Karl O. A. Yu MD, PhD, FAAP

Karl O. Yu

Karl O. A. Yu
MD, PhD, FAAP

Clinical Assistant Professor of Pediatrics (Infectious Diseases)

Department of Pediatrics

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Immunology; Infectious Disease; Microbiology; Pediatric Infectious Diseases; Pediatrics; Virology

Contact Information
UBMD Pediatrics
1001 Main Street, 5th floor
Buffalo, New York 14203
Phone: (716) 323-0150
Fax: (716) 323-0296
kyu10@buffalo.edu


Patient Care

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD


Professional Summary:

Like many (not so) junior academic physicians, I face the challenge in balancing my commitment to clinical medicine with the continuing development of my research career. But on reflection, I see my past training to have been as good as I could ask for. Solid postgraduate pediatric training has made me comfortable with the clinic even when I have a good fraction of my time and effort dedicated to research. On the other hand, my research training has ranged from microbiology/immunology work in cells, mice, and guinea pigs, through study logistics, patient recruitment, and data management in clinical research. These are tools necessary in my continuing work as a physician, scientist, and educator.

My research interests remain in the host/pathogen relationship. This is where one needs a practical knowledge of both immunology and microbiology applied onto the same problem, with potential applications to clinical infectious disease. I have made contributions in this field with relation to influenza, Staphylococcus aureus, and Legionella pneumophila. Before coming to Buffalo, I’ve gained experience on pediatric field studies and microbiologic epidemiology of pediatric acute otitis media.

Here in Buffalo, I take care of children with proven or suspected infection inpatient in Oishei Children's Hospital and outpatient in UBMD Pediatrics in the Conventus building. I have responsibilities in infection prevention in Oishei Children's Hospital, as well. My scholarly work entails investigations in bacteriophage and in hepatitis C, in collaboration with Dr. Oscar Gomez (Pediatric Infectious Disease / CTRC). My clinical interests rests with infections in the immunocompromised host, and in primary immunodeficiencies. I value my clinical work with our many patients and their physicians -- but do particularly enjoy my work with my colleagues in Allergy & Immunology and Hematology / Oncology / Stem Cell Transplantation. Outside of Buffalo, I am most active in the Pediatric Infectious Diseases Society and the Clinical Immunology Society.

My most important job, I believe, remains in what my ex-chief has told me it would be in -- this is in "training your own replacement." Since finishing medical school, I have helped train -- and have learned from -- nurses, lab scientists, medical and graduate students, residents, and infectious disease fellows. I consider it a continuing privilege for me to contribute to the pediatric infectious disease and immunology education of the next generation of physicians and scientists, and the main reason I choose to remain in academic pediatric medicine.

Education and Training:

  • Fellowship, Pediatric Infectious Diseases, University of Chicago Medical Center (2014)
  • Residency, General Pediatrics, Cohen Children‘s Medical Center of New York, Hofstra/Northwell Health (formerly North Shore LIJ Health System) (2011)
  • Internship, General Pediatrics, Cohen Children‘s Medical Center of New York, Hofstra/Northwell Health (formerly North Shore LIJ Health System) (2009)
  • MD, Medicine, Albert Einstein College of Medicine of Yeshiva University (2008)
  • PhD, Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University (2008)
  • MS, Microbiology and Immunology, Albert Einstein College of Medicine of Yeshiva University (2002)
  • BA, Biochemistry; Mathematics (minor), Hiram College, Summa Cum Laude (2000)
  • Other, Jerome K. Lemelson Fellowship, Hampshire College (1998)

Employment:

  • Consultant, Pediatric Infectious Diseases, Sisters of Charity Hospital (2019-present)
  • Attending Physician, Infectious Diseases, Oishei Children's Hospital (2018-present)
  • Clinical Assistant Professor, Pediatrics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2018-present)
  • Infection Prevention Officer, Oishei Children‘s Hospital (2018-present)
  • Assistant Director, Center for Infectious Diseases and Immunology, Rochester General Hospital Rochester General Hospital Research Institute (2017–2018)
  • Clinical Associate, Pediatrics, University of Chicago Pritzker School of Medicine (2017)
  • Inpatient Consultant, Edward Hospital (2015–2017)
  • Instructor, Pediatrics, University of Chicago Pritzker School of Medicine (2015–2017)
  • Attending Physician, University of Chicago Medical Center (2014–2017)
  • Clinical Instructor, Pediatrics, University of Chicago Pritzker School of Medicine (2014–2015)

Awards and Honors:

