University at Buffalo (UB)
Pui Man Rosalind Lai M.D.
Pui Man Rosalind Lai
M.D.
Assistant Professor
Jacobs School of Medicine & Biomedical Sciences
Specialty/Research Focus
Brain Tumor; Cardiovascular Disease; Cerebrovascular (Stroke); Clinical Outcomes; Clinical Research; Neurological Surgery; Radiology - Vascular and Interventional; Surgery - Endovascular; Surgery - Vascular; Translational Research; Tumor Microenvironment; Vascular and Interventional Radiology; Vascular Malformations; Vascular Medicine; Women’s Health
Education and Training:
- Fellowship, Neuroendovascular Surgery, University at Buffalo Neurosurgery (2023)
- Residency, Neurosurgery, Brigham and Women's Hospital/Boston Children's Hospital (2022)
- Internship, Neurosurgery, Brigham and Women's Hospital/Boston Children's Hospital (2016)
- MD, Neurosurgery, Harvard Medical School, Cum Laude (2015)
- BA, Neuroscience, Wellesley College, Summa Cum Laude (2011)
Employment:
- Associate Professor, Neurosurgery, University at Buffalo (2023-present)
Awards and Honors:
- Young Investigator Grant (2023)
- Women's Brain Initiative Grant (2018)
Journal Articles:
- Housley SB, Turner RC, Bouslama M, Lim J, Raygor KP, Lai PMR, Monteiro A, Baig AA, Nyabuto E, Davies JM, Siddiqui AH, Snyder KV, Levy EI. (2023) Expansion and Subsequent Rupture of Carotid Pseudoaneurysm After Tandem Carotid and Middle Cerebral Artery Occlusion Treated With Mechanical Thrombectomy and Carotid Stenting. Operative neurosurgery (Hagerstown, Md.) (Jun).
- Baig AA, Lai PMR, Turner RC, Donnelly BM, Kuo CC, Lim J, Raygor KP, Bouslama M, Prasad S, Fayyaz N, Snyder KV, Davies JM, Siddiqui AH, Levy EI. (2023) Hyperacute stenting and angioplasty for acute extracranial non-tandem internal carotid artery strokes within the first 48 h: A 20-year experience and a systematic review and meta-analysis. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (May)15910199231164510.
- Becerril-Gaitan A, Ding D, Ironside N, Buell TJ, Kansagra AP, Lanzino G, Brinjikji W, Kim L, Levitt MR, Abecassis IJ, Bulters D, Durnford A, Fox WC, Blackburn S, Chen PR, Polifka AJ, Laurent D, Gross B, Hayakawa M, Derdeyn C, Amin-Hanjani S, Alaraj A, van Dijk JMC, Potgieser ARE, Starke RM, Peterson EC, Satomi J, Tada Y, Abla AA, Winkler EA, Du R, Lai PMR, Zipfel GJ, Chen CJ, Sheehan JP, . (2023) The VEBAS score: a practical scoring system for intracranial dural arteriovenous fistula obliteration. Journal of neurointerventional surgery (May).
- Monteiro A, Lim J, Siddiqi M, Donnelly BM, Khawar W, Baig A, Turner RC, Bouslama M, Raygor KP, Lai PMR, Housley SB, Davies JM, Snyder KV, Siddiqui AH, Levy EI. (2023) The first decade of flow diversion for intracranial aneurysms with the Pipeline embolization device. Neurosurgical focus (May), 54(5): E2.
- Bouslama M, Kuo CC, Monteiro A, Lim J, Turner R, Raygor K, Lai PMR, Baig AA, Davies JM, Snyder KV, Levy EI, Siddiqui AH. (2023) Mechanical thrombectomy versus medical management for acute basilar artery occlusions: A meta-analysis of randomized trials. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (Apr)15910199231157924.
- Baig AA, Waqas M, Turner RC, Kuo CC, Donnelly BM, Lai PMR, Raygor KP, Bouslama M, Lim J, Neumaier Bs J, Cappuzzo JM, Davies JM, Snyder KV, Siddiqui AH, Levy EI. (2023) A propensity score-matched comparative study of balloon guide catheters versus conventional guide catheters for concurrent mechanical thrombectomy with carotid stenting in tandem strokes: comparison of first pass effect, symptomatic intracranial hemorrhage, and 90-day functional outcomes. Journal of neurointerventional surgery (Apr).
