Margarita L. Dubocovich PhD
Margarita L. Dubocovich
PhD
SUNY Distinguished Professor; Department of Pharmacology and Toxicology; Senior Associate Dean for Diversity and Inclusion
Department of Pharmacology and Toxicology
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Behavioral pharmacology; Circadian Rhythm/Chronobiology; Drug abuse; Neuropharmacology; Signal Transduction
Professional Summary:
My lab‘s research seeks to understand the mechanism of action of the hormone melatonin at the MT1 and MT2 G-protein coupled receptors. We study these receptors in the brain and through the body with the goal of identifying ligands that exhibit useful binding affinity and therapeutic potential. Our team of undergraduate and graduate students, postdoctoral fellows, technicians and senior scientists work with each other and with expert co-investigators in medicinal chemistry to discover and develop novel molecules that can mimic or counteract the actions of melatonin. These molecules may help treat a variety of diseases and conditions including insomnia, circadian sleep disorders, depression, seasonal affective disorders, and cardiovascular disease.
Our laboratory pursues these investigations from several angles. We assess the localization of the melatonin receptors, examine their cellular and molecular signaling mechanisms,and investigate receptor fate following prolonged exposure to melatonin. We study the distinct roles of selective MT1 and MT2 melatonin receptor ligands in modulating circadian rhythms, methamphetamine‘s ability to induce both sensitization to prolonged exposure, and stimulation of the reward system. We also study cell proliferation, survival, and neurogenesis in the brain, and the changes in gene expression underlying all these processes.
Our research ultimately aims to discover novel drugs with differential actions at the MT1 and MT2 receptors. We use molecular-based drug design, computer modeling and medicinal chemistry to design and synthesize small molecules that target these receptors as agonists, inverse agonists and/or antagonists. We then pharmacologically and functionally characterize these molecules using cell-based assays and bioassays and test them in circadian and behavioral animal models.
Education and Training:
- PhD, Biological Chemistry, University of Buenos Aires School of Chemistry and Natural Sciences (1976)
- BS, Biological Chemistry, University of Buenos Aires School of Chemistry and Natural Sciences (1971)
Employment:
- Co-Director, Institute for Strategic Enhancement of Eduicational Diversity (iSEED) (2013-present)
- Inaugural Senior Associate Dean, Office of Inclusion and Cultural Enhancement, University at Buffalo (2012-present)
- Program Director, The Collaborative Learning and Integrated Mentoring in the Biosciences Program at UB (2009-present)
- Program Director, The CLIMB UP (Undergraduate Program) for Summer Research at UB (2009-present)
- Program Director, The CLIMB NS (Next Step) for Postdoctoral Fellows at UB (2009-present)
- Professor Emeritus, Molecular Pharmacology and Biological Chemistry, Northwestern University, Northwestern University Feinberg School of Medicine (2008-present)
- Director, CTSA Workforce Development Core, Clinical and Translational Science Award, University at Buffalo, Clinical and Translational Science Award (2015–2019)
- Principal Investigator and Program Lead, Clinical and Translational Science Award, KL2 Mentored Career Development Award, Clinical and Translational Science Award, University at Buffalo (2015–2019)
- Professor and Chair, University at Buffalo (2008–2016)
- Education and Diversity Director, National Science Foundation BioXFEL Science and Technology Center (2013–2014)
- Program Director, The Collaborative Learning and Integrated Mentoring in the Biosciences Program at Northwestern (2007–2008)
- Adjunct Professor, Psychiatry and Behavioral Science, Northwestern University, Feinberg School of Medicine (1999–2008)
