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Mulchand Patel

Mulchand S. Patel PhD

Department of Biochemistry

SUNY Distinguished Professor,UB Distinguished Professor, Associate Dean for Research & Biomed. Ed.

 
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OverviewResearchPublicationsActivities
Professional Summary:

One research goal is to investigate the structure-function relationships and regulation of the human pyruvate dehydrogenase complex (PDC). We investigate the catalytic mechanism of the pyruvate dehydrogenase (PDH) component and its interactions with the dihydrolipoamide acetyltransferase (E2) component of PDC. We also determine the loci of interactions between PDH kinases (four PDK isoenzymes) and the lipoyl domains of E2.

Using a PDC-knockout mouse line we investigate the importance of glucose metabolism as a source of energy for fetal development as well as the role of PDC in glucose-stimulated insulin secretion by pancreatic beta cells.

Another research goal is to investigate diet-induced metabolic programming during early life. We investigate (i) the effects of an altered nutrition during the immediate postnatal life on development of adult-onset obesity and (ii) the effects of maternal obesity on fetal programming. Current research focuses on the role of the hypothalamic signaling pathways in rodents with diet-induced obesity and also in the progeny of obese mothers.

Education and Training:
  • PhD, Animal Science(Nutritional Biochemistry), University of Illinois, Urbana, Illinois (1968)
  • MS, Biochemistry, M.S. University of Baroda, Baroda, India (1964)
  • BS, Chemistry, Gujarat University, Ahmedabad, India (1961)
Employment:
  • SUNY Distinguished Professor, State University of New York at Buffalo (2008-present)
  • UB Distinguished Professor, State University of New York at Buffalo (2004-present)
  • Professor, State University of New York at Buffalo (1993-present)
  • Professor, Case Western Reserve University (1986–1993)
  • Associate Professor, Case Western Reserve University (1978–1986)
  • Research Associate Professor, Medicine and Biochemistry, Temple University (1975–1978)
  • Research Assistant Professor, Medicine, Pediatrics, and Biochemistry, Temple University (1970–1975)
Awards and Honors:
  • SUNY Distinguished Professor (2008)
  • Research and Scholarship Award, Research Foundation (2007)
  • The 2007 Pfizer Professorship in Diabetes grant (host) award (2007)
  • The Oxygen Club of California Award - Life time Honorary member (2006)
  • UB Distinguished Professor (2004)
  • Stockton Kimball Award-2004 (2004)
  • Sustained Achievement Award (Oustanding Achievements in Scholarly Activity) (2002)
  • Recognition of Success as a top 100 Federal Grantee Award (2002)
  • Fulbright Research Scholar Award (1987)
  • Vice-Chancellor C.S.P. Gold Medal in Biochemistry (1972)
Research Expertise:
  • Diet-induced obesity models
  • Metabolic Programming
  • Molecular and Cellular Biology
  • Multienzyme Complexes
  • Protein Structure-Function Relationship
Grants and Sponsored Research:
  • August 2008–May 2010
    Mechanism and molecular recognition in human pyruvate dehydrogenase complex
    NIH/NIDDK
    Role: Co-Investigator
    $125,000
  • September 2001–January 2008
    Maternal hyperinsulinemia and fetal programming
    NIH/NIDDK
    Role: Principal Investigator
    $1,691,332
  • September 2001–March 2005
    Crystal structure of human pyruvate dehydrogenase complex facilitated by microgravity
    NASA
    Role: Co-Investigator
    $147,000
  • September 2000–December 2004
    Regulation of mammalian dihydrolipoamide dehydrogenase
    Role: Co-Investigator
    $120,000
  • July 1999–December 2004
    Regulation of Mammalian Dihydrolipoamide Dehydrogenase DK-42885
    NIH
    Role: Co-Investigator
    $879,213
  • July 1998–December 2003
    Diet-induced Hyperinsulinemia and Beta Cell Function
    NIH/NIDDK
    Role: Principal Investigator
    $961,020
  • April 2002–March 2003
    A Mouse Model for Pyruvate Dehydrogenase Deficiency
    National Organization for Rare Disorders
    Role: Principal Investigator
    $30,000
  • April 2001–March 2003
    Long-term metabolic consequences of early nutritional modification
    NIH/NICHD
    Role: Principal Investigator
    $260,520
  • January 2002–December 2002
    Regulation of mammalian pyruvate dehydrogenase Complex
    ASTA Medica Ag, Germany
    Role: Principal Investigator
    $75,607
  • September 1996–April 1998
    Diet-induced hyperinsulinemia and beta cell function
    National Institute of Diabetes and Digestive and Kidney Diseases
    Role: Principal Investigator
    $160,000
  • January 1991–November 1995
    DK-20478
    Role: Co-Investigator
    $637,200
See All (11 Total) >
Evaluative Studies and Case Reports:
Journal Articles:
  • Pliss, L, Hausknecht K, Stachowiak MK, Dlugos CA, Richards JB, Patel M.. Cerebral developmental abnormalities in a mouse with systemic pyruvate dehydrogenase deficiency. PLOS One. 2013.
  • Marin-Valencia I Good LB Ma Q Malloy CR Patel MS Pascual JM. Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet 13C NMR of the adult mouse brain. Neurochemistry International. 2012.
  • Stachowiak EK Oommen S Vasu VT Srinivasan M Stachowiak M Gohil K Patel MS. Maternal obesity affects gene expression and cellular development in fetal brains Nutritional Neuroscience. 2012.
  • Patel MS Srinivasan M. High carbohydrate intake during the suckling period results in adult-onset obesity in mother as well as offspring.IN; Obesity Before Birth: Maternal and prenatal influences on the offspring.. 2011.
  • Patel MS Srinivasan M. Metabolic programming in the immediate postnatal life.. Ann. Nutr. Metab.. 2011; 58.
  • Choi CS Ghoshal P Srinivasan M Kim S Cline G. Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity.. Lipids. 2010; 45(11).
  • Halim ND, Mcfate T, Mohyeldin A, Okagaki P, Korotchkina LG, Patel MS, Jeoung NH, Harris RA, Schell MJ, Verma A. Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons. Glia. 2010; 58(10).
  • Park YH, Patel MS. Characterization of interactions of dihydrolipoamide dehydrogenase with its binding protein in the human pyruvate dehydrogenase complex. Biochem Biophys Res Commun. 2010; 395(3).
  • Bryk R, Arango N, Venugopal A, Warren JD, Park YH, Patel MS, Lima CD, Nathan C. Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry. 2010; 49(8).
  • Patel MS, Srinivasan M. Metabolic programming due to alterations in nutrition in the immediate postnatal period. J Nutr. 2010; 140(3).
  • Srinivasan M Choi CS Ghoshal P Pliss L Pandya JD Hill D Cline G Patel MS. Beta-cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion.. Amer. J. Physiol. Endocrinol. Metab.. 2010; 299.
  • Patel MS, Korotchkina LG, Sidhu S. Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex. J Mol Catal B Enzym. 2009; 61(1-2).
  • Patel MS, Srinivasan M, Laychock SG. Metabolic programming: Role of nutrition in the immediate postnatal life. J Inherit Metab Dis. 2009; 32(2).
  • Gupta A, Srinivasan M, Thamadilok S, Patel MS. Hypothalamic alterations in fetuses of high fat diet-fed obese female rats. J Endocrinol. 2009; 200(3).
  • Srinivasan M, Mitrani P, Sadhanandan G, Dodds C, Shbeir-ElDika S, Thamotharan S, Ghanim H, Dandona P, Devaskar SU, Patel MS. A high-carbohydrate diet in the immediate postnatal life of rats induces adaptations predisposing to adult-onset obesity. J Endocrinol. 2008; 197(3).
  • Srinivasan M, Patel MS. Metabolic programming in the immediate postnatal period. Trends Endocrinol Metab. 2008; 19(4).
  • Korotchkina LG, Patel MS. Binding of pyruvate dehydrogenase to the core of the human pyruvate dehydrogenase complex. FEBS Lett. 2008; 582(3).
  • Patel MS, Korotchkina, LG. Pyruvate dehydrogenase complex regulation and lipoic acid. 2008.
  • Patel MS, Sidhu, S, Gangasani, A, Korotchkina, LG, Suzuki, G, Fallavollita, JA, Canty, JM., Jr.. Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male rats. Amer. J. Physiol. Heart Circ. Physiol.. 2008; 295.
  • Patel MS, Srinivasan, M, Catherine Dodds, C, Husam Ghanim, H, Tao Gao,T, Ross, PJ, Richard W Browne, RW, Dandona, P. Maternal obesity and fetal programming: effects of a high carbohydrate nutritional modification in the immediate postnatal life of female rats. Amer. J. Physiol. Endocrinol. Metab.. 2008; 295.
  • Patel MS, Schummer, CM, Werner, U, Tennagels, N, Schmoll, D, Haschke, G, Juretschke, H-P, Kramer, W, Herling, AW. Impaired rapid reactivation of the pyruvate dehydrogenase complex in Zucker diabetic fatty rats after an oral glucose load. Am. J. Physics. Endicirnol. Metab.. 2008; 294.