- Lai PMR, Ryu JY, Park SC, Gross BA, Dickinson LD, Dagen S, Aziz-Sultan MA, Boulos AS, Barrow DL, Batjer HH, Blackburn S, Chang EF, Chen PR, Colby GP, Cosgrove GR, David CA, Day AL, Frerichs KU, Niemela M, Ojemann SG, Patel NJ, Shi X, Valle-Giler EP, Wang AC, Welch BG, Zusman EE, Weiss ST, Du R. (2022) Somatic Variants in SVIL in Cerebral Aneurysms. Neurology. Genetics (Dec), 8(6): e200040. doi:10.1212/NXG.0000000000200040
- Sanchez S, Raghuram A, Wendt L, Hayakawa M, Chen CJ, Sheehan JP, Kim LJ, Abecassis IJ, Levitt MR, Meyer RM, Guniganti R, Kansagra AP, Lanzino G, Giordan E, Brinjikji W, Bulters DO, Durnford A, Fox WC, Smith J, Polifka AJ, Gross B, Amin-Hanjani S, Alaraj A, Kwasnicki A, Starke RM, Chen SH, van Dijk JMC, Potgieser ARE, Satomi J, Tada Y, Phelps R, Abla A, Winkler E, Du R, Lai PMR, Zipfel GJ, Derdeyn C, Samaniego EA. (2022) Natural history, angiographic presentation and outcomes of anterior cranial fossa dural arteriovenous fistulas. Journal of neurointerventional surgery (Aug).
- Yearley AG, Bernstock JD, Kappel AD, Chen JA, Torio E, Gupta S, Lai PMR, Patel NJ. (2022) "Recycling" A Failed Superficial Temporal Artery Indirect Bypass into a Double Barrel Direct Bypass in Moyamoya Disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Aug), 31(8): 106581.
- Cerecedo-Lopez CD, Ng I, Nguyen HB, Lai PMR, Gormley WB, Patel N, Frerichs KU, Aziz-Sultan MA, Du R. (2022) Incidence and Outcomes of Registry-Based Acute Myocardial Infarction After Aneurysmal Subarachnoid Hemorrhage. Neurocritical care (Jun), 36(3): 772-780.
- Snider SB, Migdady I, LaRose SL, Mckeown ME, Regenhardt RW, Lai PMR, Vaitkevicius H, Du R. (2022) Transcranial-Doppler-Measured Vasospasm Severity is Associated with Delayed Cerebral Infarction After Subarachnoid Hemorrhage. Neurocritical care (Jun), 36(3): 815-821.
- Lai PMR, Jimenez M, Du R, Rexrode K. (2022) Association of Reproductive Life Span and Age at Menopause With the Risk of Aneurysmal Subarachnoid Hemorrhage. Neurology (May), 98(20): e2005-e2012. doi:10.1212/WNL.0000000000200222
- Lai PMR, Gomez-Paz S, Patel NJ, Frerichs KU, Thomas AJ, Aziz-Sultan MA, Patel AB, Ogilvy CS, Du R. (2022) Asymptomatic Moyamoya Disease in a North American Adult Cohort. World neurosurgery (May), 161: e146-e153.
- Chen CJ, Buell TJ, Ding D, Guniganti R, Kansagra AP, Lanzino G, Giordan E, Kim LJ, Levitt MR, Abecassis IJ, Bulters D, Durnford A, Fox WC, Polifka AJ, Gross BA, Hayakawa M, Derdeyn CP, Samaniego EA, Amin-Hanjani S, Alaraj A, Kwasnicki A, van Dijk JMC, Potgieser ARE, Starke RM, Sur S, Satomi J, Tada Y, Abla AA, Winkler EA, Du R, Lai PMR, Zipfel GJ, Sheehan JP, , . (2022) Intervention for unruptured high-grade intracranial dural arteriovenous fistulas: a multicenter study. Journal of neurosurgery (Apr), 136(4): 962-970.
- Abecassis IJ, Meyer RM, Levitt MR, Sheehan JP, Chen CJ, Gross BA, Lockerman A, Fox WC, Brinjikji W, Lanzino G, Starke RM, Chen SH, Potgieser ARE, van Dijk JMC, Durnford A, Bulters D, Satomi J, Tada Y, Kwasnicki A, Amin-Hanjani S, Alaraj A, Samaniego EA, Hayakawa M, Derdeyn CP, Winkler E, Abla A, Lai PMR, Du R, Guniganti R, Kansagra AP, Zipfel GJ, Kim LJ, , . (2022) Assessing the rate, natural history, and treatment trends of intracranial aneurysms in patients with intracranial dural arteriovenous fistulas: a Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR) investigation. Journal of neurosurgery (Apr), 136(4): 971-980.
- Abecassis IJ, Meyer RM, Levitt MR, Sheehan JP, Chen CJ, Gross BA, Smith J, Fox WC, Giordan E, Lanzino G, Starke RM, Sur S, Potgieser ARE, van Dijk JMC, Durnford A, Bulters D, Satomi J, Tada Y, Kwasnicki A, Amin-Hanjani S, Alaraj A, Samaniego EA, Hayakawa M, Derdeyn CP, Winkler E, Abla A, Lai PMR, Du R, Guniganti R, Kansagra AP, Zipfel GJ, Kim LJ, , . (2022) Recurrence after cure in cranial dural arteriovenous fistulas: a collaborative effort by the Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR). Journal of neurosurgery (Apr), 136(4): 981-989.