  • Buffalo Spree Magazine: Top Doctors in Western New York (2022)
  • Buffalo Spree Magazine: Top Doctors in Western New York (2021)
  • Buffalo Spree Magazine: Top Doctors in Western New York (2020)
  • Castle Connolly Medical Ltd: America‘s Top Doctors (2020)
  • University of Chicago Pediatric Research Day: Research Poster Award for Junior Faculty (Translational Research) (2016)
  • Clinical Immunology Society Annual Meeting: Travel Grant (2015)
  • ID Week: Travel Grant (2014)
  • Pediatric Infectious Diseases Society: Pediatric Fellow Poster Award (2014)
  • St. Jude Children‘s Research Hospital/Pediatric Infectious Diseases Society Research Conference: Travel Grant (2014)
  • Clinical Immunology Society School of Primary Immunodeficiencies: Travel Grant (2013)
  • Midwest AIDS Training and Education Center: MATEC Clinical Scholar (2012-2013) (2012)
  • Hiram College Department of Mathematics: Kenneth M. Hiney Mathematics Award (2000)
  • Hiram College Department of Biology: J.J. Turner Society Member (2000)
  • Albert Einstein College of Medicine Summer Undergraduate Research Program: Stipend (1999)
  • Hampshire College: Visiting Jerome K. Lemelson Fellowship (1998)
  • Hiram College: Vencl-Carr Research Assistantship (1998)
  • Hiram College Department of Biology: Paul Smey Award (1998-2000) (1998)
  • Hiram College: Alpha Society (1997-2000) (1997)
  • Hiram College: Dean‘s List (1997-2000) (1997)
  • Consortium for Mathematics and Its Applications/Mathematical Association of America: Mathematical Competition on Modeling - Honorable Mention (1997, 2000) (1997)
  • Hiram College: Trustees Global Scholar (1996-2000) (1996)
  • 37th International Mathematical Olympiad: National Delegate (1996)
  • Philippine Mathematical Olympiad: First Place (1995)

Grants and Sponsored Research:

  • April 2020–March 2021
    Immunologic and clinical studies on perinatal hepatitis C viral infection
    Wildermuth Foundation
    Role: Principal Investigator
    $35,000
  • May 2020–August 2020
    Comparing the COVID-19 antibody response of adults and children
    SUNY Research and Economic Development
    Role: Co-Investigator
    $7,500
  • December 2017–July 2018
    Microbiome and Virome in Children
    Merck
    Role: Co-Investigator

Journal Articles:

See all (16 more)

Books and Book Chapters:

  • Yu KO, Burns JL. (2018) In: "Fever, a rash, and a ... ‘bug bite‘?". Springer

Abstracts:

  • Chang A, Goetz D, Hennon T, Kozielski R, Deutsch G, Yu KOA. (2021) Chronic Epstein-Barr virus infection and atypical sarcoidosis vs. granulocytic/lymphocytic interstitial lung disease in a child hemizygous for a pathogenic variant on SKIV2L. J Clin Immunol, (Apr) S75 Poster
  • Yu KOA, Gomez-Duarte O. (2021) Lytic bacteriophage against an emergent biofilm-forming enteroinvasive Escherichia coli. J Ped Infect Dis Soc, (Mar) S9 Poster
  • Yu KOA, Mannix MK, Chang A. (2020) Multiple opportunistic infections in a hematopoietic cell transplant patient immunosuppressed with JAK and complement inhibitors. J Clin Immunol, (Apr) S66-S67 Poster
  • Yu KO, Nash CB, Nassin ML, Carlos CA, Van Slambrouck CV, Cheng JX, McNeer J, Rosebush JC. (2016) Disseminated Histoplasmosis Presenting with a Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome Phenotype in a Child with Pre-B Cell Acute Lymphoblastic Leukemia. J Clin Immunol, (Apr) 243-243 Poster
  • Yu KO, Bartlett AH. (2015) Invasive Aspergillosis and Chronic Granulomatous Disease Presenting in Early Infancy. J Clin Immunol, (Apr) 318-318
  • Yu KO, Randolph A, Bubeck Wardenburg J. (2014) Evidence for Staphylococcus aureus α-toxin as a Dominant Antigen in Severe Pediatric Influenza-staphylococcal Co-infection — Implications for Therapy. Open Forum Infect Dis, (Dec) S2-S2
  • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli S, Rawlings DJ. (2009) Evidence for B Cell Antigen Receptor (BCR)-Driven, BAFF-Facilitated Positive Selection within a Unique Population of Late Transitional B Cells. Eur J Ped, (Jan) 381-381
  • Meyer-Bahlburg A, Andrews SF, Yu KO, Porcelli S, Rawlings DJ. (2008) Evidence for B Cell Antigen Receptor (BCR)-Driven, BAFF-Facilitated Positive Selection within a Unique Population of Late Transitional B Cells. FASEB J, (Mar)
  • Yu KO, Wang C, Diamond B. (2000) Lupus: 1) Estrogen‘s Role in Autoimmune Induction and 2) An in vitro Glomerular Binding Assay for Autoantibody Pathogenicity. Ohio J Sci, (Apr) A33-A33

