Michael Buck PhD

Michael Buck

Michael Buck
PhD

Professor and Director Genetics, Genomics and Bioinformatics

Department of Biochemistry

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Bioinformatics; Computational Biology; Developmental Biology; Epigenetics; Gene Expression; Genomics and proteomics; Microbiology; Molecular and Cellular Biology; Molecular genetics; Stem Cells; Team Science; Transcription - Gene; Transcription and Translation; Transcription Factors

Contact Information
Jacobs School of Medicine and Biomedical Sciences
Office 5148
955 Main Street
Buffalo, NY 14203
Buffalo, New York 14203
Phone: (716) 881-7569
Fax: NA
mjbuck@buffalo.edu



Professional Summary:

Dr. Buck’s research is focused on uncovering how epigenetics and the microbiome regulate cellular events. Dr. Buck’s laboratory uses multiple model systems to uncover fundamental biological principles which are subsequently translated to the study of human disease.

Instructions controlling cellular functions are contained within DNA that is wrapped and packaged around proteins into chromatin. Chromatin can be modified in response to the environment and these modifications can be passed onto their daughter cells. These modifications act as a cellular memory and are known as epigenetic modifications. Changes in epigenetic modifications are essential players in many disease pathways including: cancer, diabetes, obesity, and autism. Dr. Buck’s research is focused on uncovering how epigenetic changes redirect regulatory proteins and how regulatory proteins read epigenetic modifications.

Our bodies are populated by a diverse and complex population of thousands of microbes, mostly bacteria, but also viruses, fungi and archaea, termed the human microbiota. This co-inhabiting microbial ecosystem has been associated with various human disease including colon cancer, diabetes, periodontal disease, and others. To understand how the microbiota is affecting human health the Buck lab has developed robust and reproducible high-throughput approaches to examine thousands of samples and are currently defining causal relationships between the microbiota and human health.

Education and Training:

  • Fellowship, Gene regulation, chromatin, and genomics, University of North Carolina at Chapel Hill (2007)
  • PhD, Genetics, North Carolina State University (2003)
  • BS, Biotechnology, Rutgers University, Cum Laude (1997)

Employment:

  • Director, Genetics, Genomics and Bioinformatics, Jacobs School of Medicine and Biomedical Sciences (2021-present)
  • Professor, Biochemistry, Jacobs School of Medicine and Biomedical Sciences (2021-present)
  • Professor, Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences
  • Director, Stem Cell Sequencing/Epigenomics Center, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011-present)
  • Member, Cellular and Molecular Biology Graduate Program, Roswell Park Cancer Institute (2008-present)
  • Member, The State University of New York at Buffalo Center of Excellence in Bioinformatics and Life Sciences (2007-present)
  • Associate Professor, Biochemistry, State University of New York-Buffalo Jacobs School of Medicine & Biomedical Sciences (2014–2021)
  • Co-Director, Next-Generation Sequencing & Expression Analysis Core, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2010–2016)
  • Assistant Professor, Biochemistry, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2007–2014)
  • Postdoctoral Fellow, Biology, University of North Carolina at Chapel Hill (2003–2007)

Awards and Honors:

  • Buffalo Blue Sky Bronze Coin (2021)
  • Buffalo Blue Sky Gold Coin (2018)

UB 2020 Strategic Strengths:

  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • August 2023–July 2028
    Therapeutic targeting of master regulators in non-canonical AR driven advanced lethal prostate cancers
    NCI
    Role: Co-Investigator
    $3,823,553
  • September 2020–February 2024
    Protective effects of dietary pulse flours on the transgenerational influence of maternal obesity
    United States Department of Agriculture
    Role: Co-Investigator
    $480,255
  • January 2019–December 2020
    The Microbiome in the Etiology and Prevention of Breast Cancer
    NYS Department of Health
    Role: Co-Investigator
    $359,024
  • July 2014–July 2019
    Oral microbiome and periodontitis: a prospective study in postmenopausal women
    NIH
    Role: Co-Investigator
    $4,000,000
  • August 2011–July 2015
    Western New York Stem Cell Culture and Analysis Center
    NYSTEM
    Role: Co-Investigator
    $1,068,541
  • March 2013–February 2015
    Epi)Genomic drivers of primary and metastatic pancreatic islet cell carcinoma
    National Institutes of Health
    Role: Co-Investigator
  • August 2010–July 2013
    Overlapping Clustering Analysis of Biological Networks
    NSF
    Role: Co-Principal Investigator
  • March 2020
    Genomic and functional investigations of the transcriptional regulatory network of salivary gland morphogenesis and stem cell fate choices in defined genetic models
    NIH
    Role: Co-Investigator
    $1,887,554
  • August 2019
    A high-throughput, comprehensive, and quantitative approach for measuring nucleosome-protein binding
    National Institutes of Health
    Role: Principal Investigator
    $1,415,135
  • March 2018
    Genomic and epigenomic investigations of the transcriptional regulatory network of skin keratinocytes in defined genetic models
    Role: Co-Investigator
    $1,754,500
  • October 2017
    Personalizing Head and Neck Squamous Cell Carcinoma Therapy
    Community Foundation for Greater Buffalo
    Role: Co-Principal Investigator
See all (1 more)

