Michael Buck PhD

Michael Buck

Michael Buck
PhD

Associate Professor

Department of Biochemistry

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Bioinformatics; Gene Expression; Genomics and proteomics; Molecular and Cellular Biology; Molecular genetics; Transcription and Translation

Contact Information
701 Ellicott St
Center Of Excellence in Bioinformatics
Room B3-304
Buffalo, NY 14203
Phone: (716) 881-7569
Fax: NA
mjbuck@buffalo.edu



Professional Summary:

Dr. Buck’s research is focused on uncovering how epigenetics and the microbiome regulate cellular events. Dr. Buck’s laboratory uses multiple model systems to uncover fundamental biological principles which are subsequently translated to the study of human disease.

Instructions controlling cellular functions are contained within DNA that is wrapped and packaged around proteins into chromatin. Chromatin can be modified in response to the environment and these modifications can be passed onto their daughter cells. These modifications act as a cellular memory and are known as epigenetic modifications. Changes in epigenetic modifications are essential players in many disease pathways including: cancer, diabetes, obesity, and autism. Dr. Buck’s research is focused on uncovering how epigenetic changes redirect regulatory proteins and how regulatory proteins read epigenetic modifications.

Our bodies are populated by a diverse and complex population of thousands of microbes, mostly bacteria, but also viruses, fungi and archaea, termed the human microbiota. This co-inhabiting microbial ecosystem has been associated with various human disease including colon cancer, diabetes, periodontal disease, and others. To understand how the microbiota is affecting human health the Buck lab has developed robust and reproducible high-throughput approaches to examine thousands of samples and are currently defining causal relationships between the microbiota and human health.

Education and Training:

  • Postdoctoral Fellow, Gene regulation, chromatin, and genomics, Univeristy of North Carolina at Chapel Hill (2007)
  • PhD, Genetics, North Carolina State University (2003)
  • BS, Biotechnology, Rutgers University, Cum Laude (1997)

Employment:

  • Associate Professor, Biochemistry, State University of New York-Buffalo (2014-present)
  • Director, Stem Cell Sequencing/Epigenomics Center, The State University of New York at Buffalo (2011-present)
  • Member, Cellular and Molecular Biology Graduate Program, Roswell Park Cancer Institute (2008-present)
  • Member, The State University of New York at Buffalo, Center of Excellence in Bioinformatics and Life Sciences (2007-present)
  • Co-Director, Next-Generation Sequencing & Expression Analysis Core, The State University of New York at Buffalo (2010–2016)
  • Assistant Professor, Biochemistry, The State University of New York at Buffalo (2007–2014)
  • Postdoctoral Fellow, Biology, University of North Carolina at Chapel Hill (2003–2007)

UB 2020 Strategic Strengths:

  • Molecular Recognition in Biological Systems and Bioinformatics

Grants and Sponsored Research:

  • July 2014–July 2019
    Oral microbiome and periodontitis: a prospective study in postmenopausal women
    NIH
    Role: Co-Investigator
    $4,000,000
  • August 2011–July 2015
    Western New York Stem Cell Culture and Analysis Center
    NYSTEM
    Role: Co-Investigator
    $1,068,541
  • August 2010–July 2013
    Overlapping Clustering Analysis of Biological Networks
    NSF
    Role: Co-Principal Investigator
  • Epi)Genomic drivers of primary and metastatic pancreatic islet cell carcinoma
    National Institutes of Health
    Role: Co-Investigator

Journal Articles:

See all (48 more)

Abstracts:

  • Jiao N, Baker SS, Chapa Rodriguez A, Liu W, Nugent CA, Tsompana M, Mastrandrea LD, Buck M, Baker RD, Genco RJ, Zhu R, Zhu L. Suppressed Hepatic Bile Acid Signaling Despite Elevated Production of Primary and Secondary Bile Acids in NAFLD. Gastroenterology. 2017; 152(5 S1).


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Contact Information

701 Ellicott St
Center Of Excellence in Bioinformatics
Room B3-304
Buffalo, NY 14203
Phone: (716) 881-7569
Fax: NA
mjbuck@buffalo.edu