Committee Member (2000–2006)
- Camp Sunrise; Director (1999–2005)
- Children‘s Oncology Group: Hodgkins Disease Steering Committee; Committee Member
- Comprehensive Cancer Control Plan of Maryland End of Life Committee; Committee Member
- Hodgkin‘s Disease Biology and Banking Subcommittee; Committee Member