Recent Faculty Publications
Praveen Arany
- Tang E, Khan I, Andreana S, Arany PR. Laser-activated transforming growth factor-β1 induces human β-defensin 2: implications for laser therapies for periodontitis and peri-implantitis. J Periodontal Res. 2017; 52(3)
- Rahman SU, Arany PR. 3D bioprinting: prostheses-restorations…now, tissues and organ systems! Oral Dis. 2017; 23(4)
- Engel KW, Khan I, Arany PR. Cell lineage responses to photobiomodulation therapy. J Biophotonics. 2016; 9(11-12)
James Bangs, PhD
- Umaer K, Bush PJ, Bangs JD. Rab11 mediates selective recycling and endocytic trafficking in Trypanosoma brucei. Traffic. 2018
- Kruzel EK, Zimmett GP, Bangs JD. Life Stage-Specific Cargo Receptors Facilitate Glycosylphosphatidylinositol-Anchored Surface Coat Protein Transport in Trypanosoma brucei. mSphere. 2017; 2(4)
- Tiengwe C, Bush PJ, Bangs JD. Controlling transferrin receptor trafficking with GPI-valence in bloodstream stage African trypanosomes. PLoS Pathog. 2017; 13(5)
Caroline Bass, PhD
- Bernstein DL, Badve PS, Barson JR, Bass CE, España RA. Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine. Addict Biol. 2017
- Illiano P, Bass CE, Fichera L, Mus L, Budygin EA, Sotnikova TD, Leo D, Espinoza S, Gainetdinov RR. Recombinant Adeno-Associated Virus-mediated rescue of function in a mouse model of Dopamine Transporter Deficiency Syndrome. Sci Rep. 2017; 7
- Edwards NJ, Tejeda HA, Pignatelli M, Zhang S, McDevitt RA, Wu J, Bass CE, Bettler B, Morales M, Bonci A. Circuit specificity in the inhibitory architecture of the VTA regulates cocaine-induced behavior. Nat Neurosci. 2017; 20(3)
Arin Bhattacharjee, PhD
- Gururaj S, Palmer EE, Sheehan GD, Kandula T, Macintosh R, Ying K, Morris P, Tao J, Dias KR, Zhu Y, Dinger ME, Cowley MJ, Kirk EP, Roscioli T, Sachdev R, Duffey ME, Bye A, Bhattacharjee A. A De Novo Mutation in the Sodium-Activated Potassium Channel KCNT2 Alters Ion Selectivity and Causes Epileptic Encephalopathy. Cell Rep. 2017; 21(4)
- Gururaj S, Evely KM, Pryce KD, Li J, Qu J, Bhattacharjee A. Protein Kinase A induced internalization of Slack channels from the neuronal membrane occurs by Adaptor Protein-2/Clathrin mediated endocytosis. J Biol Chem. 2017
- Tomasello DL, Hurley E, Wrabetz L, Bhattacharjee A. Slick (Kcnt2) Sodium-Activated Potassium Channels Limit Peptidergic Nociceptor Excitability and Hyperalgesia. J Exp Neurosci. 2017; 11
Ira Blader, PhD
- Jin RM, Blair SJ, Warunek J, Heffner RR, Blader IJ, Wohlfert EA. Regulatory T Cells Promote Myositis and Muscle Damage in Toxoplasma gondii Infection. J Immunol. 2017; 198(1)
- Dittmar AJ, Drozda AA, Blader IJ. Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth. mSphere. 2016; 1(2)
- Rahman K, Zhao P, Mandalasi M, van der Wel H, Wells L, Blader IJ, West CM. The E3 Ubiquitin Ligase Adaptor Protein Skp1 Is Glycosylated by an Evolutionarily Conserved Pathway That Regulates Protist Growth and Development. J Biol Chem. 2016; 291(9)
Michael Buck, PhD
- Adelaiye-Ogala R, Budka J, Damayanti NP, Arrington J, Ferris M, Hsu CC, Chintala S, Orillion A, Miles KM, Shen L, Elbanna M, Ciamporcero E, Arisa S, Pettazzoni P, Draetta GF, Seshadri M, Hancock B, Radovich M, Kota J, Buck M, Keilhack H, McCarthy BP, Pers. EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming. Cancer Res. 2017; 77(23)
- Yacoub R, Nugent M, Cai W, Nadkarni GN, Chaves LD, Abyad S, Honan AM, Thomas SA, Zheng W, Valiyaparambil SA, Bryniarski MA, Sun Y, Buck M, Genco RJ, Quigg RJ, He JC, Uribarri J. Advanced glycation end products dietary restriction effects on bacterial gut microbiota in peritoneal dialysis patients; a randomized open label controlled trial. PLoS One. 2017; 12(9)
- Jiao N, Baker SS, Chapa Rodriguez A, Liu W, Nugent CA, Tsompana M, Mastrandrea LD, Buck M, Baker RD, Genco RJ, Zhu R, Zhu L. Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD. Gut. 2017
Anthony Campagnari, PhD
- Brooks EK, Ahn R, Tobias ME, Hansen LA, Luke-Marshall NR, Wild L, Campagnari AA, Ehrensberger MT. Magnesium alloy AZ91 exhibits antimicrobial properties in vitro but not in vivo. J Biomed Mater Res B Appl Biomater. 2017
- Reddinger RM, Luke-Marshall NR, Hakansson AP, Campagnari AA. Host Physiologic Changes Induced by Influenza A Virus Lead to Staphylococcus aureus Biofilm Dispersion and Transition from Asymptomatic Colonization to Invasive Disease. MBio. 2016; 7(4)