  • Nemeria N, Korotchkina L, McLeish MJ, Kenyon GL, Patel MS, Jordan F. Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states. Biochemistry. 2007; 46(37).
  • Seifert F, Ciszak E, Korotchkina L, Golbik R, Spinka M, Dominiak P, Sidhu S, Brauer J, Patel MS, Tittmann K. Phosphorylation of serine 264 impedes active site accessibility in the E1 component of the human pyruvate dehydrogenase multienzyme complex. Biochemistry. 2007; 46(21).
  • Mitrani P, Srinivasan M, Dodds C, Patel MS. Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model. Am J Physiol Endocrinol Metab. 2007; 292(5).
  • Pliss L, Mazurchuk R, Spernyak JA, Patel MS. Brain MR imaging and proton MR spectroscopy in female mice with pyruvate dehydrogenase complex deficiency. Neurochem Res. 2007; 32(4-5).
  • Jell J, Merali S, Hensen ML, Mazurchuk R, Spernyak JA, Diegelman P, Kisiel ND, Barrero C, Deeb KK, Alhonen L, Patel MS, Porter CW. Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA. J Biol Chem. 2007; 282(11).
  • Nemeria N, Chakraborty S, Baykal A, Korotchkina LG, Patel MS, Jordan F. The 1',4'-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes. Proc Natl Acad Sci U S A. 2007; 104(1).
  • Patel MS, Srinivasan, M, Mitrani, P. Metabolic syndrome due to early life nutritional modifications. 2007.
  • Nemeria NS, Korotchkina LG, Chakraborty S, Patel MS, Jordan F. Acetylphosphinate is the most potent mechanism-based substrate-like inhibitor of both the human and Escherichia coli pyruvate dehydrogenase components of the pyruvate dehydrogenase complex. Bioorg Chem. 2006; 34(6).
  • Seifert F, Golbik R, Brauer J, Lilie H, Schröder-Tittmann K, Hinze E, Korotchkina LG, Patel MS, Tittmann K. Direct kinetic evidence for half-of-the-sites reactivity in the E1 component of the human pyruvate dehydrogenase multienzyme complex through alternating sites cofactor activation. Biochemistry. 2006; 45(42).
  • Srinivasan M, Katewa SD, Palaniyappan A, Pandya JD, Patel MS. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am J Physiol Endocrinol Metab. 2006; 291(4).
  • Patel MS, Korotchkina LG. Regulation of the pyruvate dehydrogenase complex. Biochem Soc Trans. 2006; 34(Pt 2).
  • Ciszak EM, Makal A, Hong YS, Vettaikkorumakankauv AK, Korotchkina LG, Patel MS. How dihydrolipoamide dehydrogenase-binding protein binds dihydrolipoamide dehydrogenase in the human pyruvate dehydrogenase complex. J Biol Chem. 2006; 281(1).
  • Srinivasan M, Aalinkeel R, Song F, Mitrani P, Pandya JD, Strutt B, Hill DJ, Patel MS. Maternal hyperinsulinemia predisposes rat fetuses for hyperinsulinemia, and adult-onset obesity and maternal mild food restriction reverses this phenotype. Am J Physiol Endocrinol Metab. 2006; 290(1).
  • Patel MS, Srinivasan, M. Metabolic programming as a consequence of the nutritional environment during fetal and the immediate postnatal periods. 2006.
  • Patel MS, Korotchkina, LG. Pyruvate dehydrogenase complex (A3943). 2005.
  • Patel MS, Srinivasan M, Laychock SG. Nutrient-induced maternal hyperinsulinemia and metabolic programming in the progeny. Nestle Nutr Workshop Ser Pediatr Program. 2005; 55.
  • Gangasani, A. Sidhu, S. Fallavollita, J.A. Korotchkina, L. G. Suzuki, G. Patel, M.S. Canty, J.M., Jr.. Cardiac pyruvate dehydrogenase complex (PDC) deficiency in mice leads to myocardial hypertrophy and cardiomyopathy.. Circulation. 2005; 112(II).
  • Korotchkina LG, Sidhu S, Patel MS. R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase. Free Radic Res. 2004; 38(10).
  • Starkov AA, Fiskum G, Chinopoulos C, Lorenzo BJ, Browne SE, Patel MS, Beal MF. Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. J Neurosci. 2004; 24(36).
  • Korotchkina LG, Ciszak EM, Patel MS. Function of several critical amino acids in human pyruvate dehydrogenase revealed by its structure. Arch Biochem Biophys. 2004; 429(2).
  • Klivenyi P, Starkov AA, Calingasan NY, Gardian G, Browne SE, Yang L, Bubber P, Gibson GE, Patel MS, Beal MF. Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. J Neurochem. 2004; 88(6).
  • Patel MS, Srinivasan, M, Song, F, Aalinkeel, R. Molecular adaptations in rat islets to a high carbohydrate dietary intervention in the immedicate postnatal period. 2004.
  • Patel MS, Srinivasan, M. A new perspective on metabolic programming: long-term consequences of high carbohydrate feeding in the immediate postnatal period. NeoReviews. 2004; 12.
  • Johnson MT, Mahmood S, Patel MS. Intermediary metabolism and energetics during murine early embryogenesis. J Biol Chem. 2003; 278(34).
  • Ciszak EM, Korotchkina LG, Dominiak PM, Sidhu S, Patel MS. Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase. J Biol Chem. 2003; 278(23).
  • Srinivasan M, Aalinkeel R, Song F, Patel MS. Programming of islet functions in the progeny of hyperinsulinemic/obese rats. Diabetes. 2003; 52(4).
  • Hong YS, Korman SH, Lee J, Ghoshal P, Wu Q, Barash V, Kang S, Oh S, Kwon M, Gutman A, Rachmel A, Patel MS. Identification of a common mutation (Gly194Cys) in both Arab Moslem and Ashkenazi Jewish patients with dihydrolipoamide dehydrogenase (E3) deficiency: possible beneficial effect of vitamin therapy. J Inherit Metab Dis. 2003; 26(8).
  • Patel MS, Korotchkina, LG. Anti-diabetic actions of R-lipoic acid. 2003.
  • Patel MS, Tittmann, K, Golbik, R, Uhlemann, K, Khailova, L, Schneider, G, Jordan, F, Chipman, DM, Duggleby, RG, Hubner, G. NMR Analysis of Covalent Intermediates in Thiamine Diphosphate Enzymes. Biochemistry. 2003; 42.
  • Patel MS, Srinivasan, M, Laychock, SG, Hill, DJ. Neonatal Nutrition: Metabolic Programming of Pancreatic Islets and Obesity. Exp. Bio. Med.. 2003; 228.
  • Patel MS, Korotchkina, LG. The biochemistry of the pyruvate dehydrogenase complex. Biochem. Mol. Educ. (BAMBED). 2003; 31.
  • Patel MS, Korotchkina, LG. Kinetic studies of human pyruvate dehydrogenase and its mutants: interactions with TPP. 2003.
  • Patel MS, Korotchkina, LG. Pyruvate dehydrogenase complex. 2002.
  • Patel MS, Jacobia, SJ, Korotchkina, LG. Characterization of a missense mutation at histidine-44 in a pyruvate dehydrogenase-deficient patient. Biochem. Biophys. Acta. 2002; 1586.
  • Patel MS, Srinivasan M. Metabolic programming: causes and consequences. J Biol Chem. 2002; 277(3).
  • Srinivasan M, Laychock SG, Hill DJ, Patel MS. Neonatal Nutrition: Metabolic programming of pancreatic islets and obesity. Experimental Biology & Medicine. 2002; 228(1).
  • Jacobia SJ, Korotchkina LG, Patel MS. Differential effects of two mutations at arginine-234 in the alpha subunit of human pyruvate dehydrogenase. Arch Biochem Biophys. 2001; 395(1).
  • Johnson MT, Mahmood S, Hyatt SL, Yang HS, Soloway PD, Hanson RW, Patel MS. Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development. Mol Genet Metab. 2001; 74(3).
  • Korotchkina LG, Patel MS. Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase. J Biol Chem. 2001; 276(40).
  • Srinivasan M, Song F, Aalinkeel R, Patel MS. Molecular adaptations in islets from neonatal rats reared artificially on a high carbohydrate milk formula. J Nutr Biochem. 2001; 12(10).
  • Petrick, J., Srinivasan, M., Aalinkeel, R., Coukell, S., Arany, E., Mulchand Patel, Hill, D.J.. A chronic high carbohydrate diet causes an altered ontogeny of pancreatic islets of Langerhans in neonatal rat. Pediat. Res.. 2001; 49.
  • Lee, B., Srinivasan, M., Aalinkeel, R., Mulchand Patel, Laychock, S.G.. Mitochondrial-encoded gene regulation in rat pancreatic islets. Metabolism. 2001; 50.
  • Korotchkina, L.G., Mulchand Patel. Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites. J. Biol. Chem.. 2001; 276.
  • Ciszak, E., Korotchkina, L.G., Hong, Y.S., Joachimiak, A., Mulchand Patel. Crystallization and initial X-ray diffraction analysis of human pyruvate dehydrogenase. Acta Crystallographica. 2001; D57.