- Professor, Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine (1991–2008)
- Associate Professor, Pharmacology, Northwestern University, Feinberg School of Medicine (1986–1991)
- Professor, Molecular Pharmacology and Biological Chemistry, Northwestern University, Northwestern University Feinberg School of Medicine (1982–1986)
- Visiting Professor, Pharmacology, Universidad del Pais Vasco, Spain (1983)
- Research Associate Professor, Pharmacology, University of Colorado Health Science Center (1980–1982)
- Project Leader, Biology, Synthelabo, France (1977–1980)
- Pharmacologist, Pharmacology, Wellcome Research Laboratories, United Kingdom (1976–1977)
- Instructor, Pharmacology, Buenos Aires University, School of Medicine, Argentina (1973–1976)
- Research Fellow, National Research Council, Instituto de Investigaciones Farmacologicas, Argentina (1972–1976)
- Instructor, Biochemistry, Buenos Aires University, School of Chemistry and Natural Sciences, Argentina (1971–1972)
- Teaching Assistant, Organic Chemistry, Buenos Aires University, School of Chemistry and Natural Sciences, Argentina (1970–1971)
Awards and Honors:
- 2020 Inaugural Buffalo Bussines First Inclusion, Diversity, Equity, Awarness (IDEA) Award (2020)
- 2017 Inaugural ACNP Delores C Shockley Minority Mentoring Award (2017)
- UB CSTEP Outstanding Research Mentor Award (2017)
- UB President’s Medal (2017)
- 2015-2016 Excellence in Graduate Student Mentoring Award, The Graduate School, University at Buffalo (2015)
- SUNY Distinguished Professor (2014)
- School of Medicine and Biomedical Sciences Dean's Award (2013)
- 2012 PhRMA Foundation Award in Excellence in Pharmacology/Toxicology (2012)
- Mayor Byron W Brown Hispanic Heritage Award in Medical and Health Fields (2011)
- Aaron B Lerner Award for Outstanding Contributions to Melatonin Research (2011)
- University at Buffalo Distinguished Postdoctoral Mentor Award (2011)
- PhRMA Foundation Starter Research Grant Award (1983)
- APS Travel Award to attend XXXI International Congress of Physiology- 1989
- Research Fellow of the National Research Council of Argentina (1971-1974)
- Invited speaker at 88 National and International Symposia (1979-present)
- Advance Research Fellow, National Research Council of Argentina (1974-1976)
- ASPET Travel Awards to attend IUPHAR Congresses (1981-1984-1987-1990-1998)
Research Expertise:
- Circadian Rhythms: Melatonin (MT1 and MT2) receptors as targets for the modulation of circadian rhythms
- Drug Discovery: Discovery of receptor-selective melatonin ligands for the treatment of circadian sleep disorders, depression, and cancer
- Metabolism: Metabolism, methamphetamine-induced sensitization, cell proliferation neurogenesis
- Neuropharmacology: Cellular, molecular and behavioral neuropharmacology of G protein-coupled receptors
Grants and Sponsored Research:
- March 2017–December 2021
Enabling Access To Cutting-Edge Biomedical And Behavioral Science
NIH
Role: Principal Investigator
$2,117,911 - June 2013–May 2019
iSEED – Institute of Strategic Enhancement of Educational Diversity
UB Office of the Provost-3E Fund
Role: Co-Principal Investigator - August 2015–March 2019
Clinical and Translational Science Award (KL2): Mentored Career Development Award
NCATS
Role: Principal Investigator
$1,818,928 - August 2015–March 2019
Clinical and Translational Science Award: Buffalo Clinical and Translational Research Center
National Center for Advancing Translational Sciences
Role: Co-Investigator
$13,151,902 - January 2016–January 2019
Clinical Translational Science Award (CTSA)
National Institutes of Health
Role: Principal Investigator
$16,000,000 - May 2016–August 2018
Zannoni Summer Undergraduate Research Fellowship Award
American Society for Pharmacology and Experimental Therapeutics
Role: Principal Investigator
$27,000 - July 2016–June 2017
