Randall L. Rasmusson PhD
Randall L. Rasmusson
PhD
Professor
Department of Physiology and Biophysics
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Biomedical Engineering; Biophysical Modeling; Computational Biology; Drug Development; Drug Discovery; Electrophysiology; Ion channel kinetics and structure; Ion Transport; Membrane Biophysics; Membrane Transport (Ion Transport); Neuroscience; Stem Cells
Education and Training:
- PhD, Physiology, Duke University (1991)
- MS, Electrical Engineering, Rice University (1986)
- BS, Electrical Engineering, Computer Science, Rice University (1983)
Employment:
- Professor, Biomedical Engineering, SUNY, University at Buffalo School of Engineering and Applied Sciences (2010-present)
- Professor, Physiology and Biophysics, SUNY, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2006-present)
- President, Cytocybernetics Inc. (2013–2022)
- Associate Professor, Department of Physiology and Biophysics, State University of New York at Buffalo (2000–2006)
- Associate Professor, Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine (1999–2000)
- Adjunct Assistant Professor, Program in Biomedical Engineering, Carnegie-Mellon University (1999)
- Assistant Professor, Department of Medicine and Physiology, Allegheny Universiy of Health Sciences (1998–1999)
- Research Assistant Professor, Department of Biomedical Engineering, Duke University (1991–1997)
Awards and Honors:
- UB Exceptional Scholar, Sustained Achievement Award (2011)
- Whitaker Foundation Researcher
- Established Investigator, American Heart Association
- Fellow of the American Heart Association
- National Merit Scholarship
- NIH,NRSA Training Grant HL-07063-12
- Proctor & Gamble, Alternatives to Animal Research Finalist
Research Centers:
- Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
- Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
- April 2024–April 2024
NIH R43 MH119842 Phase II Nowak, M. (Cytocybernetics PI), Rasmusson R (Subcontract PI) 1/1/2022-12/31/2023 Advanced Dynamic Clamp for Neuroscience.
NIMH
Role: Co-Principal Investigator
$1,900,000 - April 2024–April 2024
NSF SBIR 1913793 Phase II Korbel, L. (Cytocybernetics PI), Rasmusson R (Subcontract PI) 1/1/2022-12/31/2023 STTR Phase II: Developing a platform for superior predictive analysis of HERG Ion Channel-Drug Interactions for the Comprehensive In-vitro Proarrhythmia Assay (CiPA).
NSF
Role: Co-Principal Investigator
$1,000,000 - April 2024–April 2024
NIH 1R43NS125749-01 Phase I Nowak, M (Cytocybernetics PI), Rasmusson (sub-contract PI) 7/15/2022-7/14/2023 Real Time NEURON Simulation for Experimental Applications.
NINDS
Role: Co-Principal Investigator
$250,000 - April 2024–April 2024
UB CAT
Cytocybernetics
Role: Principal Investigator
$60,000 - April 2021–April 2021
K+ Channel Inactivation and Antiarrhythmic Drug Action
NIH
Role: Principal Investigator - August 2014–April 2017
Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit.
UBCAT
Role: Principal Investigator
$60,000 - May 2011–April 2012
Device to treat postpartum hemorrhage
Bill and Melinda Gates Foundation
Role: Co-Principal Investigator
$100,000 - Modulation of Ca2+ channels by dihydropyridines and Ca2+
Role: Consultant - N-terminal and beta-subunit modulation of cloned cardiac K+ channels
American Heart Association
Role: Principal Investigator - A Model of the Ferret Ventricular Action Potential
Whitaker Foundation
Role: Principal Investigator - Cardiac pacemaker activity
Role: Co-Investigator - Cardiac transient outward current
Role: Co-Investigator
Journal Articles:
- Du C, Rasmusson RL, Bett GC, Franks B, Zhang H, Hancox JC. (2021) Investigation of the Effects of the Short QT Syndrome D172N Kir2.1 Mutation on Ventricular Action Potential Profile Using Dynamic Clamp. Frontiers in pharmacology (Jan), 12: 794620. doi:10.3389/fphar.2021.794620
- Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. (2020) General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clinical pharmacology and therapeutics (Jan), 107(1): 102-111. doi:10.1002/cpt.1647
- Calorio C, Gavello D, Guarina L, Salio C, Sassoè-Pognetto M, Riganti C, Bianchi FT, Hofer NT, Tuluc P, Obermair GJ, Defilippi P, Balzac F, Turco E, Bett GC, Rasmusson RL, Carbone E. (2019) Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers. The Journal of physiology (Mar), 597(6): 1705-1733. doi:10.1113/JP277487
- Cheli VT, Santiago González DA, Zamora NN, Lama TN, Spreuer V, Rasmusson RL, Bett GC, Panagiotakos G, Paez PM. (2018) Enhanced oligodendrocyte maturation and myelination in a mouse model of Timothy syndrome. Glia (Aug).
