Jun Qu PhD

Jun Qu

Jun Qu
PhD

Contact Information
318 Pharmacy Building
Buffalo, NY 14214-8033
Phone: (716) 645-4821
Fax: (716) 645-4821
junqu@buffalo.edu



Professional Summary:

Research focus areas: Proteomics and Pharmaceutical Analysis. Major research programs in the proteomic field involve i) high-resolution and large-scale expression profiling of pathological proteomes (e.g. for cardiovascular diseases, colon cancer and infectious diseases) for the discovery of disease/therapeutic biomarkers by gel-free LC/MS methods; ii) Sensitive identification, localization and quantification of post-translational modifications in complex proteomes, with the emphases on arginine methylation and phosphorylation. Novel anti-PTM-peptides capture procedure and alternating collision induced dissociation (CID)/electron transferring dissociation (ETD) are employed to obtain abundant PTM information; iii) targeted quantification of regulatory, marker proteins for clinical study. Dr. Qu‘s lab possesses many state-of-the-art LC/MS instruments, including a high resolution/accuracy LTQ/Orbitrap XL with ETD, a highly sensitive TSQ Quantum Ultra EMR triple-quadrupole instrument, two ultra-high pressure nano-LC systems, and several HPLC instruments for pre-fraction and ion chromatography. A number of key analytical advances have been developed by his lab that greatly enhanced the proteomic coverage, sensitivity and throughput for proteomic research. As for the Pharmaceutical Analysis of small-molecule drug/markers, Dr. Qu‘s lab is focusing on the ultra-sensitive quantifications of drug, metabolites and endogenous markers (e.g. corticosteroids, di-hydroxyl-vitamin D metabolites, androgens, etc.) using a novel combination of selective enrichment and micro- or nano- LC/MS.

Education and Training:

  • PhD, Tsinghua University (2002)

Employment:

  • Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2018-present)
  • Adjunct Associate Professor, Roswell Park Cancer Institute (2013-present)
  • Associate Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2012-present)
  • Adjunct Assistant Professor, Biochemistry, University at Buffalo, Department of Biochemistry (2011-present)
  • Adjunct Assistant Professor, Ophthalmology, University at Buffalo, Department of Ophthalmology (2010-present)
  • chief scientist, New York Center of Excellence in Bioinformatics and Life ScienceNew York Center of Excellence in Bioinformatics and Life Science (2007-present)
  • Graduate Faculty, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2007-present)
  • Assistant Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2009–2013)
  • Research Assistant Professor, Pharmaceutical Sciences, University at Buffalo, department of Pharmaceutical sciences (2004–2008)

Awards and Honors:

  • UB Exceptional Scholar Sustained Achievement Award (2019)
  • Outstanding speaker award, Indian APA conference (2019)
  • Outstanding contribution award for medicinal analysis (2015)
  • Thermo Scientific Research Award (2015)
  • Selected by the Chemistry Department of Tsinghua University as one of the ten most prominent alumni graduated 2000-2010. (2012)
  • Delegate of the International Task Force for Vitamin D and MS Prevention (2011)
  • Fellow of Buffalo Clinical and Translational Research Center (2011)
  • American Heart Association Scientist Development Award (2011)
  • Clinical and Translational Award of SUNY (2010)
  • Chinese Association for Instrumental Analysis (2004)
  • outstanding academic delegate and met with Chinese President Jiang Zhemin (2001)
  • Chinese-Glories Scholarship (2000)
  • Dr. Mei Yiqi Scholarship (1999)
  • Dupont Distinguished Student Scholarship (1998)

Research Expertise:

  • Pharmaceutical Analysis: Targeted quantification of regulatory, marker proteins for clinical study, using highly-sensitive nano-LC/SRM-based methods. A number of key analytical advances have been developed in his laboratory, which greatly enhance the proteomic coverage, sensitivity and throughput for proteomic research.
  • Proteomics: i) high-resolution and large-scale expression profiling of pathological proteomes (e.g. for cardiovascular diseases, colon cancer and infectious diseases) for the discovery of disease/therapeutic biomarkers using gel-free LC/MS methods; ii) Sensitive identification, localization and quantification of post-translational modifications in complex proteomes; Here, novel anti-PTM-peptide capture procedures, and alternating collision induced dissociation /electron transferring dissociation methods are employed to obtain abundant PTM information;

Grants and Sponsored Research:

  • September 2018–August 2021
    The role of oral spirochete virulence factors in the impairment of neutrophil response
    NIH
    Role: Co-Investigator
    $1,894,065
  • August 2019–July 2021
    Novel LC-MS strategies for comprehensive in vivo investigations of antibody-drug conjugates and toxicity biomarkers.
    GSK Research
    Role: Principal Investigator
  • July 2019–December 2020
    Novel cancer-related proteases.
    AbbVie SRA
    Role: Principal Investigator
  • December 2018–November 2020
    LARGE-SCALE PROTEOME-WIDE ANALYSIS WITH HIGH ACCURACY/PRECISION TO GUIDE PANCREATIC CANCER THERAPY DEVELOPMENT.
    CA234775
    Role: Principal Investigator
  • September 2019–August 2020
    A 3D-printed micro-scaffold for MS Imaging and Spatially Resolved Determination of Mab and Receptors in Tissues.
    Center for Protein Therapeutics
    Role: Principal Investigator
  • September 2015–June 2020
    Transcription mechanism of Myrf for central nervous system myelination.
    NIH
    Role: Co-Investigator
  • September 2015–August 2019
    ER stress and diabetic retinopathy
    NIH/NEI
    Role: Co-Principal Investigator
  • August 2014–May 2019
    Function of Regulator of G protein signaling in aging skeleton
    NIH/NIA
    Role: Co-Investigator
  • June 2014–May 2019
    Regulation of skeletal development and homeostasis by IFT protein
    NIH/NIDCR
    Role: Co-Investigator
  • January 2015–December 2018
    PTPN14 and YAP tyrosine modification regulate the YAP oncogenic function
    American Cancer Society (ACS)
    Role: Co-Principal Investigator
  • December 2015–November 2017
    A high-throughput LC/MS method for quantification of biotherapeutics
    Roche-Pharmaceuticals
    Role: Principal Investigator
  • September 2012–July 2017
    Gamma-hydroxybutyrate: Toxicokinetics, Toxicodynamics and Treatment Strategies
    NIDA
    Role: Co-Investigator
  • June 2014–May 2017
    Vitamin D and Children’s Diabetes
    Murdoch Childrens Research Institute
    Role: Principal Investigator
  • December 2014–December 2016
    Study of the ER-mitochondria interface as a new target in diabetic retinopathy
    NIH, NEI
    Role: Co-Investigator
    $438,188
  • January 2012–December 2016
    Biomarker Release after Reversible Ischemia
    AHA
    Role: Principal Investigator
  • September 2015–August 2016
    Characterization of ADC in tissues and study of mAb catabolism/metabolism
    Peer-reviewed Industry Consortium Funds
    Role: Principal Investigator
  • July 2013–June 2016
    Enrichment Toolkit for Proteomic Biomarkers
    UB
    Role: Principal Investigator
  • June 2014–May 2016
    Investigation of the utility of LC/MS for characterization of the plasma and tissue PK of a novel series of antiCEA monocolonal antibodies.
    Hoffmann-La Roche Inc
    Role: Co-Investigator
  • January 2011–December 2015
    Biomarker Release after Reversible Ischemia
    American Heart Association
    Role: Principal Investigator
    $385,000
  • December 2014–October 2015
    Extensive investigation of protein binding in lipsome preparations
    Merrimack Pharma
    Role: Principal Investigator
  • June 2014–May 2015
    Brain network: Membrane permeable transcriptional regulators for retinal repair
    Center for Hearing and Deafness
    Role: Principal Investigator
  • May 2010–April 2015
    Protein arginine methylation in trypanosomes
    NIH NIAID
    Role: Co-Principal Investigator
    $250,000
  • May 2006–April 2015
    Metabolic Adaptation and Functional Recovery of Hibernating Myocardium
    NIH
    Role: Co-Investigator
  • September 2012–August 2014
    Subcellular domains of myelinating-glia: capturing axonal contact
    NIH
    Role: Co-Principal Investigator
    $435,875
See all (14 more)

Journal Articles:

See all (76 more)

Professional Memberships:

  • American Heart Association (2011)
  • AAPS (2011)
  • American Association of Pharmaceutical Scientists (AAPS) (2011–present)
  • Human Proteome Organization (HUPO) (2011–present)
  • American Heart Association (AHA) (2011–present)
  • International Society of Heart Research (ISHR) (2010–present)
  • American Society of Mass Spectrometry (2004)
  • American Society for Mass Spectrometry (ASMS) (2004–present)