- Guniganti R, Giordan E, Chen CJ, Abecassis IJ, Levitt MR, Durnford A, Smith J, Samaniego EA, Derdeyn CP, Kwasnicki A, Alaraj A, Potgieser ARE, Sur S, Chen SH, Tada Y, Winkler E, Phelps RRL, Lai PMR, Du R, Abla A, Satomi J, Starke RM, van Dijk JMC, Amin-Hanjani S, Hayakawa M, Gross BA, Fox WC, Bulters D, Kim LJ, Sheehan J, Lanzino G, Piccirillo JF, Kansagra AP, Zipfel GJ, , . (2022) Consortium for Dural Arteriovenous Fistula Outcomes Research (CONDOR): rationale, design, and initial characterization of patient cohort. Journal of neurosurgery (Apr), 136(4): 951-961.
- Samaniego EA, Roa JA, Hayakawa M, Chen CJ, Sheehan JP, Kim LJ, Abecassis IJ, Levitt MR, Guniganti R, Kansagra AP, Lanzino G, Giordan E, Brinjikji W, Bulters D, Durnford A, Fox WC, Polifka AJ, Gross BA, Amin-Hanjani S, Alaraj A, Kwasnicki A, Starke RM, Sur S, van Dijk JMC, Potgieser ARE, Satomi J, Tada Y, Abla A, Winkler E, Du R, Lai PMR, Zipfel GJ, Derdeyn CP, , . (2022) Dural arteriovenous fistulas without cortical venous drainage: presentation, treatment, and outcomes. Journal of neurosurgery (Apr), 136(4): 942-950.
- Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. (2022) Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation: A Matched Case-Control Study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Mar), 31(3): 106268.
- Lai PMR, Caragher S, Patel NJ, Du R, Ali Aziz-Sultan M. (2022) Safety Profile and Factors Associated With Good Outcome for Endovascularly Treated Infectious Intracranial Aneurysms. Neurosurgery (Feb), 90(2): 233-239.
- Li Y, Chen SH, Guniganti R, Kansagra AP, Piccirillo JF, Chen CJ, Buell T, Sheehan JP, Ding D, Lanzino G, Brinjikji W, Kim LJ, Levitt MR, Abecassis IJ, Bulters DO, Durnford A, Fox WC, Polifka AJ, Gross BA, Sur S, McCarthy DJ, Yavagal DR, Peterson EC, Hayakawa M, Derdeyn C, Samaniego EA, Amin-Hanjani S, Alaraj A, Kwasnicki A, Charbel FT, van Dijk JMC, Potgieser AR, Satomi J, Tada Y, Abla A, Phelps R, Du R, Lai PMR, Zipfel GJ, Starke RM, . (2022) Onyx embolization for dural arteriovenous fistulas: a multi-institutional study. Journal of neurointerventional surgery (Jan), 14(1).
- Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer V, Shadick N, Savova G, Murphy SN, Cai T, Weiss ST, Du R. (2021) Geometric variations associated with posterior communicating artery aneurysms. Journal of neurointerventional surgery (Nov), 13(11): 1049-1052.
- Gupta S, Vicenty-Padilla J, Lai PMR, Zhou X, Bernstock JD, Chua M, Izzy S, Aziz-Sultan MA, Du R, Patel NJ. (2021) Posterior Cerebral Artery Aneurysm Re-Rupture Following Revascularization for Moyamoya Disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (Nov), 30(11): 106048.
- Lai PMR, Ng I, Gormley WB, Patel N, Frerichs KU, Aziz-Sultan MA, Du R. (2021) Cannabis Use and Increased Nonaneurysmal Subarachnoid Hemorrhage in the Past Decade. World neurosurgery (Oct), 154: e580-e589.
- Lai PMR, Patel NJ, Frerichs KU, Patel AB, Aziz-Sultan MA, Ogilvy CS, Du R. (2021) Direct vs Indirect Revascularization in a North American Cohort of Moyamoya Disease. Neurosurgery (Jul), 89(2): 315-322.
- Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. (2021) Vascular Geometry Associated with Anterior Communicating Artery Aneurysm Formation. World neurosurgery (Feb), 146: e1318-e1325. doi:10.1016/j.wneu.2020.11.160
- Zhang J, Lai PMR, Can A, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. (2021) Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms. Scientific reports (Feb), 11(1): 4791. doi:10.1038/s41598-021-84315-5
- Lai PMR, Ng I, Gormley WB, Patel NJ, Frerichs KU, Aziz-Sultan MA, Du R. (2021) Familial Predisposition and Differences in Radiographic Patterns in Spontaneous Nonaneurysmal Subarachnoid Hemorrhage. Neurosurgery (Jan), 88(2): 413-419.
- Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. (2021) Morphological variables associated with ruptured basilar tip aneurysms. Scientific reports (Jan), 11(1): 2526. doi:10.1038/s41598-021-81364-8
- Lai PMR, Du R. (2020) Return to Driving Is a Better Predictor of Patient Outcome Than Return to Work After Aneurysmal Subarachnoid Hemorrhage. World neurosurgery (Dec), 144: e285-e295.
- Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. (2020) Surrounding vascular geometry associated with basilar tip aneurysm formation. Scientific reports (Oct), 10(1): 17928. doi:10.1038/s41598-020-74266-8
- Silva MA, Lai PMR, Du R, Aziz-Sultan MA, Patel NJ. (2020) The Ruptured Arteriovenous Malformation Grading Scale (RAGS): An Extension of the Hunt and Hess Scale to Predict Clinical Outcome for Patients With Ruptured Brain Arteriovenous Malformations. Neurosurgery (Aug), 87(2): 193-199.
- Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Yu S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. (2020) Age and morphology of posterior communicating artery aneurysms. Scientific reports (Jul), 10(1): 11545. doi:10.1038/s41598-020-68276-9
- Lai PMR, Gormley WB, Patel N, Frerichs KU, Aziz-Sultan MA, Du R. (2019) Age-Dependent Radiographic Vasospasm and Delayed Cerebral Ischemia in Women After Aneurysmal Subarachnoid Hemorrhage. World neurosurgery (Oct), 130: e230-e235.
- Lai PMR, Du R. (2019) Differentially Expressed Genes Associated with the Estrogen Receptor Pathway in Cerebral Aneurysms. World neurosurgery (Jun), 126: e557-e563.
- Can A, Lai PMR, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R. (2019) Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms. Scientific reports (Apr), 9(1): 6054. doi:10.1038/s41598-019-42622-y
- Lai PMR, See AP, Silva MA, Gormley WB, Frerichs KU, Aziz-Sultan MA, Du R. (2019) Noninfectious Fever in Aneurysmal Subarachnoid Hemorrhage: Association with Cerebral Vasospasm and Clinical Outcome. World neurosurgery (Feb), 122: e1014-e1019.
- Lai PMR, Zaazoue MA, Francois R, Dupervil DG, Berkowitz AL, Alexandrescu S, Proctor MR. (2018) Neurenteric cyst at the dorsal craniocervical junction in a child: Case report. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (Feb), 48: 86-89.
- See AP, Wu KC, Lai PM, Gross BA, Du R. (2016) Risk factors for hyponatremia in aneurysmal subarachnoid hemorrhage. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (Oct), 32: 115-8.
- Lai PM, Du R. (2016) Association between S100B Levels and Long-Term Outcome after Aneurysmal Subarachnoid Hemorrhage: Systematic Review and Pooled Analysis. PloS one (Jan), 11(3): e0151853. doi:10.1371/journal.pone.0151853
- Zygourakis CC, Vasudeva V, Lai PM, Kim AH, Wang H, Du R. (2015) Transient pupillary dilation following local papaverine application in intracranial aneurysm surgery. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (Apr), 22(4): 676-9.
- Gross BA, Lai PM, Du R. (2014) Impact of aneurysm location on hemorrhage risk. Clinical neurology and neurosurgery (Aug), 123: 78-82.
- Lai PM, Lin N, Du R. (2014) Effect of teaching hospital status on outcome of aneurysm treatment. World neurosurgery (Jan), 82(3-4): 380-385.e6.
- Lai PM, Dasenbrock H, Du R. (2014) The association between meteorological parameters and aneurysmal subarachnoid hemorrhage: a nationwide analysis. PloS one (Jan), 9(11): e112961. doi:10.1371/journal.pone.0112961
- Gross BA, Lai PM, Frerichs KU, Du R. (2013) Angiotensin-converting enzyme-inhibitors, statins and the risk of hemorrhage from cerebral dural arteriovenous fistulae. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (Sep), 20(9): 1228-31.
- Gross BA, Lai PM, Du R. (2013) Hydrocephalus after arteriovenous malformation rupture. Neurosurgical focus (May), 34(5): E11.
- Lai PM, Dasenbrock H, Lin N, Du R. (2013) The impact of insurance status on the outcomes after aneurysmal subarachnoid hemorrhage. PloS one (Jan), 8(10): e78047. doi:10.1371/journal.pone.0078047
Professional Memberships:
- American Association of Neurological Surgeons
- Congress of Neurological Surgeons
- Society of Neurointerventional Surgery