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Thomas                         Cimato

Thomas R. Cimato MD, PhD

Department of Medicine

Associate Professor

Specialty/Research Focus

Cardiology; Critical Care Medicine

Professional Summary:

I care for patients with diagnoses across the spectrum of heart disease. I see my patients at the UBMD Internal Medicine practice group in Amherst and in the Cardiac Care Unit at Buffalo General Medical Center (BGMC). I conduct stress tests, interpret cardiac imaging studies, read electrocardiograms (EKGs) and perform evaluations for advanced heart failure therapies and cardiac transplantation. My specialty is the diagnosis and treatment of congestive heart failure: I integrate information from patient history, physical exam findings and diagnostic studies, and I coordinate treatment for my patients with interventional cardiologists, heart rhythm specialists and heart surgeons.

My research is focused on new approaches to identifying patients at risk for heart attacks and strokes. I am involved in collaborative studies addressing the treatment of heart failure, and I participate in the clinical trials of new medications for congestive heart failure. I am the principal investigator of a pilot study (STEMI-HSC) to determine if the amount of hematopoietic stem cell mobilization in myocardial infarction predicts recurrent coronary events. The study is funded by the UB Translational Pilot Studies Fund, and my collaborators include other cardiology faculty and researchers at Roswell Park Cancer Institute (RPCI). I am also an investigator in the multicenter clinical trial of the drug LCZ969 (PARAGON-HF, Novartis) in patients with heart failure.

I teach and supervise internal medicine residents and cardiology fellows in all facets of my clinical practice: during inpatient hospital care, while interpreting cardiac imaging studies and in my outpatient practice. I also teach second-year medical students in small-group settings for the Human Cardiovascular System course.

Education and Training:
  • Postdoctoral Fellow, Stem Cell Biology, National Institutes of Health (2007)
  • Fellowship, Advanced Heart Failure and Cardiac Transplant, Johns Hopkins School of Medicine (2006)
  • Fellowship, Cardiovascular Medicine, Johns Hopkins School of Medicine (2006)
  • Residency, Internal Medicine, University of Pennsylvania Health System (2002)
  • PhD, Biochemistry, University at Buffalo (1999)
  • MD, University at Buffalo (1999)
  • BS, University at Buffalo, Cum Laude (1992)
  • Associate Professor, Medicine, University at Buffalo (2016-present)
  • Adjunct Member, Cell Stress Biology-Roswell Park Cancer Institute, Roswell Park Cancer Institute (2015-present)
  • Assistant Professor, Medicine, University at Buffalo (2010–2016)
  • Research Assistant Professor, Cardiology, University at Buffalo (2007–2010)
  • Assistant Clinical Investigator, National Heart Lung and Blood, and Human Genome Research Institutes, National Institutes of Health, National Institutes of Health Intramural Research Program (2006–2007)
  • Clinical Fellow, Advanced Heart Failure and Cardiac Transplantation, Medicine, Johns Hopkins University, Johns Hopkins School of Medicine (2005–2006)
  • NIH Postdoctoral Fellow, National Heart Lung and Blood Institute Intramural Research Program, National Institutes of Health, National Institutes of Health (2004–2006)
  • Clinical Fellow, Cardiology, Medicine, Johns Hopkins University, Johns Hopkins University School of Medicine (2002–2005)
  • Resident, University of Pennsylvania, Hospital of the University of Pennsylvania (2000–2002)
  • Intern, Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania (1999–2000)
  • Medical Scientist Training Program, University at Buffalo (1992–1999)
See all (1 more)
Awards and Honors:
  • American Heart Association Research Administration Recognition Award (2016)
  • Finalist, Atherosclerosis, Thrombosis & Vascular Biology Council Award for Outstanding Research by an Early Career Investigator (2013)
  • University at Buffalo, Outstanding Laboratory-based Research (2013)
  • Fellow-American Heart Association (2011)
  • Most Read Articles in Circulation Journal-Molecular Cardiology (2010)
  • Fellow-American Society of Nuclear Cardiology (2009)
  • Finalist, Northwestern Cardiovascular Young Investigator's Forum (2008)
  • Fellow-American College of Cardiology (2008)
  • Who's Who in Medicine and Healthcare (2001)
  • Sigma Xi Grant-in-Aid of Research (1995)
  • First Place-University at Buffalo School of Medicine Research Forum (1993)
  • First Place-University at Buffalo School of Medicine Research Forum (1992)
  • Early Admission Program-University at Buffalo School of Medicine (1990)

