Xiaoyan Wu MD, PhD
Xiaoyan Wu
MD, PhD
Clinical Associate Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Pediatric Nephrology; Pediatrics
Education and Training:
- Fellowship, Pediatric Nephrology, Baylor College of Medicine (2017)
- Residency, Pediatrics, Richmond University Medical Center (2014)
- Internship, Pediatrics, Richmond University Medical Center (2012)
- Postdoctoral Fellow, Medicine, University of Toronto (1997)
- PhD, Physiology, University of Toronto (1996)
- MS, Physiology, University of Toronto (1991)
- MD, Medicine, Tianjin Medical University (1982)
Employment:
- Clinical Associate Professor, Pediatrics, University at Buffalo (2017-present)
- Attending Physician, Nephrology, UBMD Pediatrics, Oishei Children's Hospital (2017-present)
- Assistant Professor, Pediatric Nephrology, Baylor College of Medicine (2017)
- Research Assistant Professor, University of Chicago, Pritzker School of Medicine (2006–2011)
- Research Associate, University of Chicago, Pritzker School of Medicine (1997–2006)
- Visiting Scholar, University of Louisville, School of Medicine (1986–1989)
Awards and Honors:
- 44th Pediatric Nephrology Seminar/Renal Pathology/CRRT Course: Partial Travel Grant (2017)
- American Society of Nephrology: Karen L. Campbell Travel Grant (2016)
- Richmond University Medical Center: Mario J. Merlino Award (2014)
- Academy of Medicine of Richmond: 3rd Prize (2013)
- University of Toronto: Nephrology Postdoctoral Fellowship (09/1996-08/1997)
- University of Toronto: Open Physiology Fellowship (09/1989-09/1996)
- University of Louisville: Nephrology Fellowship (07/1986-09/1989)
- Buffalo Spree Magazine: Top Doctors in Western New York (2020-2021)
Journal Articles:
- Sioufi HJ, Makvandi S, Masoud R, Wu X, Abdul Aziz R. Rare Presentation of Pseudotumor Cerebri in a Pediatric Patient With Granulomatosis With Polyangiitis. Cureus. 2020; 12(11).
- Wu X, Vega M, Swartz SJ, Michael M. Milky appearance of peritoneal fluid in a neonate on peritoneal dialysis due to end-stage renal disease: Questions. Pediatr Nephrol. 2018; 33(1).
- Wu X, Vega M, Swartz SJ, Michael M. Milky appearance of peritoneal fluid in a neonate on peritoneal dialysis due to end-stage renal disease: Answers. Pediatr Nephrol. 2018; 33(1).
- Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, Wu Y, Ma L, Cai X, Lin G, Wu X, Geng Z, Dong Y, Song G, Griffin PR, Lau J, Cherezov V, Yang H, Hanson MA, Stevens RC, Zhao Q, Jiang H, Wang MW, Wu B. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. 2017; 546(7657).
- Wu X, Kim H, Seravalli J, Barycki JJ, Hart PJ, Gohara DW, Di Cera E, Jung WH, Kosman DJ, Lee J. Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase. J Biol Chem. 2016; 291(18).
- Wu C, Wu X, Hack BK, Bao L, Cunningham PN. TNF causes changes in glomerular endothelial permeability and morphology through a Rho and myosin light chain kinase-dependent mechanism. Physiol Rep. 2015; 3(12).
- Aziz MM, Wu X, Thomas U. Sickle cell disease and fever. Medscape. 2013.
- Wu X, Chen P, Sonis ST, Lingen MW, Berger A, Toback FG. A novel Peptide to treat oral mucositis blocks endothelial and epithelial cell apoptosis. Int J Radiat Oncol Biol Phys. 2012; 83(3).
- Wu X, Guo R, Chen P, Wang Q, Cunningham PN. TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism. Am J Physiol Renal Physiol. 2009; 297(2).
- Wu X, Guo R, Wany Y, Cunningham PN. The role of ICAM-1 in endotoxin-induced acute renal failure. Am J Physiol Renal Physiol. 2007; 293(4).
