Keith L. Kirkwood

Keith Kirkwood

Keith L. Kirkwood

Senior Associate Dean for Research Centennial Endowed Professor

Department of Oral Biology

School of Dental Medicine


Specialty/Research Focus

Ageing; Cell Metabolism; Immunology; Inflammation; Molecular and Cellular Biology; Molecular Basis of Disease; Oral Biology; Periodontics; Transcription - Gene; Transcription and Translation; Transcriptomics

Contact Information
University of Buffalo School of Dental Medicine 3435 Main Street 645 BRB
Buffalo, New York 14214
Phone: (716)829-6667
klkirk@buffalo.edu



Professional Summary:

My current research program has been focused on the role of obesity and aging in myeloid cell biology as it relates towards oral inflammation in periodontal disease and oral cancer progression.

Education and Training:

  • Fellowship, Department of Pharmacology and Toxicology, University of Buffalo (1999)
  • PhD, Oral Biology, University of Buffalo (1997)
  • Certificate, Periodontology, State University of New York at Buffalo (1995)
  • DDS, Dentistry, West Virginia University (1991)
  • BA, Chemistry, West Virginia University, Cum Laude (1987)

Employment:

  • Senior Associate Dean for Research, School of Dental Medicine, University at Buffalo (2022-present)
  • Adjunct Research Professor of Oncology, Head & Neck/Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center (2020-present)
  • Consulting Scientist, Roswell Park Comprehensive Cancer Center, Department of Head/Neck Surgery (2020-present)
  • Centennial Endowed Professor, School of Dental Medicine, University at Buffalo (2019-present)
  • Program Member, Tumor Immunology and Immunotherapy Research Program, Roswell Park Comprehensive Cancer Center (2018-present)
  • Professor, Oral Biology, University at Buffalo (2017-present)
  • Interim Chair, Periodontics and Endodontics, University at Buffalo (2021–2022)
  • Attending Periodontist, Western NY VA Medical Center (2020–2022)
  • Associate Dean, Innovation and Technology Transfer, University at Buffalo (2019–2021)
  • Consulting Physician, Oral Oncology, Roswell Park Comprehensive Cancer Center (2018–2020)
  • Consulting Physician, Roswell Park Comprehensive Cancer Center, Department of Oral Oncology (2018–2020)
  • Adjunct Professor, Bioengineering, Clemson University (2010–2017)
  • Adjunct Professor, Microbiology and Immunology, Medical University of South Carolina (2010–2017)
  • Professor and Chair, Oral Health Sciences, Medical University of South Carolina (2010–2017)
  • Associate Dean for Research, College of Dental Medicine, Medical University of South Carolina (2008–2017)
  • Associate Professor, Microbiology and Immunology, Medical University of South Carolina (2008–2010)
  • Associate Professor and Founding Chair, Oral Health Sciences, Medical University of South Carolina (2008–2010)
  • Private Practice Limited to Periodontics, Great Expressions Specialty Practice (2006–2008)
  • Associate Professor, Periodontics and Oral Medicine, University of Michigan School of Dentistry (2007)
  • Assistant Professor, Periodontics and Oral Medicine, University of Michigan (2004–2007)
  • Research Assistant Professor, Pharmacology and Toxicology, University of Buffalo (2002–2003)
  • Assistant Professor, Periodontics And Endodontics, University of Buffalo (2000–2003)
  • Private Practice Limited to Periodontics, University Dental Associates (2000–2003)
  • Private Practice Limited to Periodontics, Barzman, Kasimov, and Vieth (1998–2000)
  • Clinical Assistant Professor, Periodontics, University of Buffalo (1997–2000)
  • Clinical Assistant Professor, Oral Biology, University of Buffalo (1997–1999)
  • Post Doctoral Fellow, Pharmacology and Toxicology, University of Buffalo (1997–1999)
  • Clinical Instructor, Periodontics And Endodontics, University of Buffalo (1995–1997)
See all (18 more)

Awards and Honors:

  • Recipient, IADR/PRG Award (2018)
  • Sunstar - AAP Foundation Research Fellowship (2016)
  • Fellow of the AADR (2016)
  • Fellow (2016)
  • IADR/GSK Innovation in Oral Care Award (2014)
  • IADR Distinguished Scientist Award for Pharmacology/Therapeutics/Toxicology Research (2013)
  • Elected, Omicron Kappa Upsilon (2011)
  • Elected, Member-at-Large (2009)
  • IADR/GSK Innovation in Oral Care Award (2008)
  • Tarrson Fellowship Career Development Award (2005)
  • American Dental Association Student Clinician Program (2002)
  • Young Investigator Award (2002)
  • Osseointegration Foundation Research Grant Award (2000)
  • Individual National Research Service Award (F32) (1997)
  • Mark Diamond Research Award (1996)
  • Quintessence Research Award for Research Achievement (1991)
  • Dentist-Scientist Award (K16) (1991)
  • First Prize (1990)
  • Cum Laude, Chemistry (1987)
  • Mary Baab Randolph Cancer Center Student Research Fellowship (1987)

Research Expertise:

  • Oral Biology: Cytokine gene regulation in bone with identification of novel therapeutics targets and applied nolecular pharmacology targeting signaling mechanisms for therapeutic purposes in inflammatory bone diseases.

Patents:

  • Auranofin Nanoparticles and Methods of Treatment of Peri-Implantitis and Periodontal Disease (2016)


Professional Memberships:

  • Erie County Dental Society; Member (2017–present)
  • Endocrine Society; Member (2012)
  • Inflammation Research Association; Member (2009–2012)
  • The American Society of Gene & Cell Therapy; Member (2008–2012)
  • American Society for Biochemistry and Molecular Biology; Member (2007–2012)
  • RNA Society; Member (2004–2010)
  • Michigan Periodontal Society; Member (2004–2007)
  • Michigan Dental Society; Member (2004–2007)
  • American Association of Dental Research; Secretary/Treasurer (2002–2005)
  • Academy of Osseointegration; Member (2000–2002)
  • New York State Society of Periodontists; Member (1997–2002)
  • Erie County Dental Society; Member, Program Director (2003) (1995–2003)
  • New York State Dental Association; Member (1995–2003)
  • American Association for Bone and Mineral Research; Member (1995–present)
  • Eight District Dental New York; Member (1995–present)
  • American Academy of Periodontology; AAP Subcommittee on Research Submissions (2001-2003, 2009-2012) Nominated for AAP Board of Trustees (7th District) (2002) (1991–present)
  • WVU Student Research Group; President (1990–1991)
  • WVU Dental Class ’91; Vice President (1988–1990)
  • American Dental Association; Member (1987–2020)
  • International Association for Dental Research; Pharmacology/Toxicology/Therapeutic Group: Secretary Treasurer (2002-2005), Vice President (2005), President Elect (2006), President (2007), Immediate Past President (2008); AADR Ethics in Dental Research Committee (2005-2008); IADR/AADR Publications Committee (2009-2011); AADR Hatton Award Committee (2011-2013); IADR Distinguished Scientist Award Committee (2017-present) (1987–present)
See all (10 more)

Presentations:

  • "New Mechanistic Insights Engaged in Obesity-associated Periodontitis" International Academy of Periodontology Research Conference (IAPRC), Harvard University (2024)
  • "The p38/MKP-1 Signaling Axis in Oral Cancer: Opportunities to Target Tumor-associated Macrophages" Boston University (2024)
  • "Post-Transcriptional Control of Aging-Associated Inflammation and Skeletal Homeostasis" Harvard University (2023)
  • "Metabolic Reprogramming of Myeloid-derived Suppressor Cells in Periodontitis" 3rd International Conference on Oral Mucosal Immunity and Microbiome (2023)
  • "Age-related metabolic dysregulation of monocytic MDSCs in osteoclastogenesis" PennPerio Meeting (2023)
  • "Aging and Oral Cancer" 2023 AADOCR Meeting within a Meeting, Aging and Oral Health Research (2023)
  • "Tristetraprolin: the fountain of youth for bone homeostasis?" 2023 Mark Wilson Conference (2023)
  • "Post-Transcriptional Control of Aging-Associated Inflammation and Skeletal Homeostasis" University at Buffalo, School of Engineering (2022)
  • "Sexual Dimorphism in Oral Inflammatory Diseases" AADOCR Annual Meeting (2022)
  • "Mechanisms controlling myeloid cell subset mobilization and osteoclast potential" 21st Annual Mark Wilson Conference, 32nd Annual Meeting of the Oral Immunology/Microbiology Research Group (2022)
  • "The p38/MKP-1 Signaling Axis in Oral Cancer: Impact of Tumor-associated Macrophages" UB Cancer Research Consortium Seminar Series (2021)
  • "Periodontal disease increases oral-gut transmission of colitogenic Haemophilus parainfluenzae in inflammatory bowel disease patients" 2nd International Conference on Oral Mucosal Immunity and Microbiome (2021)
  • "Myeloid-derived Suppressor Cells in Obesity-associated Periodontal Disease" University of Pennsylvania (2021)
  • "The p38/MKP-1 Signaling Axis in Oral Cancer: Impact of Tumor associated Macrophages" University of Arizona (2021)
  • "Metabolic Reprogramming of Tumor-associated Macrophages in Oral Cancer" Department of Oral Biology, University at Buffalo (2020)
  • "Metabolic Reprogramming of Tumor-associated Macrophages in Oral Cancer" Upstate NY Virtual Genomics Symposium, Illumina Genomics Symposium (2020)
  • "p38 MAPK/MKP-1 Signaling Axis in Oral Cancer" UCLA School of Dentistry (2019)
  • "MDSCs: new players in alveolar bone homeostasis" Rutgers University, School of Dental Medicine (2019)
  • "Myeloid-derived Suppressor Cells and Alveolar Bone Homeostasis" First Bernhard Gottlieb Conference: Periodontal Homeostasis in Disease and Regeneration; Texas A&M University, College of Dentistry (2019)
  • "Myeloid-derived Suppressor Cells in Periodontal Osteoimmunology" PennPerio Conference, University of Pennsylvania (2019)
  • "DUSP1 and Tumor-Associated Macrophage Plasticity in Oral Cancer" Roswell Park Comprehensive Cancer Center, Tumor Immunology Lecture Series (2017)
  • "Post Transcriptional Regulation of Oral Immunity and the Microbiome" UB’s Community of Excellence in Genome, Environment and Microbiome (GEM) (2017)
  • "Post Transcriptional Control of Alveolar Bone Homeostasis" New York University (2017)
  • "Post Transcriptional Control of Alveolar Bone Homeostasis" PennPerio conference; University of Pennsylvania (2017)
  • "MAPK Signaling and RNA Stability in Osteoimmunology: Therapeutic Targets for Periodontitis Control" The 60th Spring Meeting of the Japanese Society of Periodontology (2017)
