Yuhao Shi

Yuhao Shi.

Yuhao Shi

Yuhao Shi


Transitional/Brockton-BIDMC, Beth Israel Deaconess Medical Center, Brockton, Mass. Radiation Oncology, New York University School of Medicine, New York, N.Y.

Research Publications Overview

Thesis Title

Tumor Intrinsic Consequences of Acquired Resistance to PD-L1 Inhibition

Research Description

The use of immune checkpoint inhibitors has led to improved outcomes for patients in multiple disease sites; however, for some, acquired resistance limits drug efficacy. Our research examines novel mechanisms of resistance that involve intracellular PD-L1 signaling, interferon signaling, secretory pathways that can suppress anti-tumor immunity and also affect efficacy of secondary treatments given after immunotherapy failure.

Thesis Advisor