Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.
We do this using a combination of techniques and approaches including 2 electrode clamp to study heterologously expressed channels, whole cell clamp to record currents in the native cell, and mathematical modelling to understand and interpret results.
Education and Training:
BA, Physics, Oxford University
BA, Physiology, Oxford University
PhD, Oxford University
Employment:
Deputy Director, Institute for Research and Education on Women and Gender (2012-present)
Associate Professor, Obstetrics and Gynecology, State University of New York, University at Buffalo (2011-present)
Vice Chair for Research, Obstetrics and Gynecology, Jacobs School of Medicine & Biomedical Sciences (2009-present)
Director of Resident Research, Obstetrics and Gynecology, SUNY Jacobs School of Medicine & Biomedical Sciences (2007-present)
Associate Director, Center for Cellular and Systems Electrophysiology (2004-present)
Associate Director - B-SURE Program (2004-present)
Research Assistant Professor, Physiology, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2001-present)
President, American Heart Association, Buffalo Niagara Region
President, JSMBS Faculty Council (2015–2016)
Assistant Professor, Obstetrics and Gynecology, SUNY, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2005–2011)
Postdoctoral Research Associate, Physiology, The State Unviersity of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998–2001)
American Heart Association, NY State Affiliate., Biophysical Sciences, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996–1998)
Postdoctoral Research Associate, Biophysical Sciences, The State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (1995–1996)
Lecturer, Charing Cross and Westminster Medical School (1993–1995)
: Research in my lab focuses on ion channels. I am interested in how interventions such as ancillary subunits, mutations, drugs, and environmental changes affect the structure-function relationship, and ultimately how this affects cellular electrical activity.
Research Centers:
Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
Health and Wellness Across the Lifespan
Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
January 2015–January 2016 Initial Validation of a Novel in vitro Arrhythmia Drug Safety Screening Assay SUNY Role: Principal Investigator $50,000
July 2011–June 2013 Sex Differences in Molecular Heterogeneity of Cardiac Repolarization NIH Role: Principal Investigator $275,000
May 2011–April 2012 Device to treat postpartum hemorrhage Bill and Melinda Gates Foundation Role: Principal Investigator $100,000
March 2008–February 2011 Repolarizing Current in Human Myometrium March of Dimes Prematurity Initiative Role: Principal Investigator $241,170
January 2008–January 2011 Repolarizing Currents in Human Myometrium March of Dimes Role: Principal Investigator $241,170
August 2007–July 2009 Molecular Basis of Automaticity in the Myometrium NIH Role: Principal Investigator $100,000
June 2007–June 2009 Automaticity in the myometrium NIH Role: Principal Investigator $100,000
January 2004–December 2007 Pathophysiology of HERG Gating and Permeation During Ischemia: Effect of pHo and K+ American Heart Association Role: Principal Investigator $472,728
November 2004–October 2005 Role of Hyperpolarization activated cation (HCN) Channels in GnRH Neurons Interdisciplinary Research Creative Activities Fund Role: Co-Investigator $50,000
July 2017 ELECTRONIC OPTIMIZATION OF STEM CELL DERIVED HUMAN CARDIAC MYOCYTES NIH NHLBI Role: Principal Investigator $748,969
August 2014 Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit. UBCAT Role: Principal Investigator $60,000
January 2007 Molecular Basis of Automaticity in the Myometrium NIH Role: Principal Investigator $158,000
January 2006 Ion Channels in Preterm Labor Department of GYN-OB Seed Funding Role: Principal Investigator $2,000
Zeng T, Bett GC, Sachs F. (2000) Stretch-activated whole-cell currents in adult rat cardiac myocytes. American Journal of Physiology (Jan), 278: H548-557.
Bett GC. (2004) The Effects of Ischemic Conditions on HERG Channel Gating and Conductance. Recent Research Developments in Membrane Biology (Jan), 2: 1-23.
Bett GC, Sachs F. (1997) Cardiac Mechanosensitivity and Stretch Activated Ion Channels. Trends in Cardiovascular Medicine (Jan), 7: 4-8.
Bondarenko VE, Bett GCL, Rasmusson RL. (2004) A Model of Graded Calcium release and L-type Ca2+ channel inactivation in cardiac muscle. Am. J. Physiol. (Jan), 286: H1154-H1169.
Bett GC, Sachs F. (2000) Activation and Inactivation of Mechanosensitive Currents in the Chick Heart. J. Membrane Biology (Jan), 173: 255-263.
Bett GCL, Rasmusson RL. (2006) Fundamentals of Cellular Electrophysiology.
Bett GC, Rasmussson RL. (2002) In: Models of Cardiac Ion Channels. , 1-60.
