
Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Autism; Community Health Research; Epigenetics; Genome-wide Screening; Neuropsychiatric Disorders; Neuroscience; Transcriptomics
My lab investigates the genetic and neurobiological factors in neurodevelopmental disorders, particularly focusing on Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorders (ASD), and Prader-Willi Syndrome (PWS). Specifically, we are interested in developing and deploying tools to link population-level perturbations in the genome to functional and behavioral outcomes in humans. We have so far created a neurodevelopmental map that traces structural brain development with common genetic variants that are inherited. From this map, we can ask questions about variants associated with neurodevelopmental disorders and determine where in the brain they are having the most impact. We have also structured a tool that directly links structural brain variants with diagnostic and behavioral outcomes—meaning, we can establish causality of variants linked to brain development, diagnostic outcome, and associated behaviors in the same cohort.
Furthermore, we also utilize techniques such as GWAS as a jumping-off point, rather than a conclusion. After performing association analysis, we then examine weighted variants using Bayesian modeling to compute SNP colocalization Probabilities and Regional colocalization Probabilities associated with a particular phenotype across every tissue recorded (by GTEx) in the human body. We then determine how these perturbations influence gene expression in a specific tissue. This has led to a recent discovery, in which we identified that the pancreas is highly implicated in PWS and may be responsible for observed metabolic features. We also identified novel, high-confidence genes associated with ADHD that have not been previously reported and pinpointed the brain regions they are associated with. We are now investigating the functional role of these genes in ADHD pathophysiology.
Additionally, our lab is investigating ADHD-associated gene dysregulation in human and rat brain tissues using bulk and single-nuclei RNA-sequencing. We place high emphasis on robust phenotyping and linking transcriptomic changes across behavior, rather than binary classification. As of 2026, our priority is centered around using transcriptomics to elucidate mechanisms, rather than drug discovery. We are also cognizant that large-scale analysis creates more breadth than it does depth, and therefore our science is centered around questions that prioritize patient and clinical outcomes. Other work in the lab consists of a clinical trial for mindfulness interventions in children and studying negative long-term outcomes in children with ADHD, such as anxiety, major depressive disorder, suicidal behaviors, and substance use disorders.
Aside from my research, I teach lectures in Neuroscience, Genetics Genomics and Bioinformatics, and Biomedical Informatics. I am also actively engaged in community health and outreach initiatives.
For Potential Trainees: My lab is an inclusive environment that encourages creative approaches to discovering underlying mechanisms of neurodevelopment that serve the public good. We also prioritize in-person work and collaboration in the lab. Individuals are expected to show up and work both independently and as a team. We also prioritize literacy and critical thinking, and have a 0% tolerance for AI writing in the lab. We intend to preserve and support human-centered creativity, synthesis, and communication. If you are interested in joining my lab, send an (non-AI generated) email with your CV.