Stephen T. Koury BS MT (ASCP), MS, PhD
Stephen T. Koury
BS MT (ASCP), MS, PhD
Research Associate Professor
Department of Biotechnical and Clinical Laboratory Sciences
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cell growth, differentiation and development; Cytoskeleton and cell motility; Gene Expression; Gene Sequencing; Genomics and proteomics; Microbiology; Molecular and Cellular Biology; Molecular genetics; RNA
Professional Summary:
My research in recent years has evolved more toward microbial genomics. The current NIH SEPA grant is meant to be both a STEM enrichment activity for high school student and teachers, as well as to increase interest in STEM careers, particularly related to genomics.
Education and Training:
- PhD, Anatomical Sciences, University at Buffalo (1987)
- MS, Cell Biology, State University of New York at Albany (1983)
- BS, Medical Technology, State University of New York at Albany, Cum Laude (1979)
Employment:
- Director of Graduate Studies, Biotechnical and Clinical Laboratory Sciences, Jacobs School of Medicine and Biomedical Sciences (1995-present)
- Research Associate Professor, Biotechnical and Clinical Laboratory Sciences, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2015-present)
- Research Assistant Professor, Biotechnical and Clinical Laboratory Sciences, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1999–2015)
- Assistant Professor, Biotechnical and Clinical Laboratory Sciences, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1992–1999)
- Research Assistant Professor, Medicine, Vanderbilt University Medicine (1990–1992)
- Post Doctoral Fellow, Medicine, Vanderbilt University School of Medicine (1987–1990)
- Graduate Student, Pathology and Anatomical Sciences, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1982–1987)
- Electron Microscopy Technician, Albany Medical College (1981–1982)
- Clinical Microbiology Lab Technician, Veterans Administration Medical Center (1979–1980)
Awards and Honors:
- Teacher of the Year (2020)
- Teacher of the Year (2019)
- Teacher of the Year (2017)
- Teacher of the Year (2016)
- Service to Education Award (2016)
- Northeast Association of Graduate Schools (2011)
- Teacher of the Year Award (2007)
- Teacher of the Year Award (2006)
- Teacher of the Year Award (2006)
- Teacher of the Year Award (2005)
- Teacher of the Year Award (2004)
- Teacher of the Year Award (2004)
- Teacher of the Year Award (2002)
- Presidential Fellowship (1984)
- Presidential Scholarship (1982)
UB 2020 Strategic Strengths:
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- June 2020–May 2025
The Metagenomics Education Partnership: Harnessing the Power of Microbial Genome Sequencing and Big Data with High School Students and Teachers
NIH
Role: Co-Principal Investigator
$1,324,101 - June 2014–May 2019
Western New York in Genetics and Health Care Partnership
National Institutes of Health
Role: Co-Principal Investigator
$1,268,962 - May 2013–July 2016
WNY Genetics in Research Partnership: Expanding Exposure, Career Exploration and Interactive Projects in Basic Genome Analysis and Bioinformatics
National Science Foundation
Role: Co-Principal Investigator
$1,136,572 - July 2010–December 2012
Effects of Ethanol Exposure during Involution on Post-Partum Breast Cancer
NIH
Role: Co-Investigator
$432,950 - July 2010–June 2012
Effects of Ethanol Exposure During Involution on Post-Partum Breast Cancer
NIAAA
Role: Co-Investigator
$275,000 - July 2010–June 2012
Targeted Chemoprevention of Parity-Associated Breast Cancer