Presentations:

  • "Extensive investigation of ocular tissue disposition of antibody-drug conjugates and the ocular toxicity using novel LC-MS-based strategies" Protein Therapeutics Symposium, Center of Protein Therapeutics Symposium (2019)
  • "Sensitive, accurate investigation of biotherapeutics and biomarker/target levels in both fresh and FFPE tissues, and application in Inflammatory bowel diseases" Protein Therapeutics Symposium, Center of Protein Therapeutics Symposium (2019)
  • "Novel strategies for global and targeted proteomics" invited seminar, Wake Forest University, Wake Forest University (2019)
  • "Towards Highly Sensitive and Accurate Analysis of Novel Biotherapeutics in Tissues" India APA meeting (2019)
  • "Novel methods to characterize biotherapeutics and biomarkers in tissues" Beijing Conference and Exhibition on Instrumental Analysis (2018)
  • "Characterization of protein therapeutics and targets in tissue" annuval meeting of American Association of Pharmaceutical Scientists, Invited talk (2018)
  • "Comprehensive tissue analysis by LC-MS" ThermoFisher User meeting (2018)
  • "Comprehensive tissue analysis by LC-MS" ThermoFisher User meeting (2018)
  • "Comprehensive tissue analysis by LC-MS" ThermoFisher User meeting (2018)
  • "Novel bioanalytical methods to investigate cancer biotherapeutics" annual Applied Pharmaceutical Analysis conference, Invited talk (2018)
  • "Highly sensitive investigation of tissue target engagement of biotherapeutics" Delaware Valley Drug Metabolism Discussion symposium (2018)
  • "Large-cohort clinical proteomics with IonStar" Department of Transplantation Medicine, Weill Cornell Medical College (2018)
  • "Spatially-resolved tissue micro-sampling coupled to sensitive nano-LC-MS to determine the heterogeneous distribution of mAb and targets in tissues" 66th American Society of Mass Spectrometry meeting (2018)
  • "IonStar for reliable differential –omics analysis" Invited seminar, Denali Inc (2018)
  • "IonStar for robust and practical large-scale proteomics quantification" Invited talk, GSK Inc (2018)
  • "Ultra-sensitive and specific LC-MS-based quantification of biotherapeutics without antibody enrichment" European Bioanalytical Forum 2017 (2017)
  • "Investigation of mAb therapeutics with sub 1 ng/mL sensitivity by antibody-free LC-MS" 20th Annual Symposium on Clinical & Pharmaceutical Solutions through Analysis (2017)
  • "IonStar: solution for high-quality, large-scale proteomic investigation" Thermofisher Scientific user meeting, Invited talk (2017)
  • "An IonStar proteomics technique enabling in-depth and comprehensive understanding of biological and pharmaceutical system" Departmental seminar, Dept. of Microbiology, Dental School of SUNY-Buffalo (2017)
  • "Towards reliable and accurate LC-MS analysis of mAb therapeutics in tissues" Roche RPF(Roche Postdoc Fellowship Program) symposium talk, La-Roche (2017)
  • "Ionstar: extensive and reproducible proteomic measurements in large biological cohorts with high accuracy, precision and extremely-low levels of missing data" International Association for Analytical Proteomics (2017)
  • "Ultra-High-Field Orbitrap for reliable Large-scale, Accurate and Extensive Proteomics Quantification" International Association for Analytical Proteomics, workshop (2017)
  • "Important considerations for LC/MS-based analysis of Tissue Distributions of Therapeutic Monoclonal Antibody" 65th American Society of Mass Spectrometry meeting, conference talk (2017)
  • "Sate-of-the-art in LC/MS-based in vivo investigation of ADC: why it is a much better alternative?" Sino-American Pharmaceutical Professionals Association/China Bioanalytical Forum joint annual meeting (2017)
  • "Sensitive, accurate analysis of protein drugs and biomarkers using narrow-window-isolation SRM MS" 65th American Society of Mass Spectrometry meeting, Thermo Fisher, Breakfast workshop (2017)
  • "Current status Duo in protein biotherapeutics analysis by LC-MS" invited symposium talk, Sanofi Inc (2017)
  • "Quantitative proteomics in cancer research" Departmental Seminar, Roswell Park Cancer Institute, Buffalo (2017)
  • "IonStar: A promising alternative to MS2-DIA" Annual US Human Proteome Organization Conference, invited lightening talk (2017)
  • "Label-free quantitative strategies in large scale proteomics" Annual Pittcon Conference, Invited talk (2017)
  • "LC/MS quantification of mAb therapeutics" ThermoFisher Scientific User Regional Meeting, ThermoFisher Scientific (2017)
