Joseph B. Kuechle MD, PhD
Joseph B. Kuechle
MD, PhD
Clinical Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Adult Hip & Knee Arthroplasty; Arthroplasty - Hip & Knee; Gene Therapy; Knee Surgery; Lower Extremity Joint Replacement & Reconstruction; Molecular Basis of Disease; Molecular genetics; Orthopaedic Oncology; Orthopaedic Surgery; Stem Cells; Tissue Engineering; Trauma & Reconstructive Surgery
Contact Information
Patient Care
Patient Care
This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.
View this physician on UBMDEducation and Training:
- Fellowship, Musculoskeletal Oncology, Harvard University (2016)
- Residency, Orthopaedic Surgery, University at Buffalo (2015)
- MD, Doctor of Medicine, University of Illinois at Chicago (2010)
- PhD, Bioengineering, Cell and Tissue Engineering, University of Illinois at Chicago (2010)
- BS, Chemical Engineering, University at Buffalo, Magna Cum Laude (2002)
Employment:
- EMT-B, Rural/Metro Ambulance (2000–2002)
Awards and Honors:
- Top Doctors (2023)
- Top Doctors (2022)
- Top Doctors (2021)
Journal Articles:
- Fitzpatrick BR, Hasanspahic B, Kuechle JB. (2023) Subchondroplasty for Osteonecrosis of the Knee. Orthopedics (Mar)1-4.
- Martin JC, Sims JR, Gupta A, Hagoel TJ, Gao L, Lynch ML, Woloszynska A, Melendy T, Kane JF, Kuechle J, Ohm JE. (2022) CDC7 kinase (DDK) inhibition disrupts DNA replication leading to mitotic catastrophe in Ewing sarcoma. Cell death discovery (Feb), 8(1): 85. doi:10.1038/s41420-022-00877-x
- Hagoel TJ, Cortes Gomez E, Gupta A, Twist CJ, Kozielski R, Martin JC, Gao L, Kuechle J, Singh PK, Lynch M, Wei L, Liu S, Wang J, Ohm JE. (2022) Clinicopathologic and molecular analysis of a BCOR-CCNB3 undifferentiated sarcoma of the kidney reveals significant epigenetic alterations. Cold Spring Harbor molecular case studies (Jan), 8(1). doi:10.1101/mcs.a005942
- Srivastava P, Tzetzo SL, Gomez EC, Eng KH, Jani Sait SN, Kuechle JB, Singh PK, De Jong K, Wiatrowski KR, Peresie J, Dimitroff A, Lynch ML, Wang J, Abrams SI, Griffiths EA, Nemeth MJ. (2020) Inhibition of LSD1 in MDS progenitors restores differentiation of CD141Hi conventional dendritic cells. Leukemia (Sep), 34(9): 2460-2472. doi:10.1038/s41375-020-0765-5
- El Baky HA, Thomas RD, Kuechle JB, Abdul Aziz R. (2020) Acetabula Osteoid Osteoma Mimicking Juvenile Idiopathic Arthritis and Chronic Recurrent Multifocal Osteomyelitis. Case Rep Rheumatol (Aug), 2020.
- Yeung CM, Lans J, Kuechle JB, Wright Z, Chang CY, Lozano-Calderón SA. (2020) Evaluation of the Proximal Ulna Dorsal Angulation for Ulnar Component Sizing in Elbow Prosthetic Reconstruction After Distal Humeral Resection of Tumor. Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews (May), 4(5): e2000062. doi:10.5435/JAAOSGlobal-D-20-00062
- Vuyyala S, Gandhi S, Kuechle JB, George S. (2019) Complete Remission of Bone Metastases in Renal Cell Carcinoma with Nivolumab. Cureus (Aug), 11(8): e5531. doi:10.7759/cureus.5531
- Lozano Calderón SA, Kuechle J, Raskin KA, Hornicek FJ. (2018) Lower Extremity Megaprostheses in Orthopaedic Oncology. The Journal of the American Academy of Orthopaedic Surgeons (Jun), 26(12): e249-e257.
- Biermann JS, Chow W, Reed DR, Lucas D, Adkins DR, Agulnik M, Benjamin RS, Brigman B, Budd GT, Curry WT, Didwania A, Fabbri N, Hornicek FJ, Kuechle JB, Lindskog D, Mayerson J, McGarry SV, Million L, Morris CD, Movva S, O'Donnell RJ, Randall RL, Rose P, Santana VM, Satcher RL, Schwartz H, Siegel HJ, Thornton K, Villalobos V, Bergman MA, Scavone JL. (2017) NCCN Guidelines Insights: Bone Cancer, Version 2.2017. J Natl Compr Canc Netw (Jan), 15(2): 155-167.
- Kuechle JB, McGrath BE, Khoury T, Mindell ER. (2014) A case of long term survival with skeletal only metastatic breast cancer. Int J Surg Case Rep (Dec), 6C: 280-284.
- McGrath BE, Kuechle JB. (2014) Hip arthroscopic portal bridge retraction technique for improved peripheral compartment visualization. Arthrosc Tech (Aug), 3(4): 501-503.
