Clare J. Twist MD, MS

Clare Twist

Clare J. Twist
MD, MS

Clinical Professor

Department of Pediatrics

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Pediatric Hematology-Oncology; Pediatrics

Contact Information
Roswell Park Cancer Institute
Department of Pediatrics
Elm and Carlton Streets
Buffalo, NY 14263
Phone: (716) 845-2333
Fax: (716) 845-8003
ctwist@buffalo.edu
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Education and Training:
  • Fellowship, Pediatric Hematology/Oncology, Harvard Medical School (1993)
  • Fellowship, Pediatric Hematology/Oncology, Harvard Medical School (1991)
  • Residency, Pediatrics, Northwestern University (1990)
  • Internship, Pediatrics, Northwestern University (1988)
  • MD, Medicine, Albany Medical College (1987)
  • MS, Natural Sciences/Immunology, University at Buffalo/Roswell Park Memorial Institute (1984)
  • BS, University of Notre Dame (1982)

Employment:
  • Fellowship Program Director, Hematology/Oncology, Pediatrics, University at Buffalo (2018-present)
  • Professor, Oncology, Roswell Park Comprehensive Cancer Center (2016-present)
  • Clinical Professor, Pediatrics, University at Buffalo (2016-present)
  • Attending Physician, Hematology/Oncology, Pediatrics, Roswell Park Comprehensive Cancer Center (2016-present)
  • Attending Physician, Hematology/Oncology, UBMD Pediatrics, Oishei Children‘s Hospital (2016-present)
  • Director, Pediatric Experimental Therapeutics, Roswell Park Comprehensive Cancer Center (2016-present)
  • Associate Professor, Pediatrics, Stanford University, School of Medicine (2008–2016)
  • Attending Physician, Pediatric Hematology/Oncology, Lucile Packard Children‘s Hospital (1999–2016)
  • Medical Director, Pediatric Oncology Unit, El Camino Hospital (2012–2014)
  • Assistant Professor, Pediatrics, Stanford University, School of Medicine (2000–2008)
  • Acting Assistant Professor, Pediatrics, Stanford University, School of Medicine (1999–2000)
  • Attending Physician, Bone Marrow Transplant Service, Brigham and Women's Hospital (1994–1999)
  • Associate Physician, Hematology/Oncology, Brigham and Women‘s Hospital (1994–1999)
  • Attending Physician, Bone Marrow Transplant Service, Boston Children's Hospital (1993–1999)
  • Assistant in Medicine, Boston Children's Hospital (1993–1999)
  • Instructor, Pediatrics, Harvard Medical School (1993–1999)
  • Staff Physician, Pediatric Oncology, Dana-Farber Cancer Institute (1990–1999)
  • Attending Physician, Pediatric Hematology, Boston Children‘s Hospital (1990–1999)
See all (8 more)

Awards and Honors:
  • Children's Memorial Hospital: Outstanding Resident Teaching Award (1990)
  • Albany Medical College: Lamb Foundation Prize (1987)
  • Albany Medical College: Senior Medical Student Special Award (1987)

Research Expertise:
  • Early Phase Clinical Trials in Children
  • Neuroblastoma

Journal Articles:

See all (27 more)

Books and Book Chapters:

  • Twist CJ, Tedder TF. "Structure of the Mouse HB15 Gene". Leukocyte Typing V: White Cell Differentiation Antigens, Vol. 1. 1995.
  • Pauly JL, Twist CJ, Ovak G, Russell C, Constantino J. "Thymic Hormones and Lymphokines ‘83". Spring Symposium. 1983.