  • "Unambiguous and comprehensive profiling of adenocarcinoma and stromal proteomes in patient-derived xenograft models: for mechanistic studies and personalized medicine" Annual US Human Proteome Organization Conference, Invited Cancer Moonshot talk (2017)
  • "Key considerations for LC/MS-based investigation of biotherapeutics tissue distribution" Invited seminar series talk, Amgen Inc. (2017)
  • "Global proteins with high reliability, accuracy and precision" EAS annual meeting (2016)
  • "High-resolution MS1 approach for selective and sensitive quantification of large cohorts: less label, more free" invited talk, ThermoFisher Scientifics (2016)
  • "IonStar: a promising alternative to SWATH for large-scale protein quantification" Invited seminar (sponsored by ThermoFisher Scientifics), ThermoFisher Scientifics (2016)
  • "LC/MS characterization of biotherapeutics" Invited Seminar, Amgen Inc, Amgen Inc (2016)
  • "Extensive and Reproducible Proteomic Measurements in Large Biological Cohorts with High Accuracy, Precision and Low Levels of Missing data" 2016 Mass Spectrometry Symposium, University of Rochester (2016)
  • "A promising alternative to SWATH:MS1-based strategy(IonStar) enables in-depth and reproducible proteomics quantification in large cohorts with high accuracy and extremely-low-level-missing-data" 64th American Society for Mass Spectrometry Annual Meeting (2016)
  • "A Trapping micro-LC/MS strategy for ultra-sensitive, robust and high-throughput quantification of biotherapeutics and biomarkers in complex matrices" 64th American Society for Mass Spectrometry Annual Meeting (2016)
  • "Global and targeted protein quantification" 64th American Society for Mass Spectrometry Annual Meeting (2016)
  • "Use of reagent-free LC/MS for sensitive analysis of biotherapeutics" Boehringer-Ingelheim Protein Analysis Symposium (2016)
  • "LC/MS for global and targeted protein analysis" invited seminar talk, Dept. Chemistry, SUNY-Buffalo (2016)
  • "In-depth and Reproducible Proteomic Measurement in Large Pharmaceutical and Clinical Cohorts with High Accuracy and Low Missing Value" invited talk, Dept. Pharmaceutical Sciences, U. Wisconsin (2016)
  • "label free quantification with low missing data and high accuracy" 2016 Annual Conference for Association of Biomolecular Resource Facilities, Association of Biomolecular Resource Facilities (2016)
  • "LC/MS quantification of low-abundance proteins: is this real? Are we there yet?" Invited Webinar talk, Chinese Association of Analytical Techniques (2015)
  • "LC/MS, a promising alternative for biotherpeutics analysis" invited talk, Bristol-Myers Squibb (2015)
  • "A Promising Alternative to SWATH for Biomarker Discovery: An Ion-Current Based Approach for Large-Scale, Accurate and Extensive Proteomic Quantification with Extremely Low Level of Missing Data" 2015 Eastern Analytical Symposium (2015)
  • "Challenges and strategies for quantitative characterization of biotherapeutics" 5th Pharmaceutical Analysis Conference (2015)
  • "Clinical and pharmaceutical proteomics: are we there yet?" invited seminar, Department of Chemistry, Tsinghua University (2015)
  • "Investigation of protein drugs by LC/MS: how to deal with the complexity and sensitivity issues" invited speaker, Department of Medicine, Tongji Medical School (2015)
  • "LC/MS analysis of proteins and peptides by LC/MS" 2015 Eastern Analytical Symposium (2015)
  • "Ultra-Sensitive and Accurate Analysis of Biotherapeutics Using Low-Flow LC/MS" 2015 Eastern Analytical Symposium, Eastern Analytical Symposium (2015)
  • "A novel method for reproducible measurement of proteins in large-scale investigation" invited seminar, Dept. of Biology, University of Vermont (2015)
  • "A promising alternative to SWATH: an Ion-current-based strategy with extensive proteomic coverage and extremely low level of missing data" BCEIA conference 2015 (2015)
  • "Competing risk factor of heart failure vs. sudden cardiac arrest by proteomics" HUPO Human Proteome Organization World Congress, Human Proteome Organization World Congress (2015)
  • "The gaps between biomarker candidates and clinical biomarkers" 2015 Euromedlab Annual meeting, The International Federation of Clinical Chemistry and Laboratory Medicine (2015)
  • "low flow LC/MS for biotherapeutics analysis" Abbvie Inc. meeting, Abbvie Inc. (2015)
  • "Analysis of protein drugs with LC/MS" Abbvie Inc. meeting, Abbvie Inc. (2015)
  • "Proteomics for unbiased neurological investigation" SUNY Brain Network of Excellence Workshop, SUNY (2014)
  • "Bioanalysis of proteins and peptides by LC/MS" 2014 Eastern Analytical Syposium, 2014 Eastern Analytical Syposium (2014)
