Vivian Cody PhD
Vivian Cody
PhD
Professor, Structural Biology Department,Jacobs School of Medicine and Biomedical Sciences
Department of Structural Biology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Bioinformatics; Computational Chemistry; Drug Design; Protein Folding; Structural Biology; X-ray Crystallography
Professional Summary:
The long-term goal of my research has been to understand the role of key active site residues in the mechanism of molecular recognition among various classes of proteins. The primary focus has been study of folate-dependent enzyme pathways, in particular dihydrofolate reductase (DHFR). These enzymes from pathogenic Pneumocystis species are of interest for the design of selective inhibitors for the treatment of AIDS-related pneumonia. Analysis of the structural data from several classes of protein has revealed a great degree of conformational flexibility for ligand binding that result in novel modes of binding to the same active site. Understanding the role of such flexibility has aided in the design of new scaffolds for inhibitor design. Additionally, my lab has the expertise to carry out the necessary molecular biology experiments to clone, express and purify proteins for crystallographic study using both bacterial and insect cell host systems. We have a long-standing, successful collaboration with the Queener lab to study DHFR, particularly from the opportunistic pathogens Pneumocystis jirovecii (pj) and Pneumocystis carinii (pc), found in man and rats, respectively. Our lab is also studying transthyretin (TTR), the thyroid hormone transport protein, characterizing the human protein bound to inhibitors with potential to stabilize the tetrameric structure and ameliorate the effects of filbril formation. Transthyrtetin from lamprey is of interest as it is thought to be the cross-over species in the change of function from a hydrolase to hormone transport function.
Education and Training:
- PhD, Chemistry, University of Cincinnati (1969)
- BS, Chemistry, University of Michigan (1965)
Employment:
- Professor, Structural Biology Department, University at Buffalo, School of Medicine and Biomedical Sciences (2001-present)
Awards and Honors:
- University at Buffalo Sustained Achievement Award (2005)
Research Expertise:
- Computational Chemistry
- Drug Desing
- protein structutral analysis of enzymes
- Structural Biology
- X-ray Crystallography
Grants and Sponsored Research:
- April 2012–March 2016
Evaluation and Development of E1-Topo1 as a Target for Anti-HPV Therapeutics
NAID
Role: Co-Investigator
$225,000 - April 2012–March 2016
Pneumocystis jirovecii Targeted Antiopportunistic Agents
AI
Role: Co-Investigator
$75,000 - September 2010–August 2012
Oral Immunity and Adjuvant Receptors
National Institute of Dental and Craniofacial Research
Role: Co-Principal Investigator
$100,000 - September 2007–July 2011
Chemically Controlled Assembly of Therapeutic Nanostructures
NCI
Role: Co-Investigator
$140,000 - April 1995–December 2010
Structural Studies of AIDS-Responsive Drugs
NIH
Role: Principal Investigator
$189,000 - September 2008–September 2009
Structural Characterization of AlphaVBeta3 Integrin Ligand Complexes
Role: Principal Investigator
$95,000
Journal Articles:
- Greenberg SM, Ferrara AM, Nicholas ES, Dumitrescu AM, Cody V, Weiss RE, Refetoff S. A Novel Mutation in the Albumin Gene (R218S) Causing Familial Dysalbuminemic Hyperthyroxinemia in a Family of Bangladeshi Extraction. Thyroid. 2014; 24(6).
- Davis PJ, Mousa SA, Cody V, Tang HY, Lin HY. Small molecule hormone or hormone-like ligands of integrin aVß3: implications for cancer cell behavior. Horm Cancer. 2013; 4(6).
- Queener SF, Cody V, Pace J, Torkelson P, Gangjee A. Trimethoprim resistance of dihydrofolate reductase variants from clinical isolates of Pneumocystis jirovecii. Antimicrob Agents Chemother. 2013; 57(10).
- Cody V, Pace J, Queener SF, Adair OO, Gangjee A. Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants. Antimicrob Agents Chemother. 2013; 57(6).
- Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V. Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles. J Med Chem. 2013; 56(11).
- Freindorf M, Furlani TR, Kong J, Cody V, Davis FB, Davis PJ. Combined QM/MM study of thyroid and steroid hormone analogue interactions with avß3 integrin. J Biomed Biotechnol. 2012; 2012.
- Cody V, Pace J, Stewart E. Structural analysis of Pneumocystis carinii dihydrofolate reductase complexed with NADPH and 2,4-diamino-6-[2-(5-carboxypent-1-yn-1-yl)-5-methoxybenzyl]-5-methylpyrido[2,3-d]pyrimidine. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012; 68(Pt 4).