Professional Memberships:
  • American Society of Pediatric Hematology/Oncology (2006–present)
  • American Society of Clinical Oncology (2002–present)
  • American Academy of Pediatrics (2001–2005)
  • Children's Oncology Group (2001–present)
  • American Society of Hematology (2001–present)
  • American Society for Blood and Marrow Transplantation (1995–1999)
  • Massachusetts Medical Society (1994–1996)
  • American Medical Student Association (1983–1987)

Presentations:
  • "Prospective Analysis of EBV+ PTLD in a Multi-Center Study of Pediatric Transplant Recipients" American Transplant Congress, American Society of Transplant Surgeons/American Society of Transplantation (2018)
  • "Anti-Cancer Therapies" Pediatric Grand Rounds, University at Buffalo (2018)
  • "Premature Physeal Closure After Prolonged Fenretinide Exposure" Annual Meeting, Advances in Neuroblastoma Research Association (2016)
  • "Validation of Image-Defined Risk Factor (IDRF) Assignment in Patients with Intermediate-Risk Neuroblastoma: A Report from the Children’s Oncology Group Study ANBL0531" Annual Meeting, Advances in Neuroblastoma Research Association (2016)
  • "Premature Physeal Closure After Prolonged Fenretinide Exposure" Annual Meeting, American Society of Pediatric Hematology/Oncology (2016)
  • "Cancer Recurrence and Mortality After Pediatric Heart Transplantation for Anthracycline Cardiomyopathy" Annual Meeting, International Society for Heart and Lung Transplantation (2016)
  • "Neuroblastoma: Therapeutic Successes and Future Challenges" Bass Center Grand Rounds, Stanford University School of Medicine (2016)
  • "Measuring Pediatric Hematology/Oncology Fellows' Skills in Humanism and Professionalism: A Novel Assessment Instrument" Annual Meeting, American Society of Pediatric Hematology/Oncology (2015)
  • "Trends in End-of-Life Care in Pediatric Hematology, Oncology, and Stem Cell Transplant Patients" Annual Meeting, American Society of Pediatric Hematology/Oncology (2015)
  • "Neuroblastoma" Pediatric Hematology/Oncology Fellowship Core Lecture Series, Stanford University School of Medicine (2015)
  • "Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report from the Children‘s Oncology Group Study ANBL0531" Annual Meeting, American Society of Clinical Oncology (2014)
  • "Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report from the Children's Oncology Group Study ANBL0531" Annual Meeting, Advances in Neuroblastoma Research Association (2014)
  • "Post-Transplant Lymphoproliferative Disorders" Pediatric Solid Organ Transplant Symposium, Lucile Packard Children's Hospital (2014)
  • "Pediatric Oncology Highlights of the Day" Annual Meeting, American Society of Clinical Oncology (2013)
  • "Maintenance of Certification Learning Session: Neuroblastoma" Annual Meeting, American Society of Pediatric Hematology/Oncology (2013)
  • "Morbidity and Mortality Risks in Infants with Stage 4S Neuroblastoma: A Report from the Children’s Oncology Group Study ANBL0531, 'Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma'" Annual Meeting, Advances in Neuroblastoma Research Association (2012)
  • "Outcome Analysis of Non-High-Risk Neuroblastoma Patients Enrolled on Children’s Oncology Group Trials P9641 and A3961" Annual Meeting, Advances in Neuroblastoma Research Association (2012)
  • "Outcome Analysis of Non-High-Risk Neuroblastoma Patients Enrolled on Children’s Oncology Group Trials P9641 and A3961" Annual Meeting, American Society of Clinical Oncology (2012)
  • "Pediatric Oncology Highlights of the Day" Annual Meeting, American Society of Clinical Oncology (2012)
  • "Neuroblastoma" Radiation Oncology Residency Core Curriculum Lecture, Stanford University School of Medicine (2012)
