Mark D. Parker PhD
Mark D. Parker
PhD
Associate Professor
Department of Physiology and Biophysics
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Inherited Metabolic Disorders; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Molecular Basis of Disease; Molecular genetics; Protein Function and Structure; Transgenic organisms; Vision science
Professional Summary:
Most physiological processes and numerous disease states are influenced by or influence pH. Even relatively small deviations in whole body pH can have devastating consequences for our health. Our bodies are subject to a constant challenge from dietary and metabolic acids, thus it is critical for the body to have mechanisms that tightly regulate pH.
Blood plasma pH is maintained at a value close to 7.4, in part thanks to the buffering action of 24 mM bicarbonate (HCO3-). HCO3- neutralizes acid, generating carbon dioxide and water (HCO3- + H+ to CO2 + H2O), preventing lethal acidosis.
I study the SLC4 family of membrane proteins that move acid/base equivalents across cell membranes. Notable members include [1] the Na/2HCO3 cotransporter NBCe1-A that reclaims HCO3- from filtered blood plasma in kidney tubules (preventing loss of vital plasma HCO3- to the urine), [2] NBCe1-B that promotes fluid removal from the corneal stroma (preventing corneal edema and vision loss), [3] the Cl-HCO3 exchanger AE1 that promotes O2-CO2 exchange in red blood cells, and [4] SLC4A11 that conducts H+ and promotes corneal clarity.
Dysfunction of SLC4 family members is associated with renal tubular acidosis, blindness, cancer, deafness, epilepsy, and hypertension.
Course Co-Director for PGY405/505 (Cellular and Molecular Physiology)
Course Co-Director for IMC512 (Renal Module)
Education and Training:
- PhD, Biochemistry, University of Bristol (2000)
- BS, Biochemistry, University of Bristol (1995)
Employment:
- Associate Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2019-present)
- Assistant Professor, Physiology and Biophysics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2013–2019)
- Instructor, Physiology and Biophysics, Case Western Reserve University (2008–2013)
- Postdoctoral Research Associate, Cellular and Molecular Physiology, Yale University Yale School of Medicine (2003–2007)
Awards and Honors:
- Paper of The Year (2021)
- APS Select Manuscript (2020)
- New Investigator Award from the Cell and Molecular Physiology Section of the American Physiological Society (2017)
- American Physiological Society Star Reviewer (2017)
- Carl W. Gottschalk Research Fellow of the ASN Foundation for Kidney Research (2015)
- The APS Recognition Award for Meritorious Research by a Young Investigator (2012)
Research Expertise:
- Acid-base homeostasis
- Epithelial Physiology
- Ion transport
- Molecular Biology
- Renal Physiology
Grants and Sponsored Research:
- January 2018–September 2028
Investigating the Action and Physiological Role of Slc4a11 in the Cornea
NIH National Eye Institute
Role: Principal Investigator - May 2024–April 2026
Modeling and testing functional interactions among corneal endothelial acid-base transporters
NIH National Eye Institute
Role: Co-Principal Investigator - July 2020–July 2025
Investigating the role of NBCe1-B in renal and cardiac acid-base handling
NIH National Institute of Diabetes and Digestive and Kidney Diseases
Role: Consultant - September 2019–August 2024
Renal considerations in the heat stress and hydration recommendations
NIH National Institute for Occupational Safety and Health
Role: Co-Investigator - July 2015–June 2017
Cause and correction of acidosis by the renal sodium/bicarbonate cotransport NBCe1
ASN Foundation for Kidney Research
Role: Principal Investigator
$200,000 - December 2011–November 2013
Functional role of transporter Slc4a11 (BTR1/NaBC1) in the cornea
NIH National Eye Institute
Role: Co-Principal Investigator
$237,568
Journal Articles:
- Brady CT, Marshall A, Eagler LA, Pon TM, Duffey ME, Weil BR, Lang JK, Parker MD. (2024) Left Ventricular Systolic Dysfunction in NBCe1-B/C-Knockout Mice. International journal of molecular sciences (Sep), 25(17). doi:10.3390/ijms25179610
- Pasternack RA, Quade BN, Marshall A, Parker MD. (2024) NH3/NH4 + allosterically activates SLC4A11 by causing an acidic shift in the intracellular pK that governs H+(OH-) conductance. Frontiers in physiology (Jan), 15: 1440720. doi:10.3389/fphys.2024.1440720
- Cornwell AC, Tisdale AA, Venkat S, Maraszek KE, Alahmari AA, George A, Attwood K, George M, Rempinski D, Franco-Barraza J, Seshadri M, Parker MD, Cortes Gomez E, Fountzilas C, Cukierman E, Steele NG, Feigin ME. (2023) Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (Aug)OF1-OF20.
