Thomas D. Grant PhD

Thomas Grant

Thomas D. Grant
PhD

Research Assistant Professor

Department of Structural Biology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Protein Function and Structure

Contact Information
955 Main Street
Room 5128
Buffalo, NY 14203
Phone: 7168295490
Fax: 716 898 8660
tdgrant@buffalo.edu



Professional Summary:

My research focus is the development of new methods of analysis in structural biology. My lab uses tools such as X-ray crystallography and small angle scattering to probe the structure and dynamics of biological macromolecules such as proteins and nucleic acids. Our approaches include developing new computational algorithms to analyze data and using cutting edge technologies such as X-ray free electron lasers (XFELs) to collect data on ultrafast time-scales. By developing these tools, we can build pictures and movies of biological molecules to help understand how they perform their functions in the cell. These insights not only help drive advancements in basic science but also help in the design of new drugs for treating diseases.

Education and Training:

  • PhD, Structural and Computational Biology, University at Buffalo (2013)
  • BS, Mathematical Physics, University at Buffalo, Magna Cum Laude (2007)

Employment:

  • Research Assistant Professor, Structural Biology, University at Buffalo (2018-present)
  • Research Scientist, BioXFEL, University at Buffalo (2014-present)
  • Postdoctoral Research Associate, Structural Biology, Hauptman-Woodward Institute (2013–2014)

Awards and Honors:

  • Sidhu Award for Significant Contributions to the Science of Crystallography and/or Diffraction (2013)
  • 2013 Dean’s Distinguished Thesis Award (2013)
  • Margaret C. Etter Student Lecturer Award (2011)
  • Honorable Mention Recipient, NSF Graduate Research Fellowship Program (2009)

Research Expertise:

  • Iterative phasing for solution scattering: We develop algorithms that solve the phase problem for solution scattering. This provides 3D electron density maps from the 1D solution scattering profiles, giving insights into particle shape at low-resolution.
  • Serial crystallography: Serial crystallography is a type of X-ray crystallography technique that uses X-rays to take diffraction snapshots of hundreds of thousands of microcrystals in succession to build up a complete 3D diffraction pattern. This technique is most often done with X-ray free electron lasers, but can also be done with synchrotrons. We often perform serial crystallography experiments for both soluble and membrane proteins. This is one of the few approaches that is capable of determining the high-resolution structures of membrane proteins and is amenable to time-resolved studies.
  • Solution Scattering: We use solution scattering to probe the low-resolution structure of macromolecules in aqueous solution. These data are highly complementary to other structural techniques that provide high-resolution data such as X-ray crystallography, NMR and cryoEM.
  • Time-resolved X-ray scattering: We use ultrafast time-resolved X-ray scattering with X-ray free electron lasers to probe the dynamic motions of biological macromolecules. Currently we study visual rhodopsin, the core light sensing protein triggering the process of vision in humans.
  • X-ray crystallography: We routinely employ X-ray crystallography for probing the atomic scale 3D structures of biological macromolecules. We use high-throughput crystallization screening, optimization and X-ray diffraction at synchrotrons and XFELs.
  • XFEL Data Reduction and Analysis: We develop algorithms for data reduction of large data sets (>100 TB) generated by X-ray free electron lasers for both serial crystallography and solution scattering. We regularly provide data analysis support to dozens of research groups (internal and external to BioXFEL), including data reduction, analysis, modeling and interpretation.

Grants and Sponsored Research:

  • October 2013–September 2023
    Biology with X-ray free electron lasers
    National Science Foundation
    Role: Co-Investigator
    $50,000,000
  • August 2019–July 2023
    High-resolution molecular recognition of ligands using solution X-ray scattering
    National Institutes of Health
    Role: Principal Investigator
    $1,333,637
  • August 2018–July 2021
    Light-Induced Protein Quake of Visual Rhodopsin Investigated by Femtosecond Time-Resolved X-Ray Scattering
    National Science Foundation
    Role: Co-Principal Investigator
    $800,000

Journal Articles:

  • Grant TD. Ab initio electron density determination directly from solution scattering data. Nat Methods. 2018; 15(3).
  • Stachowski T, Grant TD, Snell EH. Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses. J Synchrotron Radiat. 2019; 26(Pt 4).
  • Stauch B, Johansson LC, McCorvy JD, Patel N, Han GW, Huang XP, Gati C, Batyuk A, Slocum ST, Ishchenko A, Brehm W, White TA, Michaelian N, Madsen C, Zhu L, Grant TD, Grandner JM, Shiriaeva A, Olsen RHJ, Tribo AR, Yous S, Stevens RC, Weierstall U, Katritch V, Roth BL, Liu W, Cherezov V. Structural basis of ligand recognition at the human MT1 melatonin receptor. Nature. 2019.
  • Jensen SC, Sullivan B, Hartzler DA, Aguilar JM, Awel S, Bajt S, Basu S, Bean R, Chapman HN, Conrad C, Frank M, Fromme R, Martin-Garcia JM, Grant TD, Heymann M, Hunter MS, Ketawala G, Kirian RA, Knoska J, Kupitz C, Li X, Liang M, Lisova S, Mariani V, Mazalova V, Messerschmidt M, Moran M, Nelson G, Oberthür D, Schaffer A, Sierra RG, Vaughn N, Weierstall U, Wiedorn MO, Xavier PL, Yang JH, Yefanov O, Zatsepin NA, Aquila A, Fromme P, Boutet S, Seidler GT, Pushkar Y. X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis. J Phys Chem Lett. 2019; 10(3).
  • Ishigami I, Lewis-Ballester A, Echelmeier A, Brehm G, Zatsepin NA, Grant TD, Coe JD, Lisova S, Nelson G, Zhang S, Dobson ZF, Boutet S, Sierra RG, Batyuk A, Fromme P, Fromme R, Spence JCH, Ros A, Yeh SR, Rousseau DL. Snapshot of an oxygen intermediate in the catalytic reaction of cytochrome c oxidase. Proc Natl Acad Sci U S A. 2019; 116(9).
  • Olmos JL, Pandey S, Martin-Garcia JM, Calvey G, Katz A, Knoska J, Kupitz C, Hunter MS, Liang M, Oberthuer D, Yefanov O, Wiedorn M, Heyman M, Holl M, Pande K, Barty A, Miller MD, Stern S, Roy-Chowdhury S, Coe J, Nagaratnam N, Zook J, Verburgt J, Norwood T, Poudyal I, Xu D, Koglin J, Seaberg MH, Zhao Y, Bajt S, Grant T, Mariani V, Nelson G, Subramanian G, Bae E, Fromme R, Fung R, Schwander P, Frank M, White TA, Weierstall U, Zatsepin N, Spence J, Fromme P, Chapman HN, Pollack L, Tremblay L, Ourmazd A, Phillips GN, Schmidt M, Grant TD. Enzyme intermediates captured "on the fly" by mix-and-inject serial crystallography. BMC Biol. 2018; 16(1).
  • Kupitz C, Olmos JL, Holl M, Tremblay L, Pande K, Pandey S, Obertheur D, Hunter M, Liang M, Aquila A, Tenboer J, Calvey G, Katz A, Chen Y, Wiedorn MO, Knoska J, Meents A, Majriani V, Norwood T, Poudyal I, Grant TD, Miller MD, Xu W, Tolstikova A, Morgan A, Metz M, Martin-Garcia JM, Zook JD, Roy-Chowdhury S, Coe J, Nagaratnam N, Meza D, Fromme R, Basu S, Frank M, White T, Barty A, Bajt S, Yefanov O, Chapman HN, Zatsepin N, Nelson G, Weierstall U, Spence J, Schwander P, Pollack L, Fromme P, Ourmazd A, Phillips GN, Schmidt M. Structural enzymology using X-ray free electron lasers. Struct Dyn. 2017; 4(4).
  • Stagno JR, Liu Y, Bhandari YR, Conrad CE, Panja S, Swain M, Fan L, Nelson G, Li C, Wendel DR, White TA, Coe JD, Wiedorn MO, Knoska J, Oberthuer D, Tuckey RA, Yu P, Dyba M, Tarasov SG, Weierstall U, Grant TD, Schwieters CD, Zhang J, Ferré-D'Amaré AR, Fromme P, Draper DE, Liang M, Hunter MS, Boutet S, Tan K, Zuo X, Ji X, Barty A, Zatsepin NA, Chapman HN, Spence JC, Woodson SA, Wang YX. Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography. Nature. 2017; 541(7636).
  • Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 2017; 546(7657).
  • Ishigami I, Zatsepin NA, Hikita M, Conrad CE, Nelson G, Coe JD, Basu S, Grant TD, Seaberg MH, Sierra RG, Hunter MS, Fromme P, Fromme R, Yeh SR, Rousseau DL. Crystal structure of CO-bound cytochrome c oxidase determined by serial femtosecond X-ray crystallography at room temperature. Proc Natl Acad Sci U S A. 2017; 114(30).
  • Daniel C Bailey, Eric J Drake, Thomas D Grant, Andrew M Gulick. Structural and Functional Characterization of Aerobactin Synthetase IucA from a Hypervirulent Pathotype of Klebsiella pneumoniae. Biochemistry. 2016; 55(25).