- Ren D, Almudevar AL, Murphy TF, Lafontaine ER, Campagnari AA, Luke-Marshall N, Casey JR, Pichichero ME. Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children. Vaccine. 2015; 33(43)
Terry Connell, PhD
- El-Kassas S, Faraj R, Martin K, Hajishengallis G, Connell TD, Nashar T. Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits. Cell Immunol. 2015; 295(2)
John Crane, MD, PhD
- Bunnell BE, Escobar JF, Bair KL, Sutton MD, Crane JK. Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli. PLoS One. 2017; 12(5)
- Wright TE, Boyle KK, Duquin TR, Crane JK. Propionibacterium acnes Susceptibility and Correlation with Hemolytic Phenotype Infect Dis (Auckl). 2016; 9
- Crane JK, Broome JE, Lis A. Biological Activities of Uric Acid in Infection due to Enteropathogenic and Shiga-toxigenic Escherichia coli. Infect Immun. 2016
David Dietz, PhD
- Chandra R, Engeln M, Schiefer C, Patton MH, Martin JA, Werner CT, Riggs LM, Francis TC, McGlincy M, Evans B, Nam H, Das S, Girven K, Konkalmatt P, Gancarz AM, Golden SA, Iñiguez SD, Russo SJ, Turecki G, Mathur BN, Creed M, Dietz DM, Lobo MK. Drp1 Mitochondrial Fission in D1 Neurons Mediates Behavioral and Cellular Plasticity during Early Cocaine Abstinence. Neuron. 2017; 96(6)
- Martin JA, Caccamise A, Werner CT, Viswanathan R, Polanco JJ, Stewart AF, Thomas SA, Sim FJ, Dietz DM, Dietz D. A Novel Role for Oligodendrocyte Precursor Cells (OPCs) and Sox10 in Mediating Cellular and Behavioral Responses to Heroin. Neuropsychopharmacology. 2017
- Cahill ME, Walker DM, Gancarz AM, Wang ZJ, Lardner CK, Bagot RC, Neve RL, Dietz DM, Nestler EJ. The dendritic spine morphogenic effects of repeated cocaine use occur through the regulation of serum response factor signaling. Mol Psychiatry. 2017
Margarita Dubocovich, PhD
- Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML. MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2015
Rosemary Dziak
- Liu Z, Yuan X, Fernandes G, Dziak R, Ionita C. N, Li C, .... The combination of nano-calcium sulfate/platelet rich plasma gel scaffold with BMP2 gene-modified mesenchymal stem cells promotes bone regeneration in rat critical-sized calvarial defects Stem Cell Research & Therapy. 2017; 8(1)
- Tyler Laurel, Mally Perelman Karmon, Dinh Nguyen and Rosemary Dziak. Nanocalcium sulfate and collagen biomaterials: Effects on osteoblastic cells. Dent Oral Craniofac Res. 2017; 3(4)
- Laurel T, Perelman Karmon M, Nguyen D, Dziak, R.. Nanocalcium sulfate and collagen biomaterials: Effects on osteoblastic cells. (2017) Dent Oral Craniofac Res, 3(4): 2-5: doi: 10.15761/DOCR.1000210. Dent Oral Craniofac Res. 2017; 3(4)
Arthur Edelman, PhD
- Gocher AM, Azabdaftari G, Euscher LM, Dai S, Karacosta LG, Franke TF, Edelman AM. Akt activation by Ca2+/calmodulin-dependent Kinase Kinase-2 in Ovarian Cancer Cells Journal of Biological Chemistry. 2017; 292(34)
- Karacosta LG, Kuroski LK, Hofmann WA, Azabdaftari G, Mastri M, Gocher AG, Dai S, Hoste A.J., Edelman AM. Nucleoporin 62 and Ca2+/calmodulin dependent kinase kinase 2 regulate androgen receptor activity in castrate resistant prostate cancer cells The Prostate. 2016; 76(3)
Mira Edgerton
- Du H, Puri S, McCall A, Norris HL, Russo T, Edgerton M. Human Salivary Protein Histatin 5 Has Potent Bactericidal Activity against ESKAPE Pathogens. Front Cell Infect Microbiol. 2017; 7
- Cullen PJ, Edgerton M. Unmasking fungal pathogens by studying MAPK-dependent cell wall regulation in Candida albicans. Virulence. 2016; 7(5)
- Saraswat D, Kumar R, Pande T, Edgerton M, Cullen PJ. Signalling mucin Msb2 Regulates adaptation to thermal stress in Candida albicans. Mol Microbiol. 2016; 100(3)
M. Laura Feltri, MD
- VerPlank JJS, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L. Impairment of protein degradation and proteasome function in hereditary neuropathies.. Glia. 2017; 66(2)
- Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, Moparthy K, Fink EE, Bagati A, Hurley E, Affronti HC, Bakin AV, Kandel ES, Smiraglia DJ, Feltri ML, Sousa R, Nikiforov MA. Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.. Nat Methods. 2017; 14(10)
