Jian Feng PhD

Jian Feng

Jian Feng
PhD

UB Distinguished Professor

Department of Physiology and Biophysics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Apoptosis and cell death; Cytoskeleton and cell motility; Gene Expression; Molecular and Cellular Biology; Molecular genetics; Neurobiology; Neurodegenerative disorders; Neurology; Pathophysiology; Protein Folding; Signal Transduction; Toxicology; Transcription and Translation

Contact Information
955 Main Street, Room 3148
Buffalo, New York 14203
Phone: (716) 829-2345
Fax: 716-829-2699
jianfeng@buffalo.edu



Professional Summary:

My research is aimed at finding the cause and a cure for Parkinson’s disease.

Parkinson’s disease (PD) is defined by a characteristic set of locomotor symptoms (rest tremor, rigidity, bradykinesia and postural instability) that are believed to be caused by the selective loss of dopaminergic (DA) neurons in substantia nigra. The persistent difficulties in using animals to model this human disease suggest that human nigral dopaminergic neurons have certain vulnerabilities that are unique to our species.

One of our unique features is the large size of the human brain (1350 grams on average) relative to the body. A single nigral dopaminergic neuron in a rat brain (2 grams) has a massive axon arbor with a total length of 45 centimeters. Assuming that all mammalian species share a similar brain wiring plan, we can estimate (using the cube root of brain weight) that a single human nigral dopaminergic neuron may have an axon with gigantic arborization that totals 4 meters.

Another unique feature of our species is our strictly bipedal movement, which is affected by Parkinson’s disease, in contrast to the quadrupedal movement of almost all other mammalian species. The much more unstable bipedal movement may require more dopamine, which supports the neural computation necessary for movement.

The landmark discovery of human induced pluripotent stem cells (iPSC) made it possible to generate patient-specific human midbrain dopaminergic neurons to study Parkinson’s disease. A key problem for dopaminergic neurons is the duality of dopamine as a signal required for neural computation and a toxin as its oxidation produces free radicals. Our study using iPSC-derived midbrain dopaminergic neurons from PD patients with parkin mutations and normal subjects shows that parkin sustains this necessary duality by maintaining the precision of the signal while suppressing the toxicity. Mutations of parkin cause increased spontaneous release of dopamine and reduced dopamine uptake, thereby disrupting the precision of dopaminergic transmission. On the other hand, transcription of monoamine oxidase is greatly increased when parkin is mutated. This markedly increases dopamine oxidation and oxidative stress. These phenomena have not been seen in parkin knockout mice, suggesting the usefulness of parkin-deficient iPSC-derived midbrain DA neurons as a cellular model for Parkinson’s disease.

Currently, we are using iPS cells and induced DA neurons to expand our studies on parkin to idiopathic Parkinson’s disease. We are also utilizing the molecular targets identified in our studies to find small-molecule compounds that can mimic the beneficial functions of parkin. The availability of human midbrain DA neurons should significantly speed up the discovery of a cure for Parkinson’s disease.

Education and Training:

  • PhD, Biochemistry, University of Tennessee (1997)
  • BS, Biochemistry, Nanjing University (1990)

Employment:

  • UB Distinguished Professor, Department of Physiology and Biophysics, University at Buffalo, the State University of New York (2023-present)
  • Professor, Physiology and Biophysics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2010-present)
  • Associate Professor, Physiology and Biophysics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2005–2010)
  • Assistant Professor, Physiology and Biophysics, State University of New York at Buffalo Jacobs School of Medicine & Biomedical Sciences (2000–2005)
  • Postdoctoral Research Associate, Laboratory of Molecular and Cellular Neuroscience, Rockefeller University (1997–2000)

Awards and Honors:

  • UB Distinguished Professor (2023)
  • National Research Council Prestigious Award (Society for Experimental Biology and Medicine Best Paper Award) (2022)
  • State University of New York Chancellor’s Award for Excellence in Scholarship and Creative Activities (2021)
  • University at Buffalo Exceptional Scholars – Sustained Achievement Award (2017)

Research Expertise:

  • Parkinson's disease: I am a leading expert on the molecular and cellular mechanisms of Parkinson's disease.
  • Stem Cell Biology: I have been developing novel stem cell technologies, such as induced pluripotent stem cells, transdifferentiation, and mouse-human chimeric embryos to study various human diseases.

