Roswell Park Cancer Institute Department of Pediatrics Elm and Carlton Streets Buffalo, New York 14263 Phone: (716) 845-2333 Fax: (716) 845-8003 ctwist@buffalo.edu
I joined the faculty of the Jacobs School of Medicine and Biomedical Sciences in 2016 as Professor of Oncology and Director of Pediatric Developmental Therapeutics at the Roswell Park Comprehensive Cancer Center. I am a board-certified pediatric hematologist/oncologist and clinical investigator. My area of clinical expertise focuses on solid tumor malignancies in children and young adults. My research interests have been driven by the clinical challenges in high risk pediatric malignancies. A major focus of my clinical investigation effort over the past 15 years has been in the design of clinical trials through the Children’s Oncology Group (COG) for patients with neuroblastoma. I have served since 2006 on the COG Neuroblastoma Steering Committee, helping to define and prioritize research objectives for this disease. I served as study chair of the COG Phase III study ANBL0531 for patients with Intermediate Risk Neuroblastoma, which defined a practice-changing new standard of care therapy for patients with non-high risk neuroblastoma in North America.
Since joining the faculty in the Cancer and Blood Disorders Program at Roswell Park and Oishei Children’s Hospital in 2016, I have overseen the clinical trials program for pediatric oncology and serve as the institutional principal investigator for COG. In my role as Director of Pediatric Developmental Therapeutics at Roswell Park, I am building a program to support the development and implementation of early phase trials and novel therapies for children and young adults with high risk malignancies.
I serve as the Program Director of the Pediatric Hematology/Oncology Fellowship Training Program at the Jacobs School and Roswell Park/Oishei Children’s Hospital. On a national level, I have served on the Education Committee of the American Society of Clinical Oncology (ASCO), the Training Committee and the Certification and Continuing Education Committee of the American Society of Pediatric Hematology/Oncology (ASPHO) and the National Heart, Lung, and Blood Institute (NHLBI) Taskforce on the Future of the Workforce in Hematology, as well as serving on the American Board of Pediatrics subboard in Hematology/Oncology since 2008.
Education and Training:
Fellowship, Pediatric Hematology/Oncology, Harvard Medical School (1993)
Fellowship, Pediatric Hematology/Oncology, Harvard Medical School (1991)
Residency, Pediatrics, Northwestern University (1990)
Internship, Pediatrics, Northwestern University (1988)
MD, Medicine, Albany Medical College (1987)
MS, Natural Sciences/Immunology, University at Buffalo/Roswell Park Memorial Institute (1984)
BS, University of Notre Dame (1982)
Employment:
Medical Staff, Pediatric Hematology/Oncology, Oishei Children’s Hospital
Fellowship Program Director, Hematology/Oncology, University at Buffalo (2018-present)
Medical Staff, Attending Physician, Pediatric Hematology/Oncology, Lucile Packard Children’s Hospital and Stanford University Medical Center (1999–2016)
Medical Director, Pediatric Oncology Unit, El Camino Hospital (2012–2014)
Medical Director, Pediatric Oncology unit, El Camino Hospital (2010–2014)
Assistant Professor, Pediatrics, Stanford University School of Medicine (2000–2008)
Acting Assistant Professor, Pediatrics, Stanford University School of Medicine (1999–2000)
Associate Physician, Attending Physician, Bone Marrow Transplant Service, Brigham and Women's Hospital, Boston, MA (1994–1999)
Associate Physician, Hematology/Oncology, Brigham and Women‘s Hospital (1994–1999)
Attending Physician, Bone Marrow Transplant Service, Brigham and Women's Hospital (1994–1999)
Assistant in Medicine, Boston Children's Hospital (1993–1999)
Assistant in Medicine, Attending Physician, Bone Marrow Transplant Service, Children's Hospital, Boston, MA (1993–1999)
Attending Physician, Bone Marrow Transplant Service, Boston Children's Hospital (1993–1999)
Instructor, Pediatrics, Harvard Medical School (1993–1999)
Attending Physician, Boston Children‘s Hospital (1990–1999)
Staff Physician, Hematology Clinic, Children's Hospital, Boston, MA (1990–1999)
Staff Physician, Dana-Farber Cancer Institute (1990–1999)
Staff Physician, Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA (1990–1999)
Clinic Leader, Pediatric Oncology Clinic, Dana-Farber Cancer Institute (1994–1998)
Pauly JL, Twist CJ, Pirela D, Reinertson R, Callahan J, Russell C. (1983) Studies of cultured human T lymphocytes IV: Production of serum- and mitogen-free supernatants having high levels of the human T cell growth interleukin 2. IRCS Medical Science (Jan), 11: 77-76.