  • "Post-Transplant Lymphoproliferative Disorders" Pediatric Nephrology Continuing Medical Education Lecture, Lucile Packard Children's Hospital (2012)
  • "Post-Transplant Lymphoproliferative Disorder: Is There a Role for 18F FDG PET/CT?" Annual Meeting, Radiological Society of North America (2011)
  • "Treatment of Recurrent Post-Transplant Lymphoproliferative Disorder (PTLD) of the Central Nervous System (CNS) with High-Dose Methotrexate (HD-MTX)" XI International Small Bowel Transplant Symposium, Intestinal Rehabilitation and Transplant Association (2009)
  • "Neuroblastoma" Radiation Oncology Residency Core Curriculum Lecture, Stanford University School of Medicine (2009)
  • "Pediatric Hematology: Oncology as a Career Choice" Pediatric Lecture Series, Stanford University School of Medicine (2009)
  • "Pediatric Oncology Cases" Pediatric Residency Core Lecture, Lucile Packard Children's Hospital (2009)
  • "Isolated Tumor Cells are Routinely Detected by Immunohistochemistry in Histologically Negative Bone Marrow Biopsies from Neuroblastoma Patients" Annual Meeting, Advances in Neuroblastoma Research Association (2008)
  • "Nuclear Medicine Imaging in Pediatric Malignancies" Nuclear Medicine Grand Rounds, Stanford University School of Medicine (2008)
  • "Oncologic Emergencies" Stanford/Kaiser Emergency Medicine Core Curriculum Lecture, Stanford University School of Medicine (2008)
  • "Pediatric Hematology: Oncology as a Career Choice" Pediatric Lecture Series, Stanford University School of Medicine (2008)
  • "Pediatric Oncology Cases" Pediatric Residency Core Lecture, Lucile Packard Children's Hospital (2008)
  • "A Phase I Study of a Novel Human Monoclonal Antibody (mAb216) with Chemotherapy for the Treatment of Patients with Relapsed or Refractory B-Lineage Acute Lymphoblastic Leukemia" Annual Meeting, American Society of Hematology (2007)
  • "Retrospective Survey of Children Treated for Relapsed Acute Lymphoblastic Leukemia (Complete Remission (CR) Rates): A Report from the Therapeutic Advances in Childhood Leukemia (TACL) Consortium" Annual Meeting, American Society of Hematology (2007)
  • "Intermediate-Risk Neuroblastoma" Parent Conference, Children's Neuroblastoma Cancer Foundation (2007)
  • "Neuroblastoma Update" Pediatric Oncology Grand Rounds, University of Texas Southwestern (2007)
  • "Pediatric Hematology/Oncology as a Career Choice" Pediatric Lecture Series, Stanford University School of Medicine (2007)
  • "Pediatric Oncology Cases" Pediatric Residency Core Lecture, Lucile Packard Children's Hospital (2007)
  • "Perinatal Neuroblastoma" Neonatology Lecture Series, Lucile Packard Children's Hospital (2007)
  • "Post-Transplant Lymphoproliferative Disorders" Radiation Oncology Residency Core Curriculum Lecture, Stanford University School of Medicine (2007)
  • "Treatment of Neuroblastoma: A Paradigm for Multidisciplinary Care" Leadership Forum, Lucile Packard Children's Hospital (2007)
  • "Mature Results of a Prospective Trial of Rituximab in Patients (pt) with Post-Transplant Lymphoproliferative Disorder (PTLD) Unresponsive or Ineligible for Reduced Immunosuppression (RIS)" Annual Meeting, American Society of Hematology (2006)
  • "A Phase I Clinical Trial of the Hu14.18-IL2 (EMD 273063) as a Treatment for Children with Refractory or Recurrent Neuroblastoma and Melanoma: A Study of the Children’s Oncology Group" Annual Meeting, Advances in Neuroblastoma Research Association (2006)
  • "Oncologic Emergencies" Stanford/Kaiser Emergency Medicine Core Curriculum Lecture, Stanford University School of Medicine (2006)
