Vivian Cody PhD

Vivian Cody

Vivian Cody
PhD

Professor, Structural Biology Department, School of Medicine and Biomedical Sciences

Department of Structural Biology

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Bioinformatics; Computational Chemistry; Drug Design; Protein Folding; Structural Biology; X-ray Crystallography

Contact Information
Dept of Structural Biology
Hauptman-woodward Institute
700 Ellicott Street
Buffalo, NY 14203
Phone: 898-8614
Fax: 898-8660
vcody@buffalo.edu



Professional Summary:

The long-term goal of my research has been to understand the role of key active site residues in the mechanism of molecular recognition among various classes of proteins. The primary focus has been study of folate-dependent enzyme pathways, in particular dihydrofolate reductase (DHFR). These enzymes from pathogenic Pneumocystis species are of interest for the design of selective inhibitors for the treatment of AIDS-related pneumonia. Analysis of the structural data from several classes of protein has revealed a great degree of conformational flexibility for ligand binding that result in novel modes of binding to the same active site. Understanding the role of such flexibility has aided in the design of new scaffolds for inhibitor design. Additionally, my lab has the expertise to carry out the necessary molecular biology experiments to clone, express and purify proteins for crystallographic study using both bacterial and insect cell host systems. We have a long-standing, successful collaboration with the Queener lab to study DHFR, particularly from the opportunistic pathogens Pneumocystis jirovecii (pj) and Pneumocystis carinii (pc), found in man and rats, respectively. Our lab is also studying transthyretin (TTR), the thyroid hormone transport protein, characterizing the human protein bound to inhibitors with potential to stabilize the tetrameric structure and ameliorate the effects of filbril formation. Transthyrtetin from lamprey is of interest as it is thought to be the cross-over species in the change of function from a hydrolase to hormone transport function.

Education and Training:

  • PhD, Chemistry, University of Cincinnati (1969)
  • BS, Chemistry, University of Michigan (1965)

Employment:

  • Professor, Structural Biology Department, University at Buffalo, School of Medicine and Biomedical Sciences (2001-present)

Awards and Honors:

  • University at Buffalo Sustained Achievement Award (2005)

Research Expertise:

  • Computational Chemistry
  • Drug Desing
  • protein structutral analysis of enzymes
  • Structural Biology
  • X-ray Crystallography

Grants and Sponsored Research:

  • April 2012–March 2016
    Evaluation and Development of E1-Topo1 as a Target for Anti-HPV Therapeutics
    NAID
    Role: Co-Investigator
    $225,000
  • April 2012–March 2016
    Pneumocystis jirovecii Targeted Antiopportunistic Agents
    AI
    Role: Co-Investigator
    $75,000
  • September 2010–August 2012
    Oral Immunity and Adjuvant Receptors
    National Institute of Dental and Craniofacial Research
    Role: Co-Principal Investigator
    $100,000
  • September 2007–July 2011
    Chemically Controlled Assembly of Therapeutic Nanostructures
    NCI
    Role: Co-Investigator
    $140,000
  • April 1995–December 2010
    Structural Studies of AIDS-Responsive Drugs
    NIH
    Role: Principal Investigator
    $189,000
  • September 2008–September 2009
    Structural Characterization of AlphaVBeta3 Integrin Ligand Complexes
    Role: Principal Investigator
    $95,000

Journal Articles:

See all (106 more)

Professional Memberships:

  • American Thyroid Association; member of Finance committee
  • American Crystallographic Association
  • American Institute of Physics
  • Sigma Xi
  • Endocrine Society
  • American Association of Cancer Researchers
  • American Society of Molecular Biologists and Biochemists
  • American Association for Women in Science
  • American Chemical Society

Service Activities:

  • Jacobs School of Medicine & Biomedical Sciences FPMP Governing Board; Alternate Member (2012–2013)

School News:

In the Media:


Clinical Specialties:

Clinical Offices:

Insurance Accepted:



Contact Information

Dept of Structural Biology
Hauptman-woodward Institute
700 Ellicott Street
Buffalo, NY 14203
Phone: 898-8614
Fax: 898-8660
vcody@buffalo.edu