Glenna C. Bett PhD
Glenna C. Bett
PhD
Professional Summary:
Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.
We do this using a combination of techniques and approaches including 2 electrode clamp to study heterologously expressed channels, whole cell clamp to record currents in the native cell, and mathematical modelling to understand and interpret results.
Education and Training:
- BA, Physics, Oxford University
- BA, Physiology, Oxford University
- PhD, Oxford University
Employment:
- Deputy Director, Institute for Research and Education on Women and Gender (2012-present)
- Associate Professor, Obstetrics and Gynecology, State University of New York, University at Buffalo (2011-present)
- Vice Chair for Research, Obstetrics and Gynecology, Jacobs School of Medicine & Biomedical Sciences (2009-present)
- Director of Resident Research, Obstetrics and Gynecology, SUNY Jacobs School of Medicine & Biomedical Sciences (2007-present)
- Associate Director, Center for Cellular and Systems Electrophysiology (2004-present)
- Associate Director - B-SURE Program (2004-present)
- Research Assistant Professor, Physiology, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001-present)
- President, American Heart Association, Buffalo Niagara Region
- President, JSMBS Faculty Council (2015–2016)
- Assistant Professor, Obstetrics and Gynecology, SUNY, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2005–2011)
- Postdoctoral Research Associate, Physiology, The State Unviersity of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998–2001)
- American Heart Association, NY State Affiliate., Biophysical Sciences, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996–1998)
- Postdoctoral Research Associate, Biophysical Sciences, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1995–1996)
- Lecturer, Charing Cross and Westminster Medical School (1993–1995)
Awards and Honors:
- Winner, 43North (2015)
- Fellow, American Heart Association (2010)
- Gordon K Moe Young Investigator (2003)
Research Expertise:
- : Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.
Research Centers:
- Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
- Health and Wellness Across the Lifespan
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- January 2015–January 2016
Initial Validation of a Novel in vitro Arrhythmia Drug Safety Screening Assay
SUNY
Role: Principal Investigator
$50,000 - July 2011–June 2013
Sex Differences in Molecular Heterogeneity of Cardiac Repolarization
NIH
Role: Principal Investigator
$275,000 - May 2011–April 2012
Device to treat postpartum hemorrhage
Bill and Melinda Gates Foundation
Role: Principal Investigator
$100,000 - March 2008–February 2011
Repolarizing Current in Human Myometrium
March of Dimes Prematurity Initiative
Role: Principal Investigator
$241,170 - January 2008–January 2011
Repolarizing Currents in Human Myometrium
March of Dimes
Role: Principal Investigator
$241,170 - August 2007–July 2009
Molecular Basis of Automaticity in the Myometrium
NIH
Role: Principal Investigator
$100,000 - June 2007–June 2009
Automaticity in the myometrium
NIH
Role: Principal Investigator
$100,000 - January 2004–December 2007
Pathophysiology of HERG Gating and Permeation During Ischemia: Effect of pHo and K+
American Heart Association
Role: Principal Investigator
$472,728 - November 2004–October 2005
Role of Hyperpolarization activated cation (HCN) Channels in GnRH Neurons
Interdisciplinary Research Creative Activities Fund
Role: Co-Investigator
$50,000 - July 2017
ELECTRONIC OPTIMIZATION OF STEM CELL DERIVED HUMAN CARDIAC MYOCYTES
NIH NHLBI
Role: Principal Investigator
$748,969 - August 2014
Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit.
UBCAT
Role: Principal Investigator
$60,000 - January 2007
Molecular Basis of Automaticity in the Myometrium
NIH
Role: Principal Investigator
$158,000 - January 2006
Ion Channels in Preterm Labor
Department of GYN-OB Seed Funding
Role: Principal Investigator
$2,000
Journal Articles:
- Vandenberg JI, Bett GC, Powell T. (1997) Contribution of a swelling-activated chloride current to changes in the cardiac action potential. Am J Physiol (Aug), 273(2 Pt): 541-547.
- Noble D, Bett G, Bett GC. (1993) Reconstructing the heart: a challenge for integrative physiology. Cardiovasc Res (Oct), 27(10): 1701-1712.
- Cheli VT, Santiago González DA, Zamora NN, Lama TN, Spreuer V, Rasmusson RL, Bett GC, Panagiotakos G, Paez PM. (2018) Enhanced oligodendrocyte maturation and myelination in a mouse model of Timothy syndrome. Glia (Aug).