- Ghidinelli M, Poitelon Y, Shin YK, Ameroso D, Williamson C, Ferri C, Pellegatta M, Espino K, Mogha A, Monk K, Podini P, Taveggia C, Nave KA, Wrabetz L, Park HT, Feltri ML. Laminin 211 inhibits protein kinase A in Schwann cells to modulate neuregulin 1 type III-driven myelination.. PLoS Biol. 2017; 15(6)
Jian Feng, PhD
- Z Xu, H Jiang, P Zhong, Z Yan, S Chen, J Feng. Direct Conversion of Human Fibroblasts to Induced Serotonergic Neurons Molecular Psychiatry. 2015
- Z Hu, J Pu, H Jiang, P Zhong, J Qiu, F Li, X Wang, B Zhang, Z Yan, J Feng. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson’s Disease Patients for High Efficiency Genetic Manipulation and Disease Modeling Stem Cells and Development. 2015
Steven Fliesler, PhD
- Aslebagh R, Pfeffer BA, Fliesler SJ, Darie CC. Mass spectrometry-based proteomics of oxidative stress: Identification of 4-hydroxy-2-nonenal (HNE) adducts of amino acids using lysozyme and bovine serum albumin as model proteins. Electrophoresis. 2016; 37(20)
- Pfeffer BA, Xu L, Porter NA, Rao SR, Fliesler SJ. Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density. Exp Eye Res. 2016; 145
Daniel Gewirth, PhD
- Que NLS, Crowley VM, Duerfeldt AS, Zhao J, Kent CN, Blagg BSJ, Gewirth DT. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding. J Med Chem. 2018; 61(7)
- Dalal K, Che M, Que NS, Sharma A, Yang R, Lallous N, Borgmann H, Ozistanbullu D, Tse R, Ban F, Li H, Tam KJ, Roshan-Moniri M, LeBlanc E, Gleave ME, Gewirth DT, Dehm SM, Cherkasov A, Rennie PS. Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions. Mol Cancer Ther. 2017; 16(10)
- Huck JD, Que NL, Hong F, Li Z, Gewirth DT. Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site. Cell Rep. 2017; 20(12)
Richard Gronostajski, PhD
- Ding B, Cave JW, Dobner PR, Mullikin-Kilpatrick D, Bartzokis M, Zhu H, Chow CW, Gronostajski RM, Kilpatrick DL. Reciprocal autoregulation by NFI occupancy and ETV1 promotes the developmental expression of dendrite-synapse genes in cerebellar granule neurons. Mol Biol Cell. 2016; 27(9)
- Grabowska MM, Kelly SM, Reese AL, Cates JM, Case TC, Zhang J, DeGraff DJ, Strand DW, Miller NL, Clark PE, Hayward SW, Gronostajski RM, Anderson PD, Matusik RJ. Nfib Regulates Transcriptional Networks That Control the Development of Prostatic Hyperplasia. Endocrinology. 2016; 157(3)
- Heng YH, Zhou B, Harris L, Harvey T, Smith A, Horne E, Martynoga B, Andersen J, Achimastou A, Cato K, Richards LJ, Gronostajski RM, Yeo GS, Guillemot F, Bailey TL, Piper M. NFIX Regulates Proliferation and Migration Within the Murine SVZ Neurogenic Niche. Cereb Cortex. 2015; 25(10)
Andrew Gulick, PhD
- Bailey DC, Alexander E, Rice MR, Drake EJ, Mydy LS, Aldrich CC, Gulick AM. Structural and functional delineation of aerobactin biosynthesis in hypervirulent Klebsiella pneumoniae. J Biol Chem. 2018; 293(20)
- Gulick AM. Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens. Nat Prod Rep. 2017; 34(8)
- Clevenger KD, Mascarenhas R, Catlin D, Wu R, Kelleher NL, Drake EJ, Gulick AM, Liu D, Fast W. Substrate Trapping in the Siderophore Tailoring Enzyme PvdQ. ACS Chem Biol. 2017; 12(3)
Marc Halfon, PhD
- Suryamohan K, Hanson C, Andrews E, Sinha S, Scheel MD, Halfon MS. Redeployment of a conserved gene regulatory network during Aedes aegypti development. Dev Biol. 2016
Wilma Hofmann, PhD
- Maly IV, Hofmann WA. Calcium and Nuclear Signaling in Prostate Cancer. Int J Mol Sci. 2018; 19(4)
- Maly IV, Domaradzki TM, Gosy VA, Hofmann WA. Myosin isoform expressed in metastatic prostate cancer stimulates cell invasion. Sci Rep. 2017; 7(1)
- Maly IV, Hofmann WA. Calcium-regulated import of myosin IC into the nucleus. Cytoskeleton (Hoboken). 2016; 73(7)
Amy Jacobs, PhD
- Allen WJ, Yi HA, Gochin M, Jacobs A, Rizzo RC. Small molecule inhibitors of HIVgp41 N-heptad repeat trimer formation. Bioorg Med Chem Lett. 2015; 25(14)
Jason Kay
- Croft AJ, Metcalfe S, Honma K, Kay JG. Macrophage polarization alters post-phagocytosis survivability of the commensal Streptococcus gordonii. Infect Immun. 2017
- Hirama T, Lu SM, Kay JG, Maekawa M, Kozlov MM, Grinstein S, Fairn GD. Membrane curvature induced by proximity of anionic phospholipids can initiate endocytosis. Nat Commun. 2017; 8(1)
- Hirama T, Das R, Yang Y, Ferguson C, Won A, Yip CM, Kay JG, Grinstein S, Parton RG, Fairn GD. Phosphatidylserine dictates the assembly and dynamics of caveolae in the plasma membrane. J Biol Chem. 2017