Professional Memberships:

  • American Society for Microbiology: Western New York Branch (2019–present)
  • Clinical Immunology Society (2013–present)
  • Pediatric Infectious Diseases Society (2012–present)
  • American Academy of Pediatrics: Fellow (FAAP) (2011–present)
  • American Academy of Pediatrics (2008–present)
  • American Association of Immunologists (2007–2015)
  • American Association for the Advancement of Science (2007)
  • Ohio Academy of Science (2000)

Presentations:

  • "Doctor says COVID increase in schools is due to low vaccination rates in children" Media interview: WKBW Channel 7 (local ABC affiliate) (2021)
  • "To PICC, to PO, or neither?" Grand Rounds, Department of Pediatrics. Newark-Beth Israel Medical Center (Children's Hospital of New Jersey) (2021)
  • "To PICC, to PO, or neither? Recent advances on pediatric antibiotic chemotherapy" Grand Rounds, Department of Pediatrics, St. Barnabas Medical Center (2021)
  • "Chronic Epstein-Barr virus infection and atypical sarcoidosis vs. granulocytic/lymphocytic interstitial lung disease in a child hemizygous for a pathogenic variant on SKIV2L" Clinical Immunology Society Annual Meeting (Virtual) (2021)
  • "Some caution urged after Pfizer COVID-19 found effective for adolescents" Media Interview; WBFO (2021)
  • "WNY doctors weigh in on Pfizer vaccine in children ages 12-15" Media Interview; WKBW Channel 7 News (2021)
  • "A really common immunodeficiency" Infectious Diseases Clinical Conference, Department of Medicine, University at Buffalo. (2021)
  • "COVID-19 — how the @#$! did we get here, and where are we going" Continuing education conference, Associated Physical and Occupational Therapists, LLC (2020)
  • "Rethinking infection control in the time of COVID-19" Continuing education conference, Associated Physical and Occupational Therapists, LLC (2020)
  • "COVID-19 Update" Pediatric Grand Rounds; University at Buffalo (2020)
  • "Multiple opportunistic infections in a hematopoietic cell transplant patient immunosuppressed with JAK and complement inhibitors" Clinical Immunology Society Annual Meeting (conference cancelled due to COVID-19) (2020)
  • "COVID-19: Panic and Perspective" Department of Family Medicine Grand Rounds; University at Buffalo (2020)
  • "Lytic Bacteriophage Against an Emergent Biofilm-Forming Enteroinvasive Escherichia coli" Pediatric Infectious Diseases Research Conference; St. Jude Children‘s Research Hospital/Pediatric Infectious Diseases Society (2020)
  • "Antibiotics Boot Camp" Pediatrics Teaching Conference; University at Buffalo (2019)
  • "Not MRSA...Not MSSA...but Somewhere in Between" Fall Symposium; Western New York American Society for Microbiology (2019)
  • "Fifty Shades of M.R.S.A." Pediatric Infectious Diseases Clinical Conference; University at Buffalo (2019)
  • "Brincidofovir (CMX001) in dsDNA Viral Infections" Pediatric Hematology/Oncology Clinical Conference; University at Buffalo (2019)
  • "A Green Strep in the NICU" Pediatric Infectious Diseases Clinical Conference; University at Buffalo (2019)
  • "Hedging on Handling Hepatitis C" Pediatric Infectious Diseases Clinical Conference; University at Buffalo (2019)
  • "Evaluation for Primary Immunodeficiencies: A Peds ID Perspective" Pediatric Grand Rounds; St. Barnabas Medical Center (2019)
  • "Evaluation for Primary Immunodeficiencies: A Peds ID Perspective" Pediatric Grand Rounds; Children‘s Hospital of New Jersey (2019)
  • "A Series of Salmonella Syndromes" Pediatric Infectious Diseases Clinical Conference; University at Buffalo (2019)
  • "Epidemiology of Respiratory Infections" MPH Program; Daemen College (2019)
  • "Viruses and Antiviral Therapy" Pediatric Hematology/Oncology Clinical Conference; University at Buffalo (2019)
  • "A Peds ID View on Primary Immunodeficiencies" Pediatrics Teaching Conference; University at Buffalo (2018)
  • "Pneumovirus and Metapneumovirus" Pediatrics Teaching Conference; University at Buffalo (2018)
  • "When the M.R.S.A. Won‘t Go Away" Pediatric Infectious Diseases Clinical Conference; University at Buffalo (2018)
  • "Antibiotics Review" Pediatrics Teaching Conference; University at Buffalo (2018)
  • "A Translational View of Staphylococcus aureus α-toxin in Influenza-MRSA Co-Infection" Pediatric Infectious Diseases Seminar; University of Rochester Medical Center (2018)
  • "Kikuchi-Fujimoto Disease: An Important Diagnostic Consideration for Cervical Lymphadenitis in the Pediatric Population" Pediatric Infectious Diseases Research Conference; St. Jude Children‘s Research Hospital/Pediatric Infectious Diseases Society (2018)
  • "Case Series: Potential Infectious Etiologies for Kikuchi Fujimoto Disease in Children" Pediatric Research Day; University of Chicago (2017)
  • "Evaluation of Primary Immunodeficiencies (AKA...What I Learned in the Clinical Immunology Society's Summer School)" Pediatric Infectious Diseases Teaching Conference; University of Chicago (2017)