- Ma D, Liu Z, Loh LJ, Zhao Y, Li G, Liew R, Islam O, Wu J, Chung YY, Teo WS, Ching CK, Tan BY, Chong D, Ho KL, Lim P, Yong RYY, Panama BK, Kaplan AD, Bett GCL, Ware J, Bezzina CR, Verkerk AO, Cook SA, Rasmusson RL, Wei H. (2018) Identification of an INa-dependent and Ito-mediated proarrhythmic mechanism in cardiomyocytes derived from pluripotent stem cells of a Brugada syndrome patient. Sci Rep (Jul), 8(1): 11246-11246.
- Kabitzke PA, Brunner D, He D, Fazio PA, Cox K, Sutphen J, Thiede L, Sabath E, Hanania T, Alexandrov V, Rasmusson R, Spooren W, Ghosh A, Feliciano P, Biemans B, Benedetti M, Clayton AL. (2018) Comprehensive analysis of two Shank3 and the Cacna1c mouse models of autism spectrum disorder. Genes, brain, and behavior (Jan), 17(1): 4-22.
- Sekera ER, Rudolph HL, Carro SD, Morales MJ, Bett GCL, Rasmusson RL, Wood TD. (2017) Depletion of Stercobilin in Fecal Matter from a Mouse Model of Autism Spectrum Disorders. Metabolomics (Nov), 13(11).
- Papp R, Bett GCL, Lis A, Rasmusson RL, Baczkó I, Varró A, Salama G. (2017) Genomic upregulation of cardiac Cav1.2α and NCX1 by estrogen in women. Biol Sex Differ (Aug), 8: 26-26.
- Papp R, Bett GCL, Lis A, Rasmusson RL, Baczkó I, Varró A, Salama G. (2017) Genomic upregulation of cardiac Cav1.2a and NCX1 by estrogen in women. Biology of sex differences (Aug), 8(1): 26. doi:10.1186/s13293-017-0148-4
- Cordeiro JM, Zeina T, Goodrow R, Kaplan AD, Thomas LM, Nesterenko VV, Treat JA, Hawel L, Byus C, Bett GC, Rasmusson RL, Panama BK. (2015) Regional variation of the inwardly rectifying potassium current in the canine heart and the contributions to differences in action potential repolarization. J Mol Cell Cardiol (Jul), 84: 52-60.
- Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. (2015) Modeling and study of the mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from individuals with Duchenne muscular dystrophy. Dis Model Mech (May), 8(5): 457-466.
- Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP. (2015) The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole. Cell Host Microbe (May), 17(5): 642-652.
- Rasmusson RL, Anumonwo JM. (2015) Activation of HERG channels: opening new applications for the biophysics of antiarrhythmic therapy. Biophysical journal (Mar), 108(6): 1309-1311. doi:10.1016/j.bpj.2015.01.011
- Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM. (2015) Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of physiology (Mar), 593(6): 1347-60. doi:10.1113/jphysiol.2014.281428
- Lin B, Li Y, Han L, Kaplan AD, Ao Y, Kalra S, Bett GC, Rasmusson RL, Denning C, Yang L. (2015) Modeling and studying mechanism of dilated cardiomyopathy using induced pluripotent stem cells derived from Duchenne Muscular Dystrophy (DMD) patients. Dis Model Mech (Mar).
- Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L. (2015) Reconciling Computer Models and Stem Cell Models of Human Cardiac Repolarization. Cardiovasc Res (Feb).
- Kim JJ, Yang L, Lin B, Zhu X, Sun B, Kaplan AD, Bett GC, Rasmusson RL, London B, Salama G. (2015) Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells. J Mol Cell Cardiol (Jan), 81C: 81-93.
- Han L, Li Y, Tchao J, Kaplan AD, Lin B, Li Y, Mich-Basso J, Lis A, Hassan N, London B, Bett GC, Tobita K, Rasmusson RL, Yang L. (2014) Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells. Cardiovasc Res (Nov), 104(2): 258-269.
- Bett GC, Kaplan AD, Lis A, Cimato TR, Tzanakakis ES, Zhou Q, Morales MJ, Rasmusson RL. (2013) Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells. Heart Rhythm (Dec), 10(12): 1903-1910.
- Bett GC, Kaplan AD, Lis A, Cimato TR, Tzanakakis ES, Zhou Q, Morales MJ, Rasmusson RL. (2013) Electronic "Expression" of the Inward Rectifier in Cardiocytes Derived from Human Induced Pluripotent Stem Cells. Heart Rhythm (Sep).