  • "Therapeutic Opportunities to Control Osteoclastogenesis in Periodontitis" Chinese National Oral Biomedical Conference (2016)
  • "The Quest for Small Molecule Inhibitors of Signal Transduction to Control Osteoclastogenesis in Periodontitis" Oregon Health & Science University School of Dentistry (2016)
  • "Therapeutic Opportunities to Control Osteoclastogenesis in Periodontitis" University of Louisville School of Dentistry (2016)
  • "The Quest for Small Molecule Inhibitors of Signal Transduction to Control Osteoclastogenesis in Periodontitis" MUSC College of Dental Medicine Seminar Series (2016)
  • "Sex-based Differential Regulation of Bacterial-induced Bone Resorption" 15th Annual Mark Wilson Oral Microbiology Immunology Meeting (2016)
  • "Therapeutic Opportunities to Control Osteoclastogenesis in Periodontitis" Baylor Texas A&M University Baylor College of Dentistry (2016)
  • "Local Innate Immune Signaling in Osteoclastogenesis" PennPerio Conference (2015)
  • "Understanding Innate Immune Signaling in Periodontitis" Invited Seminar New York University (2015)
  • "DUSP1 phosphatase regulates the proinflammatory milieu in oral cancer" 14th Annual Mark Wilson Oral Microbiology Immunology Meeting (2015)
  • "Lectures “Fostering Collaborative Research and Training the Next Generation of Faculty in US Dental Schools; “Ethics and Professionalism in Dentistry”; and “Development of an Evidence-Based Dentistry Curriculum”" 7th Dental Students’ Scientific Meeting. Qassim University, College of Dentistry (2015)
  • "p38 MAPK/DUSP1 Axis in Stromal-mediated Tumorigenesis" Life Sciences Baltics MAP Kinases Conference (2014)
  • "Control of MAPK Signaling in Alveolar Bone Osteoimmunology" IADR Periodontal Research Group; Symposium titled "Molecular Basis of Periodontal Tissue Homeostasis, Destruction and Regeneration" (2014)
  • "MKP-1 Signaling Nexus in Bone: Dual Roles in Pathology and Homeostasis" MUSC Dept. of Craniofacial Biology Seminar Series (2013)
  • "Immune Signaling through MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Inflammatory Bone Loss" UPenn Periodontal Conference 2013 (2013)
  • "Mechanistic Basis for Translational Studies in the Management of Periodontal Diseases" Baylor College of Dentistry, Department of Biological Sciences (2012)
  • "MAPK Signaling and RNA Stability in Osteoimmunology: Therapeutic Targets in Inflammatory Bone Loss" South Carolina College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences (2011)
  • "MAPK Signaling Mechanisms in Osteoclast-directed Alveolar Bone Loss" Gordon Research Conference on Periodontal Diseases (2011)
  • "Defining Novel Therapeutic Targets in Periodontal Diseases" Clemson University (2011)
  • "Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Inflammatory Bone Loss" University of Alabama at Birmingham (2010)
  • "Post Transcriptional Control of Periodontal Diseases and Oral Cancer Progression" Virginia Commonwealth University (2010)
  • "Innate Immune Signaling through p38 MAPK/MKP-1 Pathways in Inflammatory Bone Loss" Kaohsiung Medical University, College of Dental Medicine, Research Day-International Symposium on Oral Cancers, Systemic Diseases, and Bone (2010)
  • "Potential Role of mRNA Binding Proteins in Oral Cancer Progression" Kaohsiung Medical University, College of Dental Medicine, Research Day-International Symposium on Oral Cancers, Systemic Diseases, and Bone (2010)