SUNY Explorations in Diversity and Academic Excellence Award
SUNY
Role: Principal Investigator
$10,000 - July 2014–June 2016
Environmental Circadian Disruptors Increase Diabetes and Metabolic Disorders Risk
National Institutes of Health
Role: Principal Investigator
$437,342 - June 2013–August 2015
Zannoni Summer Undergraduate Research Fellowship Award
American Society for Pharmacology and Experimental Therapeutics
Role: Principal Investigator
$27,000 - September 2013–August 2014
National Science Foundation – Science and Technology Center (STC) Biology with X-ray Free Electron Lasers (BioXFEL)
National Science Foundation
Role: Co-Investigator - July 2007–September 2013
Modulation of Methamphetamine Action in the CNS
NIH/NIDA
Role: Principal Investigator
$1,000,000 - June 2010–August 2012
Zannoni Summer Undergraduate Research Fellowship Award
American Society for Pharmacology and Experimental Therapeutics
Role: Principal Investigator
$27,000 - April 2004–March 2011
Modulatory Role of Melatonin in CNS Function
NIH/NIMH
Role: Principal Investigator
$1,000,000 - December 2001–November 2008
Melatonin Receptors as Therapeutic Targets in Primates
NIH/NIMH
Role: Principal Investigator
$1,125,000 - August 2006–August 2008
Regulation of MT1 and MT2 Melatonin Receptor Functional Sensitivity By Therapeutic Concentrations Of Rozerem
Takeda Pharmaceuticals
Role: Principal Investigator
$221,000
Journal Articles:
- Stein RM, Kang HJ, McCorvy JD, Glatfelter GC, Jones AJ, Che T, Slocum S, Huang XP, Savych O, Moroz YS, Stauch B, Johansson LC, Cherezov V, Kenakin T, Irwin JJ, Shoichet BK, Roth BL, Dubocovich ML. Virtual discovery of melatonin receptor ligands to modulate circadian rhythms. Nature. 2020; 579(7800).
- Estrada-Reyes R, Valdés-Tovar M, Arrieta-Baez D, Dorantes-Barrón AM, Quero-Chávez D, SolÃs-Chagoyán H, Argueta J, Dubocovich ML, BenÃtez-King G. The Timing of Melatonin Administration Is Crucial for Its Antidepressant-Like Effect in Mice. Int J Mol Sci. 2018; 19(8).
- Murphy SL, Samuels EM, Kolb HR, Behar-Horenstein LS, Champagne E, Byks-Jazayeri C, Hahn J, Roth MT, Ennever F, Bajwa W, Singh M, Homish GG, Dubocovich ML. Best Practices in Social and Behavioral Research: A multisite pilot evaluation of the good clinical practice online training course. J Clin Transl Sci. 2018; 2(2).
- Valdés-Tovar M, Estrada-Reyes R, SolÃs-Chagoyán H, Argueta J, Dorantes-Barrón AM, Quero-Chávez D, Cruz-Garduño R, Cercós MG, Trueta C, Oikawa-Sala J, Dubocovich ML, BenÃtez-King G. Circadian modulation of neuroplasticity by melatonin: a target in the treatment of depression. Br J Pharmacol. 2018; 175(16).
- Clough SJ, Hudson RL, Dubocovich ML. Food-induced reinforcement is abrogated by the genetic deletion of the MT1 or MT2 melatonin receptor in C3H/HeN mice. Behav Brain Res. 2018; 343.
- Liu J, Clough SJ, Dubocovich ML. Role of the MT1 and MT2 melatonin receptors in mediating depressive- and anxiety-like behaviors in C3H/HeN mice. Genes Brain Behav. 2017; 16(5).
- Rawashdeh O, Clough SJ, Hudson RL, Dubocovich ML. Learned motivation drives circadian physiology in the absence of the master circadian clock. FASEB J. 2017; 31(1).
- Jockers R, Delagrange P, Dubocovich ML, Markus RP, Renault N, Tosini G, Cecon E, Zlotos DP. Update on melatonin receptors: IUPHAR Review 20. Br J Pharmacol. 2016; 173(18).
- Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML. MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective. Annu Rev Pharmacol Toxicol. 2015.
- Adamah-Biassi EB, Hudson RL, Dubocovich ML. Genetic deletion of MT1 melatonin receptors alters spontaneous behavioral rhythms in male and female C57BL/6 mice. Horm Behav. 2014; 66(4).
- Clough SJ, Hutchinson AJ, Hudson RL, Dubocovich ML. Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice. Physiol Behav. 2014.
- Rawashdeh O, Dubocovich ML. Long-term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta). J Pineal Res. 2014; 56(3).