  • "Pediatric Hematology/Oncology as a Career Choice" Pediatric Lecture Series, Stanford University School of Medicine (2006)
  • "Pediatric Oncologic Emergencies" Continuing Medical Education Lecture Series, Watsonville Community Hospital Emergency Department (2006)
  • "Pediatric Oncology Cases" Pediatric Residency Core Lecture, Lucile Packard Children's Hospital (2006)
  • "Neuroblastoma in a Patient with Noonan Syndrom: Possible Genotype/Phenotype Correlations in PTPN11" Annual Meeting, American Society of Human Genetics (2005)
  • "Impact of Body Composition on Pharmacokinetics of Doxorubicin in Pediatric Patients: A Glaser Pediatric Research Network Study" Annual Meeting, American Society of Clinical Oncology (2005)
  • "Low Stage Neuroblastoma" Parent Conference, Children's Neuroblastoma Cancer Foundation (2005)
  • "Pediatric Liver Tumors" Pediatric Liver Transplant Conference, Lucile Packard Children's Hospital (2005)
  • "Pediatric Oncology Cases" Pediatric Residency Core Lecture, Lucile Packard Children's Hospital (2005)
  • "Wilms Tumor" Radiation Oncology Residency Core Curriculum Lecture, Stanford University School of Medicine (2005)
  • "Age Continues to be a Powerful Predictor of EFS and OS in Neuroblastoma" Annual Meeting, Advances in Neuroblastoma Research Association (2004)
  • "Neuroblastoma" Radiation Oncology Residency Core Curriculum Lecture, Stanford University School of Medicine (2004)
  • "Update on Neuroblastoma" Nuclear Medicine Grand Rounds, Stanford University School of Medicine (2004)
  • "Monoclonal Antibody 216 (MAb 216), a VH4-34 Encoded Antibody, is a Novel Cytotoxic Agent for B-Progenitor Acute Lymphoblastic Leukemia (ALL)" Annual Meeting, American Society of Hematology (2003)
  • "Interactive Encoding of Whole Body 123I-MIBG Images in the Evaluation of Patients with Neuroblastoma" 4th European Symposium on Paediatric Nuclear Medicine, European Association of Nuclear Medicine (2003)
  • "Oncologic Emergencies" Stanford/Kaiser Emergency Medicine Core Curriculum Lecture, Stanford University School of Medicine (2003)
  • "Update on Neuroblastoma" Nuclear Medicine Grand Rounds, Stanford University School of Medicine (2003)
  • "Post-Transplant Lymphoproliferative Disorders" Pediatric Infectious Disease Conference, Lucile Packard Children's Hospital (2002)
  • "Rituximab is Effective Therapy for Post-Transplant Lymphoproliferative Disorder (PTLD) Not Responding to Reduction in Immunosuppression: A Prospective Trial in Adults and Children" Annual Meeting, American Society of Clinical Oncology (2001)
  • "Neuroblastoma 2001" Pediatric Grand Rounds, Lucile Packard Children‘s Hospital (2001)
  • "New Treatments for Genetic Diseases" Annual Meeting, New England Regional Genetics Group (1998)
  • "Cytoxan and Total Body Irradiation Conditioning Results in Stable Donor Marrow Engraftment in Patients with Metabolic Storage Diseases Undergoing Allogeneic Bone Marrow Transplantation" Annual Meeting, American Society of Pediatric Hematology/Oncology (1997)
  • "Bone Marrow Transplantation for Metabolic Storage Diseases" Pediatric Oncology Grand Rounds, Dana-Farber Cancer Institute (1997)
  • "Bone Marrow Transplantation for Metabolic Storage Diseases" Bone Marrow Transplantation Conference, Harvard Medical School (1997)
  • "The Use of Defibrotide (DF) in BMT-Associated Veno-Occlusive Disease (VOD)" Annual Meeting, American Society of Clinical Oncology (1996)
  • "Structure of the Mouse CD83 Gene" Annual Meeting, American Society of Hematology (1995)
  • "Structure of the Mouse HB15 Gene" 5th International Workshop on Human Leukocyte Differentiation Antigens, Human Cell Differentiation Molecules (1993)
See all (59 more)