John Kolega, PhD
- Tutino VM, Poppenberg KE, Jiang K, Jarvis JN, Sun Y, Sonig A, Siddiqui AH, Snyder KV, Levy EI, Kolega J, Meng H. Circulating neutrophil transcriptome may reveal intracranial aneurysm signature. PLoS One. 2018; 13(1)
- Tutino VM, Liaw N, Spernyak JA, Ionita CN, Siddiqui AH, Kolega J, Meng H. Assessment of Vascular Geometry for Bilateral Carotid Artery Ligation to Induce Early Basilar Terminus Aneurysmal Remodeling in Rats. Curr Neurovasc Res. 2016; 13(1)
- Tutino VM, Mandelbaum M, Takahashi A, Pope LC, Siddiqui A, Kolega J, Meng H. Hypertension and Estrogen Deficiency Augment Aneurysmal Remodeling in the Rabbit Circle of Willis in Response to Carotid Ligation. Anat Rec (Hoboken). 2015; 298(11)
Daniel Kosman, PhD
- Bailão EF, Lima PDE S, Silva-Bailão MG, Bailão AM, Fernandes GDA R, Kosman DJ, Soares CM. Paracoccidioides spp. ferrous and ferric iron assimilation pathways. Front Microbiol. 2015; 6
- McCarthy RC, Kosman DJ. Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier. Front Mol Neurosci. 2015; 8
- Ji C, Kosman DJ. Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons. J Neurochem. 2015; 133(5)
Jill Kramer
- Kiripolsky J, McCabe LG, Gaile DP, Kramer JM. Myd88 is required for disease development in a primary Sjogren‘s syndrome mouse model. J Leukoc Biol. 2017
- Alshagroud R, Neiders M, Kramer JM, Suresh L. Clinicopathologic significance of in vivo antinuclear autoantibodies in oral mucosal biopsies. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017
- Alhousami T, Sabharwal A, Gupta S, Aguirre A, Park E, Kramer JM. Fibromyxoma of the Jaw: Case Report and Review of the Literature. Head Neck Pathol. 2017
Te-Chung Lee, PhD
- Martin S, Lin H, Ejimadu C, Lee T. Tissue-nonspecific alkaline phosphatase as a target of sFRP2 in cardiac fibroblasts. Am J Physiol Cell Physiol. 2015; 309(3)
Alan Lesse, MD
- Shafiq I, Bulman ZP, Spitznogle SL, Osorio JE, Reilly IS, Lesse AJ, Parameswaran GI, Mergenhagen KA, Tsuji BT. A combination of ceftaroline and daptomycin has synergistic and bactericidal activity in vitro against daptomycin nonsusceptible methicillin-resistant Staphylococcus aureus (MRSA). Infect Dis (Lond). 2017
- Ibrahim LA, Sellick JA, Watson EL, McCabe LM, Schoenhals KA, Martinello RA, Lesse AJ. An Outbreak of Severe Group A Streptococcus Infections Associated with Podiatric Application of a Biologic Dermal Substitute. Infect Control Hosp Epidemiol. 2016; 37(3)
- Ibrahim LA, Sellick JA, Watson EL, McCabe LM, Schoenhals KA, Martinello RA, Lesse AJ, Sellick, Jr JA. An Outbreak of Severe Group A Streptococcus Infections Associated with Podiatric Application of a Biologic Dermal Substitute. Infect Control Hosp Epidemiol. 2015
Jun-Xu Li, MD, PhD
- Liu JF, Li JX, Li J. TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg. Front Pharmacol. 2018; 9
- Siemian JN, Jia S, Liu JF, Zhang Y, Li JX, Li J. Neuroanatomical characterization of imidazoline I2receptor agonist-induced antinociception. Eur J Neurosci. 2018
- Liu JF, Seaman R, Siemian JN, Bhimani R, Johnson B, Zhang Y, Zhu Q, Hoener MC, Park J, Dietz DM, Li JX, Li J. Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects. Neuropsychopharmacology. 2018
Michael Malkowski, PhD
- Perez AC, Johnson A, Chen Z, Wilding GE, Malkowski MG, Murphy TF. Mapping protective regions on a three-dimensional model of the Moraxella catarrhalis vaccine antigen, Oligopeptide Permease A. Infect Immun. 2017
- Murphy TF, Brauer AL, Johnson A, Wilding GE, Koszelak-Rosenblum M, Malkowski MG. A Cation-binding Surface Protein as a Vaccine Antigen to Prevent Moraxella catarrhalis Otitis Media and Infections in Chronic Obstructive Pulmonary Disease. Clin Vaccine Immunol. 2017
- Dong L, Yuan C, Orlando BJ, Malkowski MG, Smith WL. Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. J Biol Chem. 2016; 291(49)
Thomas Melendy, PhD
- Sharma R, Tzetzo S, Patel S, Zachariah M, Sharma S, Melendy T. BK Virus in Kidney Transplant: Current Concepts, Recent Advances, and Future Directions. Exp Clin Transplant. 2016; 14(4)
- Bergvall M, Gagnon D, Titolo S, Lehoux M, D'Abramo CM, Melendy T, Archambault J. Requirement for the E1 Helicase C-Terminal Domain in Papillomavirus DNA Replication In Vivo. J Virol. 2016; 90(6)
Xiuqian Mu, MD, PhD
- Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD. Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development. 2017; 144(9)
Timothy Murphy, MD
- Tsuji BT, Fisher J, Boadi-Yeboah R, Holden PN, Sethi S, Pettigrew MM, Murphy TF. Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Antimicrob Agents Chemother. 2018; 62(2)
- Murphy TF, Kirkham C, Gallo MC, Yang Y, Wilding GE, Pettigrew MM. Immunoglobulin A Protease Variants Facilitate Intracellular Survival in Epithelial Cells By Nontypeable Haemophilus influenzae That Persist in the Human Respiratory Tract in Chronic Obstructive Pulmonary Disease. J Infect Dis. 2017; 216(10)
- Perez AC, Murphy TF. A Moraxella catarrhalis vaccine to protect against otitis media and exacerbations of COPD: An update on current progress and challenges. Hum Vaccin Immunother. 2017; 13(10)
Mark O‘Brian, PhD
- Chatterjee A, O'Brian MR, O‘Brian MR. Rapid evolution of a bacterial iron acquisition system. Mol Microbiol. 2018
- Costa D, Amarelle V, Valverde C, O'Brian MR, Fabiano E, O‘Brian MR. The Irr and RirA Proteins Participate in a Complex Regulatory Circuit and Act in Concert To Modulate Bacterioferritin Expression in Ensifer meliloti 1021. Appl Environ Microbiol. 2017; 83(16)
- Dailey HA, Dailey TA, Gerdes S, Jahn D, Jahn M, O'Brian MR, Warren MJ, O‘Brian MR. Prokaryotic Heme Biosynthesis: Multiple Pathways to a Common Essential Product. Microbiol Mol Biol Rev. 2017; 81(1)
James O‘Donnell, PhD
- Huang XF, Jiang WT, Liu L, Song FC, Zhu X, Shi GL, Ding SM, Ke HM, Wang W, O'Donnell JM, Zhang HT, Luo HB, Wan YQ, Song GQ, Xu Y, O‘Donnell JM. A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling. CNS Neurosci Ther. 2018
- Liu L, Zheng J, Huang XF, Zhu X, Ding SM, Ke HM, O'Donnell JM, Zhang HT, Song GQ, Xu Y, O‘Donnell JM. The neuroprotective and antidepressant-like effects of Hcyb1, a novel selective PDE2 inhibitor. CNS Neurosci Ther. 2018
- Poloyac SM, Block KF, Cavanaugh JE, Dwoskin LP, Melchert RB, Nemire RE, O'Donnell JM, Priefer R, Touchette DR. Competency, Programming, and Emerging Innovation in Graduate Education within Schools of Pharmacy: The Report of the 2016-2017 Research and Graduate Affairs Committee. Am J Pharm Educ. 2017; 81(8)
Pablo Paez, PhD
- Siemian JN, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li JX, Li J. The imidazoline I2receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochem Pharmacol. 2018
- Santiago González DA, Cheli VT, Zamora NN, Lama TN, Spreuer V, Murphy GG, Paez PM. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice. J Neurosci. 2017; 37(42)
- Cheli VT, Santiago González DA, Namgyal Lama T, Spreuer V, Handley V, Murphy GG, Paez PM. Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice. J Neurosci. 2016; 36(42)
John Panepinto, PhD
- Bloom ALM, Leipheimer J, Panepinto JC. mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans. Wiley Interdiscip Rev RNA. 2017; 8(5)
- Banerjee D, Umland TC, Panepinto JC. De Novo Pyrimidine Biosynthesis Connects Cell Integrity to Amphotericin B Susceptibility in Cryptococcus neoformans. mSphere. 2016; 1(6)
- Banerjee D, Bloom AL, Panepinto JC. Opposing PKA and Hog1 signals control the post-transcriptional response to glucose availability in Cryptococcus neoformans. Mol Microbiol. 2016; 102(2)
Mark Parker, PhD
- Myers EJ, Marshall A, Parker MD. The role of disease-linked residue glutamine-913 in support of the structure and function of the human electrogenic sodium/bicarbonate cotransporter NBCe1-A. Sci Rep. 2018; 8(1)
- Parker MD. Mouse Models of SLC4-linked Disorders of HCO3- Transporter Dysfunction. Am J Physiol Cell Physiol. 2018
- Schlader ZJ, Chapman CL, Sarker S, Russo L, Rideout TC, Parker MD, Johnson BD, Hostler D. Firefighter Work Duration Influences the Extent of Acute Kidney Injury. Med Sci Sports Exerc. 2017
Mulchand Patel, PhD
- Guevara EL, Yang L, Birkaya B, Zhou J, Nemeria NS, Patel MS, Jordan F. Global view of cognate kinase activation by the human pyruvate dehydrogenase complex. Sci Rep. 2017; 7
- Masini T, Birkaya B, van Dijk S, Mondal M, Hekelaar J, Jäger M, Terwisscha van Scheltinga AC, Patel MS, Hirsch AK, Moman E. Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site. J Enzyme Inhib Med Chem. 2016; 31(sup4)