- Kuechle JB, Pasha S, Sadat K, Tran J, Hatipoglu B, Bui JT, Chejfec G, Oberholzer J. (2011) Pulmonary sequestration with CCAM type II appearing as adrenal tumor protruding through a Bochdalek hernia. International journal of surgical pathology (Apr), 19(2): 203-6.
- Giulianotti PC, Kuechle J, Salehi P, Gorodner V, Galvani C, Benedetti E, Oberholzer J. (2009) Robotic-assisted laparoscopic distal pancreatectomy of a redo case combined with autologous islet transplantation for chronic pancreatitis. Pancreas (Jan), 38(1): 105-7.
- Gangemi A, Salehi P, Hatipoglu B, Martellotto J, Barbaro B, Kuechle JB, Qi M, Wang Y, Pallan P, Owens C, Bui J, West D, Kaplan B, Benedetti E, Oberholzer J. (2008) Islet transplantation for brittle type 1 diabetes: the UIC protocol. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Jun), 8(6): 1250-61.
- Barbaro B, Kuechle J, Salehi P, Rodriguez L, Qi M, Gangemi A, Benedetti E, Oberholzer J. (2008) Increased albumin concentration reduces apoptosis and improves functionality of human islets. Artificial cells, blood substitutes, and immobilization biotechnology (Jan), 36(1): 74-81. doi:10.1080/10731190701857819
- Qi M, Strand BL, Mørch Y, Lacík I, Wang Y, Salehi P, Barbaro B, Gangemi A, Kuechle J, Romagnoli T, Hansen MA, Rodriguez LA, Benedetti E, Hunkeler D, Skjåk-Braek G, Oberholzer J. (2008) Encapsulation of human islets in novel inhomogeneous alginate-ca2+/ba2+ microbeads: in vitro and in vivo function. Artificial cells, blood substitutes, and immobilization biotechnology (Jan), 36(5): 403-20. doi:10.1080/10731190802369755
- Barbaro B, Salehi P, Wang Y, Qi M, Gangemi A, Kuechle J, Hansen MA, Romagnoli T, Avila J, Benedetti E, Mage R, Oberholzer J. (2007) Improved human pancreatic islet purification with the refined UIC-UB density gradient. Transplantation (Nov), 84(9): 1200-3.
- Avila JG, Wang Y, Barbaro B, Gangemi A, Qi M, Kuechle J, Doubleday N, Doubleday M, Churchill T, Salehi P, Shapiro J, Philipson LH, Benedetti E, Lakey JR, Oberholzer J. (2006) Improved outcomes in islet isolation and transplantation by the use of a novel hemoglobin-based O2 carrier. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Dec), 6(12): 2861-70.
- Avila J, Barbaro B, Gangemi A, Romagnoli T, Kuechle J, Hansen M, Shapiro J, Testa G, Sankary H, Benedetti E, Lakey J, Oberholzer J. (2005) Intra-ductal glutamine administration reduces oxidative injury during human pancreatic islet isolation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Dec), 5(12): 2830-7.
- Kalinichenko VV, Major ML, Wang X, Petrovic V, Kuechle J, Yoder HM, Dennewitz MB, Shin B, Datta A, Raychaudhuri P, Costa RH, Kuechle JB. (2004) Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19ARF tumor suppressor. Genes Dev (Apr), 18(7): 830-850.
Professional Memberships:
- American Academy of Orthopaedic Surgeons
- American Medical Association
- American Physician Scientist Association
- Biomedical Engineering Society
Presentations:
- "Impact of the addition of a fully threaded posterior screw for fixation of minimally displaced femoral neck fractures" Annual Eugene R. Mindell, M.D. Orthopaedic Residency Scientific Program (2014)
- "30 Year Single Institution Review of Osteosarcoma Survival and r GCSF Impact" Musculoskeletal Tumor Society Annual Meeting. (2013)
- "Metastatic Disease in Orthopedics" Orthopedics Grand Rounds; University at Buffalo (2013)
- "30 Year Single Institution Review of Osteosarcoma Survival and r GCSF Impact" Annual Eugene R. Mindell, M.D. Orthopaedic Residency Scientific Program (2013)
- "Reduced Titanium Biocompatibility Under Varied Cathodic Currents and Exposure Durations" Annual Eugene R. Mindell, M.D., Orthopaedic Residency Scientific Program (2012)
- "Breast Cancer Metastasis: Combating lethal seeds" Oncology Grand Rounds; University of Illinois at Chicago (2010)
- "TAT SV40T Fusion Protein Mediated Islet Cell Proliferation Induction" American Transplant Congress Conference (2008)
- "Engineering better drug delivery for colon cancer" Oncology Grand Rounds; University of Illinois at Chicago (2008)
- "Islet cell proliferation induction using cell cycle modulating TAT fusion proteins" International Pancreas & Islet Transplant Association (2007)
- "Impact of Catheter Characteristics on Pancreatic Islet Graft Integrity" Society of Interventional Radiology Annual Meeting (2007)
- "Regional Variation in the Micro-elastic Properties of the Rabbit Annulus Fibrosis upon Nano-indentation with Atomic Force Microscopy" Orthopedic Research Society Meeting (2003)
- "A Novel Cell Adhesion Studying Technique" National Science Foundation Research Experience for Undergraduates Meeting (2001)
Service Activities:
- Cancers; Reviewer (2022–present)