University at Buffalo (UB)
David M. Zlotnick MD
David M. Zlotnick
MD
Assistant Professor of Medicine
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Cardiology; Cardiovascular Disease; Endovascular Medicine; Interventional Cardiology; Vascular Medicine
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDProfessional Summary:
I am an interventional cardiologist with UBMD Cardiovascular Medicine, with specialized training in echocardiography, nuclear cardiology and noninvasive vascular interpretation (RPVI). I see outpatients through the UBMD ambulatory practice at the Amherst Clinic, and I care for patients admitted to the Buffalo General Medical Center (BGMC) consultative service and BGMC’s Cardiac Care Unit (CCU). My interventional practice involves evaluating and caring for patients with coronary and structural heart diseases. I perform diagnostic coronary angiography, percutaneous coronary intervention (PCI), coronary atherectomy, percutaneous mechanical hemodynamic support, cardiac biopsy, patent foramen ovale (PFO)/atrial spetal defect (ASD) closure and transaortic valve replacement (TAVR).
I also have a specialized focus on evaluating and managing patients with peripheral vascular disease, including noninvasive vascular testing and endovascular interventions. I see patients at the Gates Vascular Institute (GVI) where I perform diagnostic peripheral and carotid angiography and interventions for peripheral arterial diseases. These procedures include lower extremity arterial atherectomy, angioplasty and stenting, renal and mesenteric artery revascularization and subclavian intervention.
I am active in research at the GVI by participating in a number clinical trials. One aims at protecting patients from renal damage during PCI (CARIN, Ischemix). Another involves an alternative procedure to perform TAVR for intermediate-risk patients with symptomatic aortic stenosis (SURTAVI, Medtronic). A third clinical trial addresses using intracoronary delivery of stem cells in patients postanterior myocardial infarction with ischemic left ventricular dysfunction (ALLSTAR, Capricor).
As a faculty member at the University at Buffalo, I teach and mentor residents and fellows during their hospital rotations.
Education and Training:
- Fellowship, Interventional Cardiology and Peripheral Vascular Intervention, Ochsner Clinic Foundation (2014)
- Fellowship, Interventional Cardiology, Dartmouth-Hitchcock Medical Center (2013)
- Fellowship, Cardiovascular Disease, Dartmouth-Hitchcock Medical Center (2012)
- Residency, Internal Medicine, Dartmouth-Hitchcock Medical Center (2009)
- MD, Medicine, SUNY Upstate Medical University (2005)
- BA, Biology, University of Rochester (2000)
Employment:
- Clinical Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2014-present)
- Staff Interventional Cardiologist, Buffalo General Medical Center (2014-present)
- Staff Interventional Cardiologist, Gates Vascular Institute (2014-present)
- Staff Interventional Cardiologist, Great Lakes Cardiovascular (2014-present)
Awards and Honors:
- Excellence in Teaching Award of the Department of Medicine (2008)
- Dean’s Letter of Commendation for Outstanding Academic Performance during the Third Year of Medical School (2004)
Research Expertise:
- Renal injury after percutaneous intervention
Grants and Sponsored Research:
- December 2016–August 2019
PARTNER 3: A Prospective, Randomized, Controlled, Multi-Center Study to Establish the Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients who have Severe, Calcific, Aortic Stenosis Requiring Aortic Valve Replacement.
Role: Co-Investigator - August 2014–March 2019
Allstar: Randomized, Double-Blinded, Placebo-Controlled Phase II Study of the Safety and Efficacy of Intracoronary Delivery of Allogeneic Cardiosphere-Derived Cells in Patient siwth a Myocardial Infarction and Ischemic Left Ventricular Dysfunction (ALLog
Role: Co-Investigator - January 2018–February 2019
NHLBI Hybrid Coronary Revascularization: Randomized trial of hybrid coronary revascularization versus percutaneous coronary intervention.
Role: Co-Investigator - December 2016–October 2018
Armaron: A Phase II Randomized, Double-Blind, Placebo-Controlled Study of The Efficacy, Safety and Tolerability of Oral NP202 in Adults Who Have Left Ventricular Systolic Dysfunction Following Myocardial Infarction. NP202.
Role: Principal Investigator - December 2014–September 2018
Reprise III: Repositionable Percutaneous Replacement of Stenotic Aortic Valve through Implanation of Lotus TM Valve System/Randomized Clinical Evaluation.
Role: Co-Investigator - April 2017–September 2017
Leaders Free: A Prospective Study of the Biofreedom Biolimis A9 Drug Coated Stent in Patients at High Risk for Bleeding.