- Brady CT, Marshall A, Zhang C, Parker MD. (2023) NBCe1-B/C-knockout mice exhibit an impaired respiratory response and an enhanced renal response to metabolic acidosis. Frontiers in physiology (Jan), 14: 1201034. doi:10.3389/fphys.2023.1201034
- Lee SK, Occhipinti R, Moss FJ, Parker MD, Grichtchenko II, Boron WF. (2022) Distinguishing among HCO3 -, CO3 =, and H+ as Substrates of Proteins That Appear To Be "Bicarbonate" Transporters. Journal of the American Society of Nephrology : JASN (Oct).
- Quade BN, Marshall A, Parker MD. (2022) Corneal dystrophy mutations R125H and R804H disable SLC4A11 by altering the extracellular pH dependence of the intracellular pK that governs H+(OH-) transport. American journal of physiology. Cell physiology (Aug).
- Alsufayan TA, Myers EJ, Quade BN, Brady CT, Marshall A, Haque N, Duffey ME, Parker MD. (2021) Revisiting the Role of Ser982 Phosphorylation in Stoichiometry Shift of the Electrogenic Na+/qHCO3- Cotransporter NBCe1. International journal of molecular sciences (Nov), 22(23). doi:10.3390/ijms222312817
- Quade BN, Parker MD, Hoepflinger MC, Phipps S, Bisson MA, Foissner I, Beilby MJ. (2021) The molecular identity of the characean OH- transporter: a candidate related to the SLC4 family of animal pH regulators. Protoplasma (Jul).
- Chapman CL, Johnson BD, Parker MD, Hostler D, Pryor RR, Schlader Z. (2021) Kidney physiology and pathophysiology during heat stress and the modification by exercise, dehydration, heat acclimation and aging. Temperature (Austin, Tex.) (Jan), 8(2): 108-159. doi:10.1080/23328940.2020.1826841
- Quade BN, Parker MD, Occhipinti R. (2021) The therapeutic importance of acid-base balance. Biochemical pharmacology (Jan), 183: 114278. doi:10.1016/j.bcp.2020.114278
- Parker MD. (2020) Soda stream modifies airway fluid. J Physiol (Oct), 598(19): 4143-4144.
- Jones RS, Ruszaj D, Parker MD, Morris ME. (2020) Contribution of Monocarboxylate Transporter 6 to the Pharmacokinetics and Pharmacodynamics of Bumetanide in Mice. Drug Metab Dispos (Sep), 48(9): 788-795.
- Wang JL, Wang XY, Wang DK, Parker MD, Musa-Aziz R, Popple J, Guo YM, Min TX, Xia T, Tan M, Liu Y, Boron WF, Chen LM. (2020) Multiple acid-base and electrolyte disturbances upregulate NBCn1, NBCn2, IRBIT and L-IRBIT in the mTAL. J Physiol (May).
- Quade BN, Marshall A, Parker MD. (2020) pH dependence of the Slc4a11-mediated H+ conductance is influenced by intracellular lysine residues and modified by disease-linked mutations. Am J Physiol Cell Physiol (Jan), 319(2): 359-370.
- Jones RS, Parker MD, Morris ME. (2020) Monocarboxylate Transporter 6-Mediated Interactions with Prostaglandin F2alpha: In Vitro and In Vivo Evidence Utilizing a Knockout Mouse Model. Pharmaceutics (Jan), 12(3).
- Chapman CL, Johnson BD, Vargas NT, Hostler D, Parker MD, Schlader ZJ. (2020) Both hyperthermia and dehydration during physical work in the heat contribute to the risk of acute kidney injury. J Appl Physiol (1985) (Jan), 128(4): 715-728.
- Schlader ZJ, Hostler D, Parker MD, Pryor RR, Lohr JW, Johnson BD, Chapman CL. (2019) The Potential for Renal Injury Elicited by Physical Work in the Heat. Nutrients (Sep), 11(9): E2087.
- Salerno EE, Patel SP, Marshall A, Marshall J, Alsufayan T, Mballo CSA, Quade BN, Parker MD. (2019) Extrarenal Signs of Proximal Renal Tubular Acidosis Persist in Nonacidemic Nbce1b/c-Null Mice. J Am Soc Nephrol (Apr).
