Randall L. Rasmusson PhD
Randall L. Rasmusson
PhD
Education and Training:
- PhD, Physiology, Duke University (1991)
- MS, Electrical Engineering, Rice University (1986)
- BS, Electrical Engineering, Computer Science, Rice University (1983)
Employment:
- Professor, Biomedical Engineering, SUNY, University at Buffalo (2010-present)
- Professor, Physiology and Biophysics, SUNY, University at Buffalo (2006-present)
- Associate Professor, Department of Physiology and Biophysics, State University of New York at Buffalo (2000–2006)
- Associate Professor, Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine (1999–2000)
- Adjunct Assistant Professor, Program in Biomedical Engineering, Carnegie-Mellon University (1999)
- Assistant Professor, Department of Medicine and Physiology, Allegheny Universiy of Health Sciences (1998–1999)
- Research Assistant Professor, Department of Biomedical Engineering, Duke University (1991–1997)
Awards and Honors:
- UB Exceptional Scholar, Sustained Achievement Award (2011)
- National Merit Scholarship
- NIH,NRSA Training Grant HL-07063-12
- Whitaker Foundation Researcher
- Proctor & Gamble, Alternatives to Animal Research Finalist
- Established Investigator, American Heart Association
- Fellow of the American Heart Association
Research Centers:
- Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- May 2011–April 2012
Device to treat postpartum hemorrhage
Bill and Melinda Gates Foundation
Role: Co-Principal Investigator
$100,000 - August 2014
Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit.
UBCAT
Role: Principal Investigator
$60,000 - K+ Channel Inactivation and Antiarrhythmic Drug Action
NIH
Role: Principal Investigator - N-terminal and beta-subunit modulation of cloned cardiac K+ channels
American Heart Association
Role: Principal Investigator - A Model of the Ferret Ventricular Action Potential
Whitaker Foundation
Role: Principal Investigator - Cardiac pacemaker activity
Role: Co-Investigator - Cardiac transient outward current
Role: Co-Investigator - Modulation of Ca2+ channels by dihydropyridines and Ca2+
Role: Consultant
Journal Articles:
- Bett GC, Dinga-Madou I, Zhou Q, Bondarenko VE, Rasmusson RL. A model of the interaction between N-type and C-type inactivation in Kv1.4 channels. Biophys J. 2011; 100(1).
- Bondarenko VE, Rasmusson RL, Rasmusson R. Simulations of propagated mouse ventricular action potentials: effects of molecular heterogeneity. Am J Physiol Heart Circ Physiol. 2007; 293(3).
- Tian L, Jiang X, Rasmusson R, Wang S. Effect of propafenone on Kv1.4 inactivation. J Physiol Biochem. 2006; 62(4).
- Bett GC, Morales MJ, Strauss HC, Rasmusson RL. KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine. Biochem Biophys Res Commun. 2006; 340(4).
- Wang S, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. Amino acid substitutions in the pore of the CaV1.2 Ca channel reduce Ba currents without affecting calcium currents.. Biophys. J.. 2005; 89.
- Wang S, Bondarenko VE, Qu Y, Bett GCL, Morales MJ, Rasmusson RL, Stauss HC. Time- and voltage-dependent components of Kv4.3 inactivation.. Biophys. J.. 2005; 89(5).
- Wang S, Bondarenko VE, Morales MJ, Strauss H, Rasmusson R. Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence. J Physiol. 2004; 557(Pt 3).
- Bett GCL, Rasmusson RL. Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore.. J. Physiol.. 2004; 556.
- Bondarenko VE, Bett GCL, Rasmusson RL. A Model of Graded Calcium release and L-type Ca2+ channel inactivation in cardiac muscle.. Am. J. Physiol.. 2004; 286.
- Bondarenko VE, Szigeti GP, Bett GCL, Kim SJ, Rasmusson RL. A computer model of the action potential of mouse ventricular myocytes.. Am. J. Phsiol. 2004; 287.