Service Activities:
  • American Board of Pediatrics: Subboard of Pediatric Hematology/Oncology; Deputy Medical Editor (2017–present)
  • Cincinnati Children's Hospital: Data Safety and Monitoring Committee; Committee Member (2016–present)
  • American Board of Pediatrics: Subboard of Pediatric Hematology/Oncology; Past Chair (2014–2015)
  • Lucile Packard Children's Hospital: Interns/Residents; Advisor (2013–2016)
  • Stanford University Cancer Center: Scientific Review Committee; Committee Member (2013–2016)
  • Stanford University: Pediatric Hematology/Oncology Fellowship Program - Clinical Competency Committee; Chair (2013–2016)
  • Stanford University: Pediatric Hematology/Oncology Fellowship Program - Fellow Trainee; Clinical Mentor (2013–2016)
  • American Society of Pediatric Hematology/Oncology: Certification and Continuing Education Committee; Committee Member (2013–2015)
  • American Society of Clinical Oncology: Clinical Cancer Advances Journal; Editorial Advisor (2013–present)
  • National Cancer Institute: PDQ Pediatric Treatment Editorial Advisory Board; Board Member (2013–present)
  • Stanford University: Pediatric Hematology/Oncology Fellowship Program - Fellowship Recruitment Committee; Committee Member (2012–2016)
  • Stanford University: Pediatric Hematology/Oncology Fellowship Program - Fellowship Scholarly Oversight Committee; Committee Member (2012–2016)
  • American Society of Pediatric Hematology/Oncology: Training Committee; Committee Member (2012–2015)
  • Lucile Packard Children's Hospital: Medical Executive Committee; Committee Member (2012–2015)
  • American Board of Pediatrics: Subboard of Pediatric Hematology/Oncology; Chair (2012–2014)
  • National Heart, Lung, and Blood Institute: Taskforce on the Future of the Workforce in Hematology; Member (2012–2014)
  • American Society of Clinical Oncology 2013 Annual Meeting: Pediatric Oncology Education Program Committee; Committee Member (2012–2013)
  • American Society of Clinical Oncology 2013 Annual Meeting: Pediatric Oncology Scientific Program Committee; Track Leader (2012–2013)
  • Advances in Neuroblastoma Research Annual Meeting: Scientific Program Committee; Committee Member (2012)
  • Lucile Packard Children's Hospital: Tissue Committee; Committee Member (2011–2016)
  • American Society of Clinical Oncology 2012-2014 Annual Meetings: Pediatric Oncology Scientific Program Committee; Committee Member (2011–2014)
  • American Board of Pediatrics: Subboard of Pediatric Hematology/Oncology Credentials Committee; Committee Member (2010–2014)
  • Lucile Packard Children's Hospital: Bass Center Process Improvement Committee; Committee Member (2010–2012)
  • Lucile Packard Children's Hospital: Pediatric Oncology Chemotherapy Error Prevention Committee; Committee Member (2010–2012)
  • New Approaches to Neuroblastoma Therapy Consortium: Scientific Review Committee; Committee Member (2010–2012)
  • Dana-Farber Cancer Institute: Claudia Adams Barr Program in Innovative Basic Cancer Research Presidential Scientific Advisory Council; Member (2010–present)
  • American Board of Pediatrics: Subspecialties Committee; Committee Member (2009–2014)
  • Stanford University: Pediatric Hematology/Oncology Fellowship Program; Faculty Mentor (2008–2016)
  • American Board of Pediatrics: Subboard of Pediatric Hematology/Oncology; Board Member (2008–2013)
  • Pediatric Transplantation Journal; Ad Hoc Reviewer (2008–present)
  • Stanford University: Med Scholars Program; Faculty Mentor (2007–2009)
  • Stanford University School of Medicine: Pediatric Journal Club; Faculty Facilitator (2007–2008)
  • Stanford University: Pediatric Hematology/Oncology Fellowship Program - Fellowship Boot Camp Lecture Series; Lecturer (2006–2012)
  • Stanford University School of Medicine: Pediatric Lecture Series; Lecturer (2006–2010)
  • Children's Oncology Group: Neuroblastoma Steering Committee; Committee Member (2006–present)
  • Pediatric Blood and Cancer Journal; Ad Hoc Reviewer (2006–present)
