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Zhen                           Yan

Zhen Yan PhD

Department of Physiology and Biophysics

Professor of Physiology & Neuroscience

Specialty/Research Focus

Cytoskeleton and cell motility; Molecular and Cellular Biology; Molecular Basis of Disease; Neurobiology; Neurodegenerative disorders; Neuropharmacology; Pathophysiology; Signal Transduction

Professional Summary:

My lab is focused on studying the mechanisms underlying the regulation of ligand-gated ion channels and synaptic transmission, and its implication in various brain disorders.

Information processing in the central nervous system (CNS) is achieved by the interplay between chemical and electrical signals. Neuromodulators (e.g. dopamine, serotonin, acetylcholine, and corticosteroid stress hormones) influence CNS functions by regulating ion channels, which can produce short-term changes in membrane excitability and long-term changes in synaptic plasticity. Dysfunctions of these neuromodulators in specific brain regions have been implicated in the pathogenesis of various mental disorders, including schizophrenia, depression and Alzheimer’s disease. One of our major goals is to understand how these neuromodulators regulate ligand-gated ion channels and synaptic transmission in prefrontal cortex, a key region controlling cognition and emotion.

Neuromodulators exert their actions through G protein-coupled receptors or nuclear hormone receptors. These receptors link to various intracellular signaling cascades, which potentially influence different ion channels in a specific and coordinated manner. We use a combination of multiple approaches to reveal signal transduction pathways mediated by neuromodulators. Specifically,

• Electrophysiological techniques, such as whole-cell patch-clamp recordings in cultured neurons and brain slices, are used to characterize the effect of neuromodulators on glutamate and GABA receptor channels and synaptic transmission.
• Biochemical and pharmacological approaches are used to identify the signaling molecules linking neuromodulators and channels.
• Molecular and immunocytochemical techniques are used to detect the expression, localization and trafficking of receptors, ion channels and signaling components in neurons.
• Animal models carrying mutant genes for neurological disorders are used to examine the aberrant neuromodulator actions and their causal link to behavioral deficits in these pathological conditions.

Our studies will provide knowledge on the molecular and cellular mechanisms underlying the regulation of synaptic functions by neuromodulators, which is important for mental health and diseases.

Education and Training:
  • Postdoctoral Fellow, The Rockefeller University (2000)
  • PhD, University of Tennessee, College of Medicine, Memphis, TN (1997)
  • ME, Southeast University, Nanjing, China (1993)
  • BS, Xi'an Jiaotong University, Xi'an, China (1990)
  • Professor, Physiology & Biophysics, University at Buffalo, the State University of New York (2008-present)
  • Associate Professor, Physiology & Biophysics, University at Buffalo, the State University of New York (2004–2008)
  • Assistant Professor, Physiology & Biophysics, University at Buffalo, the State University of New York (2000–2004)
Awards and Honors:
  • SUNY Chancellor’s Awards for Excellence in Scholarship and Creative Activities (2013)
  • University at Buffalo Exceptional Scholar Award for Sustained Achievement (2012)
  • The George W. Thorn Young Investigator Award (2006)
  • National Alliance for Research on Schizophrenia and Depression (NARSAD) Independent Investigator Award (2004)
  • University at Buffalo Top 100 Federal Grantee (2002)
  • University at Buffalo Exceptional Scholar Award for Young Investigators (2002)
  • National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award (1999)
  • National Parkinson Foundation Menek Goldstein Research Scholar Award (1998)

