Wilfrido D. Mojica MD

Wilfrido Mojica

Wilfrido D. Mojica

Associate Professor

Department of Pathology and Anatomical Sciences

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Anatomic Pathology; Clinical Pathology; Molecular Genetic Pathology - Clinical Biochemical; Surgical Pathology

Contact Information
100 High Street
Buffalo General Hospital
Department of Pathology Room A708
Buffalo, NY 14203
Phone: (716) 859-2140

Professional Summary:

Professional Summary:
As a pathologist, I help cover the clinical duties for the Kaleida Health system’s anatomical pathologist needs at the Buffalo General Medical Center, Suburban Hospital and DeGraff Hospital. I am Board certified in Anatomic and Clinical Pathology with an interest in oncologic pathology and approaches related to precision medicine. The majority of my time is allocated for clinical service work, which includes general surgical pathology, some clinical pathology coverage, and the teaching of pathology residents. Additional clinical duties include overseeing the laboratory’s immunohistochemistry section and involvement in the build-up of the CTRC’s biobank. For resident education, one major emphasis currently being undertaken is the deciphering of the technical and bioinformatic bridges that separate pathologists from those involved in the field of genomic sequencing.

Dedicated research time has allowed me to be involved in investigations centered on improvements in sample procurement and biomarker studies for antibody-drug conjugate (ADC) characterization. Current work on the former is centered on the development of an automated prototype for the processing of cells recovered from washed core needle biopsies, but with utility for any ‘wet’ type biopsy or sample (e.g., cytology specimens). This prototype is intended to enable unfixed cells to travel through a microfluidic platform that will allow for their quantitative evaluation and assessment of their cytologic features for diagnostic purposes, and their recovery for downstream molecular studies. Because of their unfixed nature, we are assessing the utility of the DNA extracted from these cells for long read sequencing technologies, believing these devices will ultimately replace both multi-panel, next generation tests and FISH assays for the elucidation of molecular abnormalities at both the single nucleotide and structural variation level. This approach will preserve the original core needle biopsy tissue for further tissue-based testing that requires morphologic evaluation, in particular, the profiling of tumor tissue to guide treatment with the aforementioned ADC currently being tested in clinical trials. The underlying effort is to maximize the amount of informative data derived from diminutive biospecimens and prevent the current problems associated with tissue exhaustion.

Education and Training:

  • MD, St Louis University School of Medicine (1993)
  • MS, Georgetown University (1988)
  • BS, University of California (1987)


  • Director Immunohistochemistry Laboratory, Kaleida Health Immunohistochemistry Laboratories (2011-present)
  • Attending Pathologist, UB Pathologist Inc (2001-present)
  • Assistant Professor, University at Buffalo (2001-present)
  • Staff Pathologist, Eastern Great Lakes Pathology, LLC (2000–2001)
  • Staff Pathologist, ACM Laboratories (1999–2000)

Grants and Sponsored Research:

  • August 2009–July 2012
    Identification of colon cancer protein biomarkers in blood
    Role: Principal Investigator

Journal Articles:

See all (19 more)


  • Tu C, Shen S, Nouri-Nigjeh E, Mojica WD, Qu J. Large scale comparative proteomic anlaysis of colon cancer cells isolated from multiple patients using extensive ion-current-based approach. ASMS. 2013.
  • Kumparelli A, Mojica WD. Preclinical evidence DiPeptidase-1 may function as a putative biomarker for colonic adenocarcinoma. CAP. 2012.
  • Huang Y, Mojica WD. Dipeptidase-1 expression profiles in human normal and tumor tissues. CAP. 2012.
  • Kumparelli A, Marchetti E, Mojica WD. DPE1, a useful immunohistochemical tool in distinguishing primary from metasttic endometrioid and mucinous ovarian tumors. USCAP, Mod Pathol. 2012; 25(2).

Evaluative Studies and Case Reports:

Professional Memberships:

  • United States and Canadian Academy of Pathology; Member
  • College of American Pathologist; Member
  • American Association for Cancer Research; Member
  • International Society of Biological Environmental Biorepositories; Member

School News:

In the Media:

Clinical Specialties:

Clinical Offices:

Insurance Accepted:

Contact Information

100 High Street
Buffalo General Hospital
Department of Pathology Room A708
Buffalo, NY 14203
Phone: (716) 859-2140