- Zagranichnaya TK, Wu X, Villereal ML. Endogenous TRPC1, TRPC3, and TRPC7 proteins combine to form native store-operated channels in HEK-293 cells. J Biol Chem. 2005; 280(33).
- Zagranichnaya TK, Wu X, Danos AM, Villereal ML. Gene expression profiles in HEK-293 cells with low or high store-operated calcium entry: can regulatory as well as regulated genes be identified? Physiol Genomics. 2005; 21(1).
- Wu X, Zagranichnaya TK, Gurda GT, Eves EM, Villereal ML. A TRPC1/TRPC3-mediated increase in store-operated calcium entry is required for differentiation of H19-7 hippocampal neuronal cells. J Biol Chem. 2004; 279(42).
- Shalabi A, Zamudio F, Wu X, Scaloni A, Possani LD, Villereal ML. Tetrapandins, a new class of scorpion toxins that specifically inhibit store-operated calcium entry in human embryonic kidney-293 cells. J Biol Chem. 2004; 279(2).
- Babnigg G, Zagranichnaya TK, Wu X, Villereal ML. Differential tyrosine phosphorylation of plasma membrane Ca2 -ATPase and regulation of calcium pump activity by carbachol and bradykinin. J Biol Chem. 2003; 278(17).
- Wu X, Babnigg G, Zagranichnaya TK, Villereal ML. The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells. J Biol Chem. 2002; 277(16).
- Wu X, Scholey JW, Sonnenberg H, Melo LG. Renal vascular morphology and haemodynamics in Dahl salt-sensitive rats on high salt-low potassium diet: neural and genetic influences. J Hypertens. 2000; 18(6).
- Wu X, Vieth R, Milojevic S, Sonnenberg H, Melo LG. Regulation of sodium, calcium and vitamin D metabolism in Dahl rats on a high-salt/low-potassium diet: genetic and neural influences. Clin Exp Pharmacol Physiol. 2000; 27(5-6).
- Wu X, Babnigg G, Villereal ML. Functional significance of human trp1 and trp3 in store-operated Ca(2 ) entry in HEK-293 cells. Am J Physiol Cell Physiol. 2000; 278(3).
- Kang MJ, Wu X, Ly H, Thai K, Scholey JW. Effect of glucose on stress-activated protein kinase activity in mesangial cells and diabetic glomeruli. Kidney Int. 1999; 55(6).
- Wu X, Ackermann U, Sonnenberg H. Hypertension development in Dahl S and R rats on high salt-low potassium diet: calcium, magnesium and sympathetic nervous system. Clin Exp Hypertens. 1998; 20(7).
- Wu X, Scholey JW, Sonnenberg H. Renal vascular morphology in male Dahl rats on high-salt diet: effect of potassium. J Am Soc Nephrol. 1996; 7(2).
- Wu X, Sonnenberg H. Effect of renal perfusion pressure on excretion of calcium, magnesium, and phosphate in the rat. Clin Exp Hypertens. 1995; 17(8).
- Wu X, Ackermann U, Sonnenberg H. Potassium depletion and salt-sensitive hypertension in Dahl rats: effect on calcium, magnesium, and phosphate excretions. Clin Exp Hypertens. 1995; 17(6).
- Carrasquer G, Zhang JY, Wu X, Rehm WS, Schwartz M. Effect of inhibitors of gastric secretion on polarization of gastric potential by voltage clamping. Am J Physiol. 1993; 264(4 Pt1).
- Carrasquer G, Wu X, Rehm WS, Schwartz M, Dinno MA. Effect of amphotericin B and Cl- removal on basolateral membrane K conductance in frog corneal epithelium. Biochim Biophys Acta. 1991; 1069(2).
- Carrasquer G, Wu X, Kissel D, Rehm WS, Schwartz M, Dinno MA. Microelectrode studies of amphotericin B on Na and K conductance in bullfrog cornea. Biochim Biophys Acta. 1989; 982(1).