- Cody V, Pace J, Piraino J, Queener SF. Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase. J Struct Biol. 2011; 176(1).
- Cody V, Pace J, Nowak J. Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Acta Crystallogr D Biol Crystallogr. 2011; 67(Pt 10).
- Zhang X, Zhou X, Kisliuk RL, Piraino J, Cody V, Gangjee A. Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors. Bioorg Med Chem. 2011; 19(11).
- Lin HY, Cody V, Davis FB, Hercbergs AA, Luidens MK, Mousa SA, Davis PJ. Identification and functions of the plasma membrane receptor for thyroid hormone analogues. Discov Med. 2011; 11(59).
- Cody V, Pace J. Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(?-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives. Acta Crystallogr D Biol Crystallogr. 2011; 67(Pt 1).
- Bardaweel S, Pace J, Chou TF, Cody V, Wagner CR. Probing the impact of the echinT C-terminal domain on structure and catalysis. J Mol Biol. 2010; 404(4).
- Cody V, Piraino J, Pace J, Li W, Gangjee A. Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Acta Crystallogr D Biol Crystallogr. 2010; 66(Pt 12).
- Li Q, So CR, Fegan A, Cody V, Sarikaya M, Vallera DA, Wagner CR. Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic. J Am Chem Soc. 2010.
- Gangjee A, Li W, Lin L, Zeng Y, Ihnat M, Warnke LA, Green DW, Cody V, Pace J, Queener SF. Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors. Bioorg Med Chem. 2009; 17(20).
- Gangjee A, Li W, Kisliuk RL, Cody V, Pace J, Piraino J, Makin J. Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents. J Med Chem. 2009; 52(15).
- Cody V, Pace J, Lin L, Gangjee A. The Z isomer of 2,4-diaminofuro[2,3-d]pyrimidine antifolate promotes unusual crystal packing in a human dihydrofolate reductase ternary complex. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009; 65(Pt 8).
- Heltzel JM, Scouten Ponticelli SK, Sanders LH, Duzen JM, Cody V, Pace J, Snell EH, Sutton MD. Sliding clamp-DNA interactions are required for viability and contribute to DNA polymerase management in Escherichia coli J Mol Biol. 2009; 387(1).
- Cody V, Pace J, Makin J, Piraino J, Queener SF, Rosowsky A. Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes. Biochemistry. 2009; 48(8).
- Cody V, Mao Q, Queener SF. Recombinant bovine dihydrofolate reductase produced by mutagenesis and nested PCR of murine dihydrofolate reductase cDNA. Protein Expr Purif. 2008; 62(1).
- Cody V, Pace J, Rosowsky A. Structural analysis of a holoenzyme complex of mouse dihydrofolate reductase with NADPH and a ternary complex with the potent and selective inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl)methylpteridine. Acta Crystallogr D Biol Crystallogr. 2008; 64(Pt 9).
- Cody V, Davis PJ, Davis FB. Molecular modeling of the thyroid hormone interactions with alpha v beta 3 integrin. Steroids. 2007; 72(2).
- Davis PJ, Davis FB, Cody V. Membrane receptors mediating thyroid hormone action. Trends Endocrinol Metab. 2005; 16(9).
- Neumann P, Cody V, Wojtczak A. Ligand binding at the transthyretin dimer-dimer interface: structure of the transthyretin-T4Ac complex at 2.2 Angstrom resolution. Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 10).
- Cody V, Chisum K, Pope C, Queener SF. Purification and characterization of human-derived Pneumocystis jirovecii dihydrofolate reductase expressed in Sf21 insect cells and in Escherichia coli. Protein Expr Purif. 2005; 40(2).
- Cody V, Luft JR, Pangborn W. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr D Biol Crystallogr. 2005; 61(Pt 2).
- Sikazwe DM, Li S, Mardenborough L, Cody V, Roth BL, Ablordeppey SY. Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors. Bioorg Med Chem Lett. 2004; 14(23).
- Cody V, Luft JR, Pangborn W, Gangjee A, Queener SF. Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr D Biol Crystallogr. 2004; 60(Pt 4).
- Cody V, Luft JR, Pangborn W, Gangjee A. Analysis of three crystal structure determinations of a 5-methyl-6-N-methylanilino pyridopyrimidine antifolate complex with human dihydrofolate reductase. Acta Crystallogr D Biol Crystallogr. 2003; 59(Pt 9).