- Ma D, Liu Z, Loh LJ, Zhao Y, Li G, Liew R, Islam O, Wu J, Chung YY, Teo WS, Ching CK, Tan BY, Chong D, Ho KL, Lim P, Yong RYY, Panama BK, Kaplan AD, Bett GCL, Ware J, Bezzina CR, Verkerk AO, Cook SA, Rasmusson RL, Wei H. (2018) Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient. Sci Rep (Jul), 8(1): 11246-11246.
- Sekera ER, Rudolph HL, Carro SD, Morales MJ, Bett GCL, Rasmusson RL, Wood TD. (2017) Depletion of Stercobilin in Fecal Matter from a Mouse Model of Autism Spectrum Disorders. Metabolomics (Nov), 13(11).
- Papp R, Bett GCL, Lis A, Rasmusson RL, Baczkó I, Varró A, Salama G. (2017) Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women. Biol Sex Differ (Aug), 8: 26-26.
- Bett GC. (2016) Hormones and sex differences: changes in cardiac electrophysiology with pregnancy. Clin Sci (Lond) (Jan), 130(10): 747-759.
- Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. (2015) The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host Microbe (May), 17(5): 642-652.
- Cordeiro JM, Zeina T, Goodrow R, Kaplan AD, Thomas LM, Nesterenko VV, Treat JA, Hawel L, Byus C, Bett GC, Rasmusson RL, Panama BK. (2015) Regional variation of the inwardly rectifying potassium current in the canine heart and the contributions to differences in action potential repolarization. J Mol Cell Cardiol (Jul), 84: 52-60.
- Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. (2015) Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Dis Model Mech (May), 8(5): 457-466.
- Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. (2015) Modeling and studying mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from Duchenne Muscular Dystrophy (DMD) patients. Dis Model Mech (Mar).
- Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L. (2015) Reconciling Computer Models and Stem Cell Models of Human Cardiac Repolarization. Cardiovasc Res (Feb).
- Kim JJ, Yang L, Lin B, Zhu X, Sun B, Kaplan AD, Bett GC, Rasmusson RL, London B, Salama G. (2015) Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. J Mol Cell Cardiol (Jan), 81C: 81-93.
- Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L. (2014) Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells. Cardiovasc Res (Nov), 104(2): 258-269.
- Salama G, Bett GC. (2014) Sex differences in the mechanisms underlying long QT syndrome. Am J Physiol Heart Circ Physiol (Sep), 307(5): 640-648.
- Bett GC, Lis A, Wersinger SR, Baizer JS, Duffey ME, Rasmusson RL. (2012) A Mouse Model of Timothy Syndrome: a Complex Autistic Disorder Resulting from a Point Mutation in Cav1.2. N Am J Med Sci (Boston) (Jul), 5(3): 135-140.
- Bett GC, Kaplan AD, Lis A, Cimato TR, Tzanakakis ES, Zhou Q, Morales MJ, Rasmusson RL. (2013) Electronic "Expression" of the Inward Rectifier in Cardiocytes Derived from Human Induced Pluripotent Stem Cells. Heart Rhythm (Sep).
- Bett GC, Kaplan AD, Lis A, Cimato TR, Tzanakakis ES, Zhou Q, Morales MJ, Rasmusson RL. (2013) Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells. Heart Rhythm (Dec), 10(12): 1903-1910.
- Parikh A, Patel D, McTiernan CF, Xiang W, Haney J, Yang L, Lin B, Kaplan AD, Bett GC, Rasmusson RL, Shroff SG, Schwartzman D, Salama G. (2013) Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. Circ Res (Jul), 113(3): 313-321.
- Bett GC, Lis A, Guo H, Liu M, Zhou Q, Rasmusson RL. (2012) Interaction of the S6 proline hinge with N-type and C-type inactivation in Kv1.4 channels. Biophys J (Oct), 103(7): 1440-1450.
- Zhou Q, Bett GC, Rasmusson RL. (2012) Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential. PLoS One (Aug), 7(8): 42295-42295.
- Blitshteyn S, Poya H, Bett GC. (2012) Pregnancy in postural tachycardia syndrome: clinical course and maternal and fetal outcomes. J Matern Fetal Neonatal Med (Jan).
- Blitshteyn S, Poya H, Bett GC. (2011) Pregnancy in Postural Tachycardia Syndrome: Clinical Course and Maternal and Fetal Outcomes. J Matern Fetal Neonatal Med (Dec).