Patents:

  • Porphyromonas gingivalis strain detection and association with oral and systemic disease Porphyromonas gingivalis is a black-pigmented anaerobic bacterium found in the oral cavity and is one of the prime etiological agents for the onset and progression of periodontal inflammatory disease. Beyond the oral cavity, P. gingivalis has been associated with Alzheimer’s disease, coronary heart disease, stroke, diabetes mellitus, rheumatoid arthritis, cancer, and autoimmune disease. P. gingivalis’s ability to cause these systemic diseases is likely due to specific virulence factors expressed by certain strains of P. gingivalis. To determine P. gingivalis strains from saliva or plaque samples we have developed a molecular finger printing approach that can identify 178 strains and distinguish between virulent and non-virulent strains. (2021)

Journal Articles:

See all (62 more)

Abstracts:

  • Mammen MJ, Buck M, Sun Y, Waldron N, Valiyaparambil S, Wrona C, Sethi S. (2018) Distinct Airway Microbiome Patterns Associated with Lung Cancer Development in a COPD Cohort. American Journal of Respiratory and Critical Care Medicine, (May)
  • Mammen MJ, Tsompana M, Buck M, Biswal S, Criner GJ, Sethi S. (2017) Effect Of Sulforaphane Treatment On The Airway Microbiome In COPD. American Journal of Respiratory and Critical Care Medicine, (May)
  • Jiao N, Baker SS, Chapa Rodriguez A, Liu W, Nugent CA, Tsompana M, Mastrandrea LD, Buck M, Baker RD, Genco RJ, Zhu R, Zhu L. (2017) Suppressed Hepatic Bile Acid Signaling Despite Elevated Production of Primary and Secondary Bile Acids in NAFLD. Gastroenterology, (Apr) S1068-S1068

Presentations:

  • "Defining transcription factor nucleosome binding with Pioneer-seq" Systems Biology: Global Regulation of Gene Expression (2022)
  • "Breaking Into Chromatin with Pioneer Factors" Departmental Seminar, Michigan State University, Department of Biochemistry and Molecular Biology, East Lansing, MI (2021)
  • "Breaking Into Chromatin with Pioneer Factors" Departmental Seminar, University of North Carolina at Chapel Hill, Department of Biochemistry & Biophysics, Chapel Hill, NC (2020)
  • "Breaking Into Chromatin with Pioneer Factors" Departmental Seminar, University of Rochester, Biology Department, Rochester, NY (2020)

Service Activities:

  • JSMBS Committee on Promotions to Academic (2022–present)
  • Director UB Genomics, Genetics, and Bioinformatics graduate program.; Director (2021–present)
  • JSMBS PhD Program in Biomedical Sciences (PPBS); Steering committee member (2021–present)
  • Study section member NIH Emerging Centers of Excellence in Genomic Sciences; Member (2021)
  • Study section member, NIH Special Emphasis Panel 4D Nucleome Center Awards; Member (2020)
  • Study section Ad hoc member, NIH GCAT study section; Member (2020)
  • ACM-BCB annual meeting committee member; ACM-BCB annual meeting committee member (2019–present)
  • SMBS Faculty Mentoring Committee; Member (2019–present)
  • JSMBS MD-PhD Admissions Committee; Member (2018–2021)
  • Biochemistry Undergraduate Education; Member (2018–present)
  • Biochemistry Undergraduate Program; Undergraduate Advisor (2018–present)
  • Advisory Committee UB Genomics and Bioinformatics Core; Member (2017–present)
  • Steering committee member, UB Genomics, Genetics, and Bioinformatics graduate program.; Member (2014–present)
  • Manuscript reviewer for Cell, Nature Biotech, Nature Methods, Nature Comm, Genome Research, PNAS, PLOS Genetics, Genome Biology, Nucleic Acids Research, Molecular and Cellular Biology, BMC Bioinformatics, Bioinformatics, BMC Genomics

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Jacobs School of Medicine and Biomedical Sciences
Office 5148
955 Main Street
Buffalo, NY 14203
Buffalo, New York 14203
Phone: (716) 881-7569
Fax: NA
mjbuck@buffalo.edu