- Cody V, Galitsky N, Luft JR, Pangborn W, Gangjee A. Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase. Acta Crystallogr D Biol Crystallogr. 2003; 59(Pt 4).
- Carlson JC, Kanter A, Thuduppathy GR, Cody V, Pineda PE, McIvor RS, Wagner CR. Designing protein dimerizers: the importance of ligand conformational equilibria. J Am Chem Soc. 2003; 125(6).
- Cody V. Mechanisms of molecular recognition: crystal structure analysis of human and rat transthyretin inhibitor complexes. Clin Chem Lab Med. 2002; 40(12).
- Cody V, Galitsky N, Luft JR, Pangborn W, Queener SF, Gangjee A. Analysis of quinazoline and pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolates in complex with NADP+ and Pneumocystis carinii dihydrofolate reductase. Acta Crystallogr D Biol Crystallogr. 2002; 58(Pt 9).
- Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Queener SF. Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH. Acta Crystallogr D Biol Crystallogr. 2002; 58(Pt 6).
- Wang Y, Bruenn JA, Queener SF, Cody V. Isolation of rat dihydrofolate reductase gene and characterization of recombinant enzyme. Antimicrob Agents Chemother. 2001; 45(9).
- Galitsky N, Cody V, Wojtczak A, Ghosh D, Luft JR, Pangborn W, English L. Structure of the insecticidal bacterial delta-endotoxin Cry3Bb1 of Bacillus thuringiensis. Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 8).
- Wojtczak A, Cody V, Luft JR, Pangborn W. Structure of rat transthyretin (rTTR) complex with thyroxine at 2.5 A resolution: first non-biased insight into thyroxine binding reveals different hormone orientation in two binding sites. Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 8).
- Wojtczak A, Neumann P, Cody V. Structure of a new polymorphic monoclinic form of human transthyretin at 3 A resolution reveals a mixed complex between unliganded and T4-bound tetramers of TTR. Acta Crystallogr D Biol Crystallogr. 2001; 57(Pt 7).
- Nowak W, Cody V, Wojtczak A. Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim. Acta Biochim Pol. 2001; 48(4).
- Muziol T, Cody V, Luft JR, Pangborn W, Wojtczak A. Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution. Acta Biochim Pol. 2001; 48(4).
- Neumann P, Cody V, Wojtczak A. Structural basis of negative cooperativity in transthyretin. Acta Biochim Pol. 2001; 48(4).
- Gangjee A, Yu J, McGuire JJ, Cody V, Galitsky N, Kisliuk RL, Queener SF. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. J Med Chem. 2000; 43(21).
- Cody V, Chan D, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF, Laughton CA, Stevens MF. Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate. Biochemistry. 2000; 39(13).
- Rosowsky A, Cody V, Galitsky N, Fu H, Papoulis AT, Queener SF. Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain. J Med Chem. 1999; 42(23).
- Rosowsky A, Queener SF, Cody V. Inhibition of dihydrofolate reductases from Toxoplasma gondii, Pneumocystis carinii, and rat liver by rotationally restricted analogues of pyrimethamine and metoprine. Drug Des Discov. 1999; 16(1).
- Cody V, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF. Ligand-induced conformational changes in the crystal structures of Pneumocystis carinii dihydrofolate reductase complexes with folate and NADP+. Biochemistry. 1999; 38(14).
- Gangjee A, Vidwans AP, Vasudevan A, Queener SF, Kisliuk RL, Cody V, Li R, Galitsky N, Luft JR, Pangborn W. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. J Med Chem. 1998; 41(18).
- Cody V, Galitsky N, Luft JR, Pangborn W, Blakley RL, Gangjee A. Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine. Anticancer Drug Des. 1998; 13(4).
- Gangjee A, Guo X, Queener SF, Cody V, Galitsky N, Luft JR, Pangborn W. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines. J Med Chem. 1998; 41(8).
- Cody V, Galitsky N, Luft JR, Pangborn W, Rosowsky A, Blakley RL. Comparison of two independent crystal structures of human dihydrofolate reductase ternary complexes reduced with nicotinamide adenine dinucleotide phosphate and the very tight-binding inhibitor PT523. Biochemistry. 1997; 36(45).
