UB Lab Selected as Part of Statewide Effort to ID Variants

The Genomics and Bioinformatics Core in UB’s New York State Center of Excellence in Bioinformatics and Life Sciences was one of five labs chosen statewide as part of a $20 million sequencing partnership between the state Department of Health’s Wadsworth Center and external laboratories.

The effort aims to greatly expand genetic sequencing on SARS-CoV-2 positive specimens derived from the general population of New York State (outside of New York City) thus building on the state’s current robust genome/variant surveillance efforts.

In addition to surveillance, the data generated will help build the state’s understanding of disease manifestations, therapy or vaccine evasion and efficacy, and will support other discoveries to inform public health intervention.

Sequencing results from the partner laboratories will be reported to the New York State Department of Health and the Global Initiative on Sharing Avian Influenza Data.

“The University at Buffalo is pleased to be selected to contribute to this statewide effort to combat COVID-19,” says Michael E. Cain, MD, UB’s vice president for health sciences and dean of the Jacobs School of Medicine and Biomedical Sciences. “Our Genomics and Bioinformatics Core has, throughout the pandemic, played a vital role in sequencing SARS-CoV-2 and identifying COVID-19 variants in Western New York.”

The project at UB is being led by Jennifer A. Surtees, PhD, associate professor of biochemistry and co-director of UB’s Genome, Environment and Microbiome Community of Excellence.

Surtees and her colleagues at UB’s New York State Center of Excellence in Bioinformatics and Life Sciences have been conducting the only genomic sequencing of COVID-19 samples in Western New York, and are among the few labs in the state (outside of New York City) that have been sequencing throughout the pandemic.

Their work has identified the highly transmissible delta variant, among others, in Erie County.

“The more information we have about the viruses circulating in Western New York, the better prepared we are to make public health policy decisions, to respond to the current situation in terms of mitigation measures and clinical decisions and protect our communities,” says Surtees, adding that the project wouldn’t have been possible without the university’s investment in the genomics and bioinformatics core.

In April 2020, Surtees began a project to perform genomic sequencing of SARS-Cov2 in Buffalo, in collaboration with the Erie County Department of Health, which provided de-identified samples from COVID-positive patients, and the UB Genomics and Bioinformatics Core. 

“We have been sequencing SARS-CoV-2 throughout the pandemic, which has enabled us to infer migration of the virus into Erie County and evolution of the virus in the region,” she says.

The UB team has since expanded its partner network, receiving samples from Kaleida Health, Erie County Medical Center and KSL Diagnostics.

“This put us in a strong position to partner with New York State in this latest initiative to expand our sequencing capacity,” Surtees says. “We are very excited to be able to continue to contribute to the statewide effort to combat the COVID-19 pandemic by providing timely public health information.”

In addition to UB, the four other labs selected are located at:

• Cornell University
• New York Medical College
• SUNY Upstate Medical University
• University of Rochester Medical Center