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Yongho                         Bae

Yongho Bae PhD

Department of Pathology and Anatomical Sciences

Assistant Professor

Specialty/Research Focus

Apoptosis and cell death; Cell Cycle; Cytoskeleton and cell motility; Gene Expression; Genomics and proteomics; Molecular and Cellular Biology; Molecular Basis of Disease; Signal Transduction

Professional Summary:

One third of our tissue mass is extracellular matrix (ECM). The ECM provides structural support for cells in tissues and varies from being stiff like bone to soft like skin. Importantly, the stiffness of the ECM affects how cells proliferate and migrate and this can be changed by injury or disease. My research is in blood vessels and particularly in arterial stiffening, which is a significant risk factor for the progression of cardiovascular disease, (leading worldwide cause of death). While medications reduce hypertension and cholesterol, none specifically treat arterial stiffness.

My lab will identify what happens to cells when arteries become stiffened and determine how this contributes to cardiovascular disease. To understand how arterial stiffening affects cells, we will use mouse and cellular models to mimic the stiffening process in patients. We believe that cells within a stiffer matrix overproduce certain proteins that lead to uncontrolled cell growth, which then begets even more stiffening. Identifying and understanding the proteins in these pathways will allow the development of drugs to counteract their function. Our research will bring fundamental new knowledge about arterial stiffness and lead to new medications that help reduce a key cause of cardiovascular disease.

Education and Training:
  • PhD, Bioengineering, University of Pittsburgh (2010)
  • MS, Chemical and Biochemical Engineering, Rutgers University, The State University of New Jersey (2005)
  • BS, Biotechnology, AJou University (1998)
  • Assistant Professor, Pathology and Anatomical Sciences, University at Buffalo (2017-present)
  • Research Associate, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine (2015–2016)
  • Post Doctoral Fellow, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine (2010–2015)
  • American Heart Association Postdoctoral Fellow, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine (2013–2014)
Awards and Honors:
  • Eugene Mindell & Harold Brody Clinical Translational Research Award (2017)
  • Editorial Review Board (2015)
  • Cell & Molecular Bioengineering Meeting: Fellow Travel Award (2015)
  • American Heart Association Postdoctoral Fellowship (2013)

Grants and Sponsored Research:
  • January 2013–December 2014
    American Heart Association Postdoctoral Fellowship
    American Heart Association (Great Rivers Affiliate)
    Role: Principal Investigator

Journal Articles:
See all (2 more)
Books and Book Chapters:
  • Roy P, Jaramillo M, Bae YH, Das T.. Actin cytoskeleton and cancer. In The motile actin system in health and disease. (C. Ampe and A. Lambrechts, eds.). Research Signpost. 2008.

Professional Memberships:
  • Cellular and Molecular Bioengineering (2014–present)
  • American Heart Association (2012–present)
  • Biomedical Engineering Society (2008–present)
  • American Society for Cell Biology (2007–present)
  • "Apolipoprotein E interrupts a positive feedback loop that links collagen-I synthesis to intracellular stiffness" Conference, Biomedical Engineering Society, Cellular and Molecular Bioengineering (2015)
  • "A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling" Conference, Gordon Research Conference, Signal Transduction by Engineered Extracellular Matrices (2014)
  • "Matrix metalloproteinase-12 controls arterial stiffness in vascular remodeling" Conference, American Heart Association, Scientific Session (2012)
  • "The FAK/Src/p130Cas pathway controls stiffness-dependent Rac activation and cell cycling" Conference, Gordon Research Conference, Signaling by Adhesion Receptors (2012)
  • "A Novel Actin-independent Anti-migratory Function of Profilin1 in Breast Cancer Cells" Conference, American Society for Cell Biology (2010)
  • "Membrane phosphoinositide availability, regulated by profilin-1, determines breast cancer cell motility secondary to binding of lamellipodin" Conference, American Society for Cell Biology (2009)
  • "Turning Profilin-1 to an anti-migratory molecule in breast cancer cells - molecular dissection" Conference, Biomedical Engineering Society (2009)
  • "Loss of Profilin-1 expression leads to hypermotile phenotype of breast cancer cell via lamellipodial targeting of Ena/VASP" Conference, American Society for Cell Biology (2008)
  • "Profilin is a negative regulator of mammary carcinoma aggressiveness" Conference, American Association for Cancer Research (2007)
  • "Evaluation of the effect of the chemistry of biodegradable polycarbonate polymers containing iodine and PEG on cellular response of vascular cell lines" Conference, American Institute of Chemical Engineers (2005)
Service Activities:
  • Editorial Review Board; Journal of Biomedical Engineering and Informatics; Editorial Board Member (2015–present)
  • Reviewer for Journal Articles; Cancer Research, PLoS One, Integrative Biology, Current Biotechnology, Journal of Tissue Engineering, Journal of the Mechanical Behavior of Biomedical Materials, Journal of Vascular Research and Cellulose

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

311 Farber Hall, South Campus
3435 Main Street
Pathology and Anatomical Sciences
Buffalo, NY 14214
Phone: 716-829-3523
Fax: 716-829-2911

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