- Cody V, Galitsky N, Luft JR, Pangborn W, Gangjee A, Devraj R, Queener SF, Blakley RL. Comparison of ternary complexes of Pneumocystis carinii and wild-type human dihydrofolate reductase with coenzyme NADPH and a novel classical antitumor furo[2,3-d]pyrimidine antifolate. Acta Crystallogr D Biol Crystallogr. 1997; 53(Pt 6).
- Froimowitz M, Cody V. The incorporation of butyrophenones and related compounds into a pharmacophore for dopamine D2 antagonists. Drug Des Discov. 1997; 15(2).
- Wojtczak A, Cody V, Luft JR, Pangborn W. Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution. Acta Crystallogr D Biol Crystallogr. 1996; 52(Pt 4).
- Froimowitz M, Patrick KS, Cody V. Conformational analysis of methylphenidate and its structural relationship to other dopamine reuptake blockers such as CFT. Pharm Res. 1995; 12(10).
- Froimowitz M, Deng Y, Jacob JN, Li N, Cody V. Dopaminergic (4aR,10bS)-cis- and (4aS,10bS)-trans-octahydrobenzo[F]quinolines have similar pharmacophores. Drug Des Discov. 1995; 13(1).
- Cody V, Wojtczak A, Davis FB, Davis PJ, Blas SD. Structure-activity relationships of milrinone analogues determined in vitro in a rabbit heart membrane Ca(2+)-ATPase model. J Med Chem. 1995; 38(11).
- Lewis WS, Cody V, Galitsky N, Luft JR, Pangborn W, Chunduru SK, Spencer HT, Appleman JR, Blakley RL. Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers. J Biol Chem. 1995; 270(10).
- Froimowitz M, Cody V. Absolute configurations and conformations of the opioid agonist and antagonist enantiomers of picenadol. Chirality. 1995; 7(7).
- Chunduru SK, Cody V, Luft JR, Pangborn W, Appleman JR, Blakley RL. Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions. J Biol Chem. 1994; 269(13).
- Kragie L, Forrester ML, Cody V, McCourt M. Computer-assisted molecular modeling of benzodiazepine and thyromimetic inhibitors of the HepG2 iodothyronine membrane transporter. Mol Endocrinol. 1994; 8(3).
- Warnick PR, Davis PJ, Davis FB, Cody V, Galindo J, Blas SD. Rabbit skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase activity: stimulation in vitro by thyroid hormone analogues and bipyridines. Biochim Biophys Acta. 1993; 1153(2).
- Wallet JC, Cody V, Wojtczak A, Blessing RH. Structural and conformational studies on bio-active flavonoids. Crystal and molecular structure of a complex formed between 2‘,6‘-dimethoxyflavone and orthophosphoric acid: a model for flavone-nucleotide interactions. Anticancer Drug Des. 1993; 8(5).
- Wojtczak A, Luft JR, Cody V. Structural aspects of inotropic bipyridine binding. Crystal structure determination to 1.9 A of the human serum transthyretin-milrinone complex. J Biol Chem. 1993; 268(9).
- Froimowitz M, Cody V. Enantiomeric conformers of the opioid agonist ketobemidone HCl in the crystal state. Chirality. 1993; 5(7).
- Cody V, Luft JR, Jensen E, Pangborn W, English L. Purification and crystallization of insecticidal delta-endotoxin CryIIIB2 from Bacillus thuringiensis. Proteins. 1992; 14(2).
- Cody V, Luft JR, Pangborn W, Toy J, Bognar AL. Purification and crystallization of Lactobacillus casei folylpolyglutamate synthetase expressed in Escherichia coli. J Mol Biol. 1992; 224(4).
- Froimowitz M, Pangborn W, Cody V. Absolute configuration and conformation of the pure opioid antagonist (+)-2,9 alpha-dimethyl-5-(m-hydroxyphenyl)morphan. Chirality. 1992; 4(6).
- Wojtczak A, Luft J, Cody V. Mechanism of molecular recognition. Structural aspects of 3,3'-diiodo-L-thyronine binding to human serum transthyretin. J Biol Chem. 1992; 267(1).
- Cody V, Wojtczak A. Structure of 6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile hydrogen bromide. Acta Crystallogr C. 1991; 47 (.
- Cody V, Wojtczak A. Structure of two polymorphs of 2-methyl-3,4'-bipyridin-6(1H)-one. Acta Crystallogr C. 1991; 47 (.
- Deziel MR, Davis PJ, Davis FB, Cody V, Galindo J, Blas SD. Interaction of amiodarone and its analogs with calmodulin. Arch Biochem Biophys. 1989; 274(2).