Abstracts:
- Villereal ML, Wu X, Zagranichnaya TK, Gurda GT. A TRPC1/TRPC3-Mediated Increase in Store-Operated Calcium Entry is Required for Differentiation of H19-7 Hippocampal Cells. FASEB J. 2005; 19(4).
- Villereal ML, Zagranichnaya TK, Wu X. Role of Store-Operated Calcium Channels in Regulating Gene Expression. FASEB J. 2003; 17(4).
- Melo LG, Vieth R, Milojevic S, Sonnenberg H, Wu X. Regulation of Vitamin D in Dahl Rats on High Salt-Low Potassium Diet: Genetic and Neural Influences. FASEB J. 2000; 14(4).
- Wu X, Babnigg G, Villereal ML. Store-Operated Calcium Entry in HEK-293 Cells: Are Human Transient Receptor Potential (HTRP1, HTRP3 and HTRP4) Proteins Functionally Important?. FASEB J. 2000; 14(4).
- Wu X, Scholey JW, Sonnenberg H, Melo LG. Renal Vascular Morphology and Hemodynamics in Dahl Rats on High Salt-Low Potassium Diet: Neural and Genetic Influences. FASEB J. 2000; 14(4).
- Wu X, Ackermann U, Sonnenberg H. The Role of Renal Perfusion Pressure in Control of Urinary Sodium Excretion. FASEB J. 1991; 5(5).
- Carrasquer G, Wu X, Schwartz M, Rehm WS. Voltage Clamp Studies on Frog Gastric Mucosa. FASEB J. 1990; 4(3).
- Wu X, Carrasquer G, Rehm WS, Schwartz M, Dinno MA. Microelectrode Studies of Changes in Tear K+ in Presence of Amphotericin B in Frog Cornea. FASEB J. 1989; 3(3).
- Wu X, Carrasquer G, Rehm WS, Schwartz M, Dinno MA. Effects of SCN- on Electrophysiological Parameters in Cornea. FASEB J. 1988; 2(6).
Professional Memberships:
- American Society of Pediatric Nephrology
- American Academy of Pediatrics
- American Society of Nephrology
- Eastern Society for Pediatric Research
Presentations:
- "Blockade of the terminal complement cascade using Ravulizumab in a pediatric patient with aHUS: a case report and literature review" Annual Conference, Eastern Society for Pediatric Research (2021)
- "Management of Pediatric Post-renal Transplant Erythrocytosis with Enalapril: A Case Report" Annual Conference, Eastern Society for Pediatric Research (2021)
- "Complete Renal Recovery in Patient with a Rare Kidney Disease: A Case Report of C3GN" Annual Conference, Eastern Society for Pediatric Research, E-ESPR2020: 339 (2020)
- "Complete Renal Recovery in Patient with Anuria AKI of 72 hours with Hypertensive Encephalopathy: A Case Report of APSGN" Annual Conference, Eastern Society for Pediatric Research, E-ESPR2020: 289 (2020)
- "Prevalence of Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) in the Greater Buffalo Region: A Retrospective Study" Annual Conference, Eastern Society for Pediatric Research, E-ESPR2020: 308 (2020)
- "Renal Involvement and Its Treatment in Pediatric Patients with PR3 ANCA Positive Granulomatosis with Polyangiitis (GPA)" Annual Conference, Eastern Society for Pediatric Research, E-ESPR2020: 340 (2020)
- "The Effect of Intermittent Hypoxia-Hyperoxia During Nephrogenesis vs Nephronal Maturation and Risk of Kidney Disease and Hypertension in Adult Mice" Annual Meeting, Pediatric Academic Societies, Nephrology: Hypertension (2019)
- "Effects of Intermittent Hypoxia-Hyperoxia During Nephrogenesis versus Nephronal Maturation and the Risk of Chronic Kidney Disease and Hypertension in Adult Mice" Annual Conference, Eastern Society for Pediatric Research, Allergy/Immunology & Nephrology (2019)
- "Role of Hypoxia-Hyperoxia on Nephrogenesis and Nephronal Maturation and Its Risk of Kidney Disease and Hypertension in Adult Mice" Annual Conference, Eastern Society for Pediatric Research (2019)