Grants and Sponsored Research:

  • February 2023–January 2028
    Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells
    NINDS
    Role: Principal Investigator
    $1,544,282
  • December 2022–November 2027
    Transcriptomic and Circuitry Aberrations in Alzheimer’s Disease
    NIA
    Role: Principal Investigator
    $1,855,198
  • April 2023–May 2025
    Administrative Supplement to Molecular Segregation of Parkinson’s Disease by Patient-derived Neurons
    NINDS
    Role: Principal Investigator
    $401,250
  • June 2020–May 2025
    Molecular Segregation of Parkinson’s Disease by Patient-derived Neurons
    NINDS/NIH
    Role: Principal Investigator
    $2,244,925
  • April 2020–March 2023
    New Treatment Strategy for Alzheimer’s Disease
    NIA/NIH
    Role: Principal Investigator
    $438,625
  • September 2018–March 2023
    Functions of parkin in Parkinson’s disease
    NINDS/NIH
    Role: Principal Investigator
    $1,801,304
  • April 2018–March 2022
    Kinetic Barriers of Transdifferentiation
    Department of Veterans Affairs
    Role: Principal Investigator
    $833,012
  • March 2018–March 2022
    The Interaction of parkin and environmental toxins in Parkinson’s disease
    Department of Veterans Affairs
    Role: Principal Investigator
    $783,012
  • April 2017–March 2022
    A Novel Epigenetic Mechanism for Alzheimer's Disease
    NIH
    Role: Co-Investigator
    $1,993,750
  • April 2014–March 2018
    Kinetic Barriers of Transdifferentiation
    Department of Veterans Affairs
    Role: Principal Investigator
  • June 2014–May 2017
    Understand the Pathophysiology of Parkinson's Disease Using Genetically Modified iPS Cells
    NYSTEM
    Role: Principal Investigator
  • March 2013–February 2016
    Redefining Idiopathic Parkinson’s Disease through Induced Pluriopotent Stem Cells
    NYSTEM
    Role: Principal Investigator
  • January 2009–December 2013
    Cellular Functions of Parkin
    NIH/NINDS
    Role: Principal Investigator
    $1,733,595
See all (3 more)

Patents:

  • Method of Producing Naïve Pluripotent Stem Cells US Patent awarded (2023)

Journal Articles:

See all (70 more)

Abstracts:


Presentations:

  • "Deconstructing Parkinson's Disease" The First Experimental Biology and Medicine Conference (2024)
  • "Deconstructing Parkinson’s Disease in Human Models" Neuroscience Seminar at Pennsylvania State University (2023)
  • "Deconstructing Parkinson’s Disease in Human Models" Seminar at the Department of Pharmacology, University of Tennessee Health Science Center (2023)
  • "Generation of Mouse-Human Chimeric Embryos" The 7th International Experimental Biology and Medicine Conference on Regenerative Medicine (2022)

Service Activities:

  • I am elected the Treasurer of the Society for Experimental Biology and Medicine; Treasurer (2024–2026)
  • NIH Chronic Dysfunction and Integrative Neurodegeneration (CDIN) Study Section; Ad hoc reviewer (2024)
  • NIH Development and Validation of Models for ADRD (ZNS1 SRB-M (17) SEP); Ad hoc reviewer (2023)
  • NIH Chronic Dysfunction and Integrative Neurodegeneration (CDIN) Study Section; Ad hoc reviewer (2023)
  • NINDS ZNS1 SRB-M (14) Special Emphasis Panel on Functional Target Validation for Alzheimer's Disease-Related Dementias; Ad hoc reviewer (2023)
  • NIH Neurotoxicology and Alcohol Study Section (NAL) Study Section; Ad hoc reviewer (2023)
  • I have been serving on the Organizing Committee for the First Experimental Biology and Medicine Conference in Orlando, FL, October 13-16, 2024; Member of the Organizing Committee for the First Experimental Biology and Medicine Conference in Orlando, FL, October 13-16, 2024 (2022–2024)
  • I serve on the Finance and Investment Committee of the Society for Experimental Biology and Medicine and persuade the society to adopt index funds as investment strategy.; Member, Finance and Investment Committee (2017–2021)
  • I have served on the Abstract Review Committee of the International Society for Stem Cell Research since 2017.; Member of the Abstract Review Committee (2017–present)
  • Councilor, Society for Experimental Biology and Medicine I serve as a Councilor at the Society for Experimental Biology and Medicine for the term of 2015-2019.; Councilor (2015–2019)
  • I have been serving on the Parkinson Foundation Grant Review Committee since 2015.; Reviewer (2015–present)
  • I have served as the Associate Editor of Stem Cell Biology Section for the journal Experimental Biology and Medicine; Associate Editor, Stem Cell Biology (2012–2027)

School News:

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Contact Information

955 Main Street, Room 3148
Buffalo, New York 14203
Phone: (716) 829-2345
Fax: 716-829-2699
jianfeng@buffalo.edu