- Parikh A, Patel D, McTiernan CF, Xiang W, Haney J, Yang L, Lin B, Kaplan AD, Bett GC, Rasmusson RL, Shroff SG, Schwartzman D, Salama G. (2013) Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. Circ Res (Jul), 113(3): 313-321.
- Krey JF, Pasca SP, Shcheglovitov A, Yazawa M, Schwemberger R, Rasmusson R, Dolmetsch RE. (2013) Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons. Nature neuroscience (Feb), 16(2): 201-9. doi:10.1038/nn.3307
- Bett GC, Lis A, Guo H, Liu M, Zhou Q, Rasmusson RL. (2012) Interaction of the S6 proline hinge with N-type and C-type inactivation in Kv1.4 channels. Biophys J (Oct), 103(7): 1440-1450.
- Zhou Q, Bett GC, Rasmusson RL. (2012) Markov Models of Use-Dependence and Reverse Use-Dependence during the Mouse Cardiac Action Potential. PLoS One (Aug), 7(8): 42295-42295.
- Bett GC, Lis A, Wersinger SR, Baizer JS, Duffey ME, Rasmusson RL. (2012) A Mouse Model of Timothy Syndrome: a Complex Autistic Disorder Resulting from a Point Mutation in Cav1.2. N Am J Med Sci (Boston) (Jul), 5(3): 135-140.
- Petkova-Kirova PS, London B, Salama G, Rasmusson RL, Bondarenko VE. (2012) Mathematical modeling mechanisms of arrhythmias in transgenic mouse heart overexpressing TNF-a. American journal of physiology. Heart and circulatory physiology (Feb), 302(4): H934-52. doi:10.1152/ajpheart.00493.2011
- Bader PL, Faizi M, Kim LH, Owen SF, Tadross MR, Alfa RW, Bett GC, Tsien RW, Rasmusson RL, Shamloo M. (2011) Mouse model of Timothy syndrome recapitulates triad of autistic traits. Proc Natl Acad Sci U S A (Sep), 108(37): 15432-15437.
- Bett GC, Zhou Q, Rasmusson RL. (2011) Models of HERG gating. Biophys J (Aug), 101(3): 631-642.
- Bett GC, Dinga-Madou I, Zhou Q, Bondarenko VE, Rasmusson RL. (2011) A model of the interaction between N-type and C-type inactivation in Kv1.4 channels. Biophys J (Jan), 100(1): 11-21.
- Bondarenko VE, Rasmusson RL, Rasmusson R. (2010) Transmural heterogeneity of repolarization and Ca2+ handling in a model of mouse ventricular tissue. Am J Physiol Heart Circ Physiol (Aug), 299(2): 454-469.
- Xu L, Huang C, Chen J, Jiang X, Li X, Bett GC, Rasmusson RL, Wang S. (2008) Effect of amiodarone on Kv1.4 channel C-type inactivation: comparison of its effects with those induced by propafenone and verapamil. Die Pharmazie (Jun), 63(6): 475-9.
- Bett GC, Rasmusson RL. (2008) Modification of K+ channel-drug interactions by ancillary subunits. J Physiol (Feb), 586(4): 929-950.
- Bondarenko VE, Rasmusson RL, Rasmusson R. (2007) Simulations of propagated mouse ventricular action potentials: effects of molecular heterogeneity. Am J Physiol Heart Circ Physiol (Sep), 293(3): 1816-1832.
- Tian L, Jiang X, Rasmusson R, Wang S. (2006) Effect of propafenone on Kv1.4 inactivation. J Physiol Biochem (Dec), 62(4): 263-270.
- Bett GC, Morales MJ, Beahm DL, Duffey ME, Rasmusson R. (2006) Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel. J Physiol (Nov), 576(Pt 3): 755-767.
- Arroyo A, Kim B, Rasmusson R, Bett GC, Yeh J. (2006) Hyperpolarization-activated cation channels are expressed in rat hypothalamic gonadotropin-releasing hormone (GnRH) neurons and immortalized GnRH neurons. J Soc Gynecol Investig (Sep), 13(6): 442-450.
- Bett GC, Morales MJ, Strauss HC, Rasmusson RL. (2006) KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine. Biochemical and biophysical research communications (Feb), 340(4): 1167-77.
- Bett GC, Morales MJ, Strauss HC, Rasmusson RL. (2006) KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine. Biochem Biophys Res Commun (Jan), 340(4): 1167-1177.
- Wang S, Bondarenko VE, Qu YJ, Bett GC, Morales MJ, Rasmusson R, Strauss H. (2005) Time- and voltage-dependent components of Kv4.3 inactivation. Biophys J (Nov), 89(5): 3026-3041.