  • "Diagnosis and Treatment of Disseminated Toxoplasmosis Following Stem Cell Transplantation" Pediatric Infectious Diseases Research Conference; St. Jude Children's Research Hospital/Pediatric Infectious Diseases Society (2017)
  • "Translational Approaches in the Study of the Role of S. aureus α-toxin in Pediatric Influenza-Staphylococcal Co-Infection" Pediatric Grand Rounds; University at Buffalo (2017)
  • "Viruses and Antiviral Therapy" Pediatric Hematology/Oncology Teaching Conference; University of Chicago (2016)
  • "Translational Approaches in the Study of the Role of S. aureus a-toxin in Pediatric Influenza-Staphylococcal Co-Infection" Pediatric Research Day; University of Chicago (2016)
  • "Translational Approaches in the Study of the Role of S. aureus a-toxin in Pediatric Influenza-Staphylococcal Co-Infection" Pediatric Grand Rounds; Comer Children‘s Hospital (2016)
  • "Disseminated Histoplasmosis Presenting with a Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome Phenotype in a Child with Pre-B Cell Acute Lymphoblastic Leukemia" Annual Meeting; Clinical Immunology Society (2016)
  • "A Pediatric Infectious Disease/Primary Immunodeficiency Case" Pediatric Grand Rounds; Edward Hospital (2016)
  • "Peas in a Pod? Pneumovirus (RSV) and Human Metapneumovirus" Pediatric Grand Rounds; Community Hospital (2016)
  • "Influenza: Challenges and Updates" Pediatric Grand Rounds; Community Hospital (2015)
  • "Invasive Aspergillosis and Chronic Granulomatous Disease Presenting in Early Infancy" Annual Meeting; Clinical Immunology Society (2015)
  • "Evidence for Staphylococcus aureus α-toxin as a Dominant Antigen in Severe Pediatric Influenza-staphylococcal Co-Infection — Implications for Therapy" Annual Meeting; Pediatric Infectious Diseases Society (2014)
  • "Evidence for Staphylococcus aureus α-toxin as a Dominant Antigen in Severe Pediatric Influenza-staphylococcal Co-infection — Implications for Therapy" ID Week; Infectious Diseases Society of America (2014)
  • "A Translational Approach to the Investigation of Influenza-Staphylococcus aureus Co-Infection" Pediatric Infectious Diseases Research Conference; St. Jude Children's Research Hospital/Pediatric Infectious Diseases Society (2014)
  • "A Translational Approach to the Investigation of Influenza-Staphylococcus aureus Co-Infection" Pediatric Fellows Research Symposium; Comer Children's Hospital, University of Chicago (2013)
  • "An Interesting Case of Pneumonia" School on Primary Immunodeficiencies; Clinical Immunology Society (2013)
  • "Pediatric Pneumonia" Pediatric Teaching Conference; Comer Children‘s Hospital (2013)
  • "Antibiotic Restriction - The Experience from a Medium-Sized Pediatric Tertiary Care Center" Pediatric Research Day; University of Chicago (2013)
  • "What is the Best Treatment for Complicated Pneumonias?" Pediatric Evidence-Based Learning Conference; North Shore-Long Island Jewish Medical Center (2011)
  • "Pediatric Pneumonia" Pediatric Teaching Conference; South Nassau Communities Hospital (2011)
  • "Monoclonal Antibodies Against Complexes of the NKT Cell Ligand α-galactosylceramide and Mouse CD1d" Frontiers in Basic Immunology Conference; National Cancer Institute (2009)
  • "Modulation of CD1d-restricted NKT cells using N-acyl variants of a galactosylceramides" Albert Einstein College of Medicine Medical Scientist Training Program Retreat (2006)
  • "Modulation of CD1d-restricted NKT cells using N-acyl variants of a galactosylceramides" Albert Einstein College of Medicine Department of Microbiology & Immunology Retreat (2006)
  • "Modulation of CD1d-Restricted NKT Cell Responses by Using N-acyl Variants of a-galactosylceramides" Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference: Lymphocytes and the Immune System - Molecular, Cellular and Integrative Mechanisms (2005)
  • "Structural Analogues of a-galactosylceramide as Novel Immunotherapeutic Agents" NIH Lupus Grant Site Visit; Albert Einstein College of Medicine (2003)
  • "Regulation of Marginal Zone B Cell Antibody Production by CD1d-Restricted T Cells" 2nd International Workshop on CD1 Antigen Presentation and NKT Cells (2002)
  • "Lupus: 1) Estrogen‘s Role in Autoimmune Induction and 2) An in vitro Glomerular Binding Assay for Autoantibody Pathogenicity" 109th Annual Meeting; Ohio Academy of Science (2000)
  • "Interactions Between Tannic Acid and Raphanus raphanistrum Root Acid Phosphatase" 43rd Annual May Conference; Society for Applied Spectroscopy (1999)
  • "A Study of the Price-Butler Method of Analyzing Tannin Content" Honors Convocation; Hiram College (1998)
  • "A Study of the Price-Butler Method of Analyzing Tannin Content" 2nd Annual Poster Session on Capitol Hill; Council for Undergraduate Research (1998)
See all (51 more)