NIH
Role: Co-Investigator
$432,950 - March 2010–February 2012
High Density Lipoprotein in Follicular Fluid and Fertility Outcomes
NIA
Role: Co-Investigator
$275,000 - January 2008–December 2010
Clinical Lab and Manufacturing Teacher Education
NYS Dept. of Labor
Role: Co-Investigator
$228,573
Patents:
- humanized anti-tf antigenic antibodies humanized monoclonal antibodies (mabs) or fragments thereof that specifically bind to the thomsen-friedenreich (tf) human tumor antigen are provided. Three variable heavy chains and three distinct variable light chains are provided, and can be combined to make a total of twenty-five distinct heavy and light chain combinations. Methods of using the mabs and fragments thereof for cancer therapy and diagnostic imaging are provided, as are the methods for making the mabs and fragments thereof. In vitro cell cultures expressing the mabs and fragments thereof, and kits are also provided. (2014)
Journal Articles:
- Koury ST, Carlin-Menter S, Dey-Rao R, Kelly K. (2020) Gene Annotation in High Schools: Successful Student Pipeline and Teacher Professional Development in Bioscience Using GENI-ACT. Frontiers in microbiology (Jan), 11: 578747. doi:10.3389/fmicb.2020.578747
- Karacosta LG, Fisk JC, Jessee J, Tati S, Turner B, Ghazal D, Ludwig R, Johnson H, Adams J, Sajjad M, Koury S, Roy R, Olson JR, Rittenhouse-Olson K. (2018) Preclinical Analysis of JAA-F11, a Specific Anti-Thomsen-Friedenreich Antibody via Immunohistochemistry and In Vivo Imaging. Translational oncology (Apr), 11(2): 450-466. doi:10.1016/j.tranon.2018.01.008
- Tati S, Fisk JC, Abdullah J, Karacosta L, Chrisikos T, Philbin P, Morey S, Ghazal D, Zalzala F, Jessee J, Quataert S, Koury S, Moreno D, Eng JY, Glinsky VV, Glinskii OV, Sesay M, Gebhard AW, Birthare K, Olson JR, Rittenhouse-Olson K. (2018) Corrigendum to "Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and In Vitro Efficacy Analysis" [Neoplasia 19.9 (2017) 716-733]. Neoplasia (New York, N.Y.) (Jan), 20(1): 118. doi:10.1016/j.neo.2017.10.001
- Tati S, Fisk JC, Abdullah J, Karacosta L, Chrisikos T, Philbin P, Morey S, Ghazal D, Zazala F, Jessee J, Quataert S, Koury S, Moreno D, Eng JY, Glinsky VV, Glinskii OV, Sesay M, Gebhard AW, Birthare K, Olson JR, Rittenhouse-Olson K. (2017) Humanization of JAA-F11, a Highly Specific Anti-Thomsen-Friedenreich Pancarcinoma Antibody and InVitro Efficacy Analysis. Neoplasia (New York, N.Y.) (Sep), 19(9): 716-733. doi:10.1016/j.neo.2017.07.001
- Rhodes MM, Koury ST, Kopsombut P, Alford CE, Price JO, Koury MJ. (2016) Stress reticulocytes lose transferrin receptors by an extrinsic process involving spleen and macrophages. Am J Hematol (Sep), 91(9): 875-882.
- Kimiko Ferguson, Arti Yadav, Susan Morey, Julia Abdullah, Gabriel Hrysenko, Jing Ying Eng, Munawwar Sajjad, Stephen Koury, Kate Rittenhouse-Olson. (2014) Preclinical studies with JAA‐F11 anti‐Thomsen‐Friedenreich monoclonal antibody for human breast cancer. Future Oncology (Feb), 10(3): 385-399.
- Kimiko Ferguson1 , Arti Yadav1 , Susan Morey1 , Julia Abdullah1 , Gabriel Hrysenko1 , Jing Ying Eng1 , Munawwar Sajjad2 , Stephen Koury1 & Kate Rittenhouse-Olson*. (2014) Preclinical studies with JAA‑F11 anti‑Thomsen-Friedenreich monoclonal antibody for human breast cancer. Future Oncology (Jan)385-399.
- Masso-Welch PA, Tobias ME, Vasantha Kumar SC, Bodziak M, Mashtare T, Tamburlin J, Koury ST. (2012) Folate exacerbates the effects of ethanol on peripubertal mouse mammary gland development. Alcohol (May), 46(3): 285-292.