- Adamah-Biassi, E.B., Zhang Y., Jung H., Vissapragada, S., Miller, R.J., Dubocovich, M.L.. Distribution of MT1 melatonin receptor promoter-driven RFP expression in the brains of BAC C3H/HeN transgenic mice.. J Histochemistry and Cytology. 2014; 62(1).
- Hutchinson AJ, Ma J, Liu J, Hudson RL, Dubocovich ML. Role of MT1 melatonin receptors in methamphetamine-induced locomotor sensitization in C57BL/6 mice. Psychopharmacology (Berl). 2014; 231(1).
- Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M. The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol. 2013; 170(8).
- Liu J, Somera-Molina KC, Hudson RL, Dubocovich ML. Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus. J Pineal Res. 2013; 54(2).
- Adamah-Biassi EB, Stepien I, Hudson RL, Dubocovich ML. Automated Video Analysis System Reveals Distinct Diurnal Behaviors in C57BL/6 and C3H/HeN Mice. Behav Brain Res. 2013.
- Hutchinson AJ, Hudson RL, Dubocovich ML. Genetic deletion of MT(1) and MT(2) melatonin receptors differentially abrogates the development and expression of methamphetamine-induced locomotor sensitization during the day and the night in C3H/HeN mice. J Pineal Res. 2012; 53(4).
- Liu J, Somera-Molina KC, Hudson R,Dubocovich ML. Melatonin potentiates running wheel-induced neurogenesis in the dentate gyrus of adult C3H/HeN mice hippocampus.. J Pineal Res. 2012; 53(4).
- Hutchinson AJ, Hudson RL, Dubocovich ML. Genetic deletion of MT(1) and MT(2) melatonin receptors differentially abrogates the development and expression of methamphetamine-induced locomotor sensitization during the day and the night in C3H/HeN mice. J Pineal Res. 2012; 53(4).
- HUTCHINSON, A., HUDSON, R.L., DUBOCOVICH, M.L.. Methamphetamine-induced development and expression of locomotor sensitization is differentially modulated by the MT1 and/or MT2 melatonin receptors in C3H/HeN mice during the light and dark phases. Journal of Pineal Research. 2012.
- Rawashdeh O, Hudson RL, Stepien I, Dubocovich ML. Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice. Chronobiol Int. 2011; 28(1).
- Dubocovich ML, Delagrange P., Krause D.N., Sugden D., Cardinali D.P., Olcese J.. International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors. Pharmacological Reviews. 2010; 62.
- Dubocovich ML, Delagrange P, Krause DN., Sugden D, Cardinali DP, Olcese J.. International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification and Pharmacology of G Protein-Coupled Melatonin Receptors. Pharmacological Reviews. 2010; 62.
- Dubocovich ML. Melatonin receptors: role on sleep and circadian rhythm regulation. Sleep Med. 2007; 8 Sup.
- Masana MI, Sumaya IC, Becker-Andre M, Dubocovich ML, Dubocovich M. Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout. Am J Physiol Regul Integr Comp Physiol. 2007; 292(6).
- Dubocovich ML. Agomelatine targets a range of major depressive disorder symptoms. Curr Opin Investig Drugs. 2006; 7(7).
- Blask DE, Brainard GC, Dauchy RT, Hanifin JP, Davidson LK, Krause JA, Sauer LA, Rivera-Bermudez MA, Dubocovich ML, Jasser SA, Lynch DT, Rollag MD, Zalatan F. Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Cancer Res. 2005; 65(23).
- Mundey K, Benloucif S, Harsanyi K, Dubocovich ML, Zee PC. Phase-dependent treatment of delayed sleep phase syndrome with melatonin. Sleep. 2005; 28(10).
- Sumaya IC, Masana MI, Dubocovich ML. The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors. J Pineal Res. 2005; 39(2).
- Dubocovich ML, Hudson RL, Sumaya IC, Masana MI, Manna E. Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse. J Pineal Res. 2005; 39(2).
- Dubocovich ML, Markowska M. Functional MT1 and MT2 melatonin receptors in mammals. Endocrine. 2005; 27(2).