Research Expertise:
  • Alzheimer‘s Disease: beta-amyloid, cholinergic deficency, NMDA receptors
  • cytoskeleton and cell motility: microtubule motors, actin regulators, ion channel trafficking
  • Molecular and Cellular Biology: signaling molecules, regulation of ion channels
  • Molecular Basis of Disease: dopamine, serotonin, stress hormones, risk factors for mental disorders such as schizophrenia and depression
  • Neurobiology: electrophysiology, synaptic transmission and plasticity, glutamte receptors, GABA receptors, ion channel regulation
  • Neurodegenerative Disorders: pathophysiological mechanisms of Alzheimer‘s Disease and Huntington‘s Disease
  • Neuropharmacology: new antipsychotic drugs, identify novel drug targts
  • Psychiatry: pathophysiological mechanisms for schizophrenia, depression, PTSD, ADHD
  • Signal Transduction: G protein-coupled receptors, nuclear hormone recepors, protein kinases, phosphatases, proteases
Grants and Sponsored Research:
  • July 2014–June 2019
    Functions of D4 Dopamine Receptors in Prefrontal Cortex
    Role: Principal Investigator
  • July 2013–June 2015
    Synaptic Functions of Disrupted-in-Schizophrenia-1 (DISC1)
    Role: Principal Investigator
  • September 2010–June 2014
    Synaptic Changes by Stress in Prefrontal Cortex
    Role: Principal Investigator
  • July 2008–June 2013
    Functions of D4 Dopamine Receptors in Prefrontal Cortex
    Role: Principal Investigator
  • April 2010–March 2012
    Aberrant GABAAR Trafficking and Synaptic Inhibition in Huntington's Disease
    Role: Principal Investigator
  • July 2005–June 2008
    A New Protective Mechanism for Stoke: Calpain Regulation of Glutamate Receptor Functions
    American Heart Association
    Role: Principal Investigator
  • July 2004–June 2008
    Functions of D4 Dopamine Receptors in Prefrontal Cortex
    Role: Principal Investigator
  • June 2003–May 2008
    The Role of Cholinergic Functions in Alzheimer‘s Disease
    National Institute of Aging
    Role: Principal Investigator
  • December 2001–November 2006
    Neuromodulator Actions in Prefrontal Cortical Neurons
    National Institute of Mental Health
    Role: Principal Investigator
See All (9 Total) >