  • Stanford University: Pediatric Residency Program - Core Lecture Series; Lecturer (2005–2010)
  • Lucile Packard Children's Hospital: Pediatric Hematology/Oncology Bereavement Committee; Committee Member (2003–2016)
  • Stanford University: Pediatric Oncology Bereavement Program; Faculty Supervisor (2003–2016)
  • Stanford University: Pediatric Residency Program - Hematology/Oncology Ambulatory Selective Rotation; Director (2003–2015)
  • Stanford University: Pediatric Residency Program - Hematology/Oncology Inpatient Rotation; Director (2003–2012)
  • New Approaches to Neuroblastoma Therapy Consortium: Study Committee; NANT 2001-2003: A Phase I Study of CEP-701 in Patients with Refractory Neuroblastoma; Committee Member (2003–2010)
  • New Approaches to Neuroblastoma Therapy Consortium: Data Safety and Monitoring Committee; Committee Member (2003–present)
  • Lucile Packard Children‘s Hospital: Division of Hematology/Oncology Peer Review Committee; Chair (2002–2015)
  • Children's Oncology Group: Intermediate Risk Neuroblastoma Study (ANBL0531); Chair (2002–2013)
  • Stanford University School of Medicine: Medical Student Sub-Internship in Pediatric Hematology/Oncology; Director (2002–2012)
  • Lucile Packard Children's Hospital: Care Improvement Committee; Committee Member (2001–2016)
  • American Academy of Pediatrics: PREP; Editorial Board Member (2001–2003)
  • New Approaches to Neuroblastoma Therapy Consortium: Neuroblastoma Disease Committee; Committee Member (2001–present)
  • Stanford University: Pediatric Oncology Tumor Board; Faculty Supervisor (2000–2016)
  • Lucile Packard Children's Hospital: Quality Improvement Committee; Committee Member (2000–2015)
  • Lucile Packard Children's Hospital: Division of Pediatric Hematology/Oncology; Quality Assurance Liaison (2000–2014)
  • Lucile Packard Children's Hospital: Critical Care Committee; Committee Member (2000–2009)
  • Stanford University School of Medicine: Medical Student Clerkship in Pediatric Hematology/Oncology; Director (2000–2005)
  • Lucile Packard Children's Hospital: Pediatric Oncology Medication Error Committee; Committee Member (2000–2002)
  • Pediatric Bone and Marrow Transplant Consortium: Immunologic and Metabolic Disorders Strategy Group; Member (2000–2002)
  • Lucile Packard Children's Hospital: Sedation Committee; Committee Member (2000–2001)
  • Journal of Clinical Oncology; Ad Hoc Reviewer (2000–present)
  • Journal of Pediatric Hematology/Oncology; Ad Hoc Reviewer (2000–present)
  • Dana-Farber Cancer Institute: Marathon Challenge Governing Board; Board Member (1998–present)
  • Dana-Farber Cancer Institute: Committee on Sexual Harassment; In-House Sexual Harassment Trainer (1997–1999)
  • Dana-Farber Cancer Institute: Human Protection Committee; Committee Member (1996–1999)
  • Dana-Farber Cancer Institute: Pediatric Oncology Operations Committee; Committee Member (1996–1999)
  • Boston Children‘s Hospital: Oncology/Bone Marrow Transplant Resident Education Committee; Committee Member (1994–1999)
  • Dana-Farber Cancer Institute: Pediatric Oncology Clinic; Clinic Leader (1994–1998)
  • Dana-Farber Cancer Institute: Marathon Challenge Patient Partner Program Committee; Committee Member (1994–present)
  • Harvard Medical School: Patient-Doctor II Course in Physical Diagnosis; Tutor (1993–1996)
  • Dana-Farber Cancer Institute: Pediatric Oncology Protocol Conference; Coordinator (1993–1994)
  • Dana-Farber Cancer Institute: Marathon Challenge for Claudia Adams Barr Program in Innovative Basic Cancer Research; Participant (1993–present)
  • Albany Medical College: Admissions Committee; Committee Member (1985–1987)
  • Children's Oncology Group: Roswell Park Comprehensive Cancer Center; Site Principal Investigator

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Contact Information

Roswell Park Cancer Institute
Department of Pediatrics
Elm and Carlton Streets
Buffalo, NY 14263
Phone: (716) 845-2333
Fax: (716) 845-8003
ctwist@buffalo.edu
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