  • Korotchkina, L.G., Yang, H.-S., Tirosh, O., Packer, L., Mulchand Patel. Protection by thiols of the alpha-ketoacid dehydrogenase complexes from 4-hydroxy-2-nonenal-induced inactivation in situ. Free Radical Biology & Medicine. 2001; 30.
  • Aalinkeel, R., Srinivasan, M., Song, F., Mulchand Patel. Programming into adulthood of islet adaptations induces by an early nutritional intervention in the rat. Amer. J. Physiol. Endocrinol. Metab.. 2001; 281.
  • Yang, H.-S., Morris, J.I., Wang, Q., Korotchkina, L.G., Kwon, M., Mulchand Patel. Human dihydrolipoamide dehydrogenase gene transcription is mediated by cAMP-response element-like site and TACGAC direct repeat. Internatl. J. Biochem. Cell Biol.. 2001; 33.
  • Song, F., Srinivasan, M., Aalinkeel, R., Mulchand Patel. Use of a cDNA array for the identification of genes induced in islets of suckling rats by a high carbohydrate nutritional intervention. Diabetes. 2001; 50.
  • Lee B, Srinivasan M, Aalinkeel R, Patel MS, Laychock SG. Mitochondrial-encoded gene regulation in rat pancreatic islets.. Metabolism. 2001; 50(2).
  • Patel MS, Korotchkina, LG. Regulation of mammalian pyruvate dehydrogenase complex by phophorylation: complexity of multiple phosphorylation sites and kinases. Expt. Mol. Med.. 2001; 33.
  • Johnson, M.T., Yang, H.-S., Mulchand Patel. Targeting of the E3 component of the alpha-ketoacid dehydrogenase complexes. Methods Enzymol.. 2000; 324.
  • Srinivasan, M., Aalinkeel, R., Song, F., Lee, B., Laychock, S.G., Mulchand Patel. Adaptive changes in insulin secretion by islets from neonatal rats raised on a high carbohydrate formula. Amer. J. Physiol. Endocrinol. Metab.. 2000; 279.
  • Patel MS, Hong, YS, Kerr, DS. Genetic defects in the E3 component of the alpha-ketoacid dehydrogenase complex. Methods Enzymol.. 2000; 324.
  • Patel MS, Srinivasan, M, Aalinkeel, R. Metabolic programming by nutrition during early development. Indian J. Expt. Biol.. 2000; 38.
  • Aalinkeel R, Srinivasan M, Kalhan SC, Laychock SG, Patel MS. A dietary intervention (high carbohydrate) during the neonatal period causes islet dysfunction in rats.. Am J Physiol. 1999; 277(6 Pt).
  • Hong, Y.S., Jacobia, S.J., Packer, L., Mulchand Patel. The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components. Free Radical Biology & Medicine. 1999; 26.
  • Yang, H.-S., Johnson, M., Mulchand Patel. Roles of an Ets motif and a novel CACGAC direct repeat in transcription of the murine dihydrolipoamide dehydrogenase (Dld) gene. Biochem. J.. 1999; 338.
  • Tan, J., Mulchand Patel. Cloning and characterization of a 5.9 kb promoter of the human pyruvate dehydrogenase alpha-subunit gene. Biochem. Biophys. Acta. 1999; 1431.
  • Tripatara, A., Korotchkina, L.G., Mulchand Patel. Characterization of point mutations in patients with pyruvate dehydrogenase deficiency: Role of methionine-181, proline-188, and arginine-349 in the alpha subunit. Arch. Biochem. Biophys.. 1999; 367.
  • Korotchkina, L.G., Ali, M.S., Mulchand Patel. Involvement of alpha-cysteine-62 and beta tryptophan-135 in human pyruvate dehydrogenase catalysis. Arch. Biochem. Biophys.. 1999; 369.
  • Datta, U., Wexler, I.D., Kerr, D.S., Raz, I., Mulchand Patel. Characterization of the regulatory region of the human testis-specific form of the pyruvate dehydrogenase alpha subunit (PDHA2) gene. Biochem. Biophys. Acta. 1999; 1447.
  • Aalinkeel, R., Srinivasan, M., Kalhan, S.C., Laychock, S.G., Mulchand Patel. A dietary intervention (high-carbohydrate) during the neonatal period causes islet dysfunction in rats. Amer. J. Physiol. Endocrinol. Metab.. 1999; 277.
  • Liu, T,-C., Hong, Y.S., Korotchkina, L.G., Vettakkorumakankav, N.N., Mulchand Patel. Site-directed mutagenesis of human dihydrolipoamide dehydrogenase. Role of Lysine-54 and glutamate-192 in stabilizing the thiolate-FAD intermediate. Protein Expression and Purif.. 1999; 16.
  • Tan. J., Yang, H.-S., Mulchand Patel. Regulation of mammalian pyruvate dehydrogenase alpha subunit gene expression by glucose in HepG2 cells. Biochem. J.. 1998; 336.
  • Srinivasan, M., Mulchand Patel. Glycogen synthase activation in the epidydimal adipose tissue from chronic hyperinsulinemic/obese rats. J. Nutr. Biochem.. 1998; 9.
  • Patel MS, Hong, YS. Lipoic acid as an antioxidant: The role of dihydrolipoamide dehydrogenase. 1998.
  • Wexler, I.D., Hemalatha, S.G., McConnell, J., Buist, N.R.M., Dahl, H.-H.M., Berry, S.A., Cederbaum, S.D., Mulchand Patel, Kerr, D.S.. Outcome of pyruvate dehydrogenase deficiency treated with ketogenic diets. Studies in patients with identical mutations.. Neurology. 1997; 49.
  • Hong, Y.S., Kerr, D.S., Liu, T.-C., Lusk, M., Powell, B.R., Mulchand Patel. Deficiency of dihydrolipoamide dehydrogenase due to two mutant alleles (E340K and G101 del). Analysis of a family and prenatal testing. Biochim. Biophys. Acta. 1997; 1362.
  • Johnson, M., Yang, H.S., Johanning, G.L., Mulchand Patel. Characterization of the mouse dihydrolipoamide dehydrogenase (Dld) gene: Genomic structure, promoter sequence, and chromosomal localization. Genomics. 1997; 41.
  • Johnson, M.T., Yang, H.-S., Magnuson, T., Mulchand Patel. Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality. Proc. Natl. Acad. Sci., U.S.A.. 1997; 94.
  • Dey, R., Naik, S., Mulchand Patel. Tissue-specific expression of the human pyruvate dehydrogenase alpha (Pdha-1)/chloramphenicol acetyltransferase fusion gene in transgenic mice. Biochem. Biophys. Acta. 1996; 1305.
  • Tripatara, A., Kerr, D.S., Lusk, M.M., Kolli, M., Tan, J., Mulchand Patel. Pyruvate dehydrogenase deficiency: Characterization of three new mutations in the E1alpha subunit. Human Mutation. 1996; 8.
  • Vettakkorumakankav, N.N., Mulchand Patel. Dihydrolipoamide dehydrogenase: structural and mechanistic aspects. Indian J. Biochem. Biophys. 1996; 33.
  • Srinivasan, M., Vadlamudi, S., Mulchand Patel. Effect of chronic hyperinsulinemia/obesity on activation of glycogen synthase. Internat. J. Obesity and Metab. Disorders. 1996; 20.
  • Hong, Y.S., Kerr, D.S., Craigen, W.J., Tan, J., Pan, Y., Lusk, M., Mulchand Patel. Identification of two mutations in a compound heterozygous patient with dihydrolipoamide dehydrogenase deficiency. Human Mol. Genet.. 1996; 5.
  • Patel MS, Korotchkina, LG, Ali, MS. Probing the active site of mammalian pyruvate dehydrogenase. 1996.
  • Patel MS, Naik, S, Johnson, M, Dey, R. Long-term regulation and promoter analysis of mammalian pyruvate dehydrogenase complex. 1996.
  • Patel MS, Kerr, DS, Wexler, ID, Tripatara, A. Human defects in the pyruvate dehydrogenase complex. 1996.
  • Patel MS, Korotchkina, LG, Ali, MS. The active stie of residues in mammalian pyruvate dehydrogenase. 1996.
  • Laychock SG, Vadlamudi S, Patel MS. Neonatal rat dietary carbohydrate affects pancreatic islet insulin secretion in adults and progeny.. Am J Physiol. 1995; 269(4 Pt).
  • Maury, J., Kerbey, A.L., Priestman, D.A., Mulchand Patel, Girard, J., Ferre, P.. Pretranslational regulation of pyruvate dehydrogenase complex subunits in white adipose tissue during the suckling-weaning transition in the rat. Biochem. J.. 1995; 311.
  • Ali, M.S., Shenoy, B.C., Eswaran, D., Andersson, L.A., Roche, T.E., Mulchand Patel. Identification of the tryptophan residue in the thiamine pyrophosphate binding site of bovine pyruvate dehydrogenase. J. Biol. Chem.. 1995; 270.
  • Madhusudhan, K.T., Naik, S.S., Mulchand Patel. Characterization of the promoter regulatory region of the human pyruvate dehydrogenase beta gene. Biochemistry. 1995; 34.