Abstracts:
Brar MK, Bett GC, Laube D. (2007) Effect of shortening the duration of an obstetrics-gynecology clerkship from seven weeks to six on national examination performance. (Oct)
Bett GC, Madou ID, Bondarenko VE, Rasmusson RL. (2004) A Computer Model of N-and C-type inactivation in voltage-gated potassium channels. (Jan)
Bett GC, Madou ID, Rasmusson RL. (2003) A computer model of N-and C-type inactivation in voltage-gated potassium channels. (Jan)
Bett GC, Cyr V, Rasmusson RL. (2003) A mathematical model of potassium channels permiation with two binding sites and drug block. (Jan)
Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2004) A mathematical model of repolarization simulating regional heterogeneity of murine ventricular myocytes. (Jan) 298
Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2003) A mathematical model of the action potential of mouse ventricular myocytes. (Jan)
Bett GC, Cyr V, Rasmusson RL. (2003) A mathematicl model of potassium channels permeation with two binding sites. (Jan)
Bett GC, Bondarenko VE, Rasmusson RL. (2003) A model of Ca2 handling in ferret cardiac myocytes. (Jan)
Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K channels. (Jan)
Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K Channels. (Jan)
Bett GC, Duffey ME, Rasumsson RL. (2005) Ancillary Subunits Determine the Affinity and use-Dependence of Chromanol 293B for KCNQ1. (Jan)
Bett GC, Duffey ME, Beahm Dl, Katzer M, Morales MJ, Rasmusson RL. (2005) Ancillary subunits modulate block of KCNQ1 channels by chromanol and Ba2+. (Jan)
Bett GC, Jiang XJ, Bondarenko VE, Li XY, Rasmusson RL. (2003) C-type Inactivation Involves A Significant Decrease in the Intracellular Aqueouspore Volume. (Jan) 221
Bett GC, Jiang XJ, Li XY, Bondarenko VE, Rasmusson RL. (2002) C-type inactivation: a pH0 and K sensitive transmembrane mechanism. (Jan)
Bett GC, Bondarenko VE, Rasmusson RL. (2003) Cardiac Cellular Morphology and Physiology in a model of graded Ca2 release and L-type channel inactivation. (Jan)
Bett GC, Sachs F. (1998) Inactivation of Mechanosensitive Currents in Ventricular Myocytes. (Jan)
Bett GC, Morales M, Rasmusson R. (2005) KChlP2b modulates the affinity and use-dependent block of Kv4.3 by Nifedipine. (Jan)
Bett GC, Wang S, Morales M, Qu YJ, Rasmusson RL, Strauss HC. (2002) Kv1.4 Channel Block by quinidine: evidence for a drug-induced allosteric effect. (Jan)
Arroyo A, Kim B, Biehl A, Bett GCL, Yeh J. (2007) Kv4.3 and gonadotropin-releasing hormone (GnRH) are colocalized in rat hypothalamus. (Jan)
Bett GC. (1998) Mechanically activated currents in isolated rat ventricular myocytes. (Jan)
Bett GC, Sachs F. (1999) Mechanosensitive currents in the Heart. (Jan)
Bett GC, Sachs F. (1998) Mechanosensitive currents in the heart. (Jan)
Bett GC, Sachs F. (1998) Mechanosensitive ion channels in mammalian ventricular myocytes. (Jan)
Bett GC, Rasmusson RL. (2005) Molecular Mechanisms of Inactivation and Recovery of Kv1.4, an A-type current. (Jan)
Bett GC, Campbell DL. (2001) Muscarinic modulation of the L-type calcium channel in ferret right ventiruclar myocytes. (Jan) 2865
Bett GC, Kaushal V, Rasmusson RL. (2003) Optimization and parameter identification (pH0 and K+0 in a Markov Model of the HERG channel. (Jan)
Bett GC, Rasmusson RL. (2004) Proton Modification of HERG channels: two sites of functional regulation. (Jan) 281-282
Bett GC, Yoo K, Rasmusson RL. (2003) Site directed mutagenesis in a cloned Kv1.4 channel. (Jan)
Bett GC, Bondarenko VE, Rasmusson RL. (2004) Spatial Heterogeneity in a Computer Model of Graded Ca2 Release: Effects of Ca2 Loading and Ryanodine Receptor Adaptation. (Jan)
Arroyo A, Kim B, Biehl A, Bett G, Yeh J. (2008) Synaptophysin and gonadotropin-releasing hormone (GnRH) are colocalized in rat hypothalamus. (Jan)
Arroyo A, Kim B, Peresie J, Lee M, Bett GCL, Yeh J. (2007) The Kv 4.3 potassium channel is expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons. (Jan)
Bett GC, Li XY, Morales MJ, Bondarenko VE, Rasmusson RL, Jiang XJ. (2003) Transmembrane communication in cardiac potassium channels: regulation of N-and C-type inactivation by pHo and potassium in normal and mutant Kv1.4 channels. (Jan) 76A