- Mahmood S, Birkaya B, Rideout TC, Patel MS. Lack of mitochondria-generated acetyl-CoA by pyruvate dehydrogenase complex downregulates gene expression in the hepatic de novo lipogenic pathway. Am J Physiol Endocrinol Metab. 2016; 311(1)
Gabriela Popescu, PhD
- Iacobucci GJ, Popescu GK. Resident Calmodulin Primes NMDA Receptors for Ca2+-Dependent Inactivation. Biophys J. 2017; 113(10)
- Zheng W, Wen H, Iacobucci GJ, Popescu GK. Probing the Structural Dynamics of the NMDA Receptor Activation by Coarse-Grained Modeling. Biophys J. 2017; 112(12)
- Cummings KA, Belin S, Popescu GK. Residues in the GluN1 C-terminal domain control kinetics and pharmacology of GluN1/GluN3A N-methyl-d-aspartate receptors. Neuropharmacology. 2017; 119
Jun Qu, PhD
- Liu G, Cheng K, Lo CY, Li J, Qu J, Neelamegham S. A Comprehensive, Open-source Platform for Mass Spectrometry-based Glycoproteomics Data Analysis. Mol Cell Proteomics. 2017; 16(11)
- Gururaj S, Evely KM, Pryce KD, Li J, Qu J, Bhattacharjee A. Protein Kinase A induced internalization of Slack channels from the neuronal membrane occurs by Adaptor Protein-2/Clathrin mediated endocytosis. J Biol Chem. 2017
- Zhou S, Vazvaei F, Ferrari L, Qu J. Practical considerations in enhancing LC-MS sensitivity for therapeutic protein bioanalysis. Bioanalysis. 2017; 9(18)
Rajendram Rajnarayanan, PhD
- Badal S, Turfus S, Rajnarayanan R, Wilson-Clarke C, Sandiford SL. Analysis of Natural Product Regulation of Opioid Receptors in the treatment of Human Disease. Pharmacol Ther. 2017
- Asare, Bethany, Yawson, Emmanuel, Rajnarayanan R. Flexible Small Molecular Anti-estrogens with N,N-dialkylated-2,5-diethoxy-4-morpholinoaniline scaffold Targets Multiple Estrogen Receptor Conformations. Cell Cycle. 2017
- Badal S, Smith K N, Rajnarayanan R V. Analysis of Natural Product Regulation of Cannabinoid Receptors in the treatment of Human Disease. Pharmacology and Therapeutics. 2017
Rose-Anne Romano
- Gluck C, Min S, Oyelakin A, Smalley K, Sinha S, Romano RA, Romano R. RNA-seq based transcriptomic map reveals new insights into mouse salivary gland development and maturation. BMC Genomics. 2016; 17(1)
- Si H, Lu H, Yang X, Mattox A, Jang M, Bian Y, Sano E, Viadiu H, Yan B, Yau C, Ng S, Lee SK, Romano RA, Davis S, Walker RL, Xiao W, Sun H, Wei L, Sinha S, Benz CC, Stuart JM, Meltzer PS, Van Waes C, Chen Z, Romano R. TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer. Oncogene. 2016; 35(44)
- Rizzo JM, Oyelakin A, Min S, Smalley K, Bard J, Luo W, Nyquist J, Guttman-Yassky E, Yoshida T, De Benedetto A, Beck LA, Sinha S, Romano RA, Romano R. ΔNp63 regulates IL-33 and IL-31 signaling in atopic dermatitis. Cell Death Differ. 2016; 23(6)
Stefan Ruhl
- Thamadilok S, Khedri Z, Deng L, Gill A, Lettrichova I, Diaz S, Gill S, Varki A, Ruhl S. Human oral streptococci that bind to a non-human sialic acid. J. Dent. Res.. 2017; 96(A)
- Xu D, Pavlidis P, Taskent RO, Alachiotis N, Flanagan C, DeGiorgio M, Blekhman R, Ruhl S, Gokcumen O. Archaic hominin introgression in Africa contributes to functional salivary MUC7 genetic variation. Mol. Biol. Evol. (Epub). 2017
- Xu D, Pavlidis P, Thamadilok S, Redwood E, Fox S, Blekhman R, Ruhl S, Gokcumen O. Recent evolution of the salivary mucin MUC7. Sci Rep. 2016; 6
Thomas Russo, MD
- Johnson JR, Russo TA. Molecular Epidemiology of Extraintestinal Pathogenic Escherichia coli. EcoSal Plus. 2018; 8(1)
- Johnson JR, Russo TA. Acute Pyelonephritis in Adults. N Engl J Med. 2018; 378(1)
- Wang-Lin SX, Olson R, Beanan JM, MacDonald U, Balthasar JP, Russo TA. The Capsular Polysaccharide of Acinetobacter baumannii Is an Obstacle for Therapeutic Passive Immunization Strategies. Infect Immun. 2017; 85(12)
Pinaki Sarder, PhD
- Simon O, Yacoub R, Jain S, Tomaszewski JE, Sarder P. Multi-radial LBP Features as a Tool for Rapid Glomerular Detection and Assessment in Whole Slide Histopathology Images. Sci Rep. 2018; 8(1)
- Ginley BG, Emmons T, Lutnick B, Urban CF, Segal BH, Sarder P. Computational detection and quantification of human and mouse neutrophil extracellular traps in flow cytometry and confocal microscopy. Sci Rep. 2017; 7(1)
- Narla ST, Lee YW, Benson CA, Sarder P, Brennand KJ, Stachowiak EK, Stachowiak MK. Common developmental genome deprogramming in schizophrenia - Role of Integrative Nuclear FGFR1 Signaling (INFS). Schizophr Res. 2017; 185