  • Hemalatha, S.G., Kerr, D.S., Wexler, I.D., Lusk, M.M., Kuang, M., Du, Y., Kolli, M., Schelper, R.L., Mulchand Patel. Pyruvate dehydrogenase complex deficiency due to a point mutation (P188L) within the thiamine pyrophosphate binding loop of the E1 alpha subunit. Human Mol. Genet.. 1995; 4.
  • Korotchkina, L.G., Tucker, M.M., Thekkumara, T.T., Madhusudhan, K.T., Pons, G., Kim, H., Mulchand Patel. Overexpression and characterization of human tetrameric pyruvate dehydrogenase and its individual subunits. Protein Exp. Purif.. 1995; 6.
  • Mulchand Patel, Naik, S., Wexler, I.D., Kerr, D.S.. Gene regulation and genetic defects in the pyruvate dehydrogenase complex. J. Nutrition. 1995; 125.
  • Mulchand Patel, Harris, R.A.. alpha-Keto acid dehydrogenase complexes: Gene regulation and genetic defects. FASEB J.. 1995; 9.
  • Mulchand Patel, Vettakkorumakankav, N.N., Liu, T-C.. Dihydrolipoamide dehydrogenase: activity assays. Biothiols. 1995; 252.
  • Korotchkina, L.G., Mulchand Patel. Mutagenic studies of phosphorylation sites of human pyruvate dehydrogenase. J. Bio. Chem.. 1995; 270.
  • Liu, T-C., Korotchkina, L.G., Hyatt, S.L., Vettakkorumakankav, N.N., Mulchand Patel. Characterization of recombinant human dihydrolipoamide dehydrogenase and its site-directed mutants. Spectroscopic studies. J. Biol. Chem.. 1995; 270.
  • Vadlamudi, S., Kalhan, S.C., Mulchand Patel. Persistence of metabolic consequences in the progeny of rats fed an HC formula in their early postnatal life. Amer. J. Physiology: Endocrinol. & Metabolism. 1995; 269.
  • Laychock, S.G., Vadlamudi, S., Mulchand Patel. Dietary carbohydrate in neonatal rats affects insulin secretion from isolated pancreatic islets of adults and progeny. Amer. J. Physiology: Endocrinol. & Metabolism. 1995; 269.
  • Eswaran, D., Ali. M.S., Shenoy, B.C., Roche, T.E., Mulchand Patel. Arginine-239 in the beta subunit is at/or near the active-site of pyruvate dehydrogenase. Biochim. Biophys. Acta. 1995; 1252.
  • Patel MS, Vettakkorumakankav, NN. Lipoic acid requiring proteins: Recent advances. 1995.
  • Mulchand Patel, Vadlamudi, S., Johanning, G.L.. Artificial rearing of rat pups: Implications for nutrition research. Annual Rev. Nutr.. 1994; 14.
  • Wexler, I.D., Du, Y., Lisgaris, M.V., Mandal, S.K., Freytag, S.D., Yang, B-S., Liu, T-C., Kwon, M., Mulchand Patel, Kerr, D.S.. Primary amino acid sequence and structure of human pyruvate carboxylase. Biochem. Biophys. Acta. 1994; 1227(7).
  • Patel MS, Smith, RL. Biochemistry of lipoic acid containing proteins: Past and Present. 1994.
  • Borum, P.R., Mulchand Patel. Overview. Symposium: Animal models in neonatal and infant nutrition research. J. Nutr.. 1993; 123.
  • Mulchand Patel, Vadlamudi, S.P., Johanning, G.L.. Overview of pup in a cup model: Hepatic lipogenesis in rats artificially reared on a high-carbohydrate formula. J. Nutr.. 1993; 123.
  • Leung, P.S.C., Wantanabe, Y., Munoz, S., Teuber, S.S., Mulchand Patel, Korenberg, J.R., Hara, P., Coppel, R., Gershwin, M.E.. Chromosome localization and RFLP analysis of PDC-E2: The major autoantigen of primary biliary cirrhosis. Autoimmunity. 1993; 14.
  • Chang, M., Naik, S., Johanning, G., Ho, L., Mulchand Patel. Multiple protein-binding domains and functional cis-elements in the 5'-flanking region of the human pyruvate dehydro-genase alpha subunit gene. Biochemistry. 1993; 32.
  • Liu, T-C., Kim, H., Arizmendi, C., Kitano, A., Mulchand Patel. Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient. Proc. Natl. Acad. Sci. (U.S.A.). 1993; 90.
  • Hiremagalur, B.K., Vadlamudi, S., Johanning, G.L., Mulchand Patel. Long term effects of feeding high-carbohydrate diet in preweaning period by gastrostomy: A new rat model for obesity. Internatl. J. Obesity. 1993; 17.
  • Vadlamudi, S., Hiremagalur, B.K., Tao, L., Kalhan, S.C., Kalaria, R.N., Kaung, H-L.C., Mulchand Patel. Long-term effects on pancreatic function of feeding a high-carbohydrate formula to rats during the preweaning period. Amer. J. Physiol.: Endocrinol. & Metabolism. 1993; 265.
  • Ali, M.S., Roche, T.E., Mulchand Patel. Identification of the essential cysteine residue in the active site of bovine pyruvate dehydrogenase. J. Biol. Chem.. 1993; 268.
  • Mulchand Patel, Hiremagalur, B.K.. Artificial rearing technique: Its usefulness in nutrition research. J. Nutr.. 1992; 122.
  • Kim, H., Mulchand Patel. Characterization of two site-specifically mutated human dihydrolipoamide dehydrogenase (His-452 Gln and Glu-457 Gln). J. Biol. Chem.. 1992; 267.
  • Coleman, R.A., Hiremagalur, B.K., Tratchman, J., Bardes, E.S-G., Rao, P., Mulchand Patel. Alteration of enzymes of hepatic glycerolipid synthesis in artificially reared rat pups fed high carbohydrate and high fat diets. J. Nutr. Biochem.. 1992; 3.
  • Jentoft, J.E., Shoham, M., Hurst, D., Mulchand Patel. A structural model for human dihydrolipoamide dehydrogenase. Proteins, Structure, Function, and Genetics. 1992; 14.
  • Wexler, I.D., Hemalatha, S.G., Liu, T-C., Berry, S.A., Kerr, D.S., Mulchand Patel. A mutation in the alpha subunit of pyruvate dehydrogenase associated with variable expression of pyruvate dehydrogenase complex deficiency. Pediatr. Res.. 1992; 32.
  • Mulchand Patel, Kerr, D.S., Wexler, I.D.. Biochemical and molecular aspects of pyruvate dehydrogenase complex deficiency. Internatl. Pediatr.. 1992; 7.
  • Hiremagalur, B.K., Johanning, G.L., Kalhan, S.C., Mulchand Patel. Alterations in hepatic lipogenic capacity in rat pups artificially reared on a milk-substitute formula high in carbohydrate or medium-chain triglycerides. J. Nutr. Biochem.. 1992; 3.
  • Johhaning, G.L., Morris, J.I., Madhusudhan, K.T., Samols, D., Mulchand Patel. Characterization of the transcriptional regulatory region of the human dihydrolipoamide dehydrogenase gene. Proc. Natl. Acad. Sci. (U.S.A.). 1992; 89.
  • Dahl, H-H.M., Brown, G.K., Brown, R.M., Hansen, L.L., Kerr, D.S., Wexler, I.D., Mulchand Patel, DeMeirleir, L., Lissens, W., Chun, K., MacKay, N., Robinson, B.H.. Mutations and polymorphisms in the pyruvate dehydrogenase E1alpha gene. Human Mutation. 1992; 1.
  • Kim, H., Liu, T-C., Mulchand Patel. Expression of cDNA sequences encoding mature and precursor forms of human dihydrolipoamide dehydrogenase in Escherichia coli. Differences in kinetic mechanisms. J. Biol. Chem.. 1991; 266.
  • Wexler, I.D., Hemalatha, S.G., Mulchand Patel. Sequence conservation in the alpha and beta subunits of pyruvate dehydrogenase and its similarity to branched-chain acid-keto acid dehydro-genase. FESB Letters. 1991; 282.
  • John, J., Mulchand Patel, Telang, S.D.. Effects of maternal dietary protein content on cerebral ketone body-metabolizing enzymes in the progeny of rats. J. Nutr. Biochem.. 1991; 2.
  • Iwayama, T., Leung, P.S.C., Coppel, R.L., Roche, T.E., Mulchand Patel, Mizushima, Y., Dickson, R., Gershwin, M.E.. Specificity reactivity of recombinant human PDC-E1alpha in primary biliary cirrhosis. J. Autoimmunity. 1991; 4.
  • Mullis PE, Lund T, Patel MS, Brook CG, Brickell PM. Regulation of human growth hormone receptor gene expression by human growth hormone in a human hepatoma cell line. Mol Cell Endocrinol. 1991; 76(1-3).
  • Patel, MS Kim, H Jentoft, JE. Human dihydrolipoamide dehydrogenase: Expression and functional aspects of normal and modified enzymes. 1991.
  • Ho, L., Mulchand Patel. Cloning and cDNA sequence of the beta subunit component of human pyruvate dehydrogenase complex. Gene. 1990; 86.
  • Mulchand Patel, Roche, T.E.. Molecular biology and biochemistry of pyruvate dehydrogenase complex. FASEB J.. 1990; 4.