- Ferriola PC, Cody V, Middleton E. Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships. Biochem Pharmacol. 1989; 38(10).
- Sutton PA, Cody V. Structure of 1-amidino-3-(3-sulfamoylphenyl)urea hydrochloride. Acta Crystallogr C. 1989; 45 (.
- Cody V, Sutton PA. Conformational analysis of antifolates: molecular structure and enzyme binding of the 4'-COOH trimethoprim derivative. Prog Clin Biol Res. 1989; 291.
- Cody V. Crystal and molecular structures of flavonoids. Prog Clin Biol Res. 1988; 280.
- Cody V. Thyroid hormone structure-activity relationships: molecular structure of 3,5,3'-triiodothyropropionic acid. Endocr Res. 1988; 14(2-3).
- Cody V, Sutton PA. Conformational analysis of lipophilic antifolates: crystal and molecular structures of three s-triazine dihydrofolate reductase inhibitors. Anticancer Drug Des. 1987; 2(3).
- Davis PJ, Cody V, Davis FB, Warnick PR, Schoenl M, Edwards L. Competition of milrinone, a non-iodinated cardiac inotropic agent, with thyroid hormone for binding sites on human serum prealbumin (TBPA). Biochem Pharmacol. 1987; 36(21).
- Sutton PA, Cody V. Conformational analysis of antineoplastic antifolates: the crystal structure of trimetrexate and the aminopterine derivative 4-[N-[(2,4-diamino-6-pteridinyl)methyl]amino]benzoic acid. J Med Chem. 1987; 30(10).
- Koehrle J, Auf'mkolk M, Rokos H, Hesch RD, Cody V. Rat liver iodothyronine monodeiodinase. Evaluation of the iodothyronine ligand-binding site. J Biol Chem. 1986; 261(25).
- Auf'mkolk M, Koehrle J, Hesch RD, Cody V. Inhibition of rat liver iodothyronine deiodinase. Interaction of aurones with the iodothyronine ligand-binding site. J Biol Chem. 1986; 261(25).
- Auf'mkolk M, Koehrle J, Hesch RD, Ingbar SH, Cody V. Crystal structure of phlorizin and the iodothyronine deiodinase inhibitory activity of phloretin analogues. Biochem Pharmacol. 1986; 35(13).
- Cody V, Sutton PA, Welsh WJ. Conformational analysis of dihydrofolate reductase inhibitors: use of computer graphics in drug design. Proc West Pharmacol Soc. 1986; 29.
- Cody V. Crystal structure of phlorizin and its interactions in the deiodinase active-site model. Prog Clin Biol Res. 1986; 213.
- Cody V, Koehrle J, Auf'mkolk M, Hesch RD. Structure-activity relationships of flavonoid deiodinase inhibitors and enzyme active-site models. Prog Clin Biol Res. 1986; 213.
- Koehrle J, Auf'mkolk M, Spanka M, Irmscher K, Cody V, Hesch RD. Iodothyronine deiodinase is inhibited by plant flavonoids. Prog Clin Biol Res. 1986; 213.
- Mylotte KM, Cody V, Davis PJ, Davis FB, Blas SD, Schoenl M. Milrinone and thyroid hormone stimulate myocardial membrane Ca2+-ATPase activity and share structural homologies. Proc Natl Acad Sci U S A. 1985; 82(23).
- Cody V. Conformational analysis of environmental agents: use of X-ray crystallographic data to determine molecular reactivity. Environ Health Perspect. 1985; 61.
- Cody V. Design of anticancer drugs: computer graphic analysis of dihydrofolate reductase inhibitors. Prog Clin Biol Res. 1985; 172B.
- Cody V. Thyroglobulin and thyroid hormone synthesis. Endocr Res. 1984; 10(1).
- Welsh WJ, Cody V, Mark JE, Zakrzewski SF. CNDO/2 molecular orbital calculations on the antifolate DAMP and some related species: structural geometries, ring distortions, change distributions and conformational characteristics. Cancer Biochem Biophys. 1983; 7(1).
- Cody V. Crystallographic studies of the antineoplastic antifolate 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) ethanesulfonate salt. Cancer Biochem Biophys. 1983; 6(3).
- Cody V, Zakrzewski SF. Molecular structures of 2,4-diaminopyrimidine antifolates with antineoplastic activity. J Med Chem. 1982; 25(4).
- Cody V. Triiodothyronine: molecular structure and biologic function. Monogr Endocrinol. 1981; 18.