Frank Scannapieco
- Haase EM, Kou Y, Sabharwal A, Liao YC, Lan T, Lindqvist C, Scannapieco FA. Comparative genomics and evolution of the amylase-binding proteins of oral streptococci. BMC Microbiol. 2017; 17(1)
- Scannapieco FA, Amin S, Salme M, Tezal M. Factors associated with utilization of dental services in a long-term care facility: a descriptive cross-sectional study. Spec Care Dentist. 2017; 37(2)
- Passos-Soares JS, Vianna MI, Gomes-Filho IS, Cruz SS, Barreto ML, Adan LF, Rösing CK, Trindade SC, Cerqueira EM, Scannapieco FA. Association between osteoporosis treatment and severe periodontitis in postmenopausal women. Menopause. 2017
Stanley Schwartz, MD, PhD
- Aalinkeel R, Kutscher HL, Singh A, Cwiklinski K, Khechen N, Schwartz SA, Prasad PN, Mahajan SD. Neuroprotective effects of a biodegradable poly(lactic-co-glycolic acid)-ginsenoside Rg3 nanoformulation: a potential nanotherapy for Alzheimer's disease? J Drug Target. 2017
- Aalinkeel R, Mangum CS, Abou-Jaoude E, Reynolds JL, Liu M, Sundquist K, Parikh NU, Chaves LD, Mammen MJ, Schwartz SA, Mahajan SD. Galectin-1 Reduces Neuroinflammation via Modulation of Nitric Oxide-Arginase Signaling in HIV-1 Transfected Microglia: a Gold Nanoparticle-Galectin-1 "Nanoplex" a Possible Neurotherapeutic? J Neuroimmune Pharmacol. 2017; 12(1)
- Mahajan SD, Parikh NU, Woodruff TM, Jarvis JN, Lopez M, Hennon TR, Cunningham P, Quigg RJ, Schwartz SA, Alexander JJ. C5a alters blood-brain barrier integrity in a human in vitro model of systemic lupus erythematosus. Immunology. 2015; 146(1)
Ashu Sharma
- Ruscitto A, Honma K, Veeramachineni VM, Nishikawa K, Stafford GP, Sharma A. Regulation and Molecular Basis of Environmental Muropeptide Uptake and Utilization in Fastidious Oral Anaerobe Tannerella forsythia. Front Microbiol. 2017; 8
- Friedrich V, Janesch B, Windwarder M, Maresch D, Braun ML, Megson ZA, Vinogradov E, Goneau MF, Sharma A, Altmann F, Messner P, Schoenhofen IC, Schäffer C. Tannerella forsythia strains display different cell-surface nonulosonic acids: biosynthetic pathway characterization and first insight into biological implications. Glycobiology. 2017; 27(4)
- Chinthamani S, Settem RP, Honma K, Kay JG, Sharma A. Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia. PLoS One. 2017; 12(3)
Fraser Sim, PhD
- Martin JA, Caccamise A, Werner CT, Viswanathan R, Polanco JJ, Stewart AF, Thomas SA, Sim FJ, Dietz DM, Dietz D. A Novel Role for Oligodendrocyte Precursor Cells (OPCs) and Sox10 in Mediating Cellular and Behavioral Responses to Heroin. Neuropsychopharmacology. 2017
- Pol SU, Polanco JJ, Seidman RA, O‘Bara MA, Shayya HJ, Dietz KC, Sim FJ. Network-Based Genomic Analysis of Human Oligodendrocyte Progenitor Differentiation. Stem Cell Reports. 2017; 9(2)
- Wang ZJ, Martin JA, Gancarz AM, Adank DN, Sim FJ, Dietz DM. Activin A is increased in the nucleus accumbens following a cocaine binge. Sci Rep. 2017; 7
Animesh Sinha, MD, PhD
- Dey-Rao R, Sinha AA. Vitiligo blood transcriptomics provides new insights into disease mechanisms and identifies potential novel therapeutic targets. BMC Genomics. 2017; 18(1)
- Ahmed AR, Carrozzo M, Caux F, Cirillo N, Dmochowski M, Alonso AE, Gniadecki R, Hertl M, López-Zabalza MJ, Lotti R, Pincelli C, Pittelkow M, Schmidt E, Sinha AA, Sprecher E, Grando SA. Monopathogenic vs multipathogenic explanations of pemphigus pathophysiology. Exp Dermatol. 2016; 25(11)
- Hoffman MB, Bhandari RA, Sinha AA. Rituximab Use in Pediatric Dermatology. J Drugs Dermatol. 2016; 15(7)
John Sullivan, MD, PhD
- Yau EH, Butler MC, Sullivan JM. A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets. Exp Eye Res. 2016; 151
- Butler MC, Sullivan JM. A Novel, Real-Time, In Vivo Mouse Retinal Imaging System. Invest Ophthalmol Vis Sci. 2015; 56(12)
Yijun Sun, PhD
- Lott K, Mukhopadhyay S, Li J, Wang J, Yao J, Sun Y, Qu J, Read L. Arginine methylation of DRBD18 differentially impacts its opposing effects on the trypanosome transcriptome. Nucleic Acids Research. 2015; 43(11)
Jennifer Surtees, PhD
- Manhart CM, Ni X, White MA, Ortega J, Surtees JA, Alani E. The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans. PLoS Biol. 2017; 15(4)
- Rashev M, Surtees JA, Guarné A. Large-scale production of recombinant Saw1 in Escherichia coli. Protein Expr Purif. 2017; 133