- Krishnan S, Russell J, Bodziak M, Koury S, Masso-Welch P, Koury ST. (2012) Direct Effects of Conjugated Linoleic Acid Isomers on P815 Mast Cells in vitro. Immunol Invest (Jan), 41(4): 399-411.
- Chaturvedi R, Heimburg J, Yan J, Koury S, Sajjad M, Abdel-Nabi HH, Rittenhouse-Olson K, Koury ST. (2008) Tumor immunolocalization using 124 I-iodine-labeled JAA-F11 antibody to Thomsen-Friedenreich alpha-linked antigen. Appl Radiat Isot (Mar), 66(3): 278-287.
- Koury S, Yarlagadda S, Moskalik-Liermo K, Popli N, Kim N, Apolito C, Peterson A, Zhang X, Zu P, Tamburlin J, Bofinger D, Koury ST. (2007) Differential gene expression during terminal erythroid differentiation. Genomics (Nov), 90(5): 574-582.
- Browne RW, Koury ST, Marion S, Wilding G, Muti P, Trevisan M. (2007) Accuracy and biological variation of human serum paraoxonase 1 activity and polymorphism (Q192R) by kinetic enzyme assay. Clin Chem (Feb), 53(2): 310-317.
- Koury MJ, Koury ST, Kopsombut P, Bondurant MC. (2005) In vitro maturation of nascent reticulocytes to erythrocytes. Blood (Mar), 105(5): 2168-2174.
- Gosselin LE, Williams JE, Deering M, Brazeau D, Koury S, Martinez DA, Koury ST. (2004) Localization and early time course of TGF-beta 1 mRNA expression in dystrophic muscle. Muscle Nerve (Nov), 30(5): 645-653.
- Molinaro RJ, Bernstein JM, Koury ST. (2003) Localization and quantitation of eotaxin mRNA in human nasal polyps. Immunol Invest (Aug), 32(3): 143-154.
- Chen CY, Pajak L, Tamburlin J, Bofinger D, Koury ST. (2002) The effect of proteasome inhibitors on mammalian erythroid terminal differentiation. Exp Hematol (Jul), 30(7): 634-639.
- Pitt JA, Feng L, Abbott BD, Schmid J, Batt RE, Costich TG, Koury ST, Bofinger DP. (2001) Expression of AhR and ARNT mRNA in cultured human endometrial explants exposed to TCDD. Toxicol Sci (Aug), 62(2): 289-298.
- Bofinger DP, Feng L, Chi LH, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST, Olson JR. (2001) Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant cultures of human endometrium. Toxicol Sci (Aug), 62(2): 299-314.
- Bofinger DP, Feng L, Chi LH, Love J, Stephen FD, Sutter TR, Osteen KG, Costich TG, Batt RE, Koury ST, Olson JR. (2001) Effect of TCDD exposure on CYP1A1 and CYP1B1 expression in explant culturesof human endometrium. Toxicol Sci (Aug), 62(2): 299-314.
- Koury MJ, Horne DW, Brown ZA, Pietenpol JA, Blount BC, Ames BN, Hard R, Koury ST. (1997) Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production. Blood (Jun), 89(12): 4617-4623.
- Fisher JW, Koury S, Ducey T, Mendel S, Koury ST. (1996) Erythropoietin production by interstitial cells of hypoxic monkey kidneys. Br J Haematol (Oct), 95(1): 27-32.
- Wefes I, Mastrandrea LD, Haldeman M, Koury ST, Tamburlin J, Pickart CM, Finley D. (1995) Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. Proc Natl Acad Sci U S A (May), 92(11): 4982-4986.
- Shiramizu M, Katsuoka Y, Grodberg J, Koury ST, Fletcher JA, Davis KL, Sytkowski AJ. (1994) Constitutive secretion of erythropoietin by human renal adenocarcinoma cells in vivo and in vitro. Exp Cell Res (Dec), 215(2): 249-256.