- Hansen M, Janssen I, Schiff A, Zee PC, Dubocovich ML. The impact of school daily schedule on adolescent sleep. Pediatrics. 2005; 115(6).
- Gerdin MJ, Masana MI, Rivera-Bermúdez MA, Hudson RL, Earnest DJ, Gillette MU, Dubocovich ML. Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin. FASEB J. 2004; 18(14).
- Gerdin MJ, Masana MI, Dubocovich ML. Melatonin-mediated regulation of human MT(1) melatonin receptors expressed in mammalian cells. Biochem Pharmacol. 2004; 67(11).
- Rivera-Bermúdez MA, Masana MI, Brown GM, Earnest DJ, Dubocovich ML. Immortalized cells from the rat suprachiasmatic nucleus express functional melatonin receptors. Brain Res. 2004; 1002(1-2).
- Dubocovich ML, Rivera-Bermudez MA, Gerdin MJ, Masana MI. Molecular pharmacology, regulation and function of mammalian melatonin receptors. Front Biosci. 2003; 8.
- Soares JM, Masana MI, Ersahin C, Dubocovich ML. Functional melatonin receptors in rat ovaries at various stages of the estrous cycle. J Pharmacol Exp Ther. 2003; 306(2).
- Rivera-Bermúdez MA, Gerdin MJ, Earnest DJ, Dubocovich ML. Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells. Neurosci Lett. 2003; 346(1-2).
- Gerdin MJ, Mseeh F, Dubocovich ML. Mutagenesis studies of the human MT2 melatonin receptor. Biochem Pharmacol. 2003; 66(2).
- Benloucif S, Masana MI, Zee PC, Dubocovich ML. Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice. Brain Res. 2003; 966(1).
- Masana MI, Witt-Enderby PA, Dubocovich ML. Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal. Biochem Pharmacol. 2003; 65(5).
- Gerdin MJ, Masana MI, Ren D, Miller RJ, Dubocovich ML. Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors. J Pharmacol Exp Ther. 2003; 304(3).
- Masana MI, Doolen S, Ersahin C, Al-Ghoul WM, Duckles SP, Dubocovich ML, Krause DN. MT(2) melatonin receptors are present and functional in rat caudal artery. J Pharmacol Exp Ther. 2002; 302(3).
- Ersahin C, Masana MI, Dubocovich ML. Constitutively active melatonin MT(1) receptors in male rat caudal arteries. Eur J Pharmacol. 2002; 439(1-3).
- Masana MI, Dubocovich ML. Melatonin receptor signaling: finding the path through the dark. Sci STKE. 2001; 2001(107).
- Lotufo CM, Lopes C, Dubocovich ML, Farsky SH, Markus RP. Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation. Eur J Pharmacol. 2001; 430(2-3).
- Reid KJ, Chang AM, Dubocovich ML, Turek FW, Takahashi JS, Zee PC. Familial advanced sleep phase syndrome. Arch Neurol. 2001; 58(7).
- Hunt AE, Al-Ghoul WM, Gillette MU, Dubocovich ML. Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock. Am J Physiol Cell Physiol. 2001; 280(1).
- Masana MI, Benloucif S, Dubocovich ML. Circadian rhythm of mt1 melatonin receptor expression in the suprachiasmatic nucleus of the C3H/HeN mouse. J Pineal Res. 2000; 28(3).
- Ruby NF, Dubocovich ML, Heller HC. Siberian hamsters that fail to reentrain to the photocycle have suppressed melatonin levels. Am J Physiol Regul Integr Comp Physiol. 2000; 278(3).
- Benloucif S, Bauer GL, Dubocovich ML, Finkel SI, Zee PC. Nimodipine potentiates the light-induced suppression of melatonin. Neurosci Lett. 1999; 272(1).
- Benloucif S, Masana MI, Yun K, Dubocovich ML. Interactions between light and melatonin on the circadian clock of mice. J Biol Rhythms. 1999; 14(4).
- Dubocovich ML, Masana MI, Benloucif S. Molecular pharmacology and function of melatonin receptor subtypes. Adv Exp Med Biol. 1999; 460.
