Ali A. El Solh MD, MPH

Ali El Solh

Ali A. El Solh
MD, MPH

Professor

Department of Medicine

Jacobs School of Medicine & Biomedical Sciences


Specialty/Research Focus

Pulmonary & Critical Care Medicine; Sleep Medicine

Contact Information
VA Western New York
Medical Research Bldg
3495 Bailey Avenue
Buffalo, New York 14215
Phone: (716) 862-6528
Fax: (716) 862-6526
solh@buffalo.edu



Professional Summary:

I am a Professor of Medicine and Epidemiology and Environmental Health at the University at Buffalo, and I hold both a clinical appointment and an administrative position at the VA WNY Healthcare System. Aside from overseeing the Research operation at the VA Western New York, I attend and supervise the sleep clinic at the VA.

My research focuses on the association between sleep apnea and cardiovascular diseases. My laboratory examines the burden of oxidative stress on endothelial function and the link to endothelial apoptosis. As part of a VA merit review grant, we are engaged in determining the impact of obstructive sleep apnea on the manifestations of post-traumatic stress disorder (PTSD) in veterans and whether treatment of sleep apnea alleviates the debilitating symptoms of PTSD. Toward that goal, we have adopted a patented screening tool to identify patients with sleep apnea.

My research in the critical care arena involves the epidemiology and risk factors of the newly emergent COVID-19. In addition, I continue to participate in a collaborative study on examining virulent factors of Pseudomonas infections with type III secretory system. The goal is to develop a rapid diagnostic tool to identify these organisms early in the course of infection. My other projects include studying the role of adjuvant treatment with corticosteroids in the management of severe community acquired pneumonia, such as nursing home acquired pneumonia, the management of morbidly obese critically ill patients and the long-term outcomes of elderly patients after treatment from a critical care ailment.

Education and Training:

  • MPH, Public Health, Medical College of Wisconsin (2002)
  • MD, Medicine, American University of Beirut, Lebanon (1989)
  • American University of Beirut, Lebanon (1985)

Employment:

  • Lead VISN2, Research Advisory Council, VHA (2020-present)
  • Data Safety, Monitoring Board, Clinical Service R&D, VHA (2017-present)
  • Professor of Anesthesiology, Anesthesiology, University at Buffalo (2011-present)
  • Research Professor of Epidemiology & Environmental Health, School of Public Health & Health Professions, University at Buffalo (2011-present)
  • Associate Fellowship Director, Sleep Medicine, University at Buffalo (2008-present)
  • Director, Western New York Respiratory Research Center, University at Buffalo (2001-present)
  • Associate Chief of Staff for Research and Devolpment, VA Western New York Healthcare System (2013-present)
  • Professor of Medicine, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2011-present)
  • Research Professor, School of Health Related Professions, University at Buffalo School of Health Related Professions (2007-present)
  • Director, James P. Nolan Clinical Research Center, University at Buffalo (2001-present)
  • Attending Physician, Buffalo General Hospital (1996-present)
  • Interim Chief of Staff, VA Western New York Healthcare System (2013–2016)
  • Attending Physician/Pulmonary Service, VAMC (1996–2013)
  • Associate Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (2004–2011)
  • Director/Medical ICU, ECMC (1998–2008)
  • Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1998–2004)
  • Clinical Assistant Professor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1997–1998)
  • Clinical Instructor, Medicine, University at Buffalo Jacobs School of Medicine & Biomedical Sciences (1996–1997)
See all (8 more)

Awards and Honors:

  • Barnwell Award Review Panel 2021/05 ZRD1 BARN-A(01) (2021)
  • Barnwell Award 2020/05 ZRD1 BARN-A(01) (2020)
  • Visionary Innovator (2012)
  • Visionary Innovator (2009)
  • NHLBI Study Section on Clinical Trials (2016-2026)

Research Expertise:

  • Health care associated pneumonia
  • Morbid obesity in the intensive care unit
  • Sleep disordered breathing in cardiovascular disease

Grants and Sponsored Research:

  • May 2019–May 2024
    Effectiveness of Combining Behavioral and Pharmacologic Therapy for Complex Insomnia in Veterans With PTSD (PRECEPT-D)
    US Department of Veterans Affairs
    Role: Principal Investigator
  • October 2012–September 2015
    A Randomized study comparing CPAP to oral appliance in patients with PTSD and sleep apnea
    US Department of Veterans Affairs
    Role: Principal Investigator
  • January 2010–January 2015
    Randomized, Placebo-Controlled, Double-Blind Clinical Trial to Evaluate the Safety and Efficacy of Low-Dose Methylprednisolone in Hospitalized Veterans with Severe Community-Acquired Pneumonia. VA Cooperative study Program #574.
    Veterans Affairs
    Role: Principal Investigator
  • May 2011–May 2013
    VA Cooperative Study No. 574ESCAPe [Extended Steroid (in) CAP(e)]
    Veterans Administration
    Role: Principal Investigator
  • January 2010–January 2011
    Sleep apnea screening in patients with ischemic cardiac diseases. HSR&D Merit Review: PPO 10-087-1
    US Department of Veterans Affairs
    Role: Principal Investigator
  • January 1999–December 2000
    Obstructive sleep apnea in ischemic heart disease
    Research for Health in Erie County
    Role: Principal Investigator
  • January 1998–December 1999
    The use of neural network in the diagnosis of sleep apnea
    Research for Health in Erie County
    Role: Principal Investigator
  • January 2007
    Tigecycline Inhibits Staphylococcal Exotoxin-Induced Cytokines: An Anti-Inflammatory Property.
    Wyeth
    Role: Principal Investigator
  • January 2005
    Linezolid In The Treatment Of Subjects With Nosocomial Pneumonia Proven To Be Due To Methicillin-Resistant Staphylococcus Aureus. Pfizer Pharmaceuticals Group.
    Role: Principal Investigator

Patents:

  • Articial Network Artificial neural network for predicting respiratory disturbances (1969)
  • CPAP, titration using artificial neural network

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Contact Information

VA Western New York
Medical Research Bldg
3495 Bailey Avenue
Buffalo, New York 14215
Phone: (716) 862-6528
Fax: (716) 862-6526
solh@buffalo.edu