Research Expertise:
  • Atherosclerosis and vascular biology
  • Cardiovascular Stem Cell Therapy
  • Heart Failure
Research Centers:
  • Center for Research in Cardiovascular Medicine
Grants and Sponsored Research:
  • April 2017–March 2018
    Center for AIDS Research Pilot Grant
    NIH/NIAID, University of Rochester CFAR
    Role: Co-Principal Investigator
  • March 2016–March 2018
    The Mae Stone Goode Charitable Trust
    Role: Principal Investigator
  • July 2014–July 2015
    University at Buffalo Translational Studies Pilot FundSenescence As a Stimulus for Inflammation in Heart Failure
    University at Buffalo
    Role: Principal Investigator
  • July 2010–June 2014
    American Heart Association Scientist Development Grant
    American Heart Association
    Role: Principal Investigator
  • September 2013–February 2014
    Phosphodiesterase Type 5 Inhibition With Tadalafil Changes Outcomes in Heart Failure (PITCH-HF)
    National Institutes of Health/NHLBI
    Role: Contributor
  • January 2009–December 2012
    NYSTEM, IDEA in Stem Cell Research. Modification of Resident Cardiac Stem Cells by Circulating Hematopoietic Stem Cells in Ischemic Cardiomyopathy
    Role: Co-Investigator
  • July 2007–June 2008
    New York State Stem Cell Science Institutional Support Pilot Project Award
    Role: Co-Principal Investigator
  • September 2016
    An International, Multicenter, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients with Chronic Heart Failure with Reduced Ejection Fra
    Astra Zeneca
    Role: Principal Investigator
  • January 2005
    NIH Loan Repayment Program
    National Institutes of Health
    Role: Principal Investigator
  • Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction (PARAGON-HF)
    Novartis Pharmaceuticals
    Role: Co-Investigator

Journal Articles:
See all (13 more)