Pauly JL, Twist CJ, Pirela D, Russell C. (1983) Studies of cultured human T lymphocytes V: Isolation and partial purification of the human T cell growth promoter interleukin 2 by adsorption on to silicic acid. IRCS Medical Science (Jan), 11: 184-185.
Pauly JL, Ovak G, Twist CJ, Russell C. (1983) Studies of cultured human T lymphocytes VI: Culture flask compostion markedly affects IL 2-dependent T cell proliferation as defined in comparative studies of glass, polystyrene, and polymethylpentene vessels. IRCS Medical Science (Jan), 11: 534-535.
Pauly JL, Twist CJ, Pirela D, Reinertson R, Callahan J, Russell C. (1982) Studies of cultured human T lymphocytes. III: A quantitative assay of the human T cell growth-promoting lymphokine interleukin 2. IRCS Medical Science (Jan), 10: 889-900.
Twist CJ, Tedder TF. (1995) In: "Structure of the Mouse HB15 Gene". Oxford University Press, 697-699.
Pauly JL, Twist CJ, Ovak G, Russell C, Constantino J. (1983) In: "Thymic Hormones and Lymphokines ‘83". Plenum Publishing Corporation
Abstracts:
Twist CJ, Kjelson L, McKenney A, Bonham CA, Esquivel C, Castillo RO. (2009) Treatment of Recurrent Post-Transplant Lymphoproliferative Disorder (PTLD) of the Central Nervous System (CNS) with High-Dose Methotrexate (HD-MTX). Proceedings of the XI International Small Bowel Transplant Symposium (Bologna, Italy), (Sep)
Professional Memberships:
American Society of Pediatric Hematology/Oncology (2006–present)
American Society of Clinical Oncology (2002–present)
American Academy of Pediatrics (2001–2005)
American Society of Hematology (2001–present)
Children's Oncology Group (2001–present)
American Society for Blood and Marrow Transplantation (1995–1999)
Massachusetts Medical Society (1994–1996)
American Medical Student Association (1983–1987)
Presentations:
"Prospective Analysis of EBV+ PTLD in a Multi-Center Study of Pediatric Transplant Recipients" American Transplant Congress; American Society of Transplant Surgeons/American Society of Transplantation (2018)
"Anti-Cancer Therapies" Pediatric Grand Rounds; University at Buffalo (2018)
"Premature Physeal Closure After Prolonged Fenretinide Exposure" Annual Meeting; Advances in Neuroblastoma Research Association (2016)
"Validation of Image-Defined Risk Factor (IDRF) Assignment in Patients with Intermediate-Risk Neuroblastoma: A Report from the Children’s Oncology Group Study ANBL0531" Annual Meeting; Advances in Neuroblastoma Research Association (2016)
"Premature Physeal Closure After Prolonged Fenretinide Exposure" Annual Meeting; American Society of Pediatric Hematology/Oncology (2016)
"Cancer Recurrence and Mortality After Pediatric Heart Transplantation for Anthracycline Cardiomyopathy" Annual Meeting; International Society for Heart and Lung Transplantation (2016)
"Neuroblastoma: Therapeutic Successes and Future Challenges" Bass Center Grand Rounds; Stanford University School of Medicine (2016)
"Measuring Pediatric Hematology/Oncology Fellows' Skills in Humanism and Professionalism: A Novel Assessment Instrument" Annual Meeting; American Society of Pediatric Hematology/Oncology (2015)
"Trends in End-of-Life Care in Pediatric Hematology, Oncology, and Stem Cell Transplant Patients" Annual Meeting; American Society of Pediatric Hematology/Oncology (2015)
"Neuroblastoma" Pediatric Hematology/Oncology Fellowship Core Lecture Series; Stanford University School of Medicine (2015)
"Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report from the Children‘s Oncology Group Study ANBL0531" Annual Meeting; American Society of Clinical Oncology (2014)
"Maintaining Outstanding Outcomes Using Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma: A Report from the Children's Oncology Group Study ANBL0531" Annual Meeting; Advances in Neuroblastoma Research Association (2014)
"Pediatric Oncology Highlights of the Day" Annual Meeting; American Society of Clinical Oncology (2013)
"Maintenance of Certification Learning Session: Neuroblastoma" Annual Meeting; American Society of Pediatric Hematology/Oncology (2013)
"Morbidity and Mortality Risks in Infants with Stage 4S Neuroblastoma: A Report from the Children’s Oncology Group Study ANBL0531, 'Response- and Biology-Based Therapy for Intermediate-Risk Neuroblastoma'" Annual Meeting; Advances in Neuroblastoma Research Association (2012)