Journal Articles:
  • Wei J, Yuen EY, Liu W, Li X, Zhong P, Karatsoreos IN, McEwen BS, Yan Z. Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition. Molecular Psychiatry. 2014; Epub.
  • Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z. Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex.. Neuron. 2012; 73.
  • Jiang H, Ren Y, Yuen EY, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J. Parkin controls dopamine utilization in human midbrain dopaminergic neurons.. Nature Communications. 2012; 3.
  • Cheng J, Xiong Z, Duffney LJ, Wei J, Liu AY, Liu S, Chen GJ, Yan Z. Methylphenidate exerts dose-dependent effects on glutamate receptors and behaviors.. Biol. Psychiatry. 2014; 76.
  • Smith KR, Davenport EC, Wei J, Li X, Pathania M, Vaccaro V, Yan Z, Kittler JT. GIT1 and bPIX link Rac1 signalling to GABAA receptor cluster stability and inhibitory synapse strength.. Cell Reports. 2014; 9.
  • Zhong P, Yan Z. Distinct physiological effects of dopamine D4 receptors on prefrontal cortical pyramidal neurons and fast-spiking interneurons.. Cerebral Cortex. 2014.
  • Gu Z, Cheng J, Zhong P, Qin L, Liu W, Yan Z. Abeta selectively impairs mGluR7 modulation of NMDA signaling in basal forebrain cholinergic neurons: implication in Alzheimer’s disease.. J. Neurosci.. 2014; 34.
  • Yuen EY, Qin L, Wei J, Liu W, Liu A, Yan Z. Synergistic regulation of glutamatergic transmission by serotonin and norepinephrine reuptake inhibitors in prefrontal cortical neurons.. J. Biol. Chem.. 2014; 289.
  • Plattner F, Hernandez A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Weiderhold T, Yan Z, Bibb JA. Memory enhancement by targeting Cdk5 regulation of NR2B.. Neuron. 2014; 81.
  • Hayashi-Takagi A, Araki Y, Nakamura M, Vollrath B, Duron SG, Yan Z, Kasai H, Huganir RL, Campbell DA, Sawa A. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence.. Proc. Natl. Acad. Sci. USA. 2014; 111.
  • Wei J, Graziane NM, Wang H, Zhong P, Wang Q, Liu W, Hayashi-Takagi A, Korth C, Sawa A, Brandon NJ, Yan Z. Regulation of NMDA receptors by Disrupted-in-Schizophrenia-1 (DISC1).. Biol. Psychiatry. 2014; 75.
  • Duffney LJ, Wei J, Cheng J, Liu W, Smith KR, Kittler JT, Yan Z. Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism.. J. Neurosci.. 2013; 33.
  • Cheng J, Liu W, Duffney LJ, Yan Z. SNARE proteins are essential in the potentiation of NMDA receptors by group II metabotropic glutamate receptors. J Physiol. 2013; 591.
  • Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon P, Rios M, Brandon N, Yan Z, Moss SJ. Effects of BNDF on neurogenesis and depression depend upon phosphorylation of the GABAAR gamma2 subunit.. J. Neurosci.. 2013; 33.
  • Yuen EY, Zhong P, Li X, Wei J, Yan Z. Restoration of glutamatergic transmission by dopamine D4 receptors in stressed animals.. J. Biol. Chem.. 2013; 288.
  • Chen GJ, Xiong Z, Yan Z. Abeta impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex.. Molecular Neurodegeneration. 2013; 8(3).
  • Lee JB, Wei J, Liu W, Cheng J, Feng J, Yan Z. Histone Deacetylase 6 gates the synaptic action of acute stress in prefrontal cortex.. J. Physiology. 2012; 90.
  • Yuen EY, Wei J, Zhong P, Yan Z. Disrupted GABAAR trafficking and synaptic inhibition in a mouse model of Huntington’s disease.. Neurobiology of Disease. 2012; 46.
  • Gu Z, Liu W, Wei J, Yan Z. Regulation of NMDA receptors by metabotropic glutamate receptor 7.. J. Biol. Chem.. 2012; 287.
  • Yuen EY, Li X, Wei J, Horiguchi M, Meltzer HY, Yan Z. The novel antipsychotic drug lurasidone enhances NMDA receptor-mediated synaptic responses.. Mol Pharmacol. 2012; 81.
  • Liu W, Dou F, Feng J, Yan Z. RACK1 is involved in β-amyloid impairment of muscarinic regulation of GABAergic transmission. Neurobiol Aging. 2011; 32(10).
  • Mandal M, Wei J, Zhong P, Chen J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S, Li XJ, Kittler JT, Yan Z. Impaired AMPA receptor trafficking and function by mutant huntingtin.. J. Biol. Chem.. 2011; 286(39).