- Wang X, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. (2005) Amino acid substitutions in the pore of the Ca(V)1.2 calcium channel reduce barium currents without affecting calcium currents. Biophysical journal (Sep), 89(3): 1731-43. doi:10.1529/biophysj.104.058875
- Wang S, Bondarenko VE, Qu Y, Bett GCL, Morales MJ, Rasmusson RL, Stauss HC. (2005) Time- and voltage-dependent components of Kv4.3 inactivation. Biophys. J. (Jan), 89(5): 3026-3041.
- Wang S, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. (2005) Amino acid substitutions in the pore of the CaV1.2 Ca channel reduce Ba currents without affecting calcium currents. Biophys. J. (Jan), 89: 1731-1743.
- Bondarenko VE, Szigeti GP, Bett GC, Kim SJ, Rasmusson RL. (2004) Computer model of action potential of mouse ventricular myocytes. American journal of physiology. Heart and circulatory physiology (Sep), 287(3): H1378-403.
- Wang S, Bondarenko VE, Morales MJ, Strauss H, Rasmusson R. (2004) Activation properties of Kv4.3 channels: time, voltage and [K+]o dependence. J Physiol (Jun), 557(Pt 3): 705-717.
- Bett GC, Rasmusson RL. (2004) Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore. The Journal of physiology (Apr), 556(Pt 1): 109-20. doi:10.1113/jphysiol.2003.055012
- Bondarenko VE, Bett GC, Rasmusson RL. (2004) A model of graded calcium release and L-type Ca2+ channel inactivation in cardiac muscle. American journal of physiology. Heart and circulatory physiology (Mar), 286(3): H1154-69.
- Bondarenko VE, Bett GCL, Rasmusson RL. (2004) A Model of Graded Calcium release and L-type Ca2+ channel inactivation in cardiac muscle. Am. J. Physiol. (Jan), 286: H1154-H1169.
- Bondarenko VE, Szigeti GP, Bett GCL, Kim SJ, Rasmusson RL. (2004) A computer model of the action potential of mouse ventricular myocytes. Am. J. Phsiol (Jan), 287: H1378-H1403.
- Bett GCL, Rasmusson RL. (2004) Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore. J. Physiol. (Jan), 556: 109-120.
- Jiang X, Bett GC, Li X, Bondarenko VE, Rasmusson RL. (2003) C-type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 K+ channels expressed in Xenopus oocytes. The Journal of physiology (Jun), 549(Pt 3): 683-95. doi:10.1113/jphysiol.2002.034660
- Wang S, Morales MJ, Qu YJ, Bett GC, Strauss HC, Rasmusson RL. (2003) Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect. The Journal of physiology (Jan), 546(Pt 2): 387-401. doi:10.1113/jphysiol.2002.029512
- Bett GC, Rasmusson RL. (2003) Functionally-distinct proton-binding in HERG suggests the presence of two binding sites. Cell biochemistry and biophysics (Jan), 39(3): 183-93.
- Wang S, Morales MJ, Qu YJ, Bett GCL, Strauss HC, Rasmusson Rl. (2003) Kv1.4 channel block by quinidine: evidence for a drug induced allosteric effect. J. Physiol. (Jan), 546: 387-401.
- Li XY, Bett GCL, Jiang XJ, Bondarenko VE, Morales MJ, Rasmusson RL. (2003) Regulation of N- and C-type inactivation by pHo and K+ in normal and mutant Kv1.4 channels: Evidence for transmembrane communication. Am. J. Physiol. (Jan), 284: H71-H80.
- Li X, Bett GC, Jiang X, Bondarenko VE, Morales MJ, Rasmusson RL. (2003) Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication. Am J Physiol Heart Circ Physiol (Jan), 284(1): 71-80.
- Li X, Bett GC, Jiang X, Bondarenko VE, Morales MJ, Rasmusson RL. (2003) Regulation of N- and C-type inactivation of Kv1.4 by pHo and K+: evidence for transmembrane communication. Am J Physiol Heart Circ Physiol (Jan), 284(1): 71-80.
- Jiang XJ, Bett GCL, Li XY, Bondarenko VE, Rasmusson RL. (2003) C- type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 channels expressed in Xenopus oocytes. J. Physiol. (Jan), 549: 683-695.
- Bett GCL, Rasmusson RL. (2003) Functionally-distinct proton-binding in HERG suggests the presence of two binding sites. Cell Biochem. Biophys. (Jan), 39: 183-194.
- Strauss HC, Rasmusson RL,. (2002) Restitution, ventricular fibrillation, and drugs: where are we now?. J Cardiovasc Electrophysiol (Sep), 13(9): 915-917.