- Chapman CL, Johnson BD, Sackett JR, Parker MD, Schlader ZJ. (2019) Soft Drink Consumption During and Following Exercise in the Heat Elevates Biomarkers of Acute Kidney Injury. Am J Physiol Regul Integr Comp Physiol (Jan).
- Myers EJ, Marshall A, Parker MD. (2018) The role of disease-linked residue glutamine-913 in support of the structure and function of the human electrogenic sodium/bicarbonate cotransporter NBCe1-A. Sci Rep (Feb), 8(1): 3066-3066.
- Parker MD. (2018) Mouse Models of SLC4-linked Disorders of HCO3- Transporter Dysfunction. Am J Physiol Cell Physiol (Jan).
- Jones RS, Parker MD, Morris ME. (2017) Quercetin, Morin, Luteolin, and Phloretin Are Dietary Flavonoid Inhibitors of Monocarboxylate Transporter 6. Mol Pharm (May), 14(9): 2930-2936.
- Schlader ZJ, Chapman CL, Sarker S, Russo L, Rideout TC, Parker MD, Johnson BD, Hostler D. (2017) Firefighter Work Duration Influences the Extent of Acute Kidney Injury. Med Sci Sports Exerc (Mar).
- Myers EJ, Yuan L, Felmlee MA, Lin YY, Jiang Y, Pei Y, Wang O, Li M, Xing XP, Marshall A, Xia WB, Parker MD. (2016) A novel mutant Na(+) /HCO3(-) cotransporter NBCe1 in a case of compound-heterozygous inheritance of proximal renal tubular acidosis. J Physiol (Nov), 594(21): 6267-6286.
- Myers EJ, Marshall A, Jennings ML, Parker MD. (2016) Mouse Slc4a11 expressed in Xenopus oocytes is an ideally selective H+/OH- conductance pathway that is stimulated by rises in intracellular and extracellular pH. Am J Physiol Cell Physiol (Sep)00259 2016-00259 2016.
- Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S. (2015) A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation. J Gen Physiol (Oct), 146(4): 323-340.
- Patel SP, Parker MD. (2015) SLC4A11 and the Pathophysiology of Congenital Hereditary Endothelial Dystrophy. Biomed Res Int (Sep), 2015: 475392-475392.
- Wang DK, Liu Y, Myers EJ, Guo YM, Xie ZD, Jiang DZ, Li JM, Yang J, Liu M, Parker MD, Chen LM. (2015) Effects of Nt-truncation and coexpression of isolated Nt domains on the membrane trafficking of electroneutral Na(+)/HCO3(-) cotransporters. Sci Rep (Jul), 5: 12241-12241.
- Parker MD, Myers EJ, Schelling JR. (2015) Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule. Cell Mol Life Sci (Jan), 72(11): 2061-2074.
- Jalali R, Guo J, Zandieh-Doulabi B, Bervoets TJ, Paine ML, Boron WF, Parker MD, Bijvelds MJ, Medina JF, DenBesten PK, Bronckers AL. (2014) NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. Cell Tissue Res (Jul).
- Khan S, Abu Jawdeh BG, Goel M, Schilling WP, Parker MD, Puchowicz MA, Yadav SP, Harris RC, El-Meanawy A, Hoshi M, Shinlapawittayatorn K, Deschênes I, Ficker E, Schelling JR. (2014) Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis. J Clin Invest (Mar), 124(3): 1057-1068.
- Ruffin VA, Salameh AI, Boron WF, Parker MD. (2014) Intracellular pH regulation by acid-base transporters in mammalian neurons. Front Physiol (Feb), 5: 43-43.
- Geyer RR, Parker MD, Toye AM, Boron WF, Musa-Aziz R. (2013) Relative CO2/NH3 permeabilities of human RhAG, RhBG and RhCG. J Membr Biol (Dec), 246(12): 915-926.
- Liu Y, Qin X, Wang DK, Guo YM, Gill HS, Morris N, Parker MD, Chen LM, Boron WF. (2013) Effects of optional structural elements, including two alternative amino termini and a new splicing cassette IV, on the function of the sodium-bicarbonate cotransporter NBCn1 (SLC4A7). J Physiol (Oct), 591(Pt 20): 4983-5004.
- Romero MF, Chen AP, Parker MD, Boron WF. (2013) The SLC4 family of bicarbonate (HCO3) transporters. Mol Aspects Med (Apr), 34(2-3): 159-182.