- Bader PL, Faizi M, Kim LH, Owen SF, Tadross MR, Alfa RW, Bett GC, Tsien RW, Rasmusson RL, Shamloo M. (2011) Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proc Natl Acad Sci U S A (Sep), 108(37): 15432-15437.
- Bett GC, Zhou Q, Rasmusson RL. (2011) Models of HERG gating. Biophys J (Aug), 101(3): 631-642.
- Bett GC, Sachs F. (1997) Cardiac mechanosensitivity and stretch-activated ion channels. Trends Cardiovasc Med (Jan), 7(1): 4-8.
- Bett GC, Dinga-Madou I, Zhou Q, Bondarenko VE, Rasmusson RL. (2011) A model of the interaction between N-type and C-type inactivation in Kv1.4 channels. Biophys J (Jan), 100(1): 11-21.
- Arroyo A, Kim BS, Biehl A, Yeh J, Bett GC. (2011) Expression of kv4.3 voltage-gated potassium channels in rat gonadotrophin-releasing hormone (GnRH) neurons during the estrous cycle. Reprod Sci (Feb), 18(2): 136-144.
- Zhou Q, Bett GC. (2010) Regulation of the voltage-insensitive step of HERG activation by extracellular pH. Am J Physiol Heart Circ Physiol (Jun), 298(6): 1710-1718.
- Xu L, Huang C, Chen J, Jiang X, Li X, Bett GC, Rasmusson RL, Wang S. (2008) Effect of amiodarone on Kv1.4 channel C-type inactivation: comparison of its effects with those induced by propafenone and verapamil. Pharmazie (Jun), 63(6): 475-479.
- Bett GC, Rasmusson RL. (2008) Modification of K+ channel-drug interactions by ancillary subunits. J Physiol (Feb), 586(4): 929-950.
- Brar MK, Laube DW, Bett GC. (2007) Effect of quantitative feedback on student performance on the National Board Medical Examination in an obstetrics and gynecology clerkship. Am J Obstet Gynecol (Nov), 197(5): 530-535.
- Noble D, Noble SJ, Bett GC, Earm YE, Ho WK, So IK. (1991) The role of sodium-calcium exchange during the cardiac action potential. Ann N Y Acad Sci (Jan), 639: 334-353.
- Bett GC, Morales MJ, Beahm DL, Duffey ME, Rasmusson R. (2006) Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel. J Physiol (Nov), 576(Pt 3): 755-767.
- Arroyo A, Kim B, Rasmusson R, Bett GC, Yeh J. (2006) Hyperpolarization-activated cation channels are expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons. J Soc Gynecol Investig (Sep), 13(6): 442-450.
- Bett GC, Morales MJ, Strauss HC, Rasmusson RL. (2006) KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine. Biochem Biophys Res Commun (Feb), 340(4): 1167-1177.
- Wang S, Bondarenko VE, Qu YJ, Bett GC, Morales MJ, Rasmusson R, Strauss H. (2005) Time- and voltage-dependent components of Kv4.3 inactivation. Biophys J (Nov), 89(5): 3026-3041.
- Bett G, Noble D, Noble S, Earm Y, Ho WK, So IS, Bett GC. (1992) Na-Ca exchange current during the cardiac action potential. Adv Exp Med Biol (Jan), 311: 453-454.
- Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL. (2004) Computer model of action potential of mouse ventricular myocytes. Am J Physiol Heart Circ Physiol (Sep), 287(3): 1378-1403.
- Bett GC, Rasmusson RL. (2003) Functionally-distinct proton-binding in HERG suggests the presence of two binding sites. Cell Biochem Biophys (Jan), 39(3): 183-193.
- Bondarenko VE, Bett GC, Rasmusson RL. (2004) A model of graded calcium release and L-type Ca2+ channel inactivation in cardiacmuscle. Am J Physiol Heart Circ Physiol (Mar), 286(3): 1154-1169.
- Bett GC, Rasmusson RL. (2004) Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore. J Physiol (Apr), 556(Pt 1): 109-120.
- Jiang X, Bett GC, Li X, Bondarenko VE, Rasmusson RL. (2003) C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes. J Physiol (Jun), 549(Pt 3): 683-695.
- Jiang X, Bett GC, Li X, Bondarenko VE, Rasmusson RL. (2003) C-type inactivation involves a significant decrease in the intracellular aqueouspore volume of Kv1.4 K+ channels expressed in Xenopus oocytes. J Physiol (Jun), 549(Pt 3): 683-695.
