Please join us on Monday, February 22nd for a GEM Work-in-Progress talk presented by Jessy Alexander, PhD, Research Professor, Department of Medicine, Jacobs School of Medicine & Biomedical Sciences.
To Join The Zoom Meeting
Meeting ID: 940 5840 4491 Passcode: 820423
"Complement, microbiome and lupus."
Systemic lupus erythematosus (lupus) is an autoimmune disease with no effective treatment. Hence, identification of effective therapeutic targets is an urgent need. It is known that gut microbial dysbiosis can lead to the development of diseases such as lupus. In addition, complement activation occurs in lupus generating C3a and C5a that are increased in circulation and is a part of the clinical profile. Although data in lupus patients and mouse models support an association between microbiome and lupus, complement and lupus, complement and microbiome, how these three aspects – lupus, microbiome and complement are linked, their role in disease development and gender bias still remains an enigma. Our work will step into this gap and attempt to identify the connection between microbiome and complement (C) cascade, an arm of the innate immune system that is altered in lupus, using the well-established mouse model, MRL/lpr mice.
These informal talks are part of the GEM Work-in-Progress series held at 4:00 p.m. on the 4th Monday of each month. Talks will take place remotely via Zoom or Webex. The speaker schedule is available on the GEM website: www.buffalo.edu/gem.
GEM is currently seeking faculty and student speakers for our 2021 series! If you would like to present at a GEM Work-in-Progress session, please let us know (firstname.lastname@example.org) and we will get you onto the schedule.