Satpal Singh PhD

Research Expertise:

• Channelopathies: With over 400 genes coding for them in humans, ion channels play a significant role in most physiological functions. Drug-induced channel dysfunction often leads to a variety of disorders and results in significant incidence of serious injury and death. We investigate molecular mechanisms underlying neurodegenerative disorders and cardiac arrhythmias induced by ion channel dysfunction arising from genetic factors and/or drug interactions. The tools used for these investigations include genetic, electrophysiologic, pharmacologic, molecular and cell culturing methods. Preparations used for in experiments include Drosophila as a genetic model system, and human cell lines expressing human ion channels that play an important role in critical-to-life functions including cardiac rhythm, respiration and the central nervous system.

UB 2020 Strategic Strengths:

• Molecular Recognition in Biological Systems and Bioinformatics
• Health and Wellness Across the Lifespan

Grants and Sponsored Research:

• September 2011–August 2016
  Targeted MSP: The University at Buffalo/Buffalo Public Schools (UB/BPS) Interdisciplinary Science and Engineering Partnership
  National Science Foundation
  Role: Co-Investigator
  $9,831,207
• July 2010–June 2013
  Subcontract for Science support for NY State Ed Math Science Partnership - Buffalo Public Schools
  New York State Department of Education
  Role: Co-Investigator
  $254,976
• August 2008–September 2011
  A Genetic Model of Leigh Syndrome Suppression in Drosophila
  NIH (NINDS)
  Role: Principal Investigator
  $158,500
• January 2006–December 2009
  Interdisciplinary Science Research-based Curricular Innovations for Middle and High School Science and Teacher Professional Development
  John R. Oishei Foundation
  Role: Co-Investigator
  $480,000