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Gabriela                       Popescu

Gabriela K. Popescu PhD

Department of Biochemistry

Professor

Specialty/Research Focus

Ion channel kinetics and structure; Membrane Transport (Ion Transport); Molecular Basis of Disease; Neurodegenerative disorders; Neuropharmacology; Protein Function and Structure; Signal Transduction

 
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Professional Summary:

I focus my research on the activation mechanisms of fast neurotransmitter receptors. We seek to define the activation pathway, modulatory mechanisms and structure-function relationships of the N-methyl-D-aspartate (NMDA) receptor to better understand the roles played by this protein in the brain.
NMDA receptors are the most abundant glutamate-stimulated, Ca2+-conducting ion channels in brain and spinal cord. They are the predominant molecular devices for controlling synaptic development and plasticity and govern memory and learning processes. Understanding the mechanisms that control their activity may lead to more effective strategies to treat neuropathies including stroke, neurodegenerative conditions, chronic pain and addiction as well as mental disorders such as schizophrenia and epilepsy. 

Education and Training:
  • PhD, Biochemistry, University at Buffalo (1999)
  • MS, Biochemistry, University of Bucharest (1985)
Employment:
  • Professor, University at Buffalo, SUNY (2014-present)
  • Adjunct Faculty, University at Buffalo, SUNY (2006-present)
  • Adjunct Faculty, University at Buffalo, SUNY (2006-present)
  • Associate Professor, University at Buffalo, SUNY (2011–2013)
  • Assistant Professor, Biochemistry, University at Buffalo, SUNY (2006–2010)
  • Research Assistant Professor, University at Buffalo, SUNY (2004–2005)
  • Post Doctoral Fellow, Physiology and Biophysics, University at Buffalo, SUNY (2000–2004)
Awards and Honors:
  • AHA, Established Investigator Award (2012)
  • Public Lecture - Glutamate Receptors: the workhorses of your memory (2011)
  • UB Exceptional Scholars, Young Investigator Award (2010)
  • NIH/NINDS Principal Investigator (2006)
  • NIH/NIDA NRSA (2001)

Research Expertise:
  • Biophysics of ion channels
  • Electrophysiology
  • Excitotoxicity
  • Gating mechanisms
  • Glutamatergic transmission
  • Ion transport
  • Ionotropic glutamate receptors
  • Ligand gated ion-channels
  • Markov modeling
  • Molecular neurophysiology
  • Molecular neuroscience
  • Molecular pharmacology
  • Neurobiology
  • Neurodegeneration
  • Neurophysiology
  • NMDA RECEPTORS
  • Single-molecule techniques
  • Synaptic plasticity
  • Synaptic transmission
UB 2020 Strategic Strengths:
  • Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
  • January 2012–December 2016
    Selective modulation of native NMDA receptor functions
    American Heart Association
    Role: Principal Investigator
    $400,000
  • April 2011–March 2016
    Probing Allosteric Surfaces of NMDA Receptors
    NINDS
    Role: Principal Investigator
    $1,875,000
  • September 2010–May 2012
    REACH-Calcium modulation of synaptic receptors
    REACH
    Role: Co-Investigator
    $30,000
  • July 2006–April 2011
    Allosteric Modulation of NMDA receptor
    NINDS/RO1
    Role: Principal Investigator
    $1,700,000
  • June 2008–May 2010
    NMDA receptors with restricted mobility of ligand-binding domains
    NIDA/RO3
    Role: Principal Investigator
    $144,000
  • July 2005–June 2009
    Modulation of NMDA receptor by neurosteroids
    American Heart Association
    Role: Principal Investigator
    $160,000
  • August 2001–August 2004
    NMDA Receptor: kinetic modeling and mapping of the glutamate-binding domain
    NIH/NRSA F32
    Role: Principal Investigator
    $120,000
See All (7 Total) >

Journal Articles:
See All (28 Total) >

Professional Memberships:
  • ASBMB, American Society for Biochemistry and Molecular Biology (2014)
  • AAMC, American Association of Medical Colleges (2012)
  • ASPET, America Society for Pharmacology and Experimental Therapeutics (2012)
  • IBRO, International Brain Research Organization (2000)
  • SfN, Society for Neuroscience (1999)
  • BPS, Biophysical Society (1999)
  • AAAS, American Association for the Advancement of Science (1999)
  • UBAA, UB Alumni Association
Presentations:
  • "New inhibitory interface in NMDA receptors" GRC/Ion Channels (2012)
  • "Glutamate Receptors: The workhorses of your memory" Public Lecture, UB Summer Lecture Series (2011)
  • "Modes of NMDA receptor gating" Symposium on Membrane Proteins, GEPROM (2011)
Service Activities:
  • Faculty Senate; School Representative (2013–2016)
  • Faculty Senate Executive Committee; Member (2013–2016)
  • Biophysical Society, Council; Councilor (2015–2018)
  • Journal of Neurochemistry; Editorial Board Member (2013)
  • AAMC, CFAS Administrative Board; School Representative (2013–2016)
  • UB Faculty Senate, Executive Committee; Senator (2013–2016)
  • Biochemistry, Graduate Affairs Committee; Director (2013–2014)
  • MSTP, Admissions Committee; Member (2012–2014)
  • Biophysical Society, Career Conversations; Panel Member (2012)
  • Biophysical Society, Committee on Professional Opportunities for Women (CPOW); Member (2011–2015)
  • PPBS, Steering Committee; Member (2010–2012)
  • Society for Neuroscience, Buffalo Chapter; President (2009–2010)
  • Biochemistry, Seminar Program; Coordinator (2007–2008)
  • UB Postdoctoral Education, Steering Committee; Member (2005–2008)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

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Contact Information

3435 Main Street
Mail stop: 140 Farber Hall
Office: 647 BRB
Bufffalo, NY 14214
Phone: (716) 829-3807
Fax: (716) 829-2661
Email: popescu@buffalo.edu


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