  • Pande K, Hutchison CD, Groenhof G, Aquila A, Robinson JS, Tenboer J, Basu S, Boutet S, DePonte DP, Liang M, White TA, Zatsepin NA, Yefanov O, Morozov D, Oberthuer D, Gati C, Subramanian G, James D, Zhao Y, Koralek J, Brayshaw J, Kupitz C, Conrad C, Roy-Chowdhury S, Coe JD, Metz M, Xavier PL, Grant TD, Koglin JE, Ketawala G, Fromme R, Å rajer V, Henning R, Spence JC, Ourmazd A, Schwander P, Weierstall U, Frank M, Fromme P, Barty A, Chapman HN, Moffat K, van Thor JJ, Schmidt M. Femtosecond structural dynamics drives the trans/cis isomerization in photoactive yellow protein. Science. 2016; 352(6286).
  • Abdallah BG, Zatsepin NA, Roy-Chowdhury S, Coe J, Conrad CE, Dörner K, Sierra RG, Stevenson HP, Camacho-Alanis F, Grant TD, Nelson G, James D, Calero G, Wachter RM, Spence JC, Weierstall U, Fromme P, Ros A. Microfluidic sorting of protein nanocrystals by size for X-ray free-electron laser diffraction. Struct Dyn. 2015; 2(4).
  • Lawrence RM, Conrad CE, Zatsepin NA, Grant TD, Liu H, James D, Nelson G, Subramanian G, Aquila A, Hunter MS, Liang M, Boutet S, Coe J, Spence JC, Weierstall U, Liu W, Fromme P, Cherezov V, Hogue BG. Serial femtosecond X-ray diffraction of enveloped virus microcrystals. Struct Dyn. 2015; 2(4).
  • Diana CF Monteiro, Vijay Patel, Christopher P Bartlett, Shingo Nozaki, Thomas D Grant, James A Gowdy, Gary S Thompson, Arnout P Kalverda, Edward H Snell, Hironori Niki, Arwen R Pearson, Michael E Webb. The structure of the PanD/PanZ protein complex reveals negative feedback regulation of pantothenate biosynthesis by coenzyme A. Chemistry & Biology. 2015; 22(4).
  • Paolo Rossi, Lei Shi, Gaohua Liu, Christopher M Barbieri, Hsiau‐Wei Lee, Thomas D Grant, Joseph R Luft, Rong Xiao, Thomas B Acton, Edward H Snell, Gaetano T Montelione, David Baker, Oliver F Lange, Nikolaos G Sgourakis. A hybrid NMR/SAXS‐based approach for discriminating oligomeric protein interfaces using Rosetta. Proteins: Structure, Function, and Bioinformatics. 2015; 83(2).
  • Thomas D Grant, Joseph R Luft, Lester G Carter, Tsutomu Matsui, Thomas M Weiss, Anne Martel, Edward H Snell. The accurate assessment of small-angle X-ray scattering data. Acta Crystallographica Section D: Biological Crystallography. 2015; 71(1).
  • Tenboer J, Basu S, Zatsepin N, Pande K, Milathianaki D, Frank M, Hunter M, Boutet S, Williams GJ, Koglin JE, Oberthuer D, Heymann M, Kupitz C, Conrad C, Coe J, Roy-Chowdhury S, Weierstall U, James D, Wang D, Grant T, Barty A, Yefanov O, Scales J, Gati C, Seuring C, Srajer V, Henning R, Schwander P, Fromme R, Ourmazd A, Moffat K, Van Thor JJ, Spence JC, Fromme P, Chapman HN, Schmidt M, Grant TD. Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein. Science. 2014; 346(6214).
  • Andrew E Bruno, Amanda M Ruby, Joseph R Luft, Thomas D Grant, Jayaraman Seetharaman, Gaetano T Montelione, John F Hunt, Edward H Snell. Comparing chemistry to outcome: the development of a chemical distance metric, coupled with clustering and hierarchal visualization applied to macromolecular crystallography. PloS One. 2014; 9(6).
  • Joseph R Luft, Thomas D Grant, Jennifer R Wolfley, Edward H Snell. A new view on crystal harvesting. Journal of Applied Crystallography. 2014; 47(3).
  • Thomas D Grant, Joseph R Luft, Jennifer R Wolfley, Mary E Snell, Hiro Tsuruta, Stephanie Corretore, Erin Quartley, Eric M Phizicky, Elizabeth J Grayhack, Edward H Snell. The structure of yeast glutaminyl-tRNA synthetase and modeling of its interaction with tRNA. Journal of Molecular Biology. 2013; 425(14).
  • Amy L Stiegler, Thomas D Grant, Joseph R Luft, David A Calderwood, Edward H Snell, Titus J Boggon. Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex. PLoS One. 2013; 8(1).
  • Thomas D Grant, Edward H Snell, Joseph R Luft, Erin Quartley, Stephanie Corretore, Jennifer R Wolfley, M Elizabeth Snell, Andrew Hadd, John J Perona, Eric M Phizicky, Elizabeth J Grayhack. Structural conservation of an ancient tRNA sensor in eukaryotic glutaminyl-tRNA synthetase. Nucleic Acids Research. 2011; 40(8).
  • Thomas D Grant, Joseph R Luft, Jennifer R Wolfley, Hiro Tsuruta, Anne Martel, Gaetano T Montelione, Edward H Snell. Small angle X‐ray scattering as a complementary tool for high‐throughput structural studies. Biopolymers. 2011; 95(8).
See all (14 more)