  • "LC/MS analysis of therapeutic proteins and peptides" 2014 Conference of American Association of Pharmaceutical Scientists, ASMS (2014)
  • "Large-Scale Pre-Clinical/Clinical Profiling”" HUPO Human Proteome Organization World Congress, Human Proteome Organization (2014)
  • "Retinal proteome profiling for ROP using high-end LC/MS" NIH RPDP meeting (2014)
  • "Highly Sensitive Quantification of Bio-therapeutics Using Nano- and Micro-LC/MS" AB SCIEX Worldwide Webinar Series, AB SCIEX (2014)
  • "Clinical and Pharmaceutical Proteomics: Global and Targeted" Buffalo Pharmaceutics Symposium (2014)
  • "Drastically improved sensitivity and robustness for quantification of therapeutic mAb in tissue and application in PK studies at therapeutically-relevant dosing levels" Center of Protein Therapeutics Symposium (2014)
  • "Multiplexed quantification of antigen-antibody complex, free antibody and antigen in plasma and application in PK of CEA and an anti-CEA mAb (T84.66) in a xenograft tumor model" Center of Protein Therapeutics Symposium (2014)
  • "High-throughput proteomics analysis for retinopathy" NIH Webinar, NIH Webinar (2014)
  • "Characterization of biotherapetuics using cutting-edge LC/MS techniques" Janssen Pharmaceutical, Janssen Pharmaceutical (2014)
  • "Towards the sensitive and accurate analysis of biotherapeutic with Low-flow LC/MS" Roche Pharmaceutical, global, Roche Pharmaceutical (2013)
  • "Towards a Highly Sensitive and Accurate Characterization of Therapeutic mAb in Plasma and Tissues using Low-flow LC/MS" 2013 Conference of American Association of Pharmaceutical Scientists (2013)
  • "Towards the highly sensitive and accurate quantification of mAbs" Fifth Annual Symposium, Center for Protein Therapeutics (2013)
  • "Towards the highly sensitive and accurate quantification of mAbs" Center of Protein Therapeutics Symposium (2013)
  • "Use of LC-MS to measure Biotherapeutics in biological samples" 2nd BioTx ADME Workshop, Cosponsored with AAPS (2013)
  • "Does first year MRI and clinical activity correlate with long term clinical response to glatiramer acetate in multiple sclerosis patients" American Academy of Neurology, American Academy of Neurology (2013)
  • "Proteome-level Pharmacokinetic/Pharmacodynamic Analysis of Corticosteroid-responsive Proteins in Rat Liver" 2012 AAPS Annual Meeting and Exposition, AAPS (2012)
  • "An innovative dual-enzyme and dual-activation strategy for comprehensive and accurate characterization of protein arginine-methylation in Trypanosoma brucei" HUPO 2012 11th Annual World Congress, HUPO (2012)
  • "Clinical investigation of potential biomarkers for innate HIV-1 virus control in long-term-non-progressing patients using a comprehensive and reproducible ion-current-based proteomic expression profiling" HUPO 2012 11th Annual World Congress, HUPO (2012)
  • "Comparative proteomic analysis of isolated colon cancer cells from multiple patients using a comprehensive ion current based approach" HUPO 2012 11th Annual World Congress, HUPO (2012)
  • "Differential proteomic profiling of bronchoalveolar lavage fluid (BALF) for biomarker discovery in COPD" HUPO 2012 11th Annual World Congress, HUPO (2012)
  • "Extensive, proteome-level investigation of the corticosteroid pharmacodynamics with 12 time points using a reproducible and comprehensive ion-current-based profiling strategy" HUPO 2012 11th Annual World Congress, HUPO (2012)
  • "Investigation of the action mechanisms of new anti-carcinoma agents via high-resolution, comparative analysis of the drug-responsive proteomic signatures" HUPO 2012 11th Annual World Congress, HUPO (2012)
  • "MS1-based quantification: a promising strategy for large-cohort analysis" The European Bioinformatics Institute symposium, invited seminar (2012)
  • "Ultra-sensitive biomarker investigation and comprehensive proteomics profiling of drug-responsive proteins using low-flow LC/MS" XenoBiotic Laboratories, XenoBiotic Laboratories (2012)
  • "Biomarker discovery in chronic obstructive pulmonary disease: comparative proteome analysis of bronchoalveolar-lavage-fluid using a comprehensive and reproducible ion-current-based method" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
  • "Characterization of the Kinetics of Therapeutic Antibody Immune Complexes In Vivo Using Blue Native Electrophoresis and Targeted Nano-LC/MS Analysis" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
  • "Extensive, Proteome-Level Investigation of the Corticosteroid Pharmacodynamics with 12 Time Points Using a Reproducible and Comprehensive Ion-Current-Based Profiling Strategy" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