"Outcome Analysis of Non-High-Risk Neuroblastoma Patients Enrolled on Children’s Oncology Group Trials P9641 and A3961" Annual Meeting; Advances in Neuroblastoma Research Association (2012)
"Outcome Analysis of Non-High-Risk Neuroblastoma Patients Enrolled on Children’s Oncology Group Trials P9641 and A3961" Annual Meeting; American Society of Clinical Oncology (2012)
"Pediatric Oncology Highlights of the Day" Annual Meeting; American Society of Clinical Oncology (2012)
"Neuroblastoma" Radiation Oncology Residency Core Curriculum Lecture; Stanford University School of Medicine (2012)
"Post-Transplant Lymphoproliferative Disorder: Is There a Role for 18F FDG PET/CT?" Annual Meeting; Radiological Society of North America (2011)
"Treatment of Recurrent Post-Transplant Lymphoproliferative Disorder (PTLD) of the Central Nervous System (CNS) with High-Dose Methotrexate (HD-MTX)" XI International Small Bowel Transplant Symposium; Intestinal Rehabilitation and Transplant Association (2009)
"Neuroblastoma" Radiation Oncology Residency Core Curriculum Lecture; Stanford University School of Medicine (2009)
"Pediatric Hematology: Oncology as a Career Choice" Pediatric Lecture Series; Stanford University School of Medicine (2009)
"Isolated Tumor Cells are Routinely Detected by Immunohistochemistry in Histologically Negative Bone Marrow Biopsies from Neuroblastoma Patients" Annual Meeting; Advances in Neuroblastoma Research Association (2008)
"Nuclear Medicine Imaging in Pediatric Malignancies" Nuclear Medicine Grand Rounds; Stanford University School of Medicine (2008)
"Oncologic Emergencies" Stanford/Kaiser Emergency Medicine Core Curriculum Lecture; Stanford University School of Medicine (2008)
"Pediatric Hematology: Oncology as a Career Choice" Pediatric Lecture Series; Stanford University School of Medicine (2008)
"A Phase I Study of a Novel Human Monoclonal Antibody (mAb216) with Chemotherapy for the Treatment of Patients with Relapsed or Refractory B-Lineage Acute Lymphoblastic Leukemia" Annual Meeting; American Society of Hematology (2007)
"Retrospective Survey of Children Treated for Relapsed Acute Lymphoblastic Leukemia (Complete Remission (CR) Rates): A Report from the Therapeutic Advances in Childhood Leukemia (TACL) Consortium" Annual Meeting; American Society of Hematology (2007)
"Intermediate-Risk Neuroblastoma" Parent Conference; Children's Neuroblastoma Cancer Foundation (2007)
"Neuroblastoma Update" Pediatric Oncology Grand Rounds; University of Texas Southwestern (2007)
"Pediatric Hematology/Oncology as a Career Choice" Pediatric Lecture Series; Stanford University School of Medicine (2007)
"Post-Transplant Lymphoproliferative Disorders" Radiation Oncology Residency Core Curriculum Lecture; Stanford University School of Medicine (2007)
"Treatment of Neuroblastoma: A Paradigm for Multidisciplinary Care" Leadership Forum; Lucile Packard Children's Hospital (2007)
"Mature Results of a Prospective Trial of Rituximab in Patients (pt) with Post-Transplant Lymphoproliferative Disorder (PTLD) Unresponsive or Ineligible for Reduced Immunosuppression (RIS)" Annual Meeting; American Society of Hematology (2006)
"A Phase I Clinical Trial of the Hu14.18-IL2 (EMD 273063) as a Treatment for Children with Refractory or Recurrent Neuroblastoma and Melanoma: A Study of the Children’s Oncology Group" Annual Meeting; Advances in Neuroblastoma Research Association (2006)
"Oncologic Emergencies" Stanford/Kaiser Emergency Medicine Core Curriculum Lecture; Stanford University School of Medicine (2006)
"Pediatric Hematology/Oncology as a Career Choice" Pediatric Lecture Series; Stanford University School of Medicine (2006)
"Pediatric Oncologic Emergencies" Continuing Medical Education Lecture Series; Watsonville Community Hospital Emergency Department (2006)
"Neuroblastoma in a Patient with Noonan Syndrom: Possible Genotype/Phenotype Correlations in PTPN11" Annual Meeting; American Society of Human Genetics (2005)
"Impact of Body Composition on Pharmacokinetics of Doxorubicin in Pediatric Patients: A Glaser Pediatric Research Network Study" Annual Meeting; American Society of Clinical Oncology (2005)
"Low Stage Neuroblastoma" Parent Conference; Children's Neuroblastoma Cancer Foundation (2005)
"Wilms Tumor" Radiation Oncology Residency Core Curriculum Lecture; Stanford University School of Medicine (2005)