- Cody V. Role of iodine in thyroid hormones: molecular conformation of a halogen-free hormone analogue. J Med Chem. 1980; 23(5).
- Cody V. Thyroid hormone interactions: molecular conformation, protein binding, and hormone action. Endocr Rev. 1980; 1(2).
- Cody V. Molecular conformation of thyroid hormones: structure and binding interactions of thyroxine. Endocr Res Commun. 1979; 6(2).
- Duax WL, Cody V, Griffin J, Hazel J, Weeks CM. Steroid structure and function--II. Conformational transmission and receptor binding of medroxyprogesterone acetate. J Steroid Biochem. 1978; 9(10).
- Cody V. Molecular conformation of a halogen-free thyroxine analog: 4-Methoxy-3,5,3-trimethyl-L-thyronine N-acetyl ethyl ester. Science. 1978; 201(4361).
- Duax WL, Cody V, Griffin JF, Rohrer DC, Weeks CM. Molecular conformation and protein binding affinity of progestins. J Toxicol Environ Health. 1978; 4(2-3).
- Cody V. Thyroid hormones: crystal structure, molecular conformation, binding, and structure-function relationships. Recent Prog Horm Res. 1978; 34.
- Cody V, Hazel J, Langs DA, Duax WL. Molecular structure of thyroxine analogues. Crystal structure of 3,5,3'-triiodothyroacetic and 3,5,3',5'-tetraoiodothyroacetic acid N-diethanolamine (1:1) complexes. J Med Chem. 1977; 20(12).
- Duax WL, Cody V, Hazel J. Steroid structure and function:I. Conformational transmission in 17alpha-acetoxy progesterone. Steroids. 1977; 30(4).
- Cody V, Hazel J. Molecular conformation of ammonium 8-anilino-1-naphthalenesulfonate hemihydrate. A fluorescent probe for thyroxine binding to thyroxine binding globulin. J Med Chem. 1977; 20(1).
- Mazzocchi PH, Ammon HL, Colicelli E, Hohokabe Y, Cody V. NMR-studies of triiodothyropropionic acid in ethanol-HCl. Experientia. 1976; 32(4).
- Cody V, Hazel J. Crystal and molecular conformation of the fluorescent probe. 8-anilino-1-naphthalenesulfonic acid (ANS). Biochem Biophys Res Commun. 1976; 68(2).
- Cody V. Distal conformation of thyroid hormones. Crystal and molecular structure of 3,5,3'-triiodo-L-thyronine methyl ester. J Med Chem. 1975; 18(2).
- Cody V. Crystal structure and molecular conformation of the thyroid hormone distal 3,5,3'-triiodo-L-thyronine. J Am Chem Soc. 1974; 96(21).
- Cody V, Duax WL. Distal conformation of the thyroid hormone 3,5,3'-triiodo-L-thyronine. Science. 1973; 181(101).
- Cody V, Duax WL. Distal conformation of thyroid hormones. The crystal structure of 3,5,3'-triiodothyroacetic acid H-diethanolamine (1:1) complex. Biochem Biophys Res Commun. 1973; 52(2).
- Cody V, Duax WL, Hauptman H. Conformational analysis of aromatic amino acids by x-ray crystallography. Int J Pept Protein Res. 1973; 5(5).
- Nowak W, Cody V, Wojtczak A. Computer modeling studies of the structural role of NADPH binding to active site mutants of human dihydrofolate reductase in complex with piritrexim. Acta Biochim Pol. ; 48(4).
- Muziol T, Cody V, Wojtczak A. Comparison of binding interactions of dibromoflavonoids with transthyretin. Acta Biochim Pol. ; 48(4).
- Muziol T, Cody V, Luft JR, Pangborn W, Wojtczak A. Complex of rat transthyretin with tetraiodothyroacetic acid refined at 2.1 and 1.8 A resolution. Acta Biochim Pol. ; 48(4).
- Neumann P, Cody V, Wojtczak A. Structural basis of negative cooperativity in transthyretin. Acta Biochim Pol. ; 48(4).
Professional Memberships:
- American Thyroid Association; member of Finance committee
- American Crystallographic Association
- American Institute of Physics
- Sigma Xi
- Endocrine Society
- American Association of Cancer Researchers
- American Society of Molecular Biologists and Biochemists
- American Association for Women in Science
- American Chemical Society
Service Activities:
- Jacobs School of Medicine & Biomedical Sciences FPMP Governing Board; Alternate Member (2012–2013)