  • Patel MS Ho, L Carothers, DJ. Development and Molecular Biology of Mammalian Pyruvate Dehydrogenase Complex. 1990.
  • Patel MS Thekkumkara, TJ Haney, PM Ho, L. Long-term consequences of high carbohydrate intake during the suckling period on lipid synthesis in the adult rat. 1990.
  • Ho, L., Wexler, I.D., Kerr, D.S., Mulchand Patel. Genetic defects in human pyruvate dehydrogenase. Annals N.Y. Acad. Sci.. 1989; 573.
  • Serrano, E., Luis, A.M., Encabo, P., Alconada, A., Ho, L., Mulchand Patel, Cuezva, J.M.. Rapid postnatal induction of the pyruvate dehydrogenase complex in rat liver mitochondria. Annals N.Y. Acad. Sci.. 1989; 573.
  • Carothers, D.J., Pons, G., Mulchand Patel. Dihydrolipoamide dehydrogenase: Functional similarities and divergent evolution of the pyrimidine nucleotide-disulfide oxidoreductases. Arch. Biochem. Biophys.. 1989; 268.
  • Thekkumkara, T.J., Mulchand Patel. Ochratoxin A decreases the activity of phosphoenol-pyruvate carboxykinase and its mRNA content in primary cultures of rat kidney proximal convoluted tubule cells. Biochem. Biophys. Res. Commun.. 1989; 162.
  • Ho, L., Wexler, I.D., Liu, T-C., Thekkumkara, T.J., Mulchand Patel. Characterization of cDNAs encoding human pyruvate dehydrogenase alpha-subunit. Proc. Natl. Acad. Sci. (U.S.A.). 1989; 86.
  • Patel MS. CO2-fixing enzymes. 1989; 11.
  • Patel, MS Thekkumkara, TJ Pons, G Mitroo, S Jentoft, JE. Molecular biology of human pyruvate dehydrogenase complex: Structural aspects of the E2 and E3 components. Acad. Sci.. 1989; 573.
  • Carothers, D.J., Pons, G., Mulchand Patel. Induction of dihydrolipoamide dehydrogenase in 3T3-L1 cells during differentiation. Biochem. J.. 1988; 249.
  • Pons, G., Raefsky-Estrin, C., Carothers, D.J., Pepin, R.A., Javed, A.A., Jesse, B.W., Ganapathi, M.K., Samols, D., Mulchand Patel. Cloning and cDNA sequence of the dihydrolipoamide dehydrogenase component of human alpha-ketoacid dehydrogenase complexes. Proc. Natl. Acad. Sci. (U.S.A.). 1988; 85.
  • Ho, L., Javed, A.A., Pepin, R.A., Thekkumkara, T.J., Raefsky, C., Mole, J.E., Caliendo, A.M., Kwon, M.S., Kerr, D.S., Mulchand Patel. Identification of a cDNA clone for the b-subunit of the pyruvate dehydrogenase component of human pyruvate dehydrogenase complex. Biochem. Biophys. Res. Commun.. 1988; 150.
  • Kerr, D.S., Berry, S.A., Lusk, M.M., Ho, L., Mulchand Patel. A deficiency of both subunits of pyruvate dehydrogenase which is not expressed in fibroblasts. Pediatr. Res.. 1988; 24.
  • Wexler, I.D., Kerr, D.S., Ho, L., Lusk, M.M., Pepin, R.A., Javed, A.A., Mole, J.E., Jesse, B.W., Thekkumkara, T.J., Pons, G., Mulchand Patel. Heterogeneous expression of protein and mRNA in pyruvate dehydrogenase deficiency. Proc. Natl. Acad. Sci. (U.S.A.). 1988; 85.
  • Thekkumkara, T.J., Ho, L., Wexler, I.D., Liu, T-C., Mulchand Patel. Nucleotide sequence of a cDNA for the dihydrolipoamide acetyltransferase component of human pyruvate dehydro-genase complex. FEBS Letters. 1988; 240.
  • Kerr, D.S., Ho, L., Berlin, C.M., LaNoue, K.F., Towfighi, J., Hoppel, C.L., Lusk, M.M., Gondek, C.M., Mulchand Patel. Systemic deficiency of the first component of the pyruvate dehydrogenase complex. Pediatr. Res.. 1987; 22.
  • Carothers, D.J., Raefsky-Estrin, C., Pons, G, Mulchand Patel. Rat liver mitochondrial contain two immunologically-district dihydrolipoamide dehydrogenases. Arch. Biochem. Biophys.. 1987; 256.
  • Thekkumkara, T.J., Jesse, B.W., Ho, L., Raefsky, C., Pepin, R.A., Javed, A.A., Pons, G., Mulchand Patel. Isolation of a cDNA clone for the dihydrolipoamide acetyltransferase component of the human liver pyruvate dehydrogenase complex. Biochem. Biophys. Res. Commun.. 1987; 145.
  • Ganapathi, M.K., Kwon, M., Haney, P.M., McTeirnan, C., Javed, A.A., Pepin, R.A., Samoles, D., Mulchand Patel. Cloning of rat brain succinyl-CoA:3-oxoacid CoA-transferase cDNA: Regulation of the mRNA in different rat tissues and during brain development. Biochem. J.. 1987; 248.
  • Haney, P.M., Raefsky-Estrin, C., Caliendo, A., Mulchand Patel. Precocious induction of hepatic glucokinase and malic enzyme in artificially reared rat pups fed a high-carbohydrate diet. Arch. Biochem. Biophys.. 1986; 244.
  • Ganapathi, M.K., Raefsky, C., Mulchand Patel. Induction of succinyl-CoA:3-oxoacid CoA-transferase during differentiation of 3T3-L1 cells. Arch. Biochem. Biophys.. 1986; 244.
  • Ho, L., Hu, C-W.C., Packman, S., Mulchand Patel. Deficiency of the pyruvate dehydro-genase component in pyruvate dehydrogenase complex-deficient human fibroblasts: immuno-logical identification. J. Clin. Invest.. 1986; 78.
  • Kretzschmar, H.A., DeArmond, S.J., Koch, T.K., Mulchand Patel, Newth, C.J.L., Schmidt, K.A., Packman, S.. Pyruvate dehydrogenase complex deficiency as a cause of subacute necrotizing encephalopathy (Leigh's Disease). Pediatrics. 1986; 79.
  • Mulchand Patel, Raefsky, C., Hu, C-W.C.. Modulation by dexamethasone of the pyruvate dehydrogenase complex activity in 3T3-L1 adipocytes. Biochem. J.. 1985; 226.
  • Chitra, C.I., Cuezva, J.M., Mulchand Patel. Changes in the activity of 'active' pyruvate dehydrogenase complex in the newborn of normal and diabetic rats. Diabetologia. 1985; 28.
  • Haney, P.M., Mulchand Patel. Regulation of succinyl-CoA:3-oxoacid CoA-transferase in developing rat brain. Responsiveness associated with prenatal but not postnatal hyperketonemia. Arch. Biochem. Biophys.. 1985; 240.
  • Cuezva, J.M., Mulchand Patel. Effect of glucose and insulin administration on hepatic adenylate energy charge and the cytosolic redox state in the neonates of normal and insulin treated diabetic rats. Biol. Neonate. 1985; 48.
  • Haney, P.M., Bolinger, L., Raefsky, C., Mulchand Patel. Turnover of succinyl-CoA:3-oxoacid CoA-transferase in glioma and neuroblastoma cells. Biochem. J.. 1984; 244.
  • Cuezva, J.M., Mulchand Patel. Disurbances of fetal liver varbohydrate metabolism and perinatal glucose homeostasis. Biochem. Soc. Tran.. 1984; 13.
  • Johnston, K., Newth, C.J.L, Sheu, K-F.R., Mulchand Patel, Heldt, G.P., Packman, S.. Central hypoventilation syndrome in pyruvate dehydrogenase complex deficiency. Pediatrics. 1984; 74.
  • Hu, C-W.C., Utter, M.F., Mulchand Patel. Induction of pyruvate dehydrogenase in 3T3-L1 cells during differentittion. J. Biol. Chem.. 1983; 258.
  • Chuang, D.T., Hu, C-W.C, Mulchand Patel. Induction of branched-chain 2-oxo acid dehydrogenase complex in 3T3-L1 adipocytes during differentiation. Biochem. J.. 1983; 214.
  • Caliendo, A.M., Mulchand Patel. Insulin receptors in developing rat liver. Acquisition of down regulation in the immediate postnatal period. Arch. Biochem. Biophys.. 1983; 277.
  • Russell, J.J., Mulchand Patel. 3-oxo acid-CoA transferase from rat brain. J. Neurochem.. 1982; 38.
  • Cuezvz, J.M., Burkett, E.S., Kerr, D.S., Rodman, H.M., Mulchand Patel. The newborn of diabetic rat. I. Hormonal and metabolic changes in the postnatal period. Pediatr. Res.. 1982; 16.
  • Deskmukh, D.R., Mulchand Patel. Age-dependent changes in pyruvate uptake by nonsynaptic and synpatic mitochondria from rat brain. Mech. Ageing Development. 1982; 20.