"Age Continues to be a Powerful Predictor of EFS and OS in Neuroblastoma" Annual Meeting; Advances in Neuroblastoma Research Association (2004)
"Neuroblastoma" Radiation Oncology Residency Core Curriculum Lecture; Stanford University School of Medicine (2004)
"Update on Neuroblastoma" Nuclear Medicine Grand Rounds; Stanford University School of Medicine (2004)
"Monoclonal Antibody 216 (MAb 216), a VH4-34 Encoded Antibody, is a Novel Cytotoxic Agent for B-Progenitor Acute Lymphoblastic Leukemia (ALL)" Annual Meeting; American Society of Hematology (2003)
"Interactive Encoding of Whole Body 123I-MIBG Images in the Evaluation of Patients with Neuroblastoma" 4th European Symposium on Paediatric Nuclear Medicine; European Association of Nuclear Medicine (2003)
"Oncologic Emergencies" Stanford/Kaiser Emergency Medicine Core Curriculum Lecture; Stanford University School of Medicine (2003)
"Update on Neuroblastoma" Nuclear Medicine Grand Rounds; Stanford University School of Medicine (2003)
"Rituximab is Effective Therapy for Post-Transplant Lymphoproliferative Disorder (PTLD) Not Responding to Reduction in Immunosuppression: A Prospective Trial in Adults and Children" Annual Meeting; American Society of Clinical Oncology (2001)
"Neuroblastoma 2001" Pediatric Grand Rounds; Lucile Packard Children‘s Hospital (2001)
"New Treatments for Genetic Diseases" Annual Meeting; New England Regional Genetics Group (1998)
"Cytoxan and Total Body Irradiation Conditioning Results in Stable Donor Marrow Engraftment in Patients with Metabolic Storage Diseases Undergoing Allogeneic Bone Marrow Transplantation" Annual Meeting; American Society of Pediatric Hematology/Oncology (1997)
"Bone Marrow Transplantation for Metabolic Storage Diseases" Pediatric Oncology Grand Rounds; Dana-Farber Cancer Institute (1997)
"Bone Marrow Transplantation for Metabolic Storage Diseases" Bone Marrow Transplantation Conference; Harvard Medical School (1997)
"The Use of Defibrotide (DF) in BMT-Associated Veno-Occlusive Disease (VOD)" Annual Meeting; American Society of Clinical Oncology (1996)
"Structure of the Mouse CD83 Gene" Annual Meeting; American Society of Hematology (1995)
"Structure of the Mouse HB15 Gene" 5th International Workshop on Human Leukocyte Differentiation Antigens; Human Cell Differentiation Molecules (1993)
Lucile Packard Children's Hospital: Bass Center Process Improvement Committee; Committee Member (2010–2012)
Dana-Farber Cancer Institute: Claudia Adams Barr Program in Innovative Basic Cancer Research Presidential Scientific Advisory Council; Member (2010–present)
American Board of Pediatrics: Subspecialties Committee; Committee Member (2009–2014)
Stanford University: Pediatric Hematology/Oncology Fellowship Program Faculty Mentor (2008–2016)
American Board of Pediatrics: Subboard of Pediatric Hematology/Oncology; Board Member (2008–2013)
Pediatric Transplantation Journal; Ad Hoc Reviewer (2008–present)
Stanford University: Med Scholars Program Faculty Mentor (2007–2009)
Stanford University School of Medicine: Pediatric Journal Club Faculty Facilitator (2007–2008)
Stanford University: Pediatric Hematology/Oncology Fellowship Program - Fellowship Boot Camp Lecture Series Lecturer (2006–2012)
Stanford University School of Medicine: Pediatric Lecture Series Lecturer (2006–2010)
Pediatric Blood and Cancer Journal; Ad Hoc Reviewer (2006–present)
Children's Oncology Group: Neuroblastoma Steering Committee; Committee Member (2006–present)
Stanford University: Pediatric Residency Program - Core Lecture Series Lecturer (2005–2010)
Stanford University: Pediatric Oncology Bereavement Program Faculty Supervisor (2003–2016)
Stanford University: Pediatric Residency Program - Hematology/Oncology Ambulatory Selective Rotation; Director (2003–2015)
Stanford University: Pediatric Residency Program - Hematology/Oncology Inpatient Rotation; Director (2003–2012)
New Approaches to Neuroblastoma Therapy Consortium: Study Committee NANT 2001-2003: A Phase I Study of CEP-701 in Patients with Refractory Neuroblastoma; Committee Member (2003–2010)
New Approaches to Neuroblastoma Therapy Consortium: Data Safety and Monitoring Committee; Committee Member (2003–present)
Roswell Park Cancer Institute Department of Pediatrics Elm and Carlton Streets Buffalo, New York 14263 Phone: (716) 845-2333 Fax: (716) 845-8003 ctwist@buffalo.edu