- Wang S, Morales MJ, Qu YJ, Bett GC, Strauss HC, Rasmusson RL. (2003) Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect. J Physiol (Jan), 546(Pt 2): 387-401.
- Li X, Bett GC, Jiang X, Bondarenko VE, Morales MJ, Rasmusson RL. (2003) Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication. Am J Physiol Heart Circ Physiol (Jan), 284(1): 71-80.
- Li X, Bett GC, Jiang X, Bondarenko VE, Morales MJ, Rasmusson RL. (2003) Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication. Am J Physiol Heart Circ Physiol (Jan), 284(1): 71-80.
- Bett GC, Dai S, Campbell DL. (2002) Cholinergic modulation of the basal L-type calcium current in ferret right ventricular myocytes. J Physiol (Jul), 542(Pt 1): 107-117.
- Bett GC, Sachs F. (2000) Whole-cell mechanosensitive currents in rat ventricular myocytes activated by direct stimulation. J Membr Biol (Feb), 173(3): 255-263.
- Zeng T, Bett GC, Sachs F. (2000) Stretch-activated whole-cell currents in adult rat cardiac myocytes. American Journal of Physiology (Jan), 278: H548-557.
- Bett GC. (2004) The Effects of Ischemic Conditions on HERG Channel Gating and Conductance. Recent Research Developments in Membrane Biology (Jan), 2: 1-23.
- Bett GC, Sachs F. (1997) Cardiac Mechanosensitivity and Stretch Activated Ion Channels. Trends in Cardiovascular Medicine (Jan), 7: 4-8.
- Bondarenko VE, Bett GCL, Rasmusson RL. (2004) A Model of Graded Calcium release and L-type Ca2+ channel inactivation in cardiac muscle. Am. J. Physiol. (Jan), 286: H1154-H1169.
- Bett GC, Sachs F. (2000) Activation and Inactivation of Mechanosensitive Currents in the Chick Heart. J. Membrane Biology (Jan), 173: 255-263.
Books and Book Chapters:
- Bett GCL, Rasmusson RL. (2006) Fundamentals of Cellular Electrophysiology.
- Bett GC, Rasmussson RL. (2002) In: Models of Cardiac Ion Channels. , 1-60.
Abstracts:
- Brar MK, Bett GC, Laube D. (2007) Effect of shortening the duration of an obstetrics-gynecology clerkship from seven weeks to six on national examination performance. (Oct)
- Bett GC, Madou ID, Bondarenko VE, Rasmusson RL. (2004) A Computer Model of N-and C-type inactivation in voltage-gated potassium channels. (Jan)
- Bett GC, Madou ID, Rasmusson RL. (2003) A computer model of N-and C-type inactivation in voltage-gated potassium channels. (Jan)
- Bett GC, Cyr V, Rasmusson RL. (2003) A mathematical model of potassium channels permiation with two binding sites and drug block. (Jan)
- Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2004) A mathematical model of repolarization simulating regional heterogeneity of murine ventricular myocytes. (Jan) 298
- Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2003) A mathematical model of the action potential of mouse ventricular myocytes. (Jan)
- Bett GC, Cyr V, Rasmusson RL. (2003) A mathematicl model of potassium channels permeation with two binding sites. (Jan)
- Bett GC, Bondarenko VE, Rasmusson RL. (2003) A model of Ca2 handling in ferret cardiac myocytes. (Jan)
- Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K channels. (Jan)
- Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K Channels. (Jan)
- Bett GC, Duffey ME, Rasumsson RL. (2005) Ancillary Subunits Determine the Affinity and use-Dependence of Chromanol 293B for KCNQ1. (Jan)
- Bett GC, Duffey ME, Beahm Dl, Katzer M, Morales MJ, Rasmusson RL. (2005) Ancillary subunits modulate block of KCNQ1 channels by chromanol and Ba2+. (Jan)
- Bett GC, Jiang XJ, Bondarenko VE, Li XY, Rasmusson RL. (2003) C-type Inactivation Involves A Significant Decrease in the Intracellular Aqueouspore Volume. (Jan) 221
- Bett GC, Jiang XJ, Li XY, Bondarenko VE, Rasmusson RL. (2002) C-type inactivation: a pH0 and K sensitive transmembrane mechanism. (Jan)