- Lee SK, Boron WF, Parker MD. (2013) Substrate specificity of the electrogenic sodium/bicarbonate cotransporter NBCe1-A (SLC4A4, variant A) from humans and rabbits. Am J Physiol Renal Physiol (Apr), 304(7): 883-899.
- Parker MD, Boron WF. (2013) The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev (Apr), 93(2): 803-959.
- Danielsen AA, Parker MD, Lee S, Boron WF, Aalkjaer C, Boedtkjer E. (2013) Splice cassette II of Na+,HCO3- cotransporter NBCn1 (slc4a7) interacts with calcineurin A: implications for transporter activity and intracellular pH control during rat artery contractions. J Biol Chem (Mar), 288(12): 8146-8155.
- Lee SK, Boron WF, Parker MD. (2013) Monitoring ion activities in and around cells using ion-selective liquid-membrane microelectrodes. Sensors (Basel) (Jan), 13(1): 984-1003.
- Parker MD, Qin X, Williamson RC, Toye AM, Boron WF. (2012) HCO3--independent conductance with a mutant Na+/HCO3- cotransporter (SLC4A4) in a case of proximal renal tubular acidosis with hypokalaemic paralysis. J Physiol (Apr), 590(Pt 8): 2009-2034.
- Lee SK, Boron WF, Parker MD. (2012) Relief of autoinhibition of the electrogenic Na-HCO3 cotransporter NBCe1-B: role of IRBIT vs.amino-terminal truncation. Am J Physiol Cell Physiol (Feb), 302(3): 518-526.
- Valente M, Watterson SJ, Parker MD, Ford RC, Young MT. (2011) Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA. Biochim Biophys Acta (Dec), 1808(12): 2859-2866.
- Zhang K, Yin L, Zhang M, Parker MD, Binder HJ, Salzman P, Zhang L, Okunieff P, Vidyasagar S. (2011) Radiation decreases murine small intestinal HCO3- secretion. Int J Radiat Biol (Aug), 87(8): 878-888.
- Liu Y, Xu K, Chen LM, Sun X, Parker MD, Kelly ML, LaManna JC, Boron WF. (2010) Distribution of NBCn2 (SLC4A10) splice variants in mouse brain. Neuroscience (Sep), 169(3): 951-964.
- Wu F, Saleem MA, Kampik NB, Satchwell TJ, Williamson RC, Blattner SM, Ni L, Toth T, White G, Young MT, Parker MD, Alper SL, Wagner CA, Toye AM. (2010) Anion exchanger 1 interacts with nephrin in podocytes. J Am Soc Nephrol (Sep), 21(9): 1456-1467.
- Leviel F, Hubner CA, Houillier P, Morla L, El Moghrabi S, Brideau G, Hassan H, Hatim H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D. (2010) The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. J Clin Invest (May), 120(5): 1627-1635.
- Musa-Aziz R, Boron WF, Parker MD. (2010) Using fluorometry and ion-sensitive microelectrodes to study the functional expression of heterologously-expressed ion channels and transporters in Xenopus oocytes. Methods (San Diego, Calif.) (May), 51(1): 134-45. doi:10.1016/j.ymeth.2009.12.012
- Boron WF, Chen L, Parker MD. (2009) Modular structure of sodium-coupled bicarbonate transporters. J Exp Biol (Jun), 212(Pt 11): 1697-1706.
- Parker MD, Bouyer P, Daly CM, Boron WF. (2008) Cloning and characterization of novel human SLC4A8 gene products encoding Na+-driven Cl-/HCO3- exchanger variants NDCBE-A, -C, and -D. Physiol Genomics (Aug), 34(3): 265-276.
- Parker MD, Musa-Aziz R, Rojas JD, Choi I, Daly CM, Boron WF. (2008) Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity. J Biol Chem (May), 283(19): 12777-12788.
- Chen LM, Kelly ML, Parker MD, Bouyer P, Gill HS, Felie JM, Davis BA, Boron WF. (2008) Expression and localization of Na+-driven Cl-HCO3 exchanger (SLC4A8) in rodent CNS. Neuroscience (Apr), 153(1): 162-174.
- Chen LM, Kelly ML, Rojas JD, Parker MD, Gill HS, Davis BA, Boron WF. (2008) Use of a new polyclonal antibody to study the distribution and glycosylation of the sodium-coupled bicarbonate transporter NCBE in rodent brain. Neuroscience (Jan), 151(2): 374-385.
