Mark D. Parker PhD

Mark Parker

Mark D. Parker

Associate Professor

Department of Physiology and Biophysics

Jacobs School of Medicine & Biomedical Sciences

Specialty/Research Focus

Inherited Metabolic Disorders; Membrane Transport (Ion Transport); Molecular and Cellular Biology; Molecular Basis of Disease; Molecular genetics; Protein Function and Structure; Transgenic organisms; Vision science

Contact Information
4158 JSMBS
955 Main Street
Buffalo, NY 14203
Phone: 716-829-3966
Fax: NA

Professional Summary:

Most physiological processes and numerous disease states influence or are influenced by pH. Even relatively small deviations in whole body pH can have devastating consequences for our health. Our bodies are subject to a constant challenge from dietary and metabolic acids, thus it is critical for the body to have mechanisms that tightly regulate pH.

Blood plasma pH is maintained at a value close to 7.4, predominantly thanks to the buffering action of 24 mM bicarbonate (HCO3-). HCO3- neutralizes acid, generating carbon dioxide and water (HCO3- + H+ to CO2 + H2O), preventing lethal acidosis.

I study the SLC4 family of membrane proteins that move acid/base equivalents across cell membranes. Notable members include [1] the Na/2HCO3 cotransporter NBCe1-A that reclaims HCO3- from filtered blood plasma in kidney tubules (preventing loss of vital plasma HCO3- to the urine), [2] NBCe1-B that promotes fluid removal from the corneal stroma (preventing corneal edema and vision loss), [3] the Cl-HCO3 exchanger AE1 that promotes O2-CO2 exchange in red blood cells, and [4] SLC4A11 that conducts H+ and promotes corneal clarity.

Dysfunction of SLC4 family members is associated with renal tubular acidosis, blindness, cancer, deafness, epilepsy, and hypertension.

Course Director for PGY405/505 (Cellular and Molecular Physiology)
Course Co-Director for IMC512 (Renal Module)

Education and Training:

  • PhD, Biochemistry, University of Bristol (2000)
  • BS, Biochemistry, University of Bristol, with honours (1995)


  • Associate Professor, Physiology and Biophysics, University at Buffalo (2019-present)
  • Assistant Professor, Physiology and Biophysics, University at Buffalo (2013–2019)
  • Instructor, Physiology and Biophysics, Case Western Reserve University (2008–2013)
  • Postdoctoral Research Associate, Cellular and Molecular Physiology, Yale University, Yale School of Medicine (2003–2007)

Awards and Honors:

  • New Investigator Award from the Cell and Molecular Physiology Section of the American Physiological Society (2017)
  • American Physiological Society Star Reviewer (2017)
  • Carl W. Gottschalk Research Fellow of the ASN Foundation for Kidney Research (2015)
  • The Recognition Award for Meritorious Research by a Young Investigator (2012)

Research Expertise:

  • Acid-base homeostasis
  • Epithelial Physiology
  • Ion transport
  • Molecular Biology
  • Renal Physiology

Grants and Sponsored Research:

  • September 2019–August 2024
    Renal considerations in the heat stress and hydration recommendations
    NIH National Institute for Occupational Safety and Health
    Role: Co-Investigator
  • February 2018–January 2023
    Investigating the Action and Physiological Role of Slc4a11 in the Cornea
    NIH National Eye Institute
    Role: Principal Investigator
  • July 2015–June 2017
    Cause and correction of acidosis by the renal sodium/bicarbonate cotransport NBCe1
    ASN Foundation for Kidney Research
    Role: Principal Investigator
  • December 2011–November 2013
    Functional role of transporter Slc4a11 (BTR1/NaBC1) in the cornea
    NIH National Eye Institute
    Role: Co-Principal Investigator

Journal Articles:

See all (34 more)

Books and Book Chapters:

  • Boron, WF, Parker MD. Bicarbonate physiology and pathophysiology. 2012.
  • Parker MD, Boron, WF. Sodium-coupled bicarbonate transporters. 2007.

Service Activities:

  • American Journal of Physiology: Cell Physiology Editorial Advisory Board Member; Advisory Board (2016–present)
  • JSMBS Faculty Council Steering Committee; Secretary (2016–2018)

School News:

In the Media:

Clinical Specialties:

Clinical Offices:

Insurance Accepted:

Contact Information

4158 JSMBS
955 Main Street
Buffalo, NY 14203
Phone: 716-829-3966
Fax: NA