MS, Electrical Engineering, Rice University (1986)
BS, Electrical Engineering, Computer Science, Rice University (1983)
Employment:
Professor, Biomedical Engineering, SUNY, University at Buffalo School of Engineering and Applied Sciences (2010-present)
Professor, Physiology and Biophysics, SUNY, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2006-present)
Associate Professor, Department of Physiology and Biophysics, State University of New York at Buffalo (2000–2006)
Associate Professor, Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine (1999–2000)
Adjunct Assistant Professor, Program in Biomedical Engineering, Carnegie-Mellon University (1999)
Assistant Professor, Department of Medicine and Physiology, Allegheny Universiy of Health Sciences (1998–1999)
Research Assistant Professor, Department of Biomedical Engineering, Duke University (1991–1997)
Awards and Honors:
UB Exceptional Scholar, Sustained Achievement Award (2011)
Whitaker Foundation Researcher
Established Investigator, American Heart Association
Fellow of the American Heart Association
National Merit Scholarship
NIH,NRSA Training Grant HL-07063-12
Proctor & Gamble, Alternatives to Animal Research Finalist
Research Centers:
Center for Research in Cardiovascular Medicine
UB 2020 Strategic Strengths:
Molecular Recognition in Biological Systems and Bioinformatics
Grants and Sponsored Research:
May 2011–April 2012 Device to treat postpartum hemorrhage Bill and Melinda Gates Foundation Role: Co-Principal Investigator $100,000
August 2014 Optimization of a prototype for an induced pluripotent stem cell derived cardiac cybercyte to a beta testing unit. UBCAT Role: Principal Investigator $60,000
A Model of the Ferret Ventricular Action Potential Whitaker Foundation Role: Principal Investigator
K+ Channel Inactivation and Antiarrhythmic Drug Action NIH Role: Principal Investigator
N-terminal and beta-subunit modulation of cloned cardiac K+ channels American Heart Association Role: Principal Investigator
Modulation of Ca2+ channels by dihydropyridines and Ca2+ Role: Consultant
Cardiac pacemaker activity Role: Co-Investigator
Cardiac transient outward current Role: Co-Investigator
Bett GCL, Rasmusson RL. (2003) Functionally-distinct proton-binding in HERG suggests the presence of two binding sites. Cell Biochem. Biophys. (Jan), 39: 183-194.
Bondarenko VE, Doedel EJ, Rasmusson RL. (2000) Bifurcation diagrams of frequency dependence of repolarization during long QT syndrome using the Luo and Rudy model of cardiac repolarization. AIP Proceedings (Jan), 502: 175-181.
Jiang XJ, Bett GCL, Li XY, Bondarenko VE, Rasmusson RL. (2003) C- type inactivation involves a significant decrease in the intracellular aqueous pore volume of Kv1.4 channels expressed in Xenopus oocytes. J. Physiol. (Jan), 549: 683-695.
Wang S, Ponoran TA, Rasmusson RL, Ragsdale DS, Peterson BZ. (2005) Amino acid substitutions in the pore of the CaV1.2 Ca channel reduce Ba currents without affecting calcium currents. Biophys. J. (Jan), 89: 1731-1743.
Bondarenko VE, Bett GCL, Rasmusson RL. (2004) A Model of Graded Calcium release and L-type Ca2+ channel inactivation in cardiac muscle. Am. J. Physiol. (Jan), 286: H1154-H1169.
Bondarenko VE, Szigeti GP, Bett GCL, Kim SJ, Rasmusson RL. (2004) A computer model of the action potential of mouse ventricular myocytes. Am. J. Phsiol (Jan), 287: H1378-H1403.
Lieberman M, Rasmusson RL, Zhang J, Hall SK, Smith TW, Smith JJ. (1995) Swelling-activated membrane transport and signaling mechanisms in cardiac cells. Heart Vessels (Jan), 9: 129-132.
Li XY, Bett GCL, Jiang XJ, Bondarenko VE, Morales MJ, Rasmusson RL. (2003) Regulation of N- and C-type inactivation by pHo and K+ in normal and mutant Kv1.4 channels: Evidence for transmembrane communication. Am. J. Physiol. (Jan), 284: H71-H80.
Bett GC, Morales MJ, Strauss HC, Rasmusson RL. (2006) KChIP2b modulates the affinity and use-dependent block of Kv4.3 by nifedipine. Biochem Biophys Res Commun (Jan), 340(4): 1167-1177.
Wang S, Morales MJ, Qu YJ, Bett GCL, Strauss HC, Rasmusson Rl. (2003) Kv1.4 channel block by quinidine: evidence for a drug induced allosteric effect. J. Physiol. (Jan), 546: 387-401.
Bett GCL, Rasmusson RL. (2004) Inactivation and recovery in Kv1.4 K+ channels: lipophilic interactions at the intracellular mouth of the pore. J. Physiol. (Jan), 556: 109-120.
Wang S, Bondarenko VE, Qu Y, Bett GCL, Morales MJ, Rasmusson RL, Stauss HC. (2005) Time- and voltage-dependent components of Kv4.3 inactivation. Biophys. J. (Jan), 89(5): 3026-3041.
Campbell DL, Rasmusson RL, Qu Y, Strauss HC. (1993) The transient outward potassium current in isolated ferret right ventricular myocytes: I. Basic characterization and kinectic analysis. J. Gen. Physiol. (Jan), 101: 571-601.
Campbell DL,Rasmusson RL,Strauss HC. (1988) Theoretical study of the voltage and concentration dependence of the anomalous mole fraction effect in single channels: New insights into the characterization of multi-ion channels. Biophys.J. (Jan), 259: H352-H369.
