Wilfrido D. Mojica MD

Wilfrido Mojica

Wilfrido D. Mojica
MD

Associate Professor

Department of Pathology and Anatomical Sciences

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Anatomic Pathology; Clinical Pathology; Molecular Genetic Pathology - Clinical Biochemical; Surgical Pathology

Contact Information
621 10th Street
Department of Pathology
Niagara Falls, New York 14301
Phone: (716) 278-4339
mojica@buffalo.edu



Professional Summary:

Professional Summary:
As a pathologist, I help cover the clinical duties for the Kaleida Health system’s anatomical pathologist needs at the Buffalo General Medical Center, Suburban Hospital and DeGraff Hospital. I am Board certified in Anatomic and Clinical Pathology with an interest in oncologic pathology and approaches related to precision medicine. The majority of my time is allocated for clinical service work, which includes general surgical pathology, some clinical pathology coverage, and the teaching of pathology residents. Additional clinical duties include overseeing the laboratory’s immunohistochemistry section and involvement in the build-up of the CTRC’s biobank. For resident education, one major emphasis currently being undertaken is the deciphering of the technical and bioinformatic bridges that separate pathologists from those involved in the field of genomic sequencing.

Dedicated research time has allowed me to be involved in investigations centered on improvements in sample procurement and biomarker studies for antibody-drug conjugate (ADC) characterization. Current work on the former is centered on the development of an automated prototype for the processing of cells recovered from washed core needle biopsies, but with utility for any ‘wet’ type biopsy or sample (e.g., cytology specimens). This prototype is intended to enable unfixed cells to travel through a microfluidic platform that will allow for their quantitative evaluation and assessment of their cytologic features for diagnostic purposes, and their recovery for downstream molecular studies. Because of their unfixed nature, we are assessing the utility of the DNA extracted from these cells for long read sequencing technologies, believing these devices will ultimately replace both multi-panel, next generation tests and FISH assays for the elucidation of molecular abnormalities at both the single nucleotide and structural variation level. This approach will preserve the original core needle biopsy tissue for further tissue-based testing that requires morphologic evaluation, in particular, the profiling of tumor tissue to guide treatment with the aforementioned ADC currently being tested in clinical trials. The underlying effort is to maximize the amount of informative data derived from diminutive biospecimens and prevent the current problems associated with tissue exhaustion.

Education and Training:

  • MD, St Louis University School of Medicine (1993)
  • MS, Georgetown University (1988)
  • BS, University of California (1987)

Employment:

  • Attending Pathologist, NFMMC (2021-present)
  • Associate Professor, Pathology and Anatomical Sciences, University at Buffalo (2017-present)
  • Attending Pathologist, VA WNY (2020)
  • Attending Pathologist, UB Pathologist Inc (2001–2019)
  • Assistant Professor, Pathology and Anatomical Sciences, University at Buffalo (2004–2017)
  • Staff Pathologist, Eastern Great Lakes Pathology, LLC (2000–2001)
  • Staff Pathologist, ACM Laboratories (1999–2000)

Awards and Honors:

  • AACR Minority Scholar in Cancer Research (2011)
  • Pickren Pathology Award (1997)

Grants and Sponsored Research:

  • March 2020–December 2020
    Illumina Accelerator Sequencing Grant
    Role: Principal Investigator
  • October 2017–September 2019
    High quality, high integrity nucleic acid extraction from FFPE
    NIH
    Role: Co-Investigator
  • January 2018–December 2018
    Pre-Cell Wrangler: Enabling recovery of informative genomic data with lower numbers but higher quality diagnostic cells
    Research for Health in Erie County
    Role: Principal Investigator
  • August 2009–July 2012
    Identification of colon cancer protein biomarkers in the blood
    NIH
    Role: Principal Investigator
  • June 2005–May 2006
    Differential phosphoprofiling by a novel procurement protocol
    Kaleida Health Foundation
    Role: Co-Investigator

Journal Articles:

See all (26 more)

Abstracts:

  • Tu C, Shen S, Nouri-Nigjeh E, Mojica WD, Qu J. (2013) Large scale comparative proteomic anlaysis of colon cancer cells isolated from multiple patients using extensive ion-current-based approach. (Jun)
  • Kumparelli A, Mojica WD. (2012) Preclinical evidence DiPeptidase-1 may function as a putative biomarker for colonic adenocarcinoma. (Sep)
  • Huang Y, Mojica WD. (2012) Dipeptidase-1 expression profiles in human normal and tumor tissues. (Sep)
  • Kumparelli A, Marchetti E, Mojica WD. (2012) DPE1, a useful immunohistochemical tool in distinguishing primary from metasttic endometrioid and mucinous ovarian tumors. (Mar)

Professional Memberships:

  • American Association for Cancer Research; Member
  • College of American Pathologists; Member
  • United States and Canadian Academy of Pathology; Member

Presentations:

  • "Capturing dissociated cells from core needle biopsies: up front triaging enhances comprehensive diagnosis" 2nd International Cancer Study and Thearapy Conference (2017)
  • "Facilitating molecular profiling of core needle biopsies via the inclusion of a prefatory step to traditional tissue processing: The value of a simple wash" International Conference on Genomic Medicine (2017)
  • "Anticipating and Providing Solutions to Precision Medicine Before They Become Problems" Western New York Society of Pathologists (2015)
  • "Core washing of needle biopsy specimens with microfluidics: a novel approach to meet the increasing demands of ancillary testing on small specimens." Cytopathology 2015 (2015)
  • "Microfluidics for multiplexing of core needle biopsies." TechConnect World Innovation Conference (2015)
  • "Microfluidics in the Diagnosis of Anatomic Pathology Specimens: pipe-dream or pipeline?" University at Buffalo, Department of Pathology Grand Rounds (2014)

Service Activities:

  • Pathology Residency Clinical Competency Committee (2021–present)
  • Dental School Pathology 600 Course - change in presentations from pure basic science delivery to clinical application and relevance (i.e., more oral-cavity centric).; Modifications of certain labs and lectures (2021–present)
  • NFMMC - Medical Executive Committee (2021–present)
  • NFMMC - Infectious Disease Prevention Committee (2021–present)
  • NFMMC - Transfusion Committee; Transfusion Committee (2021–present)
  • North American Journal of Medicine and Science (2020)
  • Current Clinical Pharmacology (2020)
  • Biotechnology and Applied Biochemistry (2019)
  • Biotechnology and Applied Biochemistry (2019)
  • Analytical Cellular Pathology (2018)
  • Faculty Council Representative; Faculty Council Representative (2017–2019)
  • Collegiate Science and Technology Entry Program (CSTEP); Judge, Team 5 (2017)
  • BMC Cancer (2017)
  • Therapeutics and Clinical Risk Management (2016)
  • Current Medical Imaging Reviews (2016)
  • Secretary, WNYSP (2016–2017)
  • Faculty Council Representative (alternate); alternate (2015–2017)
  • Advisor, WNYSP (2014–2016)
  • PLosOne (2014)
  • NIH OMnibus SEP-5: Special emphasis panel/ Scientific Review Group 2014/10 ZCA1 TCRB-5 (02) (2014)
  • Treasurer, WNYSP (2013–2014)
  • President, WNYSP (2012–2013)
  • Secretary, WNYSP (2011–2012)
  • Immunological Investigations (2010)
  • NIH Stage 1 reviewer, Cell Biology Integrated Review Group (2009)
  • Drug Target Insight (2008)
  • Experimental and Molecular Pathology (2006)

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Contact Information

621 10th Street
Department of Pathology
Niagara Falls, New York 14301
Phone: (716) 278-4339
mojica@buffalo.edu