- "The Complement System: Why Do We Care?" Pediatric Grand Rounds, University at Buffalo (2019)
- "Chyloperitoneum in a Neonate with ESRD on Peritoneal Dialysis: A Case Report" Renal Week, American Society of Nephrology (2016)
- "Macrophage Calcium Signaling in Inbred Hypertensive Rat Lines" Annual Meeting, American Society of Pediatric Nephrology (2016)
- "Efficient Rounding Improves Patient Care and Decreases Resident Duty Hour Violations on CORE Rotation: A Quality Improvement Initiative" Pediatric Research and Fellow Symposium, Texas Children‘s Hospital and Baylor College of Medicine (2016)
- "Case Report: Flavobacteremia Meningosepticum Bacteremia in a Sickle Beta Cell Patient" 23rd Annual Meeting, Academy of Medicine of Richmond (2012)
- "Sepsis Actively Modulates Renal Expression of the Tie2-Angiopoietin System During Acute Kidney Injury" Renal Week, American Society of Nephrology (2008)
- "TNF-Induces Caspase-Dependent Inflammation in Renal Endothelial Cells" Renal Week, American Society of Nephrology (2008)
- "A Novel Method for the Separation and Primary Culture of Glomerular and Nonglomerular Renal Endothelial Cells" Renal Week, American Society of Nephrology (2007)
- "An Increase in Store-Operated Channel Activity Occurs During the Differentiation of Hippocampal Neurons" Experimental Biology, Federation of American Societies for Experimental Biology (2007)
- "Decreased Susceptibility to LPS-Induced Acute Renal Failure in Bak-Deficient Mice" Renal Week, American Society of Nephrology (2006)
- "A New Model for the Activation of Store-Operated Channels" Experimental Biology, Federation of American Societies for Experimental Biology (2006)
- "A TRPC1/TRPC3-Mediated Increase in Store-Operated Calcium Entry is Required for Differentiation of H19-7 Hippocampal Cells" Experimental Biology, Federation of American Societies for Experimental Biology (2005)
- "Role of Store-Operated Calcium Channels in Regulating Gene Expression" Experimental Biology, Federation of American Societies for Experimental Biology (2003)
- "The Role of Human Transient Receptor Potential Protein 4 (HTRP4) in the Thapsigargin-, Carbachol-, and Diacylglycerol-Stimulatedc Calcium Entry in HEK-293 Cells" Experimental Biology, Federation of American Societies for Experimental Biology (2002)
- "Regulation of Vitamin D in Dahl Rats on High Salt-Low Potassium Diet: Genetic and Neural Influences" Experimental Biology, Federation of American Societies for Experimental Biology (2000)
- "Renal Vascular Morphology and Hemodynamics in Dahl Rats on High Salt-Low Potassium Diet: Neural and Genetic Influences" Experimental Biology, Federation of American Societies for Experimental Biology (2000)
- "Store-Operated Calcium Entry in HEK-293 Cells: Are Human Transient Receptor Potential (HTRP1, HTRP3 and HTRP4) Proteins Functionally Important?" Experimental Biology, Federation of American Societies for Experimental Biology (2000)
- "The Role of Renal Perfusion Pressure in Control of Urinary Sodium Excretion" Experimental Biology, Federation of American Societies for Experimental Biology (1991)
- "Voltage Clamp Studies on Frog Gastric Mucosa" Experimental Biology, Federation of American Societies for Experimental Biology (1990)
- "Microelectrode Studies of Changes in Tear K+ in Presence of Amphotericin B in Frog Cornea" Experimental Biology, Federation of American Societies for Experimental Biology (1989)
- "Effects of SCN- on Electrophysiological Parameters in Cornea" Experimental Biology, Federation of American Societies for Experimental Biology (1988)