- Kim SJ, Kudej RK, Yatani A, Kim YK, Takagi G, Honda R, Colantonio DA, Van Eyk JE, Vatner DE, Rasmusson RL, Vatner SF. (2001) A novel mechanism for myocardial stunning involving impaired Ca(2+) handling. Circ Res (Oct), 89(9): 831-837.
- Bondarenko VE, Doedel EJ, Rasmusson RL. (2000) Bifurcation diagrams of frequency dependence of repolarization during long QT syndrome using the Luo and Rudy model of cardiac repolarization. AIP Proceedings (Jan), 502: 175-181.
- Brahmajothi MV, Campbell DL, Rasmusson R, Morales MJ, Trimmer JS, Nerbonne JM, Strauss H. (1999) Distinct transient outward potassium current (Ito) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol (Apr), 113(4): 581-600.
- Brahmajothi MV, Campbell DL, Rasmusson RL, Morales MJ, Trimmer JS, Nerbonne JM, Strauss HC. (1999) Distinct transient outward potassium current (Ito) phenotypes and distributionof fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. J Gen Physiol (Apr), 113(4): 581-600.
- Rasmusson R, Morales MJ, Wang S, Liu S, Campbell DL, Brahmajothi MV, Strauss H. (1998) Inactivation of voltage-gated cardiac K+ channels. Circ Res (Apr), 82(7): 739-750.
- Liu QY, Rasmusson RL, Liu QX, Strauss HC,. (1998) Voltage-dependent, open channel blockade of the cardiac sarcoplasmic reticulumpotassium channel by 4-aminopyridine. Can J Cardiol (Feb), 14(2): 275-280.
- Liu S, Rasmusson RL. (1998) Models of potassium channel inactivation: implications for open channel block. Can J Cardiol (Jan), 14(1): 101-107.
- Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson R. (1997) Modulation of HERG affinity for E-4031 by [K+]o and C-type inactivation. FEBS Lett (Nov), 417(1): 43-47.
- Wang S, Liu S, Morales MJ, Strauss HC, Rasmusson RL. (1997) A quantitative analysis of the activation and inactivation kinetics of HERGexpressed in Xenopus oocytes. J Physiol (Jul), 502 (: 45-60.
- Liu S, Rasmusson RL. (1997) Hodgkin-Huxley and partially coupled inactivation models yield different voltagedependence of block. Am J Physiol (Apr), 272(4 Pt): 2013-2022.
- Brahmajothi MV, Morales MJ, Rasmusson RL, Campbell DL, Strauss HC. (1997) Heterogeneity in K+ channel transcript expression detected in isolated ferretcardiac myocytes. Pacing Clin Electrophysiol (Feb), 20(2 Pt): 388-396.
- Rasmusson RL, Wang S, Castellino RC, Morales MJ, Strauss HC. (1997) The beta subunit, Kv beta 1.2, acts as a rapid open channel blocker of NH2-terminaldeleted Kv1.4 alpha-subunits. Adv Exp Med Biol (Jan), 430: 29-37.
- Morales MJ, Wee JO, Wang S, Strauss HC, Rasmusson RL. (1996) The N-terminal domain of a K+ channel beta subunit increases the rate of C-typeinactivation from the cytoplasmic side of the channel. Proc Natl Acad Sci U S A (Dec), 93(26): 15119-15123.
- Wang S, Morales MJ, Liu S, Strauss HC, Rasmusson RL. (1996) Time, voltage and ionic concentration dependence of rectification of h-ergexpressed in Xenopus oocytes. FEBS Lett (Jul), 389(2): 167-173.
- Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, Strauss HC. (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolatedferret cardiac myocytes. Circ Res (Jun), 78(6): 1083-1089.
- Liu S, Rasmusson RL, Campbell DL, Wang S, Strauss HC. (1996) Activation and inactivation kinetics of an E-4031-sensitive current from singleferret atrial myocytes. Biophys J (Jun), 70(6): 2704-2715.
- Rasmusson R, Morales MJ, Castellino RC, Zhang Y, Campbell DL, Strauss H. (1995) C-type inactivation controls recovery in a fast inactivating cardiac K+ channel (Kv1.4) expressed in Xenopus oocytes. J Physiol (Dec), 489 (: 709-721.
- Rasmusson RL, Morales MJ, Castellino RC, Zhang Y, Campbell DL, Strauss HC. (1995) C-type inactivation controls recovery in a fast inactivating cardiac K+ channel(Kv1.4) expressed in Xenopus oocytes. J Physiol (Dec), 489 (: 709-721.
- Castellino RC, Morales MJ, Strauss HC, Rasmusson RL. (1995) Time- and voltage-dependent modulation of a Kv1.4 channel by a beta-subunit(Kv beta 3) cloned from ferret ventricle. Am J Physiol (Jul), 269(1 Pt): 385-391.