  • Patel, MS Russell, JJ. Purification and properties of succinyl-CoA: 3-oxo acid-CoA transferase from rat brain. J. Neurochem. 1982; 38.
  • Patel, MS Cuezva, JM Chitra, I. The newborn of diabetic rat. II. Impaired gluconeogenesis in the postnatal period. Pediatr. Res. 1982; 16.
  • Patel, MS Van Lelyveld, P Hanson, RW. The development of the pathways of glucose homeostasis in the newborn. 1982.
  • Patel MS, Owen, OE, Reichard, GA, Jr. Kinney, JM, Boden, G, Sapire, DG. Metabolism during catabolic states of starvation, diabetes, and trauma in humans. 1982.
  • Mulchand Patel, Russell, J.J., Gershman, H.. Ketone-body metabolism in glioma and neuroblastoma cells. Proc. Natl. Acad. Sci., U.S.A.. 1981; 78.
  • Owen, O.E., Reichle, F.A., Mozzoli, M.A., Kreulen, T., Mulchand Patel, Elfenbein, I.B., Glosorkhi, M., Chang, K.H.Y., Rao, N.S., Sue, H.S.. Hepatic, gut, and renal substrate flux rates in patients with hepatic cirrhosis. J. Clin. Invest.. 1981; 68.
  • Patel, MS Owen, OE Boden, G. Substrate utilization of the human brain under normal and pathological conditions. 1981.
  • Deshmukh, D.R., Owen, O.E., Mulchand Patel. Effect of aging on the metabolism of pyruvate and 3-hydroxybutyrate in non-synaptic mitochondria from rat brain.. J. Neurochem.. 1980; 34.
  • Deshmukh, D.R., Mulchand Patel. Age-dependent changes in glutamate oxidation by non-synaptic and synaptic mitochondria from rat brain. Mech. Ageing Development. 1980; 13.
  • Owen, O.W., Mozzoli, M.A., Boden, G., Mulchand Patel, Reichard, G.A., Jr., Trapp, V., Shuman, C.R., Felig, P.. Substrate, hormone, and temperature responses in males and females to a common response. Metabolism. 1980; 29.
  • Mulchand Patel. Influence of neonatal hypothyroidism on the development of ketone body-metabolizing enzymes in rat brain. Biochem J.. 1979; 184.
  • Patel, MS Owen, OE Reichard, GA Boden, G. Energy metabolism in feasting and fasting. 1979.
  • Mulchand Patel, Owen, O.E.. The metabolism of leucine by developing rat grain: effect of leucine and 2-oxo-4-0methylvalerate on lipid synthesis from glucose and ketone bodies. J. Neurochem.. 1978; 30.
  • Patel, MS Owen, OE Boden, G. Ketone-body metabolism during health and disease. 1978.
  • Mulchand Patel, Owen, O.E.. Development and regulation of lipid synthesis from ketone bodies by rat brain. J. Neurochem.. 1977; 28.
  • Owen, O.E., Block, B.S.B., Mulchand Patel, Boden, G., McDonough, M., Kreulen, T., Shuman, C.R., Reichard, G.A., Jr.. Human splanchnic metabolism during diabetic ketoacidosis. Metabolism. 1977; 26.
  • Mulchand Patel. Age dependent changes in the oxidative metabolism in rat brain. J. Gerontology. 1977; 31.
  • Patel, MS Owen, OE Reichard, GA Jr. Boden, G Trap, VW. Interrelationships among key tissues in the utilization of metabolic substrates. 1977; 2.
  • Mulchand Patel, Owen, O. E.. Effect of hyperphenylalaninemia on lipid synthesis from ketone bodies by rat brain.. Biochem. J.. 1976; 154.
  • Mulchand Patel, Owen, O. E.. Lipogenesis from ketone bodies in rat brain. Evidence for conversion of acetoacetate to acetyl coenzyme A in the cytosol.. Biochem. J.. 1976; 156.
  • Mulchand Patel, Owen, O.E., Raefsky, C.. Effect of methylmalonate on ketone body metabolism in developing rat brain. Life Sci.. 1976; 19.
  • Patel, MS Owen, OE. Effect of branched-chain and aromatic alpha-keto acids on pyruvate and alpha-ketoglutarate metabolism. 1976.
  • Patel, MS Owen, OE Block, BSB Kreulen, TH Reichie, FA. Gluconeogenesis in normal, cirrhotic and diabetic humans. 1976.
  • Mulchand Patel, Owen, O. E., Goldman, L. I., Hanson, R. W.. Fatty acid synthesis by human adipose tissue.. Metabolism. 1975; 24.
  • Mulchand Patel, Johnson, C. A., Rajan, R., Owen, O. E.. The metabolism of ketone bodies in developing human brain: development of ketone body-utilizing enzymes an dketone bodies as precursors for lipid synthesis.. J. Neurochem.. 1975; 26.
  • Mulchand Patel. Citrate transport and oxidation byisolated rat brain mitochondria.. Brain Res.. 1975; 98.
  • Wilbor, D. O., Mulchand Patel. Development of mitochondrial pyruvate metabolism in rat brain.. J. Neurochem.. 1974; 22.
  • Mulchand Patel. The relative significance of CO2-fixing enzymes in the metabolism of rat brain.. J. Neurochem.. 1974; 22.
  • Hanson, R. W., Mulchand Patel. Lipogenesis in developing guinea pig liver.. Mechanism of Aging and Development. 1974; 3.
  • Mulchand Patel, Arinze, I. J.. Phenylketonuria: metabolic alterations induced by phenylalanine and phenylpyruvate.. Am. J. Clin. Nutr.. 1974; 28.
  • Mulchand Patel. The effect of ketone bodies on pyruvate carboxylation by rat brain mitochondria.. J. Neurochem.. 1974; 22.
  • Mulchand Patel, Tonkonnow, B. L.. Development of lipogenesis in rat brain cortex: the differential in vitro incorporation of glucose and acetate into brain lipids.. J. Neurochem.. 1974; 23.
  • Mulchand Patel. Inhibition by the branched-chain 2-oxoacids of the 2-oxo-glutarate dehdrogenase complex in developing rat and human brain.. Biochem. J.. 1974; 144.
  • Sutnick, M. R., Grover, W. D., Mulchand Patel. Impairment of hepatic pyruvate metabolism in phenylketonuria.. Life Sci.. 1974; 15.
  • Patel MS. Regulation of pyruvate carboxylase in rat brain mitochondria: effect of fluoropyruvate. Brain Res.. 1974; 76.
  • Mulchand Patel, Tilghman, S.M.. Regulation of pyruvate metabolism via pyruvate carboxylase in rat brain mitochondria. Biochem. J.. 1973; 132.
  • Mulchand Patel, Grover, W.D., Auerbach, V.H.. Pyruvate metabolism by homogenates of human brain: effects of phenylpyruvate and implications for the etiology of the mental retardation in phenylketonuria. J. Neurochem.. 1973; 20.
  • Mulchand Patel, Auerbach, V.H., Grover, W.D., Wilbur, D.O.. Effect of the branchedchain alpha-keto acids on pyruvate metabolism by homogenates of human brain. J. Neurochem.. 1973; 20.
  • Gruskin, A.B., Mulchand Patel, Linshaw, M., Ettenger, R., Huff, D., Grover, W.D.. Renal functional studies and kidney pyruvate carboxylase in subacute necrotizing encephalomyelopathy (Leigh's syndrome). Pediatr. Res.. 1973; 7.
  • Mulchand Patel, Arinze, I. J.. Inhibition by phenylpyruvate of gluconeogenesis in the perfused rat liver. Biochem.. 1973; 12.
  • Mulchand Patel. The effect of phenylpyruvate on pyruvate metabolism in rat brain. Biochem. J. 1972; 128.
  • Mulchand Patel, Grover, W.D., Auerbach, V.H.. Biochemical studies and therapy in subacute necrotizing encephalomyelopathy. J. Pediatr.. 1972; 81.
  • Mulchand Patel, Hanson, R.W, Jomain-Baum, M, Ballard, F.J. The pathway of carbon flow during fatty acids synthesis from lactate and pyruvate in rat adipose tissue. J. Lipid Res. 1971; 12.
  • Patel, MS Hanson, RW Reshef, L Ballard, FJ. The role of pyruvate carboxylase and P-enolpyruvate carboxykinase in adipose tissue. 1971.
  • Hanson, RW Jomain-Baum, M Ballard, FJ. Role of mitochondria in metabolism of pyruvate and lactate by rat adipose tissue. Metabolism. 1971; 20.
  • Mulchand Patel, Mistry, S.P. Glycogen synthesis in biotin-deficient rat liver. Proc. Soc. Expt. Biol. Med.. 1970; 235.
  • Mulchand Patel, Hanson, R.W.. Carboxylation of pyruvate by isolated rat adipose tissue mitochondria. J. Biol. Chem.. 1970; 245.
  • Mulchand Patel. Carboxylation of pyruvate by human adipose tissue mitochondria. Biochem. Biophys. Res. Commun.. 1970; 41.
  • Mulchand Patel, Mistry, S.P. Effect of food restriction on systematic oscillations in "control animals" used in studies on biotin-deficient rats. J. Nutri.. 1969; 97.