Service Activities:

  • Volunteered for vaccination efforts in children against COVID-19 (Erie County Dept of Health and Oishei Children's Hospital); Volunteer (2021)
  • Acting chief of service, Pediatric Infectious Disease, UBMD Pediatrics; Acting chief of service (2021)
  • COVID-19 Policies Committee (ad hoc committee for COVID-19), UBMD Pediatrics, Buffalo NY; Committee Member (2020–present)
  • Kaleida Health: Subject Matter Experts Committee and Communications Group; Member (2020–2021)
  • Frontiers of Pediatrics; Ad hoc Manuscript Reviewer (2020)
  • Journal of Pediatrics; Ad hoc manuscript reviewer (2020)
  • Cureus Journal of Medical Research; Ad Hoc Reviewer (2020)
  • Journal of Clinical Immunology; Ad hoc manuscript reviewer (2020–present)
  • Epidemiology of Infectious Disease course (PH 574), Daemen College, Amherst, NY; Lecturer (2019–present)
  • F1000Research; Ad Hoc Reviewer (2019–2021)
  • SOC committee member to 3 Peds ID fellows in UB; Member, Scholarship Oversight Committee (2019–present)
  • General Pediatrics; Teaching attending (2018)
  • Pediatric Infectious Diseases Society: Research Affairs Committee; Committee Member (2018–2020)
  • Pediatric Infectious Diseases Society; Grant Reviewer (2018–2020)
  • Journal of Infection; Ad Hoc Reviewer (2017)
  • Frontiers in Immunology; Ad Hoc Reviewer (2017–present)
  • Edward Hospital: Pediatric Infectious Diseases Inpatient Service; Consultant (2015–2017)
  • University of Chicago: Health4Chicago (Pediatric Infectious Diseases); Volunteer (2015–2016)
  • Health4Chicago, Department of Pediatrics (Infectious Diseases), University of Chicago; Volunteer (2015–2016)
  • Antibodies; Ad Hoc Reviewer (2014)
  • University of Chicago Pritzker School of Medicine: Microbiology - Medical Biology (MICR 35900); Teacher (2013–2016)
  • University of Chicago Medical Center: Pediatric Infectious Diseases Section Conference; Coordinator (2012–2013)
  • Einstein Journal of Biology and Medicine; Editorial Board Member (2000–2006)

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Contact Information

UBMD Pediatrics
1001 Main Street, 5th floor
Buffalo, New York 14203
Phone: (716) 323-0150
Fax: (716) 323-0296
kyu10@buffalo.edu

This faculty member is affiliated with UBMD, practicing physicians who are also professors in the Jacobs School.

View this physician on UBMD