- Dai CH, Krantz SB, Koury ST, Kollar K. (1994) Polycythaemia vera. IV. Specific binding of stem cell factor to normal and polycythaemia vera highly purified erythroid progenitor cells. Br J Haematol (Nov), 88(3): 497-505.
- Wickrema A, Koury ST, Dai CH, Krantz SB. (1994) Changes in cytoskeletal proteins and their mRNAs during maturation of human erythroid progenitor cells. J Cell Physiol (Sep), 160(3): 417-426.
- Kelley LL, Koury MJ, Bondurant MC, Koury ST, Sawyer ST, Wickrema A. (1993) Survival or death of individual proerythroblasts results from differing erythropoietin sensitivities: a mechanism for controlled rates of erythrocyte production. Blood (Oct), 82(8): 2340-2352.
- Koury ST, Bondurant MC, Semenza GL, Koury MJ. (1993) The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver. Microsc Res Tech (May), 25(1): 29-39.
- Eckardt KU, Koury ST, Tan CC, Schuster SJ, Kaissling B, Ratcliffe PJ, Kurtz A. (1993) Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia. Kidney Int (Apr), 43(4): 815-823.
- Koury ST, Koury MJ. (1993) Erythropoietin production by the kidney. Semin Nephrol (Jan), 13(1): 78-86.
- Schuster SJ, Koury ST, Bohrer M, Salceda S, Caro J. (1992) Cellular sites of extrarenal and renal erythropoietin production in anaemic rats. Br J Haematol (Jun), 81(2): 153-159.
- Semenza GL, Koury ST, Nejfelt MK, Gearhart JD, Antonarakis SE. (1991) Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice. Proc Natl Acad Sci U S A (Oct), 88(19): 8725-8729.
- Le Hir M, Eckardt KU, Kaissling B, Koury ST, Kurtz A. (1991) Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney. Klin Wochenschr (Sep), 69(13): 567-575.
- Bondurant MC, Koury MJ, Koury ST, Semenza G. (1991) Erythropoietin ontogeny and organ distribution in mice. Semin Hematol (Jul), 28(3 Sup): 20-25.
- Koury ST, Bondurant MC, Koury MJ, Semenza GL. (1991) Localization of cells producing erythropoietin in murine liver by in situ hybridization. Blood (Jun), 77(11): 2497-2503.
- Sawada K, Krantz SB, Dai CH, Koury ST, Horn ST, Glick AD, Civin CI. (1990) Purification of human blood burst-forming units-erythroid and demonstration of the evolution of erythropoietin receptors. J Cell Physiol (Feb), 142(2): 219-230.
- Koury ST, Koury MJ, Bondurant MC. (1989) Cytoskeletal distribution and function during the maturation and enucleation of mammalian erythroblasts. J Cell Biol (Dec), 109(6 Pt): 3005-3013.
- Koury ST, Koury MJ, Bondurant MC, Caro J, Graber SE. (1989) Quantitation of erythropoietin-producing cells in kidneys of mice by in situ hybridization: correlation with hematocrit, renal erythropoietin mRNA, and serum erythropoietin concentration. Blood (Aug), 74(2): 645-651.
- Sawada K, Krantz SB, Dessypris EN, Koury ST, Sawyer ST. (1989) Human colony-forming units-erythroid do not require accessory cells, but do require direct interaction with insulin-like growth factor I and/or insulin for erythroid development. J Clin Invest (May), 83(5): 1701-1709.
- Koury MJ, Koury ST, Bondurant MC, Graber SE. (1989) Correlation of the molecular and anatomical aspects of renal erythropoietin production. Contrib Nephrol (Jan), 76: 24-29.
- Koury ST, Koury MJ, Bondurant MC. (1988) Morphological changes in erythroblasts during erythropoietin-induced terminal differentiation in vitro. Exp Hematol (Oct), 16(9): 758-763.
- Koury ST, Bondurant MC, Koury MJ. (1988) Localization of erythropoietin synthesizing cells in murine kidneys by in situ hybridization. Blood (Feb), 71(2): 524-527.