Role: Co-Investigator - January 2020
GORE CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients with Patent Foramen Ovale (PFO): the REDUCE Approval Study.
Role: Co-Investigator - December 2019
CHEETAH - A Prospective, Multicenter study to Evaluate the Safety and Performance of the CAT RX Aspiration Catheter in Patients with a High Thrombus Burden Acute Coronary Vessel Occlusion.
Role: Principal Investigator - November 2019
Stemi DTU Pivotol: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction.
Role: Co-Investigator - February 2019
Henry Ford Health System National Cardiogenic Shock Initiative.
Role: Co-Investigator - December 2018
Abbott ILUMIEN IV: Optical Coherence Tomography (OCT) Guided Coronary Stent implantation Compared to Angiography: a Multicenter Randomized Trial in PCI.
Role: Co-Investigator - August 2018
KNOCOUT PE - Retrospective and prospective international EKoSoNic registry of the Treatment and Clinical Outcomes of Patients with Pulmonary Embolism.
Role: Principal Investigator
Journal Articles:
- Zlotnick DM and Canty JM Jr. (2016) Striking a balance: Individualizing antithrombotic therapy after myocardial infarction. Trends in Cardiovascular Medicine (Jan), 74: 19-30.
- Zlotnick DM, Ouellette ML, Malenka DJ, DeSimone JP, Leavitt BJ, Helm RE, Olmstead EM, Costa SP, DiScipio AW, Likosky DS, Schmoker JD, Quinn RD, Sisto D, Klemperer JD, Sardella GL, Baribeau YR, Frumiento C, Brown JR, O‘Rourke DJ. (2013) Effect of preoperative pulmonary hypertension on outcomes in patients with severe aortic stenosis following surgical aortic valve replacement. Am J Cardiol (Nov), 112(10): 1635-1640.
- Zlotnick DM, Ramanath VS, Brown JR, Kaplan AV. (2012) Classification and treatment of coronary artery bifurcation lesions: putting the Medina classification to the test. Cardiovasc Revasc Med (Jul), 13(4): 228-233.
- Zlotnick DM, Helisch A. (2012) Recurrent stress cardiomyopathy induced by Sudafed PE. Ann Intern Med (Jan), 156(2): 171-172.
- Friedman SE, Palac RT, Zlotnick DM, Chobanian MC, Costa SP. (2011) A call to action: variability in guidelines for cardiac evaluation before renal transplantation. Clin J Am Soc Nephrol (May), 6(5): 1185-1191.
- Zlotnick DM, Axelrod DA, Chobanian MC, Friedman S, Brown J, Catherwood E, Costa SP. (2010) Non-invasive detection of pulmonary hypertension prior to renal transplantation is a predictor of increased risk for early graft dysfunction. Nephrol Dial Transplant (Sep), 25(9): 3090-3096.
- Zlotnick DM, Merrens EJ, Petras ML, Tsongalis GJ, Bentley H, Fingar EL, Levy NB. (2008) Intravascular lymphoma as a recurrence of testicular Non-Hodgkin's lymphoma confirmed by polymerase chain reaction. Am J Hematol (Aug), 83(8): 681-682.
- Zlotnick DM, Merrens EJ, Fingar EL, Levy NB. (2008) A 69-year-old male presenting with hypotension and anasarca. Am J Hematol (Apr), 83(4): 311-314.
- Wakem P, Ramirez F, Zlotnick D, Gaspari AA, Zlotnick DM. (2004) Heterogeneity of CD80 gene transcription by human keratinocytes to allergens and irritants: relevance to allergic contact dermatitis in vivo. J Appl Toxicol (Nov), 24(6): 485-492.
- Wakem P, Burns RP, Ramirez F, Zlotnick D, Ferbel B, Haidaris CG, Gaspari AA, Zlotnick DM. (2000) Allergens and irritants transcriptionally upregulate CD80 gene expression in human keratinocytes. J Invest Dermatol (Jun), 114(6): 1085-1092.