  • "Periodontal Inflammation and mRNA Stability—Implications for Therapeutic Strategies" University of Medicine and Dentistry, New Jersey (2010)
  • "Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Inflammatory Bone Loss" University of Louisville (2009)
  • "Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Inflammatory Bone Loss" Harvard School of Dental Medicine (2009)
  • "Systemic Periodontal Chemotherapy" Medical University of South Carolina (2009)
  • "Innate Immune Signaling through p38 MAPK/MKP-1 Pathways: Implications in Periodontal Diseases and Oral Cancer" NIDCR Intramural Research Seminar Series (2008)
  • "Novel Strategies to Harness Periodontal Inflammation" Colgate Palmolive (2008)
  • "Signaling Mechanisms in Cytokine mRNA Stability: Impact in Inflammatory Bone Loss" University of Western Ontario (2007)
  • "Therapeutic Strategies to Disrupt Cell Signaling in Periodontal Inflammation" IADR/AADR meeting, Lunch and Learning (2007)
  • "Signaling Mechanisms Governing Cytokine mRNA Stability: Implications in Inflammatory Bone Loss and Oral Cancer" State University of New York at Buffalo (2007)
  • "Esthetic Periodontal Plastic Surgery: Present and Future Perspectives" Kuwait Dental Association Annual Meeting (2007)
  • "MAPK signaling mechanisms governing inflammatory cytokine expression" Gordon Research Conference, Periodontal Diseases (2006)
  • "Regulation of Gene Expression in Inflammation" State University of Sao Paulo (UNESP) (2006)
  • "The Role of p38 MAP Kinase in IL-6 Gene Regulation" Roswell Park Cancer Center, Department of Molecular and Cellular Biology (2003)
  • "Differential Regulation of MMP-13 by Chemical Modified Tetracyclines in Osteoblasts" 8oth Annual Session of the IADR/31th (2002)
  • "Systemic Medications and Dental Implications" ; University of Rochester (2001)
  • "Expression Profiling of Genes Regulated by Chemically Modified Tetracycline-8 in Murine Osteoblasts Cellsc Cells" Annual Session of the AADR (2001)
  • "The Effects of Titanium-Immobilized bioactive Peptides on Osteoblast Differentiation" Osseointegration Academy Meeting (2001)
  • "Chemically Modified Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" 78th Annual Session of the IADR/29th (2000)
  • "Inhibition of IL-6 Expression in Osteoblasts by Chemically Modified Tetracyclines" The Ohio State University College of Dentistry (1999)
  • "Gene Regulation by Chemically Modified Tetracyclines in Murine Osteoblasts" Gordon Research Conference, Non-Antibiotic Properties of Tetracyclines & Other Antibiotics (1999)
  • "Non-Antimicrobial and Antimicrobial Tetracyclines Inhibit IL-6 Expression in Murine Osteoblasts" New York Academy of Sciences Meeting (1998)
  • "OP-1 Induction of the Inositol Trisphosphate Receptor in Human Osteosarcoma Cells" 75th Annual Session of the AADR/25th (1997)
  • "Inositol Trisphosphate Receptor Subtype Analysis in Human Osteosarcoma Cells" 24th Session of ther AADR (1995)
  • "IgG Antibodies to A.Actinomycetemconitans 16.6 Kda OMP In Juvenile Periodontitis" 72nd Annual Session of the IADR/23th (1994)
  • "Selective Expression of Inositol Trisphosphate Rectptor Gene In Human Osteosarcoma Cells" 22nd Annual Session of the AADR (1993)
  • "Post Transcriptional Control of Alveolar Bone Homeostasis" Tokyo Medical and Dental University
See all (63 more)

