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Vijay                          Iyer

Vijay S. Iyer MD, PhD

Department of Medicine

Associate Professor

Specialty/Research Focus

Cardiology; Interventional Cardiology

Professional Summary:

I am an interventional cardiologist specializing in structural heart interventions. My clinical practice includes general cardiology, interventional cardiology and complex valvular heart diseases. I see patients at the UBMD cardiology offices--and at Buffalo General Medical Center (BGMC), where I direct the complex valve clinic. I also direct structural heart interventions at the Gates Vascular Institute (GVI) and BGMC, and in that capacity I perform transcatheter aortic valve replacements, mitral clip procedures, left atrial appendage occlusion, atrial and ventricular septal defect closure and percutaneous paravalvular leak closures. I also care for patients by performing routine diagnostic coronary angiograms and percutaneous coronary interventions (PCI)/angioplasty.

I believe that in this era of technologically advanced, modern medicine it is the physician’s responsibility to educate patients in a straightforward and open manner about the different treatment modalities. I spend time with my patients to ensure that they are comfortable with the treatment options they choose and that they have a clear understanding of the alternatives, benefits and risks.

My research interests are in new devices for aortic and mitral valve replacement, novel therapeutics in the form of stem cells and newer therapies for acute coronary syndromes. I also collaborate with the Toshiba Stroke Research Center to develop advanced imaging modalities in the cardiac catheterization laboratory. I am investigating the use of robotic PCI to improve precision in stent placement and reduce radiation dosage in the catheterization laboratory, and I serve as the local principal investigator for a number of multicenter clinical trials in these areas. For example, I am: evaluating the LOTUS transcatheter valve to CoreValve in high-risk patients (Reprise III, Boston Scientific); investigating the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with severe, symptomatic aortic stenosis (AS) at intermediate surgical risk by randomizing patients to either surgical aortic valve replacement (SAVR) or TAVI (SURTAVI, Medtronic); and determining the efficacy of cardiac stem cells in patients with recent myocardial infarction and ischemic cardiomyopathy (ALLSTAR, Capricor.

I train residents and cardiology fellows through didactic and bedside teaching, and I mentor their research projects. I also oversee cardiology fellows in outpatient settings. Additionally, I collaborate with the departments of Anesthesiology and Pediatrics and the Division of Pulmonary, Critical Care and Sleep Medicine to train their residents and fellows.

Education and Training:
  • Fellowship, Interventional Cardiology, University of Minnesota (2009)
  • Fellowship, Cardiovascular Disease, University at Buffalo (2006)
  • Postdoctoral Fellow, Division of Cardiology, University at Buffalo (2003)
  • PhD, Pharmacology, Drexel University, Philadelphia, PA (2001)
  • MD, Internal Medicine, Grant Medical College, Maharashtra University Of Health Sciences (1995)
  • Associate Professor of Medicine, University at Buffalo (2014-present)
  • Director, Structural Heart Interventions (2011-present)
  • Research Assistant Professor, Medicine, University at Buffalo (2006–2014)
Awards and Honors:
  • Northwestern University Young Investigators Forum Finalist (2006)
  • Bristol Myers Squib-ACC Travel Award (2004)
  • Young Investigator Award, NYS ACC (2003)
  • American Heart Association Postdoctoral Fellowship (2002)
  • Joel Gernsheimer Award (2001)
  • Best Research Poster Award MCP Hahnemann School of Medicine Annual Scientific Meeting (1999)
  • Awarded Distinction in Preventive and Social Medicine, University of Bombay (1994)
  • Awarded Distinction in Pharmacology and Therapeutics, University of Bombay (1992)
  • Awarded Distinction in Human Physiology, University of Bombay (1990)

Research Expertise:
  • Cardiovascular stem cell therapy
  • Percutaneous aortic/mitral valve replacement

Journal Articles:
  • Suzuki G, Iyer V, Lee TC, Canty, JM Jr.. Autologous mesenchymal stem cells mobilize cKit positive and CD133 positive bone marrow progenitor cells and improve regional function in hibernating myocardium. Circulation Research. 2011; 109(9).
  • Suzuki G, Iyer V, Cimato T, Canty JM Jr.. Pravastatin improves function in hibernating myocardium by mobilizing CD133 and cKit bone marrow progenitor cells and promoting myocytes to reenter the growth phase of the cardiac cell cycle. Circulation Research. 2009; 104.
  • Page B, Young RF, Iyer VS, Suzuki G, Lis M, Blumenthal KM and Canty JM Jr. Persistent Regional Downregulations in Mitrochondrial Enzymes and Upregulation of Stress Proteins in Swine with Chronic Hibernating Myocardium.. Circulation Research. 2008; 102(1).
  • Leiker M, Suzuki G, Iyer VS, Canty JM Fr, Lee T.. Assessment of a nuclear affinity labeling method for tracking implanted mesenchymal stem cells.. Cell Transplant. 2008; 17(8).
  • Canty JM Jr and VS Iyer. Hydrogen peroxide and metabolic coronary flow regulation. J Am College of Cardiology. 2007; 50.
  • Iyer VS and JM Canty Jr. Regional desensitization of beta-adrenergic receptor signaling in swine with chronic hibernating myocardiun. Circulation Research. 2005; 97.
  • Suzuki G, VS Iyer, AQ Shabbir, D Zisa, BA Palka, T Cimato, TC Lee and JM Canty Jr. Pravastatin followed by intracoronary fibroblast growth factor (FGF-5) synergistically amplifies endogenous cardiac repair in swine with hibernating myocardium. J. Am College of Cardiology. 2009; 53.
  • Suzuki G, V Iyer, T-C Lee and JM Canty Jr. Intracoronary mesenchymal stem cells (MSCs) increases the myocardial localization of CD133 hematopoietic stem cells (HSCs) in swine with hibernating myocardium. Circulation. 2007; 116.
  • Iyer VS, G Suzuki, JM Hardy, BM Heavey, JA Fallavollita and JM Canty Jr. Time-dependent upregulation of extracellular matrix proteins in chronic hibernating myocardium: Lack of progressive degeneration. J. Am College of Cardiology. 2004; 43.
  • Iyer VS, RF Young, M Lis, N Nowak, K Blumenthal and JM Canty Jr.. Microarray and proteomic analysis reveals a regional reduction in the expression of mitochondrial metabolic enzymes in swine with chronic hibernating myocardium. Circulation. 2003; 108.
  • Iyer VS, Canty Jr, JM. Regional reductions in b-adrenergic receptor mediated cAMP prpoduction and reciprocal alterations in Ga protein expression in swine with hibernating myocardium. FASEB J. 2003; 17(4).
  • Iyer VS Young,R.F. Lee,T.C. Nowak,N. Canty,J.M.,Jr.. Microarray analysis of differential gene expression in hibernating myocardium is consistent with regional remodeling and local neurohumoral activation. FASEB J. 2003; 17(4).

Professional Memberships:
  • Fellow, American College of Cardiology (2006–present)
  • American Heart Association (2005–present)
  • Fellow, Society for Coronary Angiography and Interventions (2000–present)
  • American Society of Echocardiography

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

Clinical and Translational Research Center
875 Ellicott Street
Suite 7030
Buffalo, NY 14203
Phone: (716) 829-2663
Fax: (716) 854-1840

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