  • Mulchand Patel, Mistry, S.P. Effect of food restriction on metabolic alterations in "control animals" used in studies on biotin-deficient rats. J. Nutr. 1969; 98.
  • Mulchand Patel, Mistry, S.P.. Effect of biotin deficiency on food intake and body and organ weights of male albino rats. Growth. 1968; 32.
  • Patel, MS Mistry, SP. Effect of sorbitol, fructose, succinate, aspartate, glutamate and fat on growth and survivial time of biotin-deficient rats.. J. Nutr.. 1968; 96.
  • Yang, H.-S., Morris, J.I., Wang, Q., Korotchkina, L.G., Kwon, M. and Patel, M.S.. Human dihydrolipoamide dehydrogenase gene transcription is mediated by cAMO-response element-like site and TACGAC direct repeat. Internatl. J. Biochem. Cell. Biol.. ; 33.
  • Thekkumkara, T.J., Pons, G., Mitroo, S., Jentoft, J.E., Mulchand Patel. Molecular biology of human pyruvate dehydrogenase complex: Structural aspects of the E2 and E3 components. Annals N.Y. Acad. Sci.. ; 573.
See All (233 Total) >
Books and Book Chapters:
  • Mulchand Patel, Korotchkina, L.G., Ali, M.S.. The active site residues in mammalian pyruvate dehydrogenase. Biochemistry and Physiology of Thiamin Diphosphate Enzymes, Bisswanger, H. and Schellenberger, A..
  • Mulchand Patel, Korotchkina, L.G., Ali, M.S.. The active site residues in mammalian pyruvate dehydrogenase.. Biochemistry and Physiology of Thiamin Diphosphate Enzymes, Bisswanger, H. and Schellenberger, A. (eds.), A.u.C. Intemann, Wissenschaftlicher Verlag, Prien..
  • Mulchand Patel, Hanson, R.W, Reshef, L, Ballard, F.J. The role of pyruvate carboxylin and P-enolpyruvate carboxykinase in adipose tissue. Regulation of Gluconeogenesis, H-D..
Professional Memberships:
  • Society for Inherited Metabolic Disorders (1990–1998)
  • International Society for Neurochemistry (1983–1995)
  • The American Society for Neurochemists (1974–1998)
  • American Society for Biochemistry and Molecular Biology (1974)
  • The American Association for the Advancement of Science (1971–2006)
  • The Society of the Sigma Xi (1971–1989)
  • American Federation for Clinical Research (1971–1989)
  • American Society for Nutritional Sciences (1971)
  • The Biochemical Society, London (1970–1998)
Presentations:
  • "Perinatal Nutritional Programming and Its Consequences in Adulthood" The 22nd International Conference of the Korean Society for Gerontology, Korea National Institute of Health (2012)
  • "Pyruvate dehydrogenase complex deficiency and brain development" International Conference on Molecular Medicine-2012 (MOLMED-2012) (2012)
  • "Programming beta cell development, impairment and regeneration" (2011)
  • "Human pyruvate dehydrogenasecomplex: Structure-function relationship and Regulation" 15th Indian Society of Chemists and Biologists International Conference (ISCBC-2011) (2011)
  • "Maternal Obesity: Fetal programming and adult-onset obesity" International Conference on Molecular Medicine, Charotar University of Science and Technology, Changa (2011)
  • "Metabolic programming due to high carbohydrate intake in the immediate postnatal period" IXth International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules (2011)
  • "Neonatal programming of metabolism" PhD Summer School on Molecular Metabolism 2010, Danish PhD School of Molecular Metabolism, GI (2010)
  • "Immediate Postnatal Nutrition, Metabolic Programming and Adult-onset in Obesity" Nutritional Experiences in Early Life as Determinants of the Adult Metabolic Phenotype, American Society of Nutrition (2009)
  • "Early Life Nutritional Experience and Metabolic Programming causing Adult-onset Obesity" International Conference on Molecular Medicine, Indian Instituteof Science, Florida International University, Laila Pharmaceuticals (2009)
  • "Human pyruvate dehydrogenase complex: Evolution, regulation and genetic defects" Workshop on Biomedical and Biotechnological Research, Education Campus Changa, Changa (2009)
  • "Metabolic Programming due to altered nutrition in early life: Development of obesity" Healthy Start: Maternal and Child Nutrition, Gujarat Government, Department of Health (2009)
  • "Metabolic Programming" 2008 Symposium of the Society for the Study of Inborn Errors of Metabolism (2008)
  • "Interactions of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex" International Conference on Chemical Biology of Thiamine (2008)
  • "Structure-function relationships of the human pyruvate dehydrogenase complex" The 8th International Symposium on Biochemical Roles of Eukaryotic Cell Surface Macromolecules (2008)
  • "How does increased carbohydrate intake lead to obesity and insulin resistance?" First Annual Society for Pediatric Research (SPR) Research Confernce (SPR-RC) (2007)
  • "A New Perspective on Obesity: Early Life Metabolic Programming" Molecular Metabolism: Ph.D. Summer School 2007, University of Southern Denmark/University of Copenhagen (2007)
  • "Animal models of the metabolic syndrome: Programming of pancreatic islets and obesity" 47th Annual Meeting of the Teratology Society (2007)
  • "Human pyruvate dehydrogenase complex: Structure-function relationship and regulation" , National Institute of Immunology (2006)
  • "The Obesity/Diabetes Epidemic: Early Life Metabolic Programming" , Diabetes Institute (2006)
  • "A new perspective on obesity: early metabolic malprogramming" Oxygen Club Annual Meeting, Oxygen Club (2005)
  • "Insulin, Calcium and the control of Mammalian Metabolism" Regulation of the Pyruvate Dehydrogenase Complex (2005)
  • "Nutritional intervention in early life predisposes to chronic hyperinsulinemia and ault-onset obesity/diabeties" The Second Russel Berry International Symposium on Diabetes and Arthrosclerosis (2005)
  • "Fetal metabolic programming predisposes to adult-onset obesity" Experimental Biology 2005 Annual Meeting, Amer. Soc. Biochem. Mol. Biol. (2005)
  • "A new perspective on Obesity: Early metabolic programming" The First International Bio-medical Science Mini-symposium in Obesity and Related Topics, Chiang Mai University (2005)
  • "A New perspective on Obesity: Metabolic Programming. Popular Lecture Series." Gujarat State Biotechnology Mission, Government of Gujarat, Department of Science and Technology (2005)
  • "Genetic defects of the pyruvate dehydrogenase complex: From man to mouse" Golden Jubilee Celebration, M.S. University of Baroda, Department of Biochemistry (2005)
  • "Maternal Hyperinsulinemia and in utero Metabolic Programming" Current Topics in Neonatal/Infant Nutrition and Metabolism V: Methionine Metabolism and Epigenetics (2005)
  • "R-Lipoic Acid inhibits Mammalian Pyruvate Dehydrogenase Kinase" the Third International Conference on Mechanisms of Action of Nutraceuticals (2004)
  • "Diet-induced maternal obesity predisposes the progeny to adult-onset obesity" 22nd Boston-Ithaca Islet Club Meeting (2004)
  • "Nutrient-induced maternal hyperinsulinemia and metabolic programming in the progeny" 55th Nestle Nutrition Workshop "Impact of maternal nutrition on the offspring" (2004)
  • "A murine model for brain-specific pyruvate dehydrogenase complex deficiency" IXth International Congress on Inborn Errors of Metabolism (2003)
  • "Anti-diabetic actions of R-lipoic acid" Free Radicals and Oxidative Stress: Chemistry, Biochemistry and Pathophysiological Implications, Society for Free Radical Research, European Section (2003)
  • "Regulation of the pyruvate dehydrogenase complex by R-lipoic acid" Joint meeting on Oxidants and Antioxidants in Biology (2003)
  • "Nutritional programming during the suckling period: altered beta cell function" 62nd Scientific Sessions of the American Diabetes Association (2002)
  • "Kinetic studies of human pyruvate dehydrogenase and its mutatns: interactions with TPP" International Conference on thiamin, its biochemistry, and structural biology, Rutgers University (2002)
  • "Structural studies of human pyruvate dehydrogenase" International Conference on thiamin, its biochemistry, and structural biology, Rutgers University (2002)
  • "Dietary patterning in the perinatal period" Experimental Biology 2002, American Society for Biochemistry and Molecular Biology (2002)
  • "Molecular adaptations in rat islets to a high carbohydrate dietary intervention in the immediate postnatal period" llnd International Symposium on Molecular Medicine (2002)
  • "Neonatal Nutritional Intervention Causes Adult-Onset Obesity" 17th International Congress of Nutrition (2001)
  • "Glucose/Carbohydrate metabolism in the neonate and extremely low birth weight infants" , NICHD and the Children’s Nutrition Research Center (2000)
  • "2000 Fall Symposium on Molecular Aspects of Human Diseases at the Post-Genomic Era" , Korean Society of Medical Biochemistry and Molecular Biology (2000)
  • "A novel rt model for metabolic patterning of hyperinsulinemia induced by a dietary modification in the neonates" 1999 ASBMB Fall Symposium: Nutritional Control of Gene Transcription (1999)