- Brown MW, Kim Y, Williams GM, Huck JD, Surtees JA, Finkelstein IJ. Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions. Nat Commun. 2016; 7
Mark Sutton, PhD
- Kim JS, Nanfara MT, Chodavarapu S, Jin KS, Babu VM, Ghazy MA, Chung S, Kaguni JM, Sutton MD, Cho Y. Dynamic assembly of Hda and the sliding clamp in the regulation of replication licensing. Nucleic Acids Res. 2017
- Babu VM, Itsko M, Baxter JC, Schaaper RM, Sutton MD. Insufficient levels of the nrdAB-encoded ribonucleotide reductase underlie the severe growth defect of the ∆hda E. coli strain. Mol Microbiol. 2017
- Yuan Q, Dohrmann PR, Sutton MD, McHenry CS. DNA Polymerase III, but not Polymerase IV, Must be Bound to t-Containing DnaX Complex to Enable Exchange into Replication Forks. J Biol Chem. 2016
Mary Taub, PhD
- Taub M F. Cutuli. . Data on Na,K-ATPase in primary cultures of renal proximal tubule cells treated with catecholamines. Data in Brief. 2016; 6
- Taub M. 59.Cancer drug troglitazone stimulates the growth and response of renal cells to hypoxia inducible factor. Biohem Biophys Res Com. 2016; 471
- D. Saidani F. Hammoudi-Triki F. Labara-Djebari Taub M. In vitro studies with renal proximal tubule cells show direct cytotoxicity of Androctonus australis hector scorpion venom triggered by oxidative stress, caspase activation and apoptosis. Toxicon. 2016; 120
John Tomaszewski, MD, MASCP
- Cruz-Roa, A, Gilmore, H, Basavanhally, A, Feldman, M, Ganesan, S, Shih, NNC, Tomaszewski JE, Gonzalez, FA, Madabhushi, A. Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent Sci Rep. 2017; 10(1038)
- Cruz-Roa, A, Gilmore, H, Basavanhally, A, Feldman, M, Ganesan, S, Shih, NNC, Tomaszewski JE, Gonzalaez, FFA, Medabhushi, A. Accurate and reproducible invasive breast cancer detection in whole-slide images: A Deep Learning approach for quantifying tumor extent Sci Rep. 2017
- Ginley, B, Tomaszewski JE, Yacoub R, Chen F, Sarder P. Unsupervised labeling of glomerular boundaries using Gabor filters and statisical testing in renal histology epub. 2017
Susan Udin, PhD
- Personius KE, Slusher BS, Udin SB. Neuromuscular NMDA Receptors Modulate Developmental Synapse Elimination. J Neurosci. 2016; 36(34)
Noreen Williams, PhD
- Kamina AD, Jaremko D, Christen L, Williams N. Essential Assembly Factor Rpf2 Forms Novel Interactions within the 5S RNP in Trypanosoma brucei. mSphere. 2017; 2(5)
- Kamina AD, Williams N. Non-canonical binding interactions of the RNA recognition motif (RRM) domains of P34 protein modulate binding within the 5S ribonucleoprotein particle (5S RNP). PLoS One. 2017; 12(5)
- Kamina AD, Williams N. Ribosome Assembly in Trypanosomatids: A Novel Therapeutic Target. Trends Parasitol. 2017; 33(4)
Ding Xu, PhD
- Li M, Yang S, Xu D. Heparan Sulfate Regulates the Structure and Function of Osteoprotegerin in Osteoclastogenesis. J Biol Chem. 2016; 291(46)
- Durning SP, Preston-Hurlburt P, Clark PR, Xu D, Herold KC. The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus. Journal of Immunology. 2016; 197(8)
- Xu D, Olson J, Cole JN, van Wijk XM, Brinkmann V, Zychlinsky A, Nizet V, Esko JD, Chang YC. Heparan sulfate modulates neutrophil and endothelial function in antibacterial innate immunity Infection and immunity. 2015; 83(9)
Zhen Yan, PhD
- Qin L, Ma K, Wang ZJ, Hu Z, Matas E, Wei J, Yan Z. Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition. Nature Neuroscience. 2018; 21
- Zhong P, Hu Z, Jiang H, Yan Z, Feng J. Dopamine induces oscillatory activity in human midbrain neurons with Parkin mutation. Cell Reports. 2017; 19
- Wei J, Zhong P, Qin L, Tan T, Yan Z. Chemicogenetic restoration of the prefrontal cortex to amygadala pathway ameliorates stress-induced deficits. Cerebral Cortex. 2017; 00
Sarah Zhang, MD
- McLaughlin T, Falkowski M, Park JW, Keegan S, Elliott M, Wang JJ, Zhang SX. Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. Mol Neurodegener. 2018; 13(1)
- Bhatta M, Chatpar K, Hu Z, Wang JJ, Zhang SX. Reduction of Endoplasmic Reticulum Stress Improves Angiogenic Progenitor Cell function in a Mouse Model of Type 1 Diabetes. Cell Death Dis. 2018; 9(5)
- McLaughlin T, Falkowski M, Wang JJ, Zhang SX. Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases. Adv Exp Med Biol. 2018; 1074