  • Wang Q, Charych EI, Pulito VL, Lee JB, Graziane NM, Crozier RA, Revilla-Sanchez R, Kelly MP, Dunlop AJ, Murdoch H, Taylor N, Xie Y, Pausch M, Hayashi-Takagi A, Ishizuka K, Seshadri S, Bates B, Kariya K, Sawa A, Weinberg RJ, Moss SJ, Houslay MD, Yan Z, Brandon NJ. The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function. Molecular Psychiatry. 2011; 16.
  • Yuen EY, Yan Z.. Cellular mechanisms for dopamine D4 receptor-induced homeostatic regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors.. J Biol Chem.. 2011; 286(28).
  • Yuen EY, Liu W, Karatsoreos IN, Ren Y, McEwen BS, Yan Z, Feng J. Mechanisms for acute stress-induced enhancement of glutamatergic transmission and working memory.. Molecular Psychiatry. 2011; 16(2).
  • Yuen EY, Liu W, Kafri T, van Praag H, Yan Z. Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase slingshot in cortical neurons.. J. Physiology. 2010.
  • Liu W, Yuen EY, Yan Z. The stress hormone corticosterone increases synaptic AMPA receptors via SGK regulation of the GDI-Rab4 complex.. J. Biol. Chem.. 2010; 285.
  • Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A. Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.. Nat Neurosci.. 2010; 13.
  • Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin.. Neuron. 2010; 65.
  • Joiner MA, Lisé MF, Yuen EY, Kam A, Hall DD, Malik ZA, Qian H, Chen Y, Ulrich JD, Burette AC, Weinberg RJ, Law PY, El-Husseini A, Yan Z, Hell JW. Assembly of a b2-adrenergic receptor- GluR1 signaling complex for localized cAMP signaling. EMBO J. 2010; 29.
  • Mandal M, Yan Z. PIP2 Regulation of NMDA Receptor Channels in Cortical Neurons. Mol Pharmacol. 2009; 76.
  • Saliba RS, Gu Z, Yan Z, Moss SJ. Blocking L-type voltage-gated Ca2+ channels with dihydropyridines reduces gamma-aminobutyric acid type A receptor expression and synaptic inhibition. J Biol Chem. 2009; 284(47).
  • Arancibia-Cárcamo IL, Yuen EY, Muir J, Lumb MJ, Michels G, Saliba RS, Smart TG, Yan Z, Kittler JT, Moss SJ. Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. Proc Natl Acad Sci U S A. 2009; 106(41).
  • Yuen EY, Liu W, Karatsoreos IN, Feng J, McEwen BS, Yan Z. Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory.. Proc. Natl. Acad. Sci. USA. 2009; 106.
  • Gu Z, Liu W, Yan Z. {beta}-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution. J Biol Chem. 2009; 284(16).
  • Graziane NM, Yuen EY, Yan Z. Dopamine D4 Receptors Regulate GABAA Receptor Trafficking via an Actin/Cofilin/Myosin-dependent Mechanism. J Biol Chem. 2009; 284(13).
  • Yuen EY, Yan Z. Dopamine D4 receptors regulate AMPA receptor trafficking and glutamatergic transmission in GABAergic interneurons of prefrontal cortex. J Neurosci. 2009; 29(2).
  • Chen G, Chen P, Tan H, Ma D, Dou F, Feng J, Yan Z. Regulation of the NMDA receptor-mediated synaptic response by acetylcholinesterase inhibitors and its impairment in an animal model of Alzheimer’s disease.. Neurobiol. Aging. 2008; 29.
  • Yuen EY, Gu Z, Yan Z. Calpain regulation of AMPA receptor channels in cortical pyramidal neurons. J Physiol. 2007; 580.
  • Gu Z, Jiang Q, Yan Z. RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia. Mol Pharmacol. 2007; 71.
  • Yuen EY, Liu W, Yan Z. The phosphorylation state of GluR1 subunits determines the susceptibility of AMPA receptors to calpain cleavage. J Biol Chem. 2007; Epub.
  • Kastning K, Kukhtina V, Kittler JT, Chen G, Enders S, Pechstein A, Lee SH, Sheng M, Yan Z, Haucke V. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc. Natl. Acad. Sci. USA. 2007; 104.
  • Chen P, Gu Z, Liu W, Yan Z. Glycogen synthase kinase 3 regulates NMDA receptor channel trafficking and function in cortical neurons. Mol Pharmacol. 2007; Epub.
  • Liu W, Yuen EY, Allen P, Feng J, Greengard P, Yan Z. a1 and a2 adrenergic regulation of NMDA receptor currents in prefrontal cortical neurons: distinct roles of spinophilin and RGS proteins.. Proc. Natl. Acad. Sci. USA. 2006; 108.
  • Jiang Q, Yan Z, Feng J. Neurotrophic factors protect against rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Biol Chem. 2006; 281.
