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Thomas                         Guttuso

Thomas J. Guttuso Jr., MD

Department of Neurology

Associate Professor; Director of Movement Disorder and Menopause Therapy Centers

Specialty/Research Focus

Movement Disorders; Neurology; Parkinson's

Professional Summary:

I am a movement disorder neurologist, and I care for patients with involuntary movements such as Parkinson‘s disease, tremor disorders and dystonia at our UBMD neurology clinic on Essjay Rd. I manage the care of patients with medication and counseling, and I also perform botulinum toxin (Botox) injections to treat dystonia, blepharospasm, hemifacial spasm, spasticity and certain types of tremors and headaches. I collaborate with UBMD neurosurgeons specializing in movement disorders in order to give patients the best possible and coordinated care. For instance, I refer patients to my neurosurgery collaborators for deep brain stimulation (DBS) when I know this surgical therapy treatment will help my patients. I am also a member of the Parkinson Study Group, an international organization of clinical research centers. My involvement with this group allows me to identify opportunities for my patients to enroll in cutting-edge research studies and clinical trials that could benefit them.

I also direct the Menopause Therapy Center at the UBMD neurology clinic on Essjay Rd. I treat peri and postmenopausal women for hot flashes, night sweats and sleeping problems with effective, non-hormonal medications.

My research has focused primarily on conducting clinical trials with the goal of finding new treatments for a variety of conditions. These conditions have included hot flashes, chemotherapy-induced nausea, hyperemesis gravidarum, Parkinson‘s disease and concussion. Thus far, my research has shown the drug gabapentin to be an effective treatment for hot flashes in postmenopausal women and to possibly be an effective treatment for nausea and vomiting. Currently, I am conducting two clinical trials in collaboration with faculty in UB’s Department of Obstetrics and Gynecology. We are exploring the effects of gabapentin on prolonging pregnancy in women with preterm labor, and we are comparing the benefit of gabapentin and ondansetron in patients with hyperemesis gravidarum. In addition, I am collaborating with the Buffalo Neuroimaging Analysis Center (BNAC) to assess an MRI imaging modality called diffusion tensor imaging to determine if it can detect changes in cognitive performance over time in patients with Parkinson‘s disease.

I teach medical students and residents about movement disorders in classroom settings as well as at the bedside in my outpatient clinic and on inpatient rounds at Buffalo General Medical Center.

Education and Training:
  • Fellowship, University of Rochester (2003)
  • Residency, University of Rochester (2000)
  • MD, University at Buffalo (1996)
  • MS, University at Buffalo (1992)
  • BA, Cornell University (1988)
  • Associate Professor, Neurology, University at Buffalo

Research Expertise:
  • Movement disorders
  • Neuro-obstetrics and gynecology
Grants and Sponsored Research:
  • January 2014–December 2017
    Comparison of gabapentin and ondansetron for treating hyperemesis gravidarum
    Role: Principal Investigator
  • May 2014–April 2016
    Effect of 2.5 years of rasagiline therapy on progression of cognitive biomarkers assessed by MRI in Parkinson’s disease
    Teva Pharmaceuticals
    Role: Principal Investigator

Evaluative Studies and Case Reports:
Journal Articles:
See all (1 more)

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

5851 Main Street
Williamsville, NY 14221
Phone: 716-932-6080
Fax: 716-332-4245

Patient Care

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