- Al-Ghoul WM, Herman MD, Dubocovich ML. Melatonin receptor subtype expression in human cerebellum. Neuroreport. 1998; 9(18).
- Dubocovich ML, Yun K, Al-Ghoul WM, Benloucif S, Masana MI. Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms. FASEB J. 1998; 12(12).
- Witt-Enderby PA, Masana MI, Dubocovich ML. Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor. Endocrinology. 1998; 139(7).
- Beresford IJ, Browning C, Starkey SJ, Brown J, Foord SM, Coughlan J, North PC, Dubocovich ML, Hagan RM. GR196429: a nonindolic agonist at high-affinity melatonin receptors. J Pharmacol Exp Ther. 1998; 285(3).
- Benloucif S, Masana MI, Dubocovich ML. Responsiveness to melatonin and its receptor expression in the aging circadian clock of mice. Am J Physiol. 1997; 273(6 Pt).
- Benloucif S, Masana MI, Dubocovich ML. Light-induced phase shifts of circadian activity rhythms and immediate early gene expression in the suprachiasmatic nucleus are attenuated in old C3H/HeN mice. Brain Res. 1997; 747(1).
- Masana MI, Benloucif S, Dubocovich ML. Light-induced c-fos mRNA expression in the suprachiasmatic nucleus and the retina of C3H/HeN mice. Brain Res Mol Brain Res. 1996; 42(2).
- Jansen JM, Copinga S, Gruppen G, Molinari EJ, Dubocovich ML, Grol CJ. The high affinity melationin binding site probed with conformationally restricted ligand--I. Pharmacophore and minireceptor models. Bioorg Med Chem. 1996; 4(8).
- Witt-Enderby PA, Dubocovich ML. Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells. Mol Pharmacol. 1996; 50(1).
- Benloucif S, Dubocovich ML. Melatonin and light induce phase shifts of circadian activity rhythms in the C3H/HeN mouse. J Biol Rhythms. 1996; 11(2).
- Larson-Prior LJ, Siuciak JA, Dubocovich ML. Localization of 2-[125I]iodomelatonin binding sites in visual areas of the turtle brain. Eur J Pharmacol. 1996; 297(1-2).
- Dubocovich ML, Benloucif S, Masana MI. Melatonin receptors in the mammalian suprachiasmatic nucleus. Behav Brain Res. 1996; 73(1-2).
- Dubocovich ML. Melatonin receptors: are there multiple subtypes? Trends Pharmacol Sci. 1995; 16(2).
- Popova JS, Dubocovich ML. Melatonin receptor-mediated stimulation of phosphoinositide breakdown in chick brain slices. J Neurochem. 1995; 64(1).
- Masana MI, Brown RC, Pu H, Gurney ME, Dubocovich ML. Cloning and characterization of a new member of the G-protein coupled receptor EDG family. Receptors Channels. 1995; 3(4).
- Krause DN, Siuciak JA, Dubocovich ML. Unilateral optic nerve transection decreases 2-[125I]-iodomelatonin binding in retinorecipient areas and visual pathways of chick brain. Brain Res. 1994; 654(1).
- Carneiro RC, Markus RP, Dubocovich ML. Presynaptic modulation by melatonin of the nicotine-induced calcium-dependent release of norepinephrine from rat vas deferens. Biol Signals. 1993; 2(4).
- Carneiro RC, Markus RP, Dubocovich ML. 2-[125I]iodomelatonin binding sites in the rat vas deferens. Biol Signals. 1993; 2(4).
- Pang SF, Dubocovich ML, Brown GM. Melatonin receptors in peripheral tissues: a new area of melatonin research. Biol Signals. 1993; 2(4).
- Siuciak JA, Dubocovich ML. Effect of pinealectomy and the light/dark cycle on 2-[125I]iodomelatonin binding in the chick optic tectum. Cell Mol Neurobiol. 1993; 13(3).
- Krause DN, Siuciak JA, Dubocovich ML. Optic nerve transection decreases 2-[125I]iodomelatonin binding in the chick optic tectum. Brain Res. 1992; 590(1-2).
- Siuciak JA, Gamache PH, Dubocovich ML. Monoamines and their precursors and metabolites in the chicken brain, pineal, and retina: regional distribution and day/night variations. J Neurochem. 1992; 58(2).