  • Allen PB, Zachariou V, Svenningsson P, Lepore AC, Centonze D, Costa C, Rossi S, Bender G, Chen G, Feng J, Snyder GL, Yan Z, Calabresi P, Greengard P. Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity. Neurosci. 2006; 140.
  • Jiang Q, Yan Z, Feng J. Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on dopaminergic neurons through a microtubule-dependent mechanism. J Neurosci. 2006; 26.
  • Chen G, Kittler JT, Moss SJ, Yan Z. Dopamine D3 receptors regulate GABAA receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci. 2006; 26.
  • Gu Z, Jiang Q, Yuen EY, Yan Z. Activation of dopamine D4 receptors induces synaptic translocation of CaMKII in cultured prefrontal cortical neurons. Mol Pharmacol. 2006; 69.
  • Wang X, Gu Z, Zhong P, Chen G, Feng J, Yan Z. Aberrant regulation of NMDAR functions by dopamine D4 receptors in rats after phencyclidine exposure. Mol and Cell Neurosci. 2006; 31.
  • Kittler JT, Chen G, Honing S, Bogdanov Y, McAinsh K, Arancibia-Carcamo IL, Jovanovic JN, Pangalos MN, Haucke V, Yan Z, Moss SJ. Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci USA. 2005; 102.
  • Yuen EY, Jiang Q, Feng J, Yan Z. Microtubule regulation of NMDA receptor channels in neurons. J Biol Chem. 2005; 280.
  • Tyszkiewicz JP Yan Z. b-Amyloid peptides impair PKC-dependent functions of metabotropic glutamate receptors in prefrontal cortical neurons.. J Neurophysiol. 2005; 93.
  • Wu HY Yuen EY Lu YF Matsushita M Matsui H Yan Z Tomizawa K. Regulation of NMDA receptors by calpain in cortical neurons.. J Biol Chem. 2005; 280.
  • Yuen EY Jiang Q Chen P Gu Z Feng J Yan Z. Serotonin 5-HT1A receptors regulate NMDA receptor channels through a microtubule-dependent mechanism.. J Neurosci. 2005; 25.
  • Gu Z Jiang Q Fu AKY Ip NY Yan Z. Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex.. J Neurosci. 2005; 25.
  • Gu Z Yan Z. Bi-directional regulation of CaMKII activity by dopamine D4 receptors in prefrontal cortex.. Mol Pharmacol. 2004; 66.
  • Tan H, Zhong P, YAN Z. Corticotropin-releasing factor and acute stress prolongs serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons.. J Neurosci. 2004; 24(21).
  • Tyszkiewicz JP, Gu Z, Wang X, Cai X, Yan Z. Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurons of rat prefrontal cortex.. J Physiol. 2004; 554(3).
  • Chen G, Greengard P, YAN Z. Potentiation of NMDA receptor currents by dopamine D1 receptors in prefrontal cortex.. Proc Natl Acad Sci U S A. 2004; 101.
  • Zhong P Yan Z. Chronic antidepressant treatment alters the serotonergic regulation of GABA transmission in prefrontal cortical pyramidal neurons.. Neurosci. 2004; 129.
  • Wang X, Zhong P, Gu Z, Yan Z. Regulation of NMDA receptors by dopamine D4 signaling in prefrontal cortex.. J Neurosci. 2003; 23(30).
  • Davila V, Yan Z, Craciun LC, Logothetis D, Sulzer D. D3 dopamine autoreceptors do not activate G-protein-gated inwardly rectifying potassium channel currents in substantia nigra dopamine neurons.. J Neurosci. 2003; 23(13).
  • Zhong P, Gu Z, Wang X, Jiang H, Feng J, Yan Z. Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.. J Biol Chem. 2003; 278(29).
  • Gu Z, Zhong P, Yan Z. Activation of muscarinic receptors inhibits beta-amyloid peptide – induced signaling in cortical slices.. J Biol Chem. 2003; 278.
  • Ma XH, Zhong P, Gu Z, Feng J, Yan Z. Muscarinic potentiation of GABA(A) receptor currents is gated by insulin signaling in the prefrontal cortex.. J Neurosci. 2003; 23(4).
  • Wang X, Zhong P, Yan Z. Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex.. J Neurosci. 2002; 22(21).
  • Cai X, Gu Z, Zhong P, Ren Y, Yan Z. Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons.. J Biol Chem. 2002; 277(39).
  • Yan Z, Chi P, Bibb JA, Ryan TA, Greengard P. Roscovitine: a novel regulator of P/Q-type calcium channels and transmitter release in central neurons.. J Physiol. 2002; 540(Pt 3).
  • Cai X, Flores-Hernandez J, Feng J, Yan Z. Activity-dependent bidirectional regulation of GABA(A) receptor channels by the 5-HT(4) receptor-mediated signalling in rat prefrontal cortical pyramidal neurons.. J Physiol. 2002; 540(Pt 3).