- Parker MD, Young MT, Daly CM, Meech RW, Boron WF, Tanner MJ. (2007) A conductive pathway generated from fragments of the human red cell anion exchanger AE1. J Physiol (May), 581(Pt 1): 33-50.
- Toye AM, Parker MD, Daly CM, Lu J, Virkki LV, Pelletier MF, Boron WF. (2006) The human NBCe1-A mutant R881C, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia. Am J Physiol Cell Physiol (Oct), 291(4): 788-801.
- Lu J, Daly CM, Parker MD, Gill HS, Piermarini PM, Pelletier MF, Boron WF. (2006) Effect of human carbonic anhydrase II on the activity of the human electrogenic Na/HCO3 cotransporter NBCe1-A in Xenopus oocytes. J Biol Chem (Jul), 281(28): 19241-19250.
- Parker MD, Tanner MJ. (2004) The disruption of the third extracellular loop of the red cell anion exchanger AE1 does not affect electroneutral Cl-/HCO3- exchange activity. Blood Cells Mol Dis (May), 32(3): 379-383.
- Parker MD, Ourmozdi EP, Tanner MJ. (2001) Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney. Biochem Biophys Res Commun (Apr), 282(5): 1103-1109.
- Groves, JD, Parker MD, Askin, D, Falson, P, le Maire, M, Tanner, MJ. (1999) Heterologous expression of the red-cell anion exchanger(band 3; AE1). Biochem Soc Trans (Jan), 27: 917-923.
Books and Book Chapters:
- Brady CT, Dugandzic A, Parker MD, and Romero MF. (2020) NBCe1: An Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia. In: Studies of Epithelial Transporters and Ion Channels Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 3. Springer, 93-213.
- Boron, WF, Parker MD. (2012) McGraw-Hill Yearbook of Science and Technology 2013. In: Bicarbonate physiology and pathophysiology. McGraw-Hill
- Parker MD, Boron, WF. (2007) Seldin and Giebisch‘s The Kidney: Physiology and Pathophysiology. In: Sodium-coupled bicarbonate transporters. Elsevier
Abstracts:
Professional Memberships:
- The Biophysical Society (2022–present)
- The Association for Research in Vision and Ophthalmology; Member (2016–present)
- Council on Undergraduate Research; Member (2016–present)
- American Society of Nephrology; Member (2013–present)
- American Physiological Society; Member (2011–present)
Presentations:
- "The role of NH3 in promoting H+/OH– flux through the alkali-activated channel protein SLC4A11" Biophysical Society Conference: Proton Reactions: From Basic Science to Biomedical Applications (2023)
- "Progressive Corneal Edema and Loss of the Antioxidant lncRNA Neat1 in a Novel Slc4a11+/W214S Mouse Model of Late-Onset Fuchs Endothelial Corneal Dystrophy" Association for Research in Vision and Ophthalmology Annual Meeting (2023)
- "SLC4A11: A proton channel, vital for vision, hiding in a family of bicarbonate transporters" Department of Physiology Seminar, University of Sao Paulo (2021)
- "The Role of SLC4A11 in corneal physiology and dystrophy" Department of Ophthalmology Visual Sciences Research Center Seminar (2021)
- "Cloudy with a chance of funding: some new projects on cataracts and corneal edema in mice" Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital (2021)
- "Taking a good look at the corneal H+ transporter SLC4A11" Department of Physiology and Biophysics Seminar, University at Buffalo (2020)
- "Dispatches from the anterior segment" Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital (2019)
- "A novel mouse model demonstrates the vital importance of bicarbonate transport" UB School of Pharmacy and Pharmaceutical Sciences Seminar (2018)
- "All About That Base: The Vital Importance of Bicarbonate Transport" Buffalo State University Seminar (2018)
- "All About That Base: A novel mouse model demonstrates the Vital Importance of Bicarbonate Transport" Department of Physiology and Biophysics Seminar, University at Buffalo (2018)
- "Features of the pH-sensitive H+/OH- conduction mediated by SLC4A11" Canadian Society for Molecular Biosciences 61st Annual Conference; Satellite Meeting on pH regulation (2018)
- "Signs of proximal renal tubular acidosis without acidemia in an Nbce1b-null mouse" Canadian Society for Molecular Biosciences 61st Annual Conference (2018)
- "Blood Acid and Blindness" Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital (2017)
- "Slc4a11: a H+ channel in HCO3- transporter’s clothing" Department of Physiology and Biophysics Research Seminar (2017)
- "Blood Acid and Blindness" MSTP Seminar, University at Buffalo (2017)