- Siuciak JA, Krause DN, Dubocovich ML. Quantitative pharmacological analysis of 2-125I-iodomelatonin binding sites in discrete areas of the chicken brain. J Neurosci. 1991; 11(9).
- Stanton TL, Siuciak JA, Dubocovich ML, Krause DN. The area of 2-[125I] iodomelatonin binding in the pars tuberalis of the ground squirrel is decreased during hibernation. Brain Res. 1991; 557(1-2).
- Blazynski C, Dubocovich ML. Localization of 2-[125I]iodomelatonin binding sites in mammalian retina. J Neurochem. 1991; 56(6).
- Dubocovich ML. Melatonin receptors in the central nervous system. Adv Exp Med Biol. 1991; 294.
- Krause DN, Dubocovich ML. Melatonin receptors. Annu Rev Pharmacol Toxicol. 1991; 31.
- Krause DN, Dubocovich ML. Regulatory sites in the melatonin system of mammals. Trends Neurosci. 1990; 13(11).
- Dubocovich ML, Mogilnicka E, Areso PM. Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test. Eur J Pharmacol. 1990; 182(2).
- Fang JM, Dubocovich ML. Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/HeN mouse hypothalamus. J Neurochem. 1990; 55(1).
- Dubocovich ML. Presynaptic receptors in the visual system. Ann N Y Acad Sci. 1990; 604.
- Duncan MJ, Fang JM, Dubocovich ML. Effects of melatonin agonists and antagonists on reproduction and body weight in the Siberian hamster. J Pineal Res. 1990; 9(4).
- Duncan MJ, Takahashi JS, Dubocovich ML. Characteristics and autoradiographic localization of 2-[125I]iodomelatonin binding sites in Djungarian hamster brain. Endocrinology. 1989; 125(2).
- Timmerman W, Dubocovich ML, Westerink BH, De Vries JB, Tepper PG, Horn AS. The enantiomers of the dopamine agonist N-0437: in vivo and in vitro effects on the release of striatal dopamine. Eur J Pharmacol. 1989; 166(1).
- Watson JM, Vogel SM, Cotterell DJ, Dubocovich ML. Cholinergic antagonism of beta-adrenergic stimulated action potentials and adenylate cyclase activity in rabbit ventricular cardiomyocytes. Eur J Pharmacol. 1988; 155(1-2).
- Dubocovich ML. Pharmacology and function of melatonin receptors. FASEB J. 1988; 2(12).
- Dubocovich ML. Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther. 1988; 246(3).
- Duncan MJ, Takahashi JS, Dubocovich ML. 2-[125I]iodomelatonin binding sites in hamster brain membranes: pharmacological characteristics and regional distribution. Endocrinology. 1988; 122(5).
- Dubocovich ML, Takahashi JS. Use of 2-[125I]iodomelatonin to characterize melatonin binding sites in chicken retina. Proc Natl Acad Sci U S A. 1987; 84(11).
- Hensler JG, Dubocovich ML. D1-dopamine receptor activation mediates [3H]acetylcholine release from rabbit retina. Brain Res. 1986; 398(2).
- Dubocovich ML, Lucas RC, Takahashi JS. Light-dependent regulation of dopamine receptors in mammalian retina. Brain Res. 1985; 335(2).
- Scatton B, Dubois A, Dubocovich ML, Zahniser NR, Fage D. Quantitative autoradiography of 3H-nomifensine binding sites in rat brain. Life Sci. 1985; 36(9).
- Dubocovich ML. Modulation of [3H]dopamine release from rabbit retina. Fed Proc. 1984; 43(12).
- Dubocovich ML. Alpha-2 adrenoceptors modulate [3H]dopamine release from rabbit retina. J Pharmacol Exp Ther. 1984; 230(1).
- Dubocovich ML. Presynaptic alpha-adrenoceptors in the central nervous system. Ann N Y Acad Sci. 1984; 430.
- Dubocovich ML. Melatonin is a potent modulator of dopamine release in the retina. Nature. 1983; 306(5945).
