Examining the Impact of Stress and β-adrenergic Signaling on Mouse Models of Cancer (completed 2014)

My project focuses on exploring the cause behind specific discrepancies in therapeutic response observed in pre-clinical mouse models and humans. In particular, I am examining how classical stress responses and the immune system may alter the ability for tumors to undergo apoptosis in response to treatment and skew data in these animal studies. These alterations in experimental therapeutic efficacy could have significant implications for the success or failure of novel drugs in the treatment of cancer.

Elizabeth Repasky, PhD and Bonnie Hylander, PhD