Shen WK, Hill JA, Rasmusson RL, Strauss HC. (1990) In: Reconstitution of the K channel of cardiac sarcoplasmic reticulum. , 205-230.
Campbell DL, Rasmusson RL, Comer MB, Strauss HC. (1994) In: The cardiac calcium-independent transient outward potassium current: Kinetics, molecular properties and possible role in ventricular repolarization. In: Cardiac electrophysiology: from cell to bedside. , 83-95.
Rasmusson RL. (2001) In: Voltage-gated sodium and potassium channels. In: The Corsini encyclopedia of psychology and behavioral science 3rd edition. , 1749-1753.
Morales MJ, Rasmusson RL, Castellino RC, Crews AL, Zhang Y, Johnson LG, Lamson DR, Liu S, Comer MB, Strauss HC. (1995) In: A voltage-gated K+ channel ß -subunit cloned from ferret ventricle: Implications for cardiac K+ channel function. In: Potassium channels in normal and pathological conditions. , 205-220.
Rasmusson RL, Campbell DL, Qu Y, Strauss HC. (1994) In: Conformation dependent drug binding to cardiac potassium channels. Ion channels in the cardiovascular system. , 387-414.
Campbell DL, Rasmusson RL, Strauss HC. (1991) In: Electrophysiology and pharmacology of the heart: A clinical guide. , 59-108.
Bett GCL, Rasmusson RL. (2006) Fundamentals of Cellular Electrophysiology.
Bett GC, Rasmussson RL. (2002) In: Models of Cardiac Ion Channels. , 1-60.
Morales MJ, Rasmusson RL, Castellino RC, Crews AL, Zhang Y, Johnson LG, Lamson DR, Liu S, Comer MB, Strauss H. (1995) Potassium Channels in Normal and Pathological Conditions. In: Molecular biology and physiology of a cardiac voltage-gated K+ channel ß subunit. Leuven University Press, 205-208.
Rasmusson RL, Liu S, Strauss HC. (1999) In: Pharmacology of K+ channels. In: Cardiac electrophysiology: from cell to bedside. , 156-167.
Abstracts:
Bett GC, Cyr V, Rasmusson RL. (2003) A mathematical model of potassium channels permiation with two binding sites and drug block. (Jan)
Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2004) A mathematical model of repolarization simulating regional heterogeneity of murine ventricular myocytes. (Jan) 298
Bett GC, Bondarenko VE, Szigeti GP, Kim SJ, Rasmusson RL. (2003) A mathematical model of the action potential of mouse ventricular myocytes. (Jan)
Bett GC, Cyr V, Rasmusson RL. (2003) A mathematicl model of potassium channels permeation with two binding sites. (Jan)
Bett GC, Bondarenko VE, Rasmusson RL. (2003) A model of Ca2 handling in ferret cardiac myocytes. (Jan)
Bett GC, Madou ID, Bondarenko VE, Rasmusson RL. (2004) A Computer Model of N-and C-type inactivation in voltage-gated potassium channels. (Jan)
Bett GC, Madou ID, Rasmusson RL. (2003) A computer model of N-and C-type inactivation in voltage-gated potassium channels. (Jan)
Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K channels. (Jan)
Bett GC, Rasmusson RL. (2003) Allosteric mechanisms dominate coupling of N-and C-type inactivation in voltage-gated K Channels. (Jan)
Bett GC, Duffey ME, Rasumsson RL. (2005) Ancillary Subunits Determine the Affinity and use-Dependence of Chromanol 293B for KCNQ1. (Jan)
Bett GC, Duffey ME, Beahm Dl, Katzer M, Morales MJ, Rasmusson RL. (2005) Ancillary subunits modulate block of KCNQ1 channels by chromanol and Ba2+. (Jan)
Bett GC, Jiang XJ, Bondarenko VE, Li XY, Rasmusson RL. (2003) C-type Inactivation Involves A Significant Decrease in the Intracellular Aqueouspore Volume. (Jan) 221
Bett GC, Jiang XJ, Li XY, Bondarenko VE, Rasmusson RL. (2002) C-type inactivation: a pH0 and K sensitive transmembrane mechanism. (Jan)
Bett GC, Bondarenko VE, Rasmusson RL. (2003) Cardiac Cellular Morphology and Physiology in a model of graded Ca2 release and L-type channel inactivation. (Jan)
Bett GC, Morales M, Rasmusson R. (2005) KChlP2b modulates the affinity and use-dependent block of Kv4.3 by Nifedipine. (Jan)
Bett GC, Wang S, Morales M, Qu YJ, Rasmusson RL, Strauss HC. (2002) Kv1.4 Channel Block by quinidine: evidence for a drug-induced allosteric effect. (Jan)
Bett GC, Rasmusson RL. (2005) Molecular Mechanisms of Inactivation and Recovery of Kv1.4, an A-type current. (Jan)
Bett GC, Kaushal V, Rasmusson RL. (2003) Optimization and parameter identification (pH0 and K+0 in a Markov Model of the HERG channel. (Jan)
Bett GC, Rasmusson RL. (2004) Proton Modification of HERG channels: two sites of functional regulation. (Jan) 281-282
Bett GC, Yoo K, Rasmusson RL. (2003) Site directed mutagenesis in a cloned Kv1.4 channel. (Jan)
Bett GC, Bondarenko VE, Rasmusson RL. (2004) Spatial Heterogeneity in a Computer Model of Graded Ca2 Release: Effects of Ca2 Loading and Ryanodine Receptor Adaptation. (Jan)
Bett GC, Li XY, Morales MJ, Bondarenko VE, Rasmusson RL, Jiang XJ. (2003) Transmembrane communication in cardiac potassium channels: regulation of N-and C-type inactivation by pHo and potassium in normal and mutant Kv1.4 channels. (Jan) 76A