- Black JD, Koury ST, Bankert RB, Repasky EA. (1988) Heterogeneity in lymphocyte spectrin distribution: ultrastructural identification of a new spectrin-rich cytoplasmic structure. J Cell Biol (Jan), 106(1): 97-109.
- Koury ST, Repasky EA, Eckert BS. (1987) The cytoskeleton of isolated murine primitive erythrocytes. Cell Tissue Res (Jul), 249(1): 69-77.
- Koury ST. (1985) Ultrastructural changes during reticulopod withdrawal in the foraminiferan protozoan Allogromia sp., strain N.F. Protoplasma (Jan), 129(2-3): 149-156.
Professional Memberships:
- American Society for Clinical Pathologists; Certification as Clinical Laboratory Scientist (1979–2022)
- National Science Teachers Association; Also part of Science Teachers Association of NY State
Presentations:
- "Metagenomics Education Partnership: Harnessing the Power of Microbial Genome Sequencing and Big Data with High School Students and Teachers." Bio-IT World Conference & Expo (2021)
- "The Western New York Genetics in Research Partnership" Summer 2014 NYS STEM Education Collaborative Institute; NYS STEM Education Collaborative Institute; Poster Session (2014)
Service Activities:
- Ad Hoc Committee on Promotions to Research Ranks; Member (2022–2025)
- Developed a “distance research” opportunity for students from the University of Hawaii involving basic bioinformatics. Working with 5-10 students per year from high schools and colleges in collaboration with Dr. Kelly Withy at the University of Hawaii.; Student Mentor (2020–2022)
- Science Day Presentation, Olmstead High School of the Buffalo Public School System. Gave three presentations to different groups of students about careers in science, with special emphasis on being an academic scientist, a medical technologist and a biotechnologist.; Presenter (2017)
- Reviewer for NIH SEPA Special Review Panel. October 2016, February 2018, October 2018, October 2020, and November 2021.; Panel Member (2016–2021)
- Faculty Diversity and Inclusion Advocate, Jacobs School of Medicine and Biomedical Sciences; Member (2015–2022)
- Review Graduate School policies and procedures; representative of Jacobs School; Graduate School Executive Committee (2013–2022)
- Selected to be an IMG-ACT Faculty Mentor Trainer. June, 2012. Received training to conduct workshops for new faculty adopting the Genetics Education National Intiative- Annotation Collaboration Toolkit. GENI-ACT is an integral part of the genome annotation course taught by myself and in past and future grants/proposals involving bringing genomics technology to area high schools. Workshops given: Minnesota State University, Moorhead, October 19-20, 2012 Trinity College, Washington, DC. March 9, 2013 Currently active with promotion of GENI-ACT with any interested parties; Trainer (2012–2022)
- Board Member, Niagara Frontier Chapter of the New York State Society for Clinical Laboratory Science; Board Member (1996–2000)
- Health Related Professions Research Committee; Member (1996–2000)
- Graduate Curriculum Committee; Chair (1995–2012)
- Director of Graduate Studies; Director (1995–2012)
- Health Sciences Divisional Committee - BCLS representative (1994–2022)
- Health Sciences Divisional Committee; Member (1994–2012)
- Health Related Professions Grievance Committee; Member (1994–1996)
- J. Warren Perry Scholarship Committee School of Health-Related Professions; Member (1994–1995)
- Health Related Professions/Nursing Relocation Subcommittee Health Related Professions; Member (1994–1995)
- Biosafety Committee; Chair (1993–1996)
- Reviewer for various journals Served as reviewer for the following journals: American Journal of Physiology, Blood, European Journal of Physiology, Experimental Hematology, The Journal of Histochemistry and Cytochemistry, Kidney International, Nature, Proceedings of the National Academy of Sciences (USA), Immunologic Investigations; Reviewer (1993–2022)
- NIH Science Education Partnership special panel for grant application review to take place November 2022; Panel Review Chairperson