Abstracts:
- Rajagopalan B, Malhotra S, Iyer V, Morris W and Zlotnick D. (2015) Too much calcium, too little gradient: An unusual case of low gradient aortic stenosis. J Am Coll Cardiol, (Jan) A662
- Wakem, P, Zlotnick DM, Gaspari, A. (2000) A serum response-like element is important in the upregulation of the CD80 promoter in keratinocytes, HaCat and HELA cells exposed to allergens and irritants. The Journal of Investigative Dermatology, (Jan) 771
Professional Memberships:
- Fellow, The Society for Cardiovascular Angiography and Interventions (FSCAI); Fellow of FSCAI (2016–present)
- ARDMS; RPVI (2014–present)
- Fellow, American College of Cardiology (2014–present)
- American College of Cardiology (2009–2014)
Presentations:
- "Vacuum It Out: Single Center Experience with AngioVac for Right Heart Thrombus and Endocarditis" Society for Cardiovascular Angiography & Interventions Annual Meeting; SCAI (2019)
- "Early Experience with Pulmonary Embolism Response Team (PERT)" Chest 2017 Annual Meeting; Buffalo General Medical Center (2017)
- "Rapid Improvement of Right Ventricular Systolic Function in Patients with Pulmonary Embolism Treated with Ultrasound-Assisted Catheter Directed Thrombolysis." American College of Cardiology 2017 Annual Meeting; American College of Cardiology (2017)
- "PERT: A Multi-disciplinary Approach to Treating Pulmonary Embolism" Grand Rounds; Catholic Health System (2017)
- "Too much Calcium; Too Little Gradient: An Unusual Case of Low Gradient Aortic Stenosis" American College of Cardiology 2014 Annual Meeting; American College of Cardiology (2014)
- "Is the Use of Drug-Eluting Stents Related to the Risk of Target Vessel Revascularization." American College of Cardiology 2013 Annual Meeting; ACC (2013)
- "Management of Cardiogenic Shock." Northern New England Cardiovascular Disease Study Group Fall Regional Meeting; Northern New England Cardiovascular Disease Study Group (2012)
- "Pulmonary Hypertension and Outcomes of Aortic Valve Replacement for Severe Aortic Stenosis – New Insights." - Northern New England Cardiovascular Disease Study Group Spring Regional Meeting; Northern New England Cardiovascular Disease Study Group (2012)
- "Special Topic: Case Studies: High Output Failure." The 8th Annual Dartmouth Conference on Advances in Heart Failure; Dartmouth-Hitchcock Medical Center (2012)
- "Severe Pulmonary Hypertension is an Independent Predictor of In-Hospital Mortality and Acute Kidney Injury after Aortic Valve Replacement for Severe Aortic Stenosis." - Northern New England Cardiovascular Disease Study Group Winter Regional Meeting; Northern New England Cardiovascular Disease Study Group (2012)
- "Severe Pulmonary Hypertension is an Independent Predictor of In-Hospital Mortality and Acute Kidney Injury after Aortic Valve Replacement for Severe Aortic Stenosis." American College of Cardiology 2012 Annual Meeting; ACC (2012)
- "Chronic Kidney Disease as a Risk Factor of Cardiovascular Disease." Dartmouth-Hitchcock Medical Center Cardiovascular Disease Update Symposium 2011; Dartmouth-Hitchcock Medical Center (2011)
- "Classification and Treatment of Coronary Artery Bifurcation Lesions: Putting the Medina Classification System to the Test." American College of Cardiology 2011 Annual Meeting; ACC (2011)
- "Pulmonary Hypertension in Renal Transplant Candidates: Can Hemodynamic Profiles Help Provide Insights for Therapeutic Options?" American Heart Association 2011 Annual Meeting; AHA (2011)
- "Special Topic: Non-ischemic Cardiomyopathy." The 6th Annual Dartmouth Conference on Advances in Heart Failure; Dartmouth-Hitchcock Medical Center (2010)
- "Pulmonary Hypertension Predicts Early Graft Dysfunction Following Deceased Donor Renal Transplantation." Medicine Grand Rounds; Dartmouth-Hitchcock Medical Center; Internal Medicine (2008)
- "Pulmonary Hypertension in Renal Disease." - 2nd Annual Northern New England Pulmonary Hypertension Symposium (2007)
- "Wegener's Granulomatosis" 2007 New Hampshire/Vermont American College of Physicians Regional Meeting; New Hampshire/Vermont American College of Physicians (2007)
- "Intravascular Lymphoma Presenting with Systemic Capillary Leak" Society of General Internal Medicine New England Regional Meeting (2007)
- "Pulmonary Hypertension Predicts Poor Outcome Following Renal Transplantation: Clinical and Echocardiographic Characterization" American Transplant Congress 2007 Annual Meeting (2007)
- "Allergens and Irritants Transcriptionally Upregulate CD80 Gene Expression in Human Keratinocytes" University of Rochester Conference Undergraduate Research and Creativity; University of Rochester (2000)
- "Allergents and Irritants Transcriptionally Upregulate CD80 Gene Expression in Human Keratinocytes" The Strong children's Research Center Tenth Annual Summer Student Scholar Poster Day Symposium 1999; Strong Memorial (1999)
Service Activities:
- Director, Pulmonary Embolism Response Team; Director (2016–present)