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Yongho                         Bae

Yongho Bae PhD

Department of Pathology and Anatomical Sciences

Assistant Professor

Specialty/Research Focus

Apoptosis and cell death; Cell Cycle; Cytoskeleton and cell motility; Gene Expression; Genomics and proteomics; Molecular and Cellular Biology; Molecular Basis of Disease; Signal Transduction

 
Professional Summary:

One-third of our tissue mass is extracellular matrix (ECM). The ECM provides structural support for cells in tissues and varies from being stiff, like bone, to soft, like skin. Importantly, the stiffness of the ECM, which can be changed by injury or disease, affects how cells proliferate and migrate. My research is in blood vessels, particularly in arterial stiffening, which is a significant risk factor for the progression of cardiovascular disease- the leading worldwide cause of death. While medications reduce hypertension and cholesterol, none specifically treat arterial stiffness.

My lab will identify what happens to cells when arteries become stiffened, and determine how this contributes to cardiovascular disease. To understand how arterial stiffening affects cells, my lab will use mouse and cellular models to mimic the stiffening process in patients. We believe that cells within a stiffer matrix overproduce certain proteins that lead to uncontrolled cell growth, which then begets even more stiffening. Identifying and understanding the proteins in these pathways will allow for the development of drugs to counteract their function. The goal of my research is to contribute new fundamental knowledge about arterial stiffness, which will lead to new medications that help reduce a key cause of cardiovascular disease.

Education and Training:
  • PhD, Bioengineering, University of Pittsburgh (2010)
  • MS, Chemical and Biochemical Engineering, Rutgers University, The State University of New Jersey (2005)
  • BS, Biotechnology, AJou University (1998)
Employment:
  • Assistant Professor, Pathology and Anatomical Sciences, University at Buffalo (2017-present)
  • Research Associate, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine (2015–2016)
  • Post Doctoral Fellow, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine (2010–2015)
  • American Heart Association Postdoctoral Fellow, Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Perelman School of Medicine (2013–2014)
Awards and Honors:
  • Eugene Mindell & Harold Brody Clinical Translational Research Award (2017)
  • Editorial Review Board (2015)
  • Cell & Molecular Bioengineering Meeting: Fellow Travel Award (2015)
  • American Heart Association Postdoctoral Fellowship (2013)

Research Expertise:
  • Atomic Force Microscopy
  • Cell and Cancer Biology
  • Cell Mechanics and Mechanobiology
  • Optogenetics and Optogenomics
Grants and Sponsored Research:
  • August 2017–July 2020
    Networked Nanophotonic Devices for Stem Cell Regulation: From Optogenetics to Optogenomics
    National Science Foundation
    Role: Co-Principal Investigator
  • January 2013–December 2014
    American Heart Association Postdoctoral Fellowship
    American Heart Association
    Role: Principal Investigator

Journal Articles:
See all (2 more)
Books and Book Chapters:
  • Roy P, Jaramillo M, Bae YH, Das T.. Actin cytoskeleton and cancer. In The motile actin system in health and disease. (C. Ampe and A. Lambrechts, eds.). Research Signpost. 2008.

Professional Memberships:
  • Cellular and Molecular Bioengineering (2014–present)
  • American Heart Association (2012–present)
  • Biomedical Engineering Society (2008–present)
  • American Society for Cell Biology (2007–present)
Presentations:
  • "Apolipoprotein E interrupts a positive feedback loop that links collagen-I synthesis to intracellular stiffness" Conference, Biomedical Engineering Society, Cellular and Molecular Bioengineering (2015)
  • "A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling" Conference, Gordon Research Conference, Signal Transduction by Engineered Extracellular Matrices (2014)
  • "Matrix metalloproteinase-12 controls arterial stiffness in vascular remodeling" Conference, American Heart Association, Scientific Session (2012)
  • "The FAK/Src/p130Cas pathway controls stiffness-dependent Rac activation and cell cycling" Conference, Gordon Research Conference, Signaling by Adhesion Receptors (2012)
  • "A Novel Actin-independent Anti-migratory Function of Profilin1 in Breast Cancer Cells" Conference, American Society for Cell Biology (2010)
  • "Membrane phosphoinositide availability, regulated by profilin-1, determines breast cancer cell motility secondary to binding of lamellipodin" Conference, American Society for Cell Biology (2009)
  • "Turning Profilin-1 to an anti-migratory molecule in breast cancer cells - molecular dissection" Conference, Biomedical Engineering Society (2009)
  • "Loss of Profilin-1 expression leads to hypermotile phenotype of breast cancer cell via lamellipodial targeting of Ena/VASP" Conference, American Society for Cell Biology (2008)
  • "Profilin is a negative regulator of mammary carcinoma aggressiveness" Conference, American Association for Cancer Research (2007)
  • "Evaluation of the effect of the chemistry of biodegradable polycarbonate polymers containing iodine and PEG on cellular response of vascular cell lines" Conference, American Institute of Chemical Engineers (2005)
Service Activities:
  • Editorial Board; Journal of Microbiology and Pathology; Editorial Board Member (2017–present)
  • Editorial Review Board; Journal of Biomedical Engineering and Informatics; Editorial Board Member (2015–present)
  • Reviewer for Journal Articles; Cancer Research, PLoS One, Integrative Biology, Current Biotechnology, Journal of Tissue Engineering, Journal of the Mechanical Behavior of Biomedical Materials, Journal of Vascular Research and Cellulose; Peer Reviewer

School News:
In the Media:

Clinical Specialties:
Clinical Offices:
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Contact Information

311 Farber Hall, South Campus
3435 Main Street
Pathology and Anatomical Sciences
Buffalo, NY 14214
Phone: 716-829-3523
Fax: 716-829-2911
Email: yonghoba@buffalo.edu


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