  • "A session at the Annual Meeting of the Oxygen Club of California" 98 World Congress, Oxygen Club of California (1998)
  • "Regulation of pyruvate dehydrogenase complex by lipoic compounds" Oxygen Club of California Annual Meeting on Biological Oxidants and Antioxidants, Oxygen Club of California (1997)
  • "Regulation of the human pyruvate dehydrogenase alpha-subunit (Pdha1) gene" The 65th Annual Meeting of the Society of Biological Chemists (India) and comemoration of the Platinum Jubilee (1921-1996), Indian Institute of Science, Department of Biochemistry (1996)
  • "Overview: Introduction to Obesity" Symposium on "Obesity: Heredity-Genes verus diet?", American Institute of Nutrition, Experimental Biology 96 (1996)
  • "The active site residues in mammalian pyruvate dehydrogenase" International Meeting on "Biochemistry and Physiology of Thiamni-Diphosphate Enzymes" (1996)
  • "Metabolic Antioxidants and Disease: Thiols" The Annual Meeting on Biological Oxidants and Antioxidants, Oxygen Club of California (1996)
  • "Dihydrolipoamide dehydrogenase: structure, function, and regulation" International Congress on Free Radicals in Health and Disease (1995)
  • "Role of alpha-lipoic acid in alpha-keto acid dehydrogenase complexes" The Annual Meeting of Oxygen Club of California: Oxidants and Antioxidatns in Biology, Oxygen Club of California (1995)
  • "Probing the catalytic site of the human pyruvate dehydrogenase complex" Symposium on Enzyme Catalytic Mechanisms, International Congress of Biochemistry and Molecular Biology (1994)
  • "Recent advances in lipoic acid-requiring proteins" Antioxidants in Biology (1994)
  • "The Evolution of Antioxidants in Modern Medicine" The First International Scientific Saas Fee Forum (1992)
  • "The Second Annual Miami Children's Hospital Research Institute Symposium" The Second Annual Miami Children's Hospital Research Institute Symposium (1991)
  • "The Annual Meeting of the Society for Inherited Metabolic Disorders in Santa Fe" The Annual Meeting of the Society for Inherited Metabolic Disorders in Santa Fe, Society for Inherited Metabolic Disorders in Santa Fe (1991)
  • "Research Seminars in the Department of Genetic Engineering" , Sung Kyun Kwan University, Department of Genetic Engineering (1990)
  • "The Tenth International Symposium on Flavins and Flavoproteins." The Tenth International Symposium on Flavins and Flavoproteins. (1990)
  • "Applications of Homologous Recombination to Human Disease" , NIH (1989)
  • "Biochemical Development of the Fetus and the Neonate" , Perinatal Biochemical Group of the Spanish Biochemical Society (1988)
  • "alpha-Ketoacid Dehydrogenase Complexes: Organization, Regulation, and Biomedical Aspects" , New York Academy of Sciences and Clayton Foundation for Research (1988)
  • "Workshop on the Role of Ochratoxins in the Etiology of Balkan Endemic Nephropathy in Zabreb and Slavonski Brod" (1985)
  • "Effect of aromatic and branched-chain alpha-keto acids on pyruvate and alpha-ketoglutarate metabolism in brain" The second Japan U.S.- Japan seminar on thiamine (1974)
  • "Conference on nurtition and aging process" , NIH, National Institute of Child Health and Human Development, Adult Development and Aging Branch (1973)
  • "2000 Fall Symposium on Molecular Aspects of Human Diseases at the Post-Genomic Era" , Korean Society of Medical Biochemistry and Molecular Biology
  • "Alpha-Keto Acid Dehydrogenase Complexes: Nutrient Control, Gene Regulation, and Genetic Defects" , American Institute of Nutrition Symposium
  • "Animal Models in Neonatal and Infant Nutrition Research" , American Institute of Nutrition
  • "Annual Meeting of the Society for Inherited Metabolic Disorders" , Society for Inherited Metabolic Disorders
  • "Biochemistry and Molecular Basis: An Overview" Workshop on Inborn Errors of Metabolism-From Biochemistry and Molecular Basis of Clinic, Diagnosis, Therapeutical Approaches: Pyruvate Dehyrogenase Complex Deficiencies, Sociedade Portuguesa de doencas Metabolicas
  • "Dihydrolipoamide dehydrogenase: structure, function, and regulation" International Congress on Free Radicals in Health and Disease
  • "First International Scientific Saas Fee Forum on The Evolution of Antioxidants in Modern Medicine"
  • "Introduction to Obesity" Obesity: Heredity-Genes versus diet?, American Institute of Nutrition
  • "Metabolic Antioxidants and Disease: Thiols” at the annual meeting on Biological Oxidants and Antioxidants" , Oxygen Club of California
  • "Mitochondrial alpha-Keto Acid Dehydrogenase Complexes" , National Science Foundation and the Japanese Society for the Promotion of Science
  • "Molecular Biology and Biochemistry of Pyruvate Dehydrogenase Complexes" , American Society for Biochemistry and Molecular Biology
  • "Neonatal Nutritional Intervention Causes Adult-Onset Obesity" 17th International Congress of Nutrition
  • "Probing the catalytic site of the human pyruvate dehydrogenase complex" Symposium on Enzyme Catalytic Mechanisms at the International Congress of Biochemistry and Molecular Biology
  • "Regulation of pyruvate dehydrogenase complex by lipoic compounds" Oxygen Club of California Annual Meeting on Biological Oxidants and Antioxidants, Oxygen Club of California
  • "Regulation of the human pyruvate dehydrogenase alpha subunit (Pdha1) gene" 65th Annual Meeting of the Society of Biological Chemists (India), Society of Biological Chemists (India)
  • "Research Seminars in the Department of Genetic Engineering" , Sung Kyun Kwan University
  • "Role of alpha-lipoic acid in alpha-keto acid dehydrogenase complexes" Annual Meeting of Oxygen Club of California: Oxidants and Antioxidants in Biology, Oxygen Club of California
  • "Second Annual Miami Children's Hospital Research Institute Symposium" , Miami Children's Hospital Research Institute
  • "Tenth International Symposium on Flavins and Flavoproteins"
  • "The active site residues in mammalian pyruvate dehydrogenase" International Meeting on “Biochemistry and Physiology of Thiamin-Diphosphate Enzymes
See All (83 Total) >
Service Activities:
  • The International Conference on Molecular Medicine-2012; Vellore Institute of Technology, Vellore, India; Coordinator (2012)
  • The International Conference on Molecular Medicine; Charotar University of Science and Technology, Changa, Gujarat, India; Coordinator (2011)
  • Healthy Start: Maternal and Child Nutrition; A Nutrition Conference sponsored by the Department of Health, Gujarat Government, India; Coordinator (2009)
  • Mini-Symposium on "Metabolic Diseases" at the "International Conference on Moleuclar Medicine"; Organized by Laila Pharmaceuticals (India), Indian Institute of Science, Chennai, India, and Florida International University, Miami, Florida, in Chennai, India; Coordinator (2009)
  • The Journal of Biological Chemistry; Editorial Board Member (2006–2011)
  • The International Symposium on Molecular Medicine with Special Reference to the Metabolic Diseases; Held in Vadodara, India; Coordinator (2004)
  • Metabolic Syndrome and Related Disorders Member; Editorial Board Member (2003–2012)
  • International Conference on Thiamine, Its Biochemistry, and Structural Biology; Rutgers University, Newark, New Jersey; Coordinator (2002)
  • The Journal of Biological Chemistry; Editorial Board Member (1999–2004)
  • International Japan Program, the development of a bilateral seminar-conference entitled: " Mitochondrial alpha-Keto Scid Dehydrogenase Complexes"; Jointly sponsored by the National Science Foundation and the Japanese Society for the Promotion of Science; Coordinator (1994)
  • Alpha-Keto Acid Dehydrogenase Complexes: Nutrient Control, Gene Regulation, and Genetic Defects; American Institute of Nutrition Symposium; Co-Chair (1994)
  • Animal Models in Neonatal and Infant Nutrition Research; By the American Institute of Nutrition presented at its 1992 annual meeting during the FASEB Meetings in Anaheim, California.; Coordinator (1992)
  • The Journal of Biological Chemistry; Editorial Board Member (1991–1997)
  • NIH/NIDDK, Diabetes and Digestive and Kidney Diseases Special Grant Review Committee, Subcommittee B; Member (1991–1995)
  • The Biochemical Journal; Editor (1991–1998)
  • Symposium on "Molecular Biology and Biochemistry of Pyruvate Dehydrogenase Complexes"; Sponsored by the American Society for Biochemistry and Molecular Biology, New Orleans; Coordinator (1990)
  • Alpha-Ketoacid Dehydrogenase Complexes: Organization, Regulation, and Biomedical Aspects; co-sponsored by the New York Academy of Sciences and Clayton Foundation for Research , Houston.; Co-Chair (1988)
  • American Journal of Physiology: Endocrinology and Metabolism; Editorial Board Member (1988–1994)
  • N.I.H. Biochemistry Study Section 2; Member (1984–1988)
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Contact Information

140 Farber Hall
3435 Main Street
south Campus
Buffalo, NY 14214
Phone: (716) 829-3074
Fax: (716) 829-2725
Email: mspatel@buffalo.edu
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