- Li XY, Bett GCL, Jiang XJ, Bondarenko VE, Morales MJ, Rasmusson RL. Regulation of N- and C-type inactivation by pHo and K+ in normal and mutant Kv1.4 channels: Evidence for transmembrane communication.. Am. J. Physiol.. 2003; 284.
- Wang S, Morales MJ, Qu YJ, Bett GCL, Strauss HC, Rasmusson Rl. Kv1.4 channel block by quinidine: evidence for a drug induced allosteric effect.. J. Physiol.. 2003; 546.
- Jiang XJ, Bett GCL, Li XY, Bondarenko VE, Rasmusson RL. C- type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 channels expressed in Xenopus oocytes.. J. Physiol.. 2003; 549.
- Bett GCL, Rasmusson RL. Functionally-distinct proton-binding in HERG suggests the presence of two binding sites.. Cell Biochem. Biophys.. 2003; 39.
- Strauss HC, Rasmusson RL,. Restitution, ventricular fibrillation, and drugs: where are we now? J Cardiovasc Electrophysiol. 2002; 13(9).
- Kim SJ, Kudej RK, Yatani A, Kim YK, Takagi G, Honda R, Colantonio DA, Van Eyk JE, Vatner DE, Rasmusson RL, Vatner SF. A novel mechanism for myocardial stunning involving impaired Ca(2+) handling. Circ Res. 2001; 89(9).
- Bondarenko VE, Doedel EJ, Rasmusson RL. Bifurcation diagrams of frequency dependence of repolarization during long QT syndrome using the Luo and Rudy model of cardiac repolarization. AIP Proceedings. 2000; 502.
- Brahmajothi MV, Campbell DL, Rasmusson RL, Morales MJ, Trimmer JS, Nerbonne JM, Strauss HC. Distinct transient outward potassium current (Ito) phenotypes and distributionof fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol. 1999; 113(4).
- Rasmusson R, Morales MJ, Wang S, Liu S, Campbell DL, Brahmajothi MV, Strauss H. Inactivation of voltage-gated cardiac K+ channels. Circ Res. 1998; 82(7).
- Liu QY, Rasmusson RL, Liu QX, Strauss HC,. Voltage-dependent, open channel blockade of the cardiac sarcoplasmic reticulumpotassium channel by 4-aminopyridine. Can J Cardiol. 1998; 14(2).
- Liu S, Rasmusson RL. Models of potassium channel inactivation: implications for open channel block. Can J Cardiol. 1998; 14(1).
- Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson R. Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation. FEBS Lett. 1997; 417(1).
- Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL. A quantitative analysis of the activation and inactivation kinetics of HERGexpressed in Xenopus oocytes. J Physiol. 1997; 502 (.
- Liu S, Rasmusson RL. Hodgkin-Huxley and partially coupled inactivation models yield different voltagedependence of block. Am J Physiol. 1997; 272(4 Pt).
- Brahmajothi MV, Morales MJ, Rasmusson RL, Campbell DL, Strauss HC. Heterogeneity in K+ channel transcript expression detected in isolated ferretcardiac myocytes. Pacing Clin Electrophysiol. 1997; 20(2 Pt).
- Rasmusson RL, Wang S, Castellino RC, Morales MJ, Strauss HC. The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminaldeleted Kv1.4 alpha-subunits. Adv Exp Med Biol. 1997; 430.
- Morales MJ, Wee JO, Wang S, Strauss HC, Rasmusson RL. The N-terminal domain of a K+ channel beta subunit increases the rate of C-typeinactivation from the cytoplasmic side of the channel. Proc Natl Acad Sci U S A. 1996; 93(26).
- Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson RL. Time, voltage and ionic concentration dependence of rectification of h-ergexpressed in Xenopus oocytes. FEBS Lett. 1996; 389(2).