  • "Identification of Novel HIV-invasion-markers by Comparing Long-term-non-progressor vs. Normal-progressors among HIV-infected patients using comprehensive and reproducible ion-current-based proteomic expression profiling" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
  • "Ultrasensitive, high-throughput and Robust Quantification of monoclonal antibodies in tissues and plasma using a novel Trapping-micro-LC/MS strategy and OAO optimization" 60th ASMS conference on Mass Spectrometry and Allied Topics, ASMS (2012)
  • "accelerated Method Development for Sensitive, Accurate and Reproducible Quantification of Therapeutic Monoclonal Antibodies in Various Tissues Using Orthogonal-array-optimization and Nano-LC/SRM-MS" 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "An innovative dual-enzyme and dual-activation strategy for comprehensive and accurate characterization of protein arginine-methylation in Trypanosoma brucei." 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "An ion-current-based, comprehensive and reproducible proteomic strategy for comparative characterization anti-cancer agents in a prostate cell model" 2011 American Society for Mass Spectrometry annual meeting, ASMS (2011)
  • "An ion-overfilling approach that significantly improves the sensitivity of Orbitrap and application in highly sensitive and accurate proteomic profiling" 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "An ion-overfilling approach that significantly improves the sensitivity of Orbitrap and application in highly sensitive and accurate proteomic profiling" 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "Investigation of the effect of cocaine use and withdrawal in rat models using comprehensive and reproducible ion-current-based proteomic expression profiling" 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "Large-scale comparative proteomic analysis of isolated colon cancer cells from multiple patients using a comprehensive and reproducible ion-current-based method" 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "Molecular-level elucidation of the anti-carcinoma mechanisms of new agents via high-resolution, comparative analysis of the drug-responsive proteomic signatures" 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "Retina Proteome Profiling in a Rat Model of Smith-Lemli-Opitz Syndrome Using a comprehensive, precise and reproducible Ion-current-Based Method" 2011 American Society for Mass Spectrometry annual meeting (2011)
  • "Cutting edge LC/MS-based method for investigation of Ophthalmological proteome" (2011)
  • "Accurate quantification and validation of therapeutic macromolecules" "The Delaware Valley DRUG METABOLISM DISCUSSION GROUP Symposium" (2010)
  • "Targeted investigation of mAB by nano-LC/MS/MS" (2010)
  • "Ultra-sensitive quantification of therapeutic proteins" Buffalo Pharmaceutical Syposium (2010)
  • "A comprehensive analysis of Swine Plasma Proteome Using Combinatorial Peptide Ligand Libraries (CPLL), Dual-Enzyme Digestion and Dual-Activation sequencing with LTQ/Orbitrap/ETD" 2011 American Society for Mass Spectrometry annual meeting (2010)
  • "A high resolution, highly reproducible and sensitive nano_LC configuration that is particularly suitable for large-scale label-free expression profiling" 2010 American Society for Mass Spectrometry annual meeting (2010)
  • "A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application in clinical analysis" 2010 ASMS Anuual Meeting (2010)
  • "A rapid, reproducible, on-the-fly orthogonal array optimization method for targeted protein quantification by LC/MS and its application in clinical analysis" 2010 ASMS Anuual Meeting (2010)
  • "Exploring Cyclic Peptide Fragmentation by Electron Transfer Dissociation Coupled to Orbitrap Mass Spectrometry" 2010 American Society for Mass Spectrometry annual meeting (2010)
  • "Vitamin D and cognitive impairment in multiple sclerosis (MS)" American Academy of Neurology (2010)
  • "Vitamin D metabolites are linked to clinical and MRI outcomes in multiple sclerosis patients" American Academy of Neurology (2010)
  • "Photoaffinity labeling studies to better define the mechanism of action for Phase II oncology drug KX2-391 (KX01)" 239th National ACS Meeting, San Francisco, CA, March 22, 2010 (2010)
  • "Identification Of Cysteine Residues In ALDH2 Responsible" Experimental Biology 2009, FASEB (2009)
  • "High-resolution MS1 approach for selective and sensitive quantification of large cohorts: less label, more free" invited talk at Broad Institute by MIT-Harvard, ThermoFisher Scientifics
See all (102 more)