- Langer SZ, Moret C, Raisman R, Dubocovich ML, Briley M. High-affinity [3H]imipramine binding in rat hypothalamus: association with uptake of serotonin but not of norepinephrine. Science. 1980; 210(4474).
- Dubocovich ML, Langer SZ. Pharmacological differentiation of presynaptic inhibitory alpha-adrenoceptors and opiate receptors in the cat nictitating membrane. Br J Pharmacol. 1980; 70(3).
- Dubocovich ML, Langer SZ. Dopamine and alpha adrenoceptor agonists inhibit neurotransmission in the cat spleen through different presynaptic receptors. J Pharmacol Exp Ther. 1980; 212(1).
- Massingham R, Dubocovich ML, Langer SZ. Effect of the alpha-adrenoreceptor agonist LD 3098 (cirazoline) on the magnitude of end-organ responses induced by nerve stimulation and exogenous noradrenaline in a variety of sympathetically innervated animal tissues. Clin Sci (Lond). 1979; 57 Su.
- Garcia-Sevilla JA, Dubocovich ML, Langer SZ. Angiotensin II facilitates the potassium-evoked release of 3H-noradrenaline from the rabbit hypothalamus. Eur J Pharmacol. 1979; 56(1-2).
- Celuch SM, Dubocovich ML, Lander SZ. Stimulation of presynaptic beta-adrenoceptors enhances [3H]-noradrenaline release druing nerve stimulation in the perfused cat spleen. Br J Pharmacol. 1978; 63(1).
- Dubocovich ML, Langer SZ. Influence of the frequency of nerve stimulation on the metabolism of 3H-norepinephrine released from the perfused cat spleen: differences observed during and after the period of stimulation. J Pharmacol Exp Ther. 1976; 198(1).
Professional Memberships:
- American College of Neuropsychopharmacology- Fellow (2012–present)
- European Circadian Rhythms Society (2009–present)
- American Association of Pharmacology Chairs (2009–present)
- Society for Advancement of Chicanos and Native Americans in Science (SACNAS) (2002–present)
- American College of Neuropsychopharmacology- Member (1998–2012)
- Catecholamine Club (1990–present)
- Serotonin Club (1987–present)
- American Society for Pharmacology and Experimental Therapeutics (1983–present)
- Society of Neuroscience (1981–present)
- French Association of Pharmacology (1979–1989)
- British Pharmacological Society (1978–present)
Service Activities:
- Western New York ASPET Chapter; President (2010–present)
- Professional Development Committee, Society for Neuroscience.; Committee Member (2009–present)
- Diversity In Neuroscience (DIN) Committee, Society for Neuroscience; Committee Member (2008–2009)
- Division for Neuropharmacology of ASPET; Secretary/Treasurer (2006–2010)
- ASPET Committee on Minorities Affairs; Past President (2005–2006)
- Great Lakes Chapter ASPET; Committee Member (2005–2007)
- Biological Rhythms and Sleep Study Section; Member (2003–2004)
- ASPET Committee on Minorities Affairs; Chair (2002–2005)
- Division of Pharmacology Education of ASPET; Executive Board (2001–2005)
- Integrative, Functional and Cognitive Neuroscience 3 (IFCN-3) Study Section; Member (2000–2003)
- IUPHAR Subcommittee for Melatonin Receptor Nomenclature and Classification; Chair (1995–present)
- NIMH Neurochemistry and Neuropharmacology Review Committee (NIH); Member (1992–1996)
- Various Insitutes; Northwestern University Neuroscience Institute, Robert H. Lurie Cancer Center, The Asher Center for the Study & Treatment of Depressive Disorders, Center for Drug Discovery and Chemical Biology, Center for Sleep and Circadian Biology; Participant (1989–2008)
- Doctoral Fellowships in Biol. Science, Review Panel, Howard Hughes Medical Institute; Reviewer (1989–1992)
- Grants-In-Aid Review Committee, American Heart Association, Chicago; Member (1988)
- Chicago Chapter Society for Neuroscience; Councilor, Secretary Treasurer, Treasurer, President Elect, President, Past President (1985–1996)