- Liu S, Rasmusson RL, Campbell DL, Wang S, Strauss HC. Activation and inactivation kinetics of an E-4031-sensitive current from singleferret atrial myocytes. Biophys J. 1996; 70(6).
- Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, Strauss HC. In situ hybridization reveals extensive diversity of K+ channel mRNA in isolatedferret cardiac myocytes. Circ Res. 1996; 78(6).
- Rasmusson RL, Morales MJ, Castellino RC, Zhang Y, Campbell DL, Strauss HC. C-type inactivation controls recovery in a fast inactivating cardiac K+ channel(Kv1.4) expressed in Xenopus oocytes. J Physiol. 1995; 489 (.
- Castellino RC, Morales MJ, Strauss HC, Rasmusson RL. Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit(Kv beta 3) cloned from ferret ventricle. Am J Physiol. 1995; 269(1 Pt).
- Rasmusson RL, Zhang Y, Campbell DL, Comer MB, Castellino RC, Liu S, Strauss HC. Bi-stable block by 4-aminopyridine of a transient K+ channel (Kv1.4) clonedfrom ferret ventricle and expressed in Xenopus oocytes. J Physiol. 1995; 485 (.
- Morales MJ, Castellino RC, Crews AL, Rasmusson RL, Strauss HC. A novel beta subunit increases rate of inactivation of specific voltage-gatedpotassium channel alpha subunits. J Biol Chem. 1995; 270(11).
- Rasmusson, RL, Zhang Y, Campbell DL, Comer MB, Castellino RC, Liu S, Morales MJ, Strauss HC,. Molecular mechanisms of K+ channel blockade: 4-aminopyridine interaction witha cloned cardiac transient K+ (Kv1.4) channel. Biophys Journal. 1995; 382.
- Lieberman M, Rasmusson RL, Zhang J, Hall SK, Smith TW, Smith JJ. Swelling-activated membrane transport and signaling mechanisms in cardiac cells.. Heart Vessels. 1995; 9.
- Himmel HM, Rasmusson RL, Strauss HC. Agonist-induced changes of [Ca2+]i and membrane currents in single bovine aorticendothelial cells. Am J Physiol. 1994; 267(5 Pt).
- Comer MB, Campbell DL, Lamson DR, Morales MJ, Zhang Y, Strauss H, Rasmusson R. Cloning and characterization of an Ito-like potassium channel from ferret ventricle. Am J Physiol. 1994; 267(4 Pt).
- Zhang J, Rasmusson RL, Hall SK, Lieberman M. A chloride current associated with swelling of cultured chick heart cells. J Physiol. 1993; 472.
- Shen WK, Rasmusson RL, Liu QY, Crews AL, Strauss HC. Voltage and temperature dependence of single K+ channels isolated from caninecardiac sarcoplasmic reticulum. Biophys J. 1993; 65(2).
- Campbell DL, Qu Y, Rasmusson RL, Strauss HC. The calcium-independent transient outward potassium current in isolated ferretright ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine. J Gen Physiol. 1993; 101(4).
- Rasmusson RL, Davis DG, Lieberman M. Amino acid loss during volume regulatory decrease in cultured chick heart cells. Am J Physiol. 1993; 264(1 Pt).
- Campbell DL, Rasmusson RL, Qu Y, Strauss HC. The transient outward potassium current in isolated ferret right ventricular myocytes: I. Basic characterization and kinectic analysis.. J. Gen. Physiol.. 1993; 101.
- Smith TW, Rasmusson RL, Lobaugh LA, Lieberman M. Na+/K+ pump inhibition induces cell shrinkage in cultured chick cardiac myocytes. Basic Res Cardiol. 1993; 88(5).
- Rasmusson RL, Campbell DL. Interaction of ICa with INa/Ca2 [Ca++]i and Ca++ binding proteins in frog atrium:a theoretical study. Adv Exp Med Biol. 1992; 311.