- Rasmusson RL, Zhang Y, Campbell DL, Comer MB, Castellino RC, Liu S, Strauss HC. (1995) Bi-stable block by 4-aminopyridine of a transient K+ channel (Kv1.4) clonedfrom ferret ventricle and expressed in Xenopus oocytes. J Physiol (May), 485 (: 59-71.
- Morales MJ, Castellino RC, Crews AL, Rasmusson RL, Strauss HC. (1995) A novel beta subunit increases rate of inactivation of specific voltage-gatedpotassium channel alpha subunits. J Biol Chem (Mar), 270(11): 6272-6277.
- Lieberman M, Rasmusson RL, Zhang J, Hall SK, Smith TW, Smith JJ. (1995) Swelling-activated membrane transport and signaling mechanisms in cardiac cells. Heart Vessels (Jan), 9: 129-132.
- Rasmusson, RL, Zhang Y, Campbell DL, Comer MB, Castellino RC, Liu S, Morales MJ, Strauss HC,. (1995) Molecular mechanisms of K+ channel blockade: 4-aminopyridine interaction witha cloned cardiac transient K+ (Kv1.4) channel. Biophys Journal (Jan), 382: 11-22.
- Himmel HM, Rasmusson RL, Strauss HC. (1994) Agonist-induced changes of [Ca2+]i and membrane currents in single bovine aorticendothelial cells. Am J Physiol (Nov), 267(5 Pt): 1338-1350.
- Comer MB, Campbell DL, Lamson DR, Morales MJ, Zhang Y, Strauss H, Rasmusson R. (1994) Cloning and characterization of an Ito-like potassium channel from ferret ventricle. Am J Physiol (Oct), 267(4 Pt): 1383-1395.
- Zhang J, Rasmusson RL, Hall SK, Lieberman M. (1993) A chloride current associated with swelling of cultured chick heart cells. J Physiol (Dec), 472: 801-820.
- Shen WK, Rasmusson RL, Liu QY, Crews AL, Strauss HC. (1993) Voltage and temperature dependence of single K+ channels isolated from caninecardiac sarcoplasmic reticulum. Biophys J (Aug), 65(2): 747-754.
- Campbell DL, Rasmusson RL, Qu Y, Strauss HC. (1993) The calcium-independent transient outward potassium current in isolated ferret right ventricular myocytes. I. Basic characterization and kinetic analysis. The Journal of general physiology (Apr), 101(4): 571-601. doi:10.1085/jgp.101.4.571
- Campbell DL, Qu Y, Rasmusson RL, Strauss HC. (1993) The calcium-independent transient outward potassium current in isolated ferretright ventricular myocytes. II. Closed state reverse use-dependent block by 4-aminopyridine. J Gen Physiol (Apr), 101(4): 603-626.
- Smith TW, Rasmusson RL, Lobaugh LA, Lieberman M. (1993) Na+/K+ pump inhibition induces cell shrinkage in cultured chick cardiac myocytes. Basic Res Cardiol (Jan), 88(5): 411-420.
- Rasmusson RL, Davis DG, Lieberman M. (1993) Amino acid loss during volume regulatory decrease in cultured chick heart cells. Am J Physiol (Jan), 264(1 Pt): 136-145.
- Campbell DL, Rasmusson RL, Qu Y, Strauss HC. (1993) The transient outward potassium current in isolated ferret right ventricular myocytes: I. Basic characterization and kinectic analysis. J. Gen. Physiol. (Jan), 101: 571-601.
- Campbell DL, Qu Y, Rasmusson RL, Strauss HC. (1992) ‘Reverse use-dependent‘ effects of 4-aminopyridine on the transient outwardpotassium current in ferret right ventricular myocytes. Adv Exp Med Biol (Jan), 311: 357-358.
- Rasmusson RL, Campbell DL. (1992) Interaction of ICa with INa/Ca2 [Ca++]i and Ca++ binding proteins in frog atrium:a theoretical study. Adv Exp Med Biol (Jan), 311: 359-361.
- Campbell DL, Rasmusson RL, Strauss HC. (1992) Ionic current mechanisms generating vertebrate primary cardiac pacemaker activityat the single cell level: an integrative view. Annu Rev Physiol (Jan), 54: 279-302.
- Murphey CR, Clark JW, Giles WR, Rasmusson RL, Halter JA, Hicks K, Hoyt B. (1991) Conduction in bullfrog atrial strands: simulations of the role of disc andextracellular resistance. Math Biosci (Sep), 106(1): 39-84.
