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Mark                           Parker

Mark D. Parker PhD

Department of Physiology and Biophysics

Assistant Professor

Professional Summary:

Most physiological processes and numerous disease states influence or are influenced by pH. Even relatively small deviations in whole body pH can have devastating consequences for our health. Our bodies are subject to a constant challenge from dietary and metabolic acids, thus it is critical for the body to have mechanisms that tightly regulate pH.

Blood plasma pH is maintained at a value close to 7.4, predominantly thanks to the buffering action of 24 mM bicarbonate (HCO3-). HCO3- neutralizes acid, generating carbon dioxide and water (HCO3- + H+ to CO2 + H2O), preventing lethal acidosis.

I study the SLC4 family of membrane proteins that move HCO3- across cell membranes. Notable members include [1] the Na/2HCO3 cotransporter NBCe1-A that reclaims HCO3- from filtered blood plasma in kidney tubules (preventing loss of vital plasma HCO3- to the urine), [2] NBCe1-B that promotes fluid removal from the corneal stroma (preventing corneal edema and vision loss), [3] the Cl-HCO3 exchanger AE1 that promotes O2-CO2 exchange in red blood cells, and [4] SLC4A11 that conducts H+ and promotes corneal clarity.

Dysfunction of SLC4 family members is associated with renal tubular acidosis, blindness, cancer, deafness, epilepsy, and hypertension.

Education and Training:
  • PhD, Biochemistry, University of Bristol (2000)
  • BS, Biochemistry, University of Bristol, with honours (1995)
  • Instructor, Physiology and Biophysics, Case Western Reserve University (2008–2013)
Awards and Honors:
  • Carl W. Gottschalk Research Fellow of the ASN Foundation for KIdney Research (2015)
  • The Recognition Award for Meritorious Research by a Young Investigator (2012)

Research Expertise:
  • Acid-base homeostasis
  • Ion transport
  • Molecular Biology
Grants and Sponsored Research:
  • December 2011–November 2013
    Functional role of transporter Slc4a11 (BTR1/NaBC1) in the cornea
    NIH National Eye Institute
    Role: Co-Investigator

Journal Articles:
See all (24 more)
Books and Book Chapters:
  • Boron, WF, Parker MD. Bicarbonate physiology and pathophysiology. 2012.
  • Parker MD, Boron, WF. Sodium-coupled bicarbonate transporters. 2007.

School News:
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Clinical Specialties:
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Contact Information

202 Cary Hall
Buffalo, NY 14214
Phone: 716-829-3966
Fax: NA

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