- Campbell DL, Qu Y, Rasmusson RL, Strauss HC. ‘Reverse use-dependent‘ effects of 4-aminopyridine on the transient outwardpotassium current in ferret right ventricular myocytes. Adv Exp Med Biol. 1992; 311.
- Campbell DL, Rasmusson RL, Strauss HC. Ionic current mechanisms generating vertebrate primary cardiac pacemaker activityat the single cell level: an integrative view. Annu Rev Physiol. 1992; 54.
- Murphey CR, Clark JW, Giles WR, Rasmusson RL, Halter JA, Hicks K, Hoyt B. Conduction in bullfrog atrial strands: simulations of the role of disc andextracellular resistance. Math Biosci. 1991; 106(1).
- Rasmusson RL, Clark JW, Giles WR, Robinson K, Clark RB, Shibata EF, Campbell DL. A mathematical model of electrophysiological activity in a bullfrog atrialcell. Am J Physiol. 1990; 259(2 Pt).
- Rasmusson RL, Clark JW, Giles WR, Shibata EF, Campbell DL. A mathematical model of a bullfrog cardiac pacemaker cell. Am J Physiol. 1990; 259(2 Pt).
- Campbell DL,Rasmusson RL,Strauss HC. Theoretical study of the voltage and concentration dependence of the anomalous mole fraction effect in single channels: New insights into the characterization of multi-ion channels.. Biophys.J.. 1988; 259.
- Hume JR, Giles W, Robinson K, Shibata EF, Nathan RD, Kanai K, Rasmusson RL. A time- and voltage-dependent K+ current in single cardiac cells from bull frog atrium. J Gen Physiol. 1986; 88(6).
- Hume JR, Giles W, Robinson K, Shibata EF, Nathan RD, Kanai K, Rasmusson R. A time- and voltage-dependent K+ current in single cardiac cells from bullfrog atrium. J Gen Physiol. 1986; 88(6).
Books and Book Chapters:
- Bett GCL, Rasmusson RL. Fundamentals of Cellular Electrophysiology.. Springer. 2006.
- Bett GC, Rasmussson RL. Models of Cardiac Ion Channels. Quantitative Cardiac Electrophysiology. 2002.
- Rasmusson RL. Voltage-gated sodium and potassium channels. In: The Corsini encyclopedia of psychology and behavioral science 3rd edition.. John Wiley & Sons Inc., N.Y.. 2001.
- Rasmusson RL, Liu S, Strauss HC. Pharmacology of K+ channels. In: Cardiac electrophysiology: from cell to bedside.. W.B. Saunders Co., Phila.. 1999.
- Morales MJ, Rasmusson RL, Castellino RC, Crews AL, Zhang Y, Johnson LG, Lamson DR, Liu S, Comer MB, Strauss HC. A voltage-gated K+ channel ß -subunit cloned from ferret ventricle: Implications for cardiac K+ channel function. In: Potassium channels in normal and pathological conditions.. Leuven University Press, Belgium. 1995.
- Rasmusson RL, Campbell DL, Qu Y, Strauss HC. Conformation dependent drug binding to cardiac potassium channels. Ion channels in the cardiovascular system.. Futura, N.Y.. 1994.
- Campbell DL, Rasmusson RL, Comer MB, Strauss HC. The cardiac calcium-independent transient outward potassium current: Kinetics, molecular properties and possible role in ventricular repolarization. In: Cardiac electrophysiology: from cell to bedside.. W.B. Saunders Co., Phila.. 1994.
- Campbell DL, Rasmusson RL, Strauss HC. Electrophysiology and pharmacology of the heart: A clinical guide.. Marcel Dekker, Inc. Pub., N.Y.. 1991.
- Shen WK, Hill JA, Rasmusson RL, Strauss HC. Reconstitution of the K channel of cardiac sarcoplasmic reticulum. Prog Clin Biol Res. 1990; 334.
Professional Memberships:
- Biophysical Society
- Physiological Society
- IEEE
- NASPE
- AHA Basic Sciences Council
- American Physiological Society