- Rasmusson RL, Clark JW, Giles WR, Shibata EF, Campbell DL. (1990) A mathematical model of a bullfrog cardiac pacemaker cell. Am J Physiol (Aug), 259(2 Pt): 352-369.
- Rasmusson RL, Clark JW, Giles WR, Robinson K, Clark RB, Shibata EF, Campbell DL. (1990) A mathematical model of electrophysiological activity in a bullfrog atrialcell. Am J Physiol (Aug), 259(2 Pt): 370-389.
- Campbell DL, Rasmusson RL, Strauss HC. (1988) Theoretical study of the voltage and concentration dependence of the anomalous mole fraction effect in single calcium channels. New insights into the characterization of multi-ion channels. Biophysical journal (Nov), 54(5): 945-54. doi:10.1016/S0006-3495(88)83030-3
- Campbell DL,Rasmusson RL,Strauss HC. (1988) Theoretical study of the voltage and concentration dependence of the anomalous mole fraction effect in single channels: New insights into the characterization of multi-ion channels. Biophys.J. (Jan), 259: H352-H369.
- Hume JR, Giles W, Robinson K, Shibata EF, Nathan RD, Kanai K, Rasmusson RL. (1986) A time- and voltage-dependent K+ current in single cardiac cells from bull frog atrium. J Gen Physiol (Dec), 88(6): 777-798.
- Hume JR, Giles W, Robinson K, Shibata EF, Nathan RD, Kanai K, Rasmusson R. (1986) A time- and voltage-dependent K+ current in single cardiac cells from bullfrog atrium. J Gen Physiol (Dec), 88(6): 777-798.
Books and Book Chapters:
- Bett GCL, Rasmusson RL. (2006) Fundamentals of Cellular Electrophysiology.
- Bett GC, Rasmussson RL. (2002) In: Models of Cardiac Ion Channels. , 1-60.
- Rasmusson RL. (2001) In: Voltage-gated sodium and potassium channels. In: The Corsini encyclopedia of psychology and behavioral science 3rd edition. , 1749-1753.
- Rasmusson RL, Liu S, Strauss HC. (1999) In: Pharmacology of K+ channels. In: Cardiac electrophysiology: from cell to bedside. , 156-167.
- Morales MJ, Rasmusson RL, Castellino RC, Crews AL, Zhang Y, Johnson LG, Lamson DR, Liu S, Comer MB, Strauss H. (1995) Potassium Channels in Normal and Pathological Conditions. In: Molecular biology and physiology of a cardiac voltage-gated K+ channel ß subunit. Leuven University Press, 205-208.
- Morales MJ, Rasmusson RL, Castellino RC, Crews AL, Zhang Y, Johnson LG, Lamson DR, Liu S, Comer MB, Strauss HC. (1995) In: A voltage-gated K+ channel ß -subunit cloned from ferret ventricle: Implications for cardiac K+ channel function. In: Potassium channels in normal and pathological conditions. , 205-220.
- Rasmusson RL, Campbell DL, Qu Y, Strauss HC. (1994) In: Conformation dependent drug binding to cardiac potassium channels. Ion channels in the cardiovascular system. , 387-414.
- Campbell DL, Rasmusson RL, Comer MB, Strauss HC. (1994) In: The cardiac calcium-independent transient outward potassium current: Kinetics, molecular properties and possible role in ventricular repolarization. In: Cardiac electrophysiology: from cell to bedside. , 83-95.
- Campbell DL, Rasmusson RL, Strauss HC. (1991) In: Electrophysiology and pharmacology of the heart: A clinical guide. , 59-108.
- Shen WK, Hill JA, Rasmusson RL, Strauss HC. (1990) In: Reconstitution of the K channel of cardiac sarcoplasmic reticulum. , 205-230.