Service Activities:

  • Member of the SDM Facilities Management Committee; Committee Member (2022–present)
  • Member of the University Associate Deans for Research Committee; Committee Member (2022–present)
  • SDM Information Technology Steering Committee; ITSC Committee Member (2022–present)
  • Member of Oversight Committee, Buffalo Translational Consortium (BTC) Clinical Research Achievement Awards; Oversight Committee Member (2022–present)
  • School of Dental Medicine, Executive Council; Member (2019–present)
  • School of Dental Medicine, Graduate Committee, Recruiting; Member (2019–present)
  • Executive Council, School of Dental Medicine; Executive Council Member (2019–present)
  • Served on the SDM Student Research Review Committee; Student Research Review Committee Member (2018–2020)
  • School of Dental Medicine Search Committee for Core Facility Manager for the Department of Oral Biology; Search Committee Member (2018)
  • Basic Sciences Representative, Clinical Practice Management Plan (CPMP) Governing Board; Representative (2018–present)
  • Member of the UB Clinical and Translational Science Institute (CTSI) Steering Committee; Steering Committee Member (2018–present)
  • Member of the UB Clinical and Translational Science Institute (CTSI) Workforce Development Steering Committee; Steering Committee Member (2018–present)
  • Tenure-track committee for Dr. Praveen Arany, Assistant Professor in the Dept. of Oral Biology; Tenure-track Committee Member (2018–present)
  • School of Dental Medicine, Student Research and Honors Committee (2017–2020)
  • School of Dental Medicine, Research Committee; Member (2017–2020)
  • Served on Thesis Committee Meetings for the following students: PhD Candidates: Jiho Sohn (MD/PhD) (Major Professor: K.L. Kirkwood) Yin Luo (Major Professor: D. Xu) Natalie Anselmi (Major Professor: J. Kay) Armond June (MD/PhD) (Major Professor: P. Diaz) Edwin Ovalle (Major Professor: J. Kay) Dayron M Leyva Rodriguez (Major Professor: M. Visser) Omar Glover (Perio/PhD) (Major Professor: K.L. Kirkwood) Masters Candidates: Yuxiang Pan (Major Professor: K.L. Kirkwood) Cameron Kirkwood (Major Professor: K.L. Kirkwood); Committee Member (2017–present)
  • NIH; Oral Dental Craniofacial Sciences;; Panel Member (2016–present)
  • Oral Cancer Screenings for Hollings Cancer Center; Provider (2012–2017)
  • Served on the Thesis Committee for the following students: PhD Candidates: Matt Ruddy (Major Professor: Sarah Gaffen, Oral Biology, defended 2003) Pedro Li (Major Professor: Stelios Andreadis, Chemical Engineering, defended 2004) Masters Candidates: Lynn Solomon (Major Professor: Mizrda Neiders, defended 2004); Committee Member (2003–2004)
  • Major Professor to the following students: Dr. Troy Thompson (defended May 2002) Dr. Fuwad Al-Sabek (defended May 2003); Major Professor (2002–2003)
  • Ad Hoc committee for accreditation; Chair (2002–2003)
  • Served as Program Director for the Erie County Dental Society; Program Director (2002–2003)
  • Served on Preliminary Exam Committee for Xin Liu (Oral Biology); Committee Member (2002)
  • Institute on Research in Women and Gender Grant; Evaluation of the Molecular Events; Evaluation of the Molecular Events Underlying the Enchancement of Osteobast Activity by Immobilized BMP-7 Derived Bioactive Peptides. the goal of this ongoing pilot project is to measure osteoblast specific differentiation gene expression of primary rat calvarial cells grown in tissue culture on glass coverslips where BMP-7 derived eptides are covalently attached.; (2001–2002)
  • International Federation of Endodontists; In Vitro Biomineralization of Cenemtoblasts on MTA; The major goal of this project is to determine if immortalized cementoblasy poulations can differentiation on the endodontic material mineral trioxide aggregate uner tissue culture conditions.; (2001–2002)
  • American Academy of Endodontists Association Foundation; Attachment and Differentiation of Cementoblasts on MTA; The major goal of this project is to determine if immortalized cementoblast populations can attach on the endodontic material mineral trioxide aggregate under tissue culture conditions; (2001)
  • Served on Bylaws Committee; Committee Member (2001–2003)
  • Served on Curriculum Committee; Committee Member (2001–2003)
  • Served on Student Research Committee; Committee Member (2000–2003)
  • The Osseointegration Foundation; Titanium-Immobilized; The Effects of Titanium-Immobilized Bioactive Peptides on Osteoblast Differentiation; (2000–2001)
  • School of Dental Medicine, Curriculum Committee (2000–present)
  • School of Dental Medicine, Student Research and Honors Committee (2000–present)
  • School of Dental Medicine, ByLaws Committee (2000–present)
  • American Academy of Implant Dentistry Foundation; Effects of DGEA; The In Vitro Effects of The In Viitro Effects of DGEA Peptide and Bone Morphogenetic Protein-7 on Bone Formation ; (1999–2001)
  • CollaGenex Pharmaceuticals; Therapeutic Targets; Analysis of Novel CMT Theraeutic Targets through Gene Arrays; (1999–2000)
  • ADA Health foundation; Tetracycline Analogs; Molecular Studies of Tetracycline Analogs in Osteoporisis and Oral Bone Loss; (1999–2000)
  • Moir P. Tanner Research Fund; Modified Tetracyclines; Inhibition of IL-6 Expression in Osteoblasts by Chemically Modified Tetracyclines; (1999–2000)
  • CollaGenex Pharmaceuticals; Cytokine Secretions; The role of Chemically Modified Tetracyclines in Agonist Induced Cytokine Secretion in Osteoblastic Cells.; (1997–1998)
  • National Institute of Dental research (RO3); Estrogen Regulation; Estrogen Regulation of the Osteoblast InsP3 Receptor.; (1997–1999)

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Contact Information

University of Buffalo School of Dental Medicine 3435 Main Street 645 BRB
Buffalo, New York 14214
Phone: (716)829-6667
klkirk@buffalo.edu