Professional Memberships:
  • Member, International Society for Stem Cell Research (2006–present)
  • Member, Heart Failure Society of America (2006–present)
  • Member, American Society of Echocardiography (2006–present)
  • Fellow, American Society of Nuclear Cardiology (2006–present)
  • Fellow, American Heart Association (2002–present)
  • Fellow, American College of Cardiology (2002–present)
  • "Hematopoietic Progenitors in Cancer and Heart Disease" UB Clinical and Translational Research Colloquium, University at Buffalo, Translational Research (2016)
  • "Flow Cytometry Analysis of Hematopoietic Progenitors in Cancer and Cardiovascular Disease" International Society for Advancement of Cytometry, Webinar Series (2016)
  • "Hematopoietic Progenitors in Cancer and Heart Disease" Roswell Park Cancer Institute Immunology Research Conference, Roswell Park Cancer Institute, Department of Immunology (2016)
  • "Prevention of Heart Attack: Overview of the New Cholesterol Guidelines" SUNY at Buffalo-Dept Family Medicine, SUNY at Buffalo Sch of Medicine, Medical Grand Rounds (2013)
  • "Diagnosis and Management of Congestive Heart Failure" SUNY at Buffalo-Dept Medicine, SUNY at Buffalo Sch of Medicine, Medical Grand Rounds (2013)
  • "Master Cardiac Transcription Factor MESP1 is Highly Expressed in Adult Human CD34+ Hematopoietic Stem Cells and Its Levels are Modulated by Body Mass Index" American Heart Association Scientific Sessions, American Heart Assocation, ATVB/Stem and Progenitor Cells (2013)
  • "The Interaction of Cholesterol and Inflammation with Hematopoietic Stem Cells: A Potential Target For Therapy in Atherosclerosis" SUNY at Buffalo-Dept Medicine, SUNY at Buffalo Sch of Medicine, Research Grand Rounds (2013)
  • "Ciliary Neurotrophic Factor Increases the Angiogenic Properties of Human Pluirpotent Stem Cell Derived Neuropilin-1+ CD34+ Nascent Endothelial Cells Via a Jak2 Dependent Pathway" American Heart Association Scientific Sessions, American Heart Association, ATVB (2012)
  • "Component currents of cardiac myocytes derived from human induced pluripotent stem cells" Biophysical Society, Biophysical Society (2012)
  • "Intracoronary infusion of cardiosphere-derived cells (icCDCs) improves cardiac function by stimulating myocyte-proliferation in non-infarcted hibernating myocardium with no effect on normal myocardium" American Heart Association Scientific Sessions, American Heart Association (2011)
  • "Simplified Monolayer Differentiation of Human-Induced Pluripotent Stem Cells to Functional Cardiac Myocytes" Basic Cardiovascular Sciences (BCVS) Scientific Sessions 2011, American Heart Association (2011)
  • "Transcriptonal Profiling of Pluripotent Stem-Cell Derived Neuropilin-1+ CD34- Vascular Precursors Reveals Significant Overlap with Ventral Mesoderm and Identifies Signaling Pathways in Differentiation to Vascular Cells" Basic Cardiovascular Sciences (BCVS) Scientific Sessions 2011, American Heart Association (2011)
  • "Genomic analysis of early endothelial differentiation from human stem cells identifies novel growth factor signaling pathways involved in vasculogenesis" Atherosclerosis Thrombosis and Vascular Biology (2011)
  • "Drug therapy for Heart Failure and Heart Failure with Normal LV systolic function" University at Buffalo School of Medicine, Update for Primary Care Providers (2011)
  • "Neuropilins in Cardiac and Vascular Differentiation of Pluripotent Stem Cells" Roswell Park Cancer Institute, Cellular and Molecular Biology (2010)
  • "Pravastatin Increases Clonogenic Growth of Late Outrowth Endothelial Progenitor Cells (LOEPCs) and Increases Myocardial Capillary Density in Swine with Chronic Coronary Occlusion and Hibernating Myocardium" Northwestern University Cardiovascular Young Investigators Forum (2009)
  • "Vascular Precursors from Adult and Embryonic Stem Cells" Upstate New York Cardiovascular Research Symposium, University of Rochester School of Medicine & Dentistry (2008)
  • "Chronic stenosis of the proximal left anterior descending artery in juvenile rats results in a critical impairment in coronary flow reserve and leads to the development of hibernating myocardium without necrosis" American Heart Association Scientific Sessions (2008)
  • "Neuropilin 1 identifies endothelial precursors in murine and human embryonic stem cells prior to CD34 expression." American Heart Association Scientific Sessions (2007)
  • "NHLBI Symposium on Cardiovascular Regenerative Medicine" NHLBI Symposium on Cardiovascular Regenerative Medicine, National Institutes of Health, National Institutes of Health (2007)
  • "Identification of Vascular Precursors from Human Stem Cells" University of Miami School of Medicine, Medicine Grand Rounds (2006)
  • "Identification of Vascular Precursors from Human Stem Cells" Cornell University-Weill School of Medicine, Cardiology Grand Rounds (2006)
See all (12 more)
Service Activities:
  • Faculty Senate; School Representative (2010–2012)
  • European Journal of Heart Failure; Peer Reviewer (2016–present)
  • European Heart Journal Peer Review; Peer Reviewer (2015–present)
  • NIH/NHLBI Cardiovascular SBIR Peer Review; Panel Member (2014–present)
  • UB School of Medicine Faculty Council; Alternate Member (2014–present)
  • Pharmacy and Therapeutics Committee-Buffalo General Medical Center; Panel Member (2014–present)
  • Biology of Blood and Bone Marrow Transplantation-Peer Reviewer; Peer Reviewer (2014–present)
  • Consulting Physician-Cardiology-Roswell Park Cancer Institute; Consultant (2013–present)
  • University at Buffalo: Scholarly Exchange Day; Research Facilitator (2013); Panel Member (2012)
  • American Heart Association-Innovative Research Grant Study Section Member; Committee Member (2012–present)
  • Biosafety Committee-SUNY at Buffalo; Panel Member (2012–present)
  • Journal of Cardiovascular Pharmacology and Therapeutics; Peer Reviewer (2012–present)
  • Journal of Cardiovascular Translational Research; Peer Reviewer (2012–present)
  • PLoS One Peer Reviewer; Peer Reviewer (2012–present)
  • Stem Cells Translational Medicine-Peer Reviewer; Peer Reviewer (2012–present)
  • University at Buffalo Faculty Senate Representative-School of Medicine; Senator (2011–2012)
  • Atherosclerosis, Thrombosis and Vascular Biology-Peer Reviewer; Peer Reviewer (2011–present)
  • Cardiovascular Research; Peer Reviewer (2011–present)
  • Experimental Biology and Medicine-Peer Reviewer; Peer Reviewer (2011–present)
  • Stem Cells-Peer Reviewer; Peer Reviewer (2011–present)
  • American Heart Association-Basic Cell Regenerative Cell Biology Study Section; Grant Reviewer (2009–present)
  • American Journal of Physiology-Peer Reviewer; Peer Reviewer (2009–present)
  • Echocardiography Reading Panel-Buffalo General Medical Center; Panel Member (2009–present)
  • Nuclear Cardiology Reading Panel-Buffalo General Medical Center; Clinical Staff (2009–present)
  • Nuclear Cardiology Reading Panel-Buffalo General Hospital; Panel Member (2008–present)
  • American Journal of Cardiology-Peer Reviewer; Peer Reviewer (2008–present)
  • Journal of Cellular Biochemistry-Peer Reviewer; Peer Reviewer (2008–present)
  • Radiation Safety Officer-UB|MD Cardiology at Dent Tower; Director (2008–present)
  • Staff Physician-Buffalo General Medical Center; Clinical Staff (2008–present)
  • Director-Nuclear Stress Testing Lab-UB|MD Cardiology; Director (2007–present)
  • Staff Physician-WNY VA Medical Center; Clinical Staff (2007–2009)
  • Attending Physician-Cardiology Buffalo General Hospital; Clinical Staff (2007–present)
  • Circulation Research Peer Reviewer; Reviewer (2007–present)
  • NHLBI Symposium on Cardiovascular Regenerative Medicine; Advisory Board (2006–2007)

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Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, NY 14203
Phone: 716-829-2663
Fax: 716-854-1840

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