Service Activities:

  • Pharmacy Practice, School of Pharmacy Curriculum Committee; Member (2011)
  •  Evaluation of tenure and promotion case for Roswell Park Cancer Institute; Evaluation of tenure and promotion case for Roswell Park Cancer Institute; Committee Member (2019)
  •  Evaluation of tenure and promotion case; Evaluation of tenure and promotion case for University of Rochester; Other (2017)
  • Session organizer and chair; Session organizer and chair: US Human Proteome Organization; Chair (2017)
  •  Chair; Chair, Committee on Career and Professional Development, Chinese American Association of Mass Spectrometry (2107-); Chair (2017–present)
  • Session Chair; Session Chair: Eastern Analytical Symposium (2016)
  •  Grant reviewing panel; Grant reviewing panel: Hong Kong Research Grants Council: Collaborative Grants Scheme; Grant Reviewer (2016)
  • UB Faculty Senate; 2016-present UB Faculty Senate; Senator (2016–present)
  •  Grant reviewing panel;  Grant reviewing panel: NASA Human Exploration Research Opportunities Omics grants; Grant Reviewer (2015–2016)
  •  Committee organizer;  Committee organizer for Early Career Competition, HUMAN PROTEOME ORGANIZATION; Committee Member (2015)
  • Session organizer; Session organizer of the American Society of Mass Spectrometry 2015 conference; Other (2015)
  • Committee; 2015-present Committee for selection of applicants to NSF-Major Research Instrumentation Program of UB; Committee Member (2015–present)
  •  Co-Organizer;  Co-Organizer of the Clinical Day, HUMAN PROTEOME ORGANIZATION 2014; Committee Member (2014)
  • Reviewer; Reviewer for Buffalo IMPACT grants; Reviewer (2014)
  • Chair; 2012–2013 Chair of Departmental Seminar Series; Chair (2012–2013)
  •  Abstract reviewer and oral session co-organizer; Abstract reviewer and oral session co-organizer, 2012 American Society for Mass Spectrometry (ASMS) Meeting; Reviewer (2012)
  • Committee member; 2012 Committee member for the recruitment of research assistant professor (Department of Pharmaceutical Sciences); Committee Member (2012)
  • Runing the proteomics and pharmaceutical analysis facility; Assist and provide expertise and resource to the faculty member in PHC and other departments for proteomic analysis and pharmaceutical analysis. collaborated with >20 groups.; Other (2009)
  • Journal peer-review activities; Analytical Chemistry, Circulation Research, Journal of Chromatography A, Journal of Chromatography B, Journal of Separation Sciences, Journal of Proteomics, Proteomics, Journal of Pharmaceutical and Biomedical Analysis, Journal of Proteome Research, Journal of American Society for Mass Spectrometry, Journal of the American College of Cardiology, American Association of Pharmaceutical Science Journal, Rapid Communications in Mass Spectrometry, Journal of Proteomics, Molecular Vision, Nature Nanotechnology, Nature Method, Nature Biotechnology, Nature Communications, Scientific Reports .; Peer Reviewer (2005–present)
  • Running the COE proteomics core facility; Other

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Contact Information

318 Pharmacy Building
Buffalo, NY 14214-8033
Phone: (716) 645-4821
Fax: (716) 645-4821
junqu@buffalo.edu