- Bett GC, Bondarenko VE, Rasmusson RL. (2003) Cardiac Cellular Morphology and Physiology in a model of graded Ca2 release and L-type channel inactivation. (Jan)
- Bett GC, Sachs F. (1998) Inactivation of Mechanosensitive Currents in Ventricular Myocytes. (Jan)
- Bett GC, Morales M, Rasmusson R. (2005) KChlP2b modulates the affinity and use-dependent block of Kv4.3 by Nifedipine. (Jan)
- Bett GC, Wang S, Morales M, Qu YJ, Rasmusson RL, Strauss HC. (2002) Kv1.4 Channel Block by quinidine: evidence for a drug-induced allosteric effect. (Jan)
- Arroyo A, Kim B, Biehl A, Bett GCL, Yeh J. (2007) Kv4.3 and gonadotropin-releasing hormone (GnRH) are colocalized in rat hypothalamus. (Jan)
- Bett GC. (1998) Mechanically activated currents in isolated rat ventricular myocytes. (Jan)
- Bett GC, Sachs F. (1999) Mechanosensitive currents in the Heart. (Jan)
- Bett GC, Sachs F. (1998) Mechanosensitive currents in the heart. (Jan)
- Bett GC, Sachs F. (1998) Mechanosensitive ion channels in mammalian ventricular myocytes. (Jan)
- Bett GC, Rasmusson RL. (2005) Molecular Mechanisms of Inactivation and Recovery of Kv1.4, an A-type current. (Jan)
- Bett GC, Campbell DL. (2001) Muscarinic modulation of the L-type calcium channel in ferret right ventiruclar myocytes. (Jan) 2865
- Bett GC, Kaushal V, Rasmusson RL. (2003) Optimization and parameter identification (pH0 and K+0 in a Markov Model of the HERG channel. (Jan)
- Bett GC, Rasmusson RL. (2004) Proton Modification of HERG channels: two sites of functional regulation. (Jan) 281-282
- Bett GC, Yoo K, Rasmusson RL. (2003) Site directed mutagenesis in a cloned Kv1.4 channel. (Jan)
- Bett GC, Bondarenko VE, Rasmusson RL. (2004) Spatial Heterogeneity in a Computer Model of Graded Ca2 Release: Effects of Ca2 Loading and Ryanodine Receptor Adaptation. (Jan)
- Arroyo A, Kim B, Biehl A, Bett G, Yeh J. (2008) Synaptophysin and gonadotropin-releasing hormone (GnRH) are colocalized in rat hypothalamus. (Jan)
- Arroyo A, Kim B, Peresie J, Lee M, Bett GCL, Yeh J. (2007) The Kv 4.3 potassium channel is expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons. (Jan)
- Bett GC, Li XY, Morales MJ, Bondarenko VE, Rasmusson RL, Jiang XJ. (2003) Transmembrane communication in cardiac potassium channels: regulation of N-and C-type inactivation by pHo and potassium in normal and mutant Kv1.4 channels. (Jan) 76A
Professional Memberships:
- American Heart Association
- Biophysical Society
- Organization for the Study of Sex Differences
- Physiological Society (UK)
- Society for Gynecological Investigation
- Upstate NY Cardiac Electrophysiology Society
Service Activities:
- President, Faculty Council; President (2015–2016)
- Chair, AHA Peer Review Panel; Chair (2014–present)
- Chair, Faculty Senate Committee on Equity and Diversity; Chair (2014–present)
- Collaborative Sciences Award;; Grant Reviewer (2013–present)
- Cardiac Electrophysiology BSc;; Chair (2012–present)
- Secretary, Faculty Council; Secretary (2012–present)
- Co-Chair, AHA Peer Review Panel; Co-Chair (2012–present)
- NIH; NIH Bioengineering Sciences and Technologies (BST) Special Emphasis Panel;; Ad Hoc Reviewer (2011)
- American Heart Association; Unified Peer Review Consortium, Cardiac Electrophysiology, Basic sciences 2;; Grant Reviewer (2010)
- American Heart Association; Unified Review, Cardiac Electrophysiol & Arrhythmias Clinical/Translational;; Charter Member (2010–2014)
- The Netherlands Organisation for Health Research and Development; ZonMw Translational Research Programme;; Grant Reviewer (2010)
- American Heart Association; Region I Cardiac Electrophysiology;; Charter Member (2009)
- OSSD Membership Committee; Chair
- J Biomathematics; Editorial Board Member
- NIH; Peer Reviewer
- American Heart Association; Peer Reviewer
- Vice Chair For Research; Vice-Chair