Abstracts:
- Anthony Costantino, Brian K. Panama, Mark W. Nowak, Randall L. Rasmusson, Glenna CL. Bett. (2021) Calibration of optical measurement of membrane potential in eukaryotic cells. Annual Meeting of the Society for Neuroscience. (Nov)
- A. COSTANTINO, B. K. PANAMA, M. W. NOWAK, R. L. RASMUSSON, G. C. L. BETT. (2021) Calibration of optical measurement of membrane potential in eukaryotic cells. Annual Meeting of the Society for Neuroscience. (Nov) Poster
- Mark W Nowak, Brian K Panama, Leigh Korbel, Randall L Rasmusson, Glenna Bett. (2021) Electronic Expression of Background and Delayed Rectifier Currents via Dynamic Clamp Produces Physiological Action Potentials in Stem Cell Derived Glutamatergic Neurons. Biophysical Journal, Annual Meeting of the Biophysical Society. (Feb) 352a
- Bett GC, Duffey ME, Rasumsson RL. (2005) Ancillary Subunits Determine the Affinity and use-Dependence of Chromanol 293B for KCNQ1. Biophys J, (Jan)
- Bett GC, Duffey ME, Beahm Dl, Katzer M, Morales MJ, Rasmusson RL. (2005) Ancillary subunits modulate block of KCNQ1 channels by chromanol and Ba2+. Proceedings of the 35th Meeting of the International Union of Physiological Sciences, (Jan)
- Bett GC, Morales M, Rasmusson R. (2005) KChlP2b modulates the affinity and use-dependent block of Kv4.3 by Nifedipine. Biophys J, (Jan)
- Bett GC, Rasmusson RL. (2005) Molecular Mechanisms of Inactivation and Recovery of Kv1.4, an A-type current. Proceedings of the 35th Meeting of the International Union of Physiological Sciences, (Jan)
- Bett GC, Madou ID, Bondarenko VE, Rasmusson RL. (2004) A Computer Model of N-and C-type inactivation in voltage-gated potassium channels. Proceedings of the12th Annual National McNair Research Conference, (Jan)
- Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2004) A mathematical model of repolarization simulating regional heterogeneity of murine ventricular myocytes. Biophys J, (Jan) 298
- Bett GC, Rasmusson RL. (2004) Proton Modification of HERG channels: two sites of functional regulation. Biophy J, (Jan) 281-282
- Bett GC, Bondarenko VE, Rasmusson RL. (2004) Spatial Heterogeneity in a Computer Model of Graded Ca2 Release: Effects of Ca2 Loading and Ryanodine Receptor Adaptation. Proceedings of the 25th Meeting of the North American Society for Pacing and Electrophyisology - Heart Rhythm Society, (Jan)
- Bett GC, Li XY, Morales MJ, Bondarenko VE, Rasmusson RL, Jiang XJ. (2003) Transmembrane communication in cardiac potassium channels: regulation of N-and C-type inactivation by pHo and potassium in normal and mutant Kv1.4 channels. Biophys J, (Jan) 76A
- Bett GC, Yoo K, Rasmusson RL. (2003) Site directed mutagenesis in a cloned Kv1.4 channel. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
- Bett GC, Bondarenko VE, Rasmusson RL. (2003) Cardiac Cellular Morphology and Physiology in a model of graded Ca2 release and L-type channel inactivation. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
- Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2003) A mathematical model of the action potential of mouse ventricular myocytes. Biomedical Engineering in NY, Alfred University, (Jan)
- Bett GC, Cyr V, Rasmusson RL. (2003) A mathematicl model of potassium channels permeation with two binding sites. Proceeding B-SURE Conference, SUNY@Buffalo, (Jan)
- Bett GC, Bondarenko VE, Rasmusson RL. (2003) A model of Ca2 handling in ferret cardiac myocytes. Proceedings Biomedical Engineering in NY, Alfred University, (Jan)
- Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K channels. Proceedings of the 13th Annual Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
- Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K Channels. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
- Bett GC, Madou ID, Rasmusson RL. (2003) A computer model of N-and C-type inactivation in voltage-gated potassium channels. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
- Bett GC, Cyr V, Rasmusson RL. (2003) A mathematical model of potassium channels permiation with two binding sites and drug block. Proceedings Biomedical Engineering in NY. Alfred University, (Jan)
- Bett GC, Kaushal V, Rasmusson RL. (2003) Optimization and parameter identification (pH0 and K+0 in a Markov Model of the HERG channel. Proceedings Biomedical Engineering in NY, Alfred University, (Jan)
- Bett GC, Jiang XJ, Bondarenko VE, Li XY, Rasmusson RL. (2003) C-type Inactivation Involves A Significant Decrease in the Intracellular Aqueouspore Volume. Biophys J, (Jan) 221
- Bett GC, Jiang XJ, Li XY, Bondarenko VE, Rasmusson RL. (2002) C-type inactivation: a pH0 and K sensitive transmembrane mechanism. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society, (Jan)
- Bett GC, Wang S, Morales M, Qu YJ, Rasmusson RL, Strauss HC. (2002) Kv1.4 Channel Block by quinidine: evidence for a drug-induced allosteric effect. Proceedings of the 12th Meeting of Upstate New York Cardiac Electrophysiology Society, Buffalo, NY, (Jan)
Professional Memberships:
- AHA Basic Sciences Council
- American Physiological Society
- Biophysical Society
- IEEE
- NASPE
- Physiological Society
Service Activities:
- NHLBI fellowship study section meets three times a year once on site per year; Member (2020–present)
- Frontiers Journals Parmacology and Neurology; assign and review submissions
- Plos 1 Assign and review manuscripts; board member
- Committee on Academic Freedom and Responsibility; Chair