  • Feng J, Cai X, Zhao J, Yan Z. Serotonin receptors modulate GABA(A) receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons.. J Neurosci. 2001; 21(17).
  • Liu F, Ma XH, Ule J, Bibb JA, Nishi A, DeMaggio AJ, Yan Z, Nairn AC, Greengard P. Regulation of cyclin-dependent kinase 5 and casein kinase 1 by metabotropic glutamate receptors.. Proc Natl Acad Sci U S A. 2001; 98(20).
  • Bibb JA, Chen J, Taylor JR, Svenningsson P, Nishi A, Snyder GL, Yan Z, Sagawa ZK, Ouimet CC, Nairn AC, Nestler EJ, Greengard P. Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5.. Nature. 2001; 410(6826).
  • Yan Z, Flores-Hernandez J, Surmeier DJ. Coordinated expression of muscarinic receptor mRNAs in striatal medium spiny neurons.. Neuroscience. 2001; 103.
  • Feng J, Yan Z, Ferreira A, Tomizawa K, Liauw JA, Zhuo M, Allen PB, Ouimet CC, Greengard P. Spinophilin regulates the formation and function of dendritic spines.. Proc Natl Acad Sci U S A. 2000; 97(16).
  • Bibb JA, Yan Z, Svenningsson P, Snyder GL, Pieribone VA, Horiuchi A, Nairn AC, Messer A, Greengard P. Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice.. Proc Natl Acad Sci U S A. 2000; 97(12).
  • Flores-Hernandez J, Hernandez S, Snyder GL, Yan Z, Fienberg AA, Moss SJ, Greengard P, Surmeier DJ. D(1) dopamine receptor activation reduces GABA(A) receptor currents in neostriatal neurons through a PKA/DARPP-32/PP1 signaling cascade.. J Neurophysiol. 2000; 83(5).
  • Bibb JA, Snyder GL, Nishi A, Yan Z, Meijer L, Fienberg AA, Tsai LH, Kwon YT, Girault JA, Czernik AJ, Huganir RL, Hemmings HC, Nairn AC, Greengard P. Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons.. Nature. 1999; 402(6762).
  • Yan Z, Feng J, Fienberg AA, Greengard P. D(2) dopamine receptors induce mitogen-activated protein kinase and cAMP response element-binding protein phosphorylation in neurons.. Proc Natl Acad Sci U S A. 1999; 96(20).
  • Yan Z, Hsieh-Wilson L, Feng J, Tomizawa K, Allen PB, Fienberg AA, Nairn AC, Greengard P. Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin.. Nat Neurosci. 1999; 2(1).
  • Stewart AE, Yan Z, Surmeier DJ, Foehring RC. Muscarine modulates Ca2+ channel currents in rat sensorimotor pyramidal cells via two distinct pathways.. J Neurophysiol. 1999; 81(1).
  • Mermelstein PG, Song WJ, Tkatch T, Yan Z, Surmeier DJ. Inwardly rectifying potassium (IRK) currents are correlated with IRK subunit expression in rat nucleus accumbens medium spiny neurons.. J Neurosci. 1998; 18(17).
  • Chen Q, Veenman L, Knopp K, Yan Z, Medina L, Song WJ, Surmeier DJ, Reiner A. Evidence for the preferential localization of glutamate receptor-1 subunits of AMPA receptors to the dendritic spines of medium spiny neurons in rat striatum.. Neuroscience. 1998; 83(3).
  • Yan Z, Surmeier DJ. D5 dopamine receptors enhance Zn2+-sensitive GABA(A) currents in striatal cholinergic interneurons through a PKA/PP1 cascade.. Neuron. 1997; 19(5).
  • Yan Z, Song WJ, Surmeier J. D2 dopamine receptors reduce N-type Ca2+ currents in rat neostriatal cholinergic interneurons through a membrane-delimited, protein-kinase-C-insensitive pathway.. J Neurophysiol. 1997; 77(2).
  • Surmeier DJ, Song WJ, Yan Z. Coordinated expression of dopamine receptors in neostriatal medium spiny neurons.. J Neurosci. 1996; 16(20).
  • Yan Z, Surmeier DJ. Muscarinic (m2/m4) receptors reduce N- and P-type Ca2+ currents in rat neostriatal cholinergic interneurons through a fast, membrane-delimited, G-protein pathway.. J Neurosci. 1996; 16(8).
See All (87 Total) >

Service Activities:
  • Regular Member of NIH Study Section (PMDA); Member (2015–2021)
  • Editorial Board Member of JBC; Board Member (2010–2015)
  • Regular Member of NIH Study Section (NTRC); Member (2009–2013)

Clinical Specialties:
Clinical Offices:
Insurance Accepted:

Contact Information

124 Sherman Hall
Buffalo, NY 14214
Phone: (716) 829-3058
Fax: (716) 829-2699

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