- "Bicarbonate transporters and eye pathophysiology" International Union of Physiological Sciences (IUPS) 38th World Congress (2017)
- "A Shortage of Baking Soda: Defective bicarbonate transport in individuals with acidic blood" School of Exercise and Nutrition Sciences Seminar, UB (2017)
- "The role of a novel proton channel in corneal health and disease" Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital (2016)
- "A Shortage of Baking Soda: Defective bicarbonate transport in individuals with acidic blood and abnormal teeth" Oral Biology Seminar, University at Buffalo (2016)
- "What is a boron transporter doing in the corneal endothelium?" Department of Ophthalmology Joint Vision Lab Group Meeting, VA Hospital (2015)
- "A Shortage of Baking Soda: Defective bicarbonate transport in individuals with acidic blood" Membrane Transport Group Seminar. University of Alberta (2014)
- "The basis of eye diseases associated with defective bicarbonate transporters" SUNY Eye Institute Symposium (2014)
- "The molecular basis of eye diseases associated with defective bicarbonate transporters" Department of Ophthalmology Joint Vision Lab Group Meeting, Veterans Administration (VA) Hospital (2014)
- "Bicarbonate transport in health and disease" Medical School Training Program (MSTP) Seminar (2014)
- "The importance of sodium-coupled bicarbonate transporters" Molecular and Developmental Genetics Seminar, Roswell Park Cancer Institute (2014)
Service Activities:
- Teaching and Learning Committee; assessing how teaching effectiveness is reported in promotion dossiers; Committee Chair (2023–present)
- PPBS Steering Committee (2022–present)
- Ad hoc committee for the study of a Faculty Satisfaction Survey (2021–present)
- Director of Assessment Search Committee (2021–present)
- Frontiers in Physiology – Membrane Physiology and Membrane Biophysics; Review Editor (2021–present)
- "Metabolic Acidosis: New Challenges and New Solutions" for the 56th Annual Congress of the Brazilian Physiological Society; Plenary Session Organizer and Co-chair (2021)
- "The Clinical and Physiological Importance of Acid-Base Balance" for the 56th Annual Congress of the Brazilian Physiological Society; Symposium Session Organizer and Co-chair (2021)
- Graduate Women in Science (GWIS) National Fellowship Program Committee; Reviewer (2020)
- ; Departmental Seminar Series Coordinator (2020–2021)
- IFR Policy Review Committee (2020)
- ad hoc Committee to Promote Wellness at the Jacobs School; Ad hoc Committee Member (2020)
- ; Senator (2019–2020)
- Kidney 360 (online journal for the Journal of the American Society of Nephrology; Editorial Board Member (2019–present)
- Curriculum Advisory Task Force member (Phase1 subcommittee) (2019–2020)
- Select Committee for Facilities Planning and Space Allocation; JSMBS Select Committee Member (2019–2020)
- Physiology Chair Search (2019)
- Medical School Curriculum Redesign: Phase 1 and Phase 3 subcommittees (2019–present)
- Hong Memorial Lecture Committee; Committee Chair (2019–present)
- JSMBS Appeals Committee; Committee Member and occasional ad hoc Chair (2019–present)
- Graduate Program Admissions Committee; Member (2019–present)
- 2019 Experimental Biology meeting in Orlando, FL (sponsored by the American Physiological Society). “pH Homeostasis and Acid-Base Transport”; Symposium Session Organizer and Co-chair (2019)
- Fight for Sight Foundation Postdoctoral Grant Application; Reviewer (2018)
- American Society of Nephology’s TREKS (Kidney Tutored Research and Education for Kidney Scholars) program; Mentor (2018–present)
- Hosted local high school student for a summer research project; Mentor (2017)
- American Journal of Physiology: Cell Physiology Editorial Advisory Board Member; Advisory Board (2016–present)
- JSMBS Faculty Council Steering Committee; Secretary (2016–2018)
- Search for new faculty member (2016–2017)
- Hosted local Notre Dame undergraduate student for a summer research project; Mentor (2016)
- UB Medical School Research Forum; Poster Judge (2016–present)
- PPBS Admissions Committee; Reviewer/ Alternate Reviewer (2014–2019)
- The American Journal of Physiology: Renal Physiology, The British Journal of Ophthalmology, Human Molecular Genetics, Human Mutation, Biochim Biophys Acta, The Journal of Physiology, Science Signaling, Scientific Reports, Frontiers in Membrane Physiology and Biophysics; ad hoc reviewer (2013–present)