Books and Book Chapters:

  • Eaton E Lattman, Thomas D Grant, Edward H Snell. Biological Small Angle Scattering: Theory and Practice. 2018; 29.

Professional Memberships:

  • American Crystallographic Association (2008–present)

Presentations:

  • "Ab initio electron density determination directly from solution scattering data" Computational and Experimental Techniques for Small Angle Scattering (2019)
  • "KEYNOTE: Ab initio electron density determination directly from solution scattering data" Frontiers in the Analysis of Intermolecular Interactions by BioSAXS (2019)
  • "Introduction to XFEL Science" BioXFEL Summer Intern Orientation (2019)
  • "BioXFEL Knowledge Transfer" BioXFEL Annual NSF Site Visit (2019)
  • "Solving the Phase Problem in Solution Scattering" CECAM simSAS 2019 Workshop (2019)
  • "DENSS: Ab initio electron density maps from biological SAXS data" SBGrid Online Webinar, SBGrid (2019)
  • "Solving the Phase Problem in Solution Scattering" 2018 International Small Angle Scattering Conference, Biomolecular: Complex Nucleoproteins Cellular Machines (2018)
  • "Overview of Solution Scattering Techniques for Structural Biology" HWI Structural Biology Workshop (2018)
  • "Solving the Phase Problem in Solution Scattering" 2018 Gordon Conference on Diffraction Methods in Structural Biology (2018)
  • "Solving the Phase Problem in Solution Scattering" 2018 Meeting of the American Crystallographic Association, Hybrid Methods (2018)
  • "Solving the Phase Problem in Solution Scattering" 2018 Meeting of the American Crystallographic Association, Applications of Small Angle Scattering to Structural Biology Workshop (2018)
  • "Introduction to XFEL Science" BioXFEL Summer Intern Orientation (2018)
  • "BioXFEL Knowledge Transfer" BioXFEL Annual NSF Site Visit (2018)
  • "Beyond Profiles: Envelopes and More" CHESS BioSAXS Essentials Workshop (2018)
  • "Solving the Phase Problem in Solution Scattering" CHESS BioSAXS Essentials Workshop (2018)
  • "Solving the phase problem in solution scattering" CXFEL Workshop #2: Research opportunities for structure and dynamics in biology (2018)
  • "Ab initio electron density determination directly from solution scattering data" 5th BioXFEL International Conference, External Advisors Meeting (2018)
  • "Live monitoring of time-resolved solution scattering data at XFELs" 5th BioXFEL International Conference (2018)
  • "Overview of unique source properties, sample delivery, time-resolved options, detectors, and more at the EuXFEL" 5th BioXFEL International Conference, New Opportunities at the European XFEL Workshop (2018)
  • "Ab initio electron density determination directly from solution scattering data" Buffalo Protein Science Group (2017)
  • "Ab initio electron density determination directly from solution scattering data" 26th Annual Buffalo-Hamilton-Toronto Symposium (2017)
  • "Ab initio electron density determination directly from solution scattering data" 75th Annual Pittsburgh Diffraction Conference (2017)
  • "Overview of Solution Scattering Techniques for Structural Biology" HWI Structural Biology Workshop (2017)
  • "Introduction to XFEL Science" BioXFEL Summer Intern Orientation (2017)
  • "Beyond Profiles: Envelopes and More" CHESS BioSAXS Essentials Workshop (2017)
  • "BioXFEL Knowledge Transfer" BioXFEL Annual NSF Site Visit (2017)
  • "Time-resolved SAXS, modeling and complementary methods" CHESS BioSAXS Essentials Workshop (2017)
  • "Live monitoring of time-resolved solution scattering data at XFELs" 4th BioXFEL International Conference (2017)
  • "The determination of electron density directly from solution scattering data" 4th BioXFEL International Conference (2017)
  • "Data Reduction at LCLS with Cheetah" 2016 Meeting of the American Crystallographic Association, Serial Crystallography Data Analysis Workshop (2016)
  • "Lectures and Hands-on Tutorials Describing XFEL Data Reduction and Analysis" 2016 Meeting of the American Crystallographic Association, Serial Crystallography Data Analysis Workshop (2016)
  • "BioXFEL Knowledge Transfer" BioXFEL Annual NSF Site Visit (2016)
  • "Introduction to XFEL Science" BioXFEL Summer Intern Orientation (2016)
  • "Overview of Industrial Applications of Solution Scattering at XFELs" XFEL Lightsources and Applications for Industry Workshop (2016)
  • "Beyond Profiles: Envelopes and More" CHESS BioSAXS Essentials Workshop (2016)
  • "Time-resolved SAXS, modeling and complementary methods" CHESS BioSAXS Essentials Workshop (2016)
  • "Ab initio modeling of time-resolved difference scattering profiles at XFELs" 3rd BioXFEL International Conference (2016)
  • "Data Reduction at LCLS with Cheetah" 2015 Meeting of the American Crystallographic Association, Serial Crystallography Data Analysis Workshop (2015)
  • "Lectures and Hands-on Tutorials Describing XFEL Data Reduction and Analysis" 2015 Meeting of the American Crystallographic Association, Serial Crystallography Data Analysis Workshop (2015)
  • "BioXFEL Knowledge Transfer" BioXFEL Annual NSF Site Visit (2015)
  • "HWI Crystallization Workshop" HWI Crystallization Workshop (2015)
  • "Introduction to XFEL Science" BioXFEL Summer Intern Orientation (2015)
  • "Practical Considerations for Crystallographic Data Analysis" HWI Crystallization Workshop (2015)
  • "The accurate assessment of small angle scattering data" 2nd BioXFEL International Conference (2015)
  • "SAXS Part II: Advanced Applications of Biological Small Angle Scattering" SBGrid Online Webinar, SBGrid (2014)
  • "Intro to BioSAXS Modeling" CHESS BioSAXS Essentials Workshop (2014)
  • "Lectures and Hands-on Tutorials Describing XFEL Data Reduction and Analysis" Serial Crystallography Data Analysis Workshop (2014)
  • "The accurate assessment of small angle scattering data" 2014 Gordon Research Conference on Diffraction Methods in Structural Biology (2014)
  • "Introduction to XFEL Science" BioXFEL Summer Intern Orientation (2014)
  • "The Structure and Dynamics of the Appended Domain of Eukaryotic Gln-tRNA Synthetase" 2014 Meeting of the American Crystallographic Association (2014)
  • "Applications of SAXS to a High-throughput Structural Pipeline" Guest Seminar Speaker, Arizona State University (2014)
  • "SAXS Part I: Introduction to Biological Small Angle Scattering" SBGrid Online Webinar, SBGrid (2014)
  • "Understanding the Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase" 71st Annual Pittsburgh Diffraction Conference (2013)
  • "Understanding the Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase" The Many Lives of RNA Research Symposium (2013)
  • "Understanding the Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase" 2013 Advanced Light Source Users Meeting (2013)
  • "Understanding the Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase" CASIS Protein Crystal Growth Summit 2013 (2013)
  • "Understanding the Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase" 71st Annual Pittsburgh Diffraction Conference, Sidhu Awardee Lecture (2013)
  • "High-throughput SAXS: Overcoming Practical Limitations Through Statistics" Northeast Structural Genomics Consortium Annual Retreat (2013)
  • "Intro to BioSAXS Modeling" CHESS BioSAXS Essentials Workshop (2013)
  • "Understanding the Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase" 70th Annual Pittsburgh Diffraction Conference (2012)
  • "Understanding the Structure and Dynamics of Eukaryotic Glutaminyl-tRNA Synthetase" Biodynamics@Buffalo (2012)
  • "High-Throughput SAXS: Pitfalls and Payoffs" Rigaku BioSAXS Workshop, Rigaku Americas Corporation (2012)
  • "High-Throughput SAXS: Pitfalls and Payoffs" CHESS BioSAXS Essentials Workshop (2012)
  • "Small Angle X-ray Scattering as a Complementary Tool for High-Throughput Structural Studies" XDL 2011 Hard X-ray Diffraction Workshop (2011)
  • "High-Throughput SAXS: Pitfalls and Payoffs" CHESS BioSAXS Essentials Workshop (2011)
  • "High-Throughput SAXS: Pitfalls and Payoffs" Guest Seminar Speaker, Astbury Centre for Structural Molecular Biology (2011)
  • "Small Angle X-ray Scattering as a Complementary Tool for High-Throughput Structural Studies" 2011 Meeting of the American Crystallographic Association, Margaret C. Etter Student Lecture (2011)
  • "Small Angle X-ray Scattering as a Complementary Tool for High-Throughput Structural Studies" 2011 Meeting of the American Crystallographic Association (2011)
  • "Dr. Hauptman’s Legacy" 25th Anniversary Celebration of Dr. Herbert Hauptman’s Nobel Prize (2011)
  • "High-Throughput SAXS: Pitfalls and Payoffs" Rigaku BioSAXS Workshop, Rigaku Americas Corporation (2011)
  • "High-Throughput SAXS: Pitfalls and Payoffs" CHESS BioSAXS Essentials Workshop (2011)
  • "High-Throughput SAXS: Pitfalls and Payoffs" Rigaku BioSAXS Workshop, Rigaku Americas Corporation (2011)
  • "Structural Information from 77% of Targets: High-Throughput SAXS as a Complementary Component to a Structural Pipeline" 13th International Conference on the Crystallization of Biological Macromolecules (2010)
  • "Structural Information from 77% of Targets: High-Throughput SAXS as a Complementary Component to a Structural Pipeline" 2010 Methods in Structural Biology and Biophysics Symposium (2010)
  • "Structural Information from 77% of Targets: High-Throughput SAXS as a Complementary Component to a Structural Pipeline" 2010 NIGMS Workshop: Enabling Technologies in Structure and Function (2010)
  • "Probing the Dynamics of the tRNA Synthetase Gln4 Using Small Angle X-ray Scattering" 18th Annual Buffalo-Hamilton-Toronto Symposium (2009)
  • "Probing the Dynamics of the tRNA Synthetase Gln4 Using Small Angle X-ray Scattering" 67th Annual Pittsburgh Diffraction Conference (2009)
  • "Probing the Dynamics of the tRNA Synthetase Gln4 Using Small Angle X-ray Scattering" 11th Annual Upstate New York NMR Symposium (2009)
See all (68 more)

Service Activities:

  • Jacobs School of Medicine & Biomedical Sciences Faculty Council; Alternate Member (2018)
  • BioXFEL 6th International Conference Organizing Committee; Selecting speakers, designing agenda, etc for the 2019 BioXFEL Conference.; Organizing Committee Member (2018–2019)
  • BioXFEL Education and Diversity Committee; This committee governs all aspects of the education and diversity programs in the BioXFEL Center.; Member (2014–present)

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Contact Information

955 Main Street
Room 5128
Buffalo, NY 14203
Phone: 